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Q62424

- HXA13_MOUSE

UniProt

Q62424 - HXA13_MOUSE

Protein

Homeobox protein Hox-A13

Gene

Hoxa13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi320 – 37960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: MGI
    5. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. anatomical structure morphogenesis Source: MGI
    2. artery morphogenesis Source: MGI
    3. branching involved in prostate gland morphogenesis Source: MGI
    4. embryonic forelimb morphogenesis Source: MGI
    5. endothelial cell fate specification Source: MGI
    6. endothelial cell morphogenesis Source: MGI
    7. inner ear development Source: MGI
    8. male genitalia development Source: MGI
    9. organ morphogenesis Source: MGI
    10. positive regulation of mesenchymal cell apoptotic process Source: MGI
    11. positive regulation of mitosis Source: MGI
    12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    13. regulation of BMP signaling pathway Source: MGI
    14. tissue homeostasis Source: MGI
    15. transcription, DNA-templated Source: UniProtKB-KW
    16. vasculogenesis Source: MGI
    17. ventricular septum development Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A13
    Alternative name(s):
    Homeobox protein Hox-1.10
    Gene namesi
    Name:Hoxa13
    Synonyms:Hox-1.10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96173. Hoxa13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Hoxa13 are the cause of hypodactyly (Hd), a condition characterized by profound deficiency of digital arch structures.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi366 – 3661I → A: Decreased DNA binding and transcriptional activity. 1 Publication
    Mutagenesisi370 – 3701N → A: Decreased DNA binding and transcriptional activity. 1 Publication
    Mutagenesisi373 – 3731V → A: Decreased DNA binding and transcriptional activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Homeobox protein Hox-A13PRO_0000200102Add
    BLAST

    Proteomic databases

    PRIDEiQ62424.

    PTM databases

    PhosphoSiteiQ62424.

    Expressioni

    Gene expression databases

    CleanExiMM_HOXA13.
    GenevestigatoriQ62424.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Meis1Q60954-23EBI-925160,EBI-445723

    Protein-protein interaction databases

    BioGridi200366. 4 interactions.
    IntActiQ62424. 3 interactions.

    Structurei

    Secondary structure

    1
    386
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi329 – 34113
    Helixi347 – 35711
    Helixi362 – 38120

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LD5NMR-A320-386[»]
    ProteinModelPortaliQ62424.
    SMRiQ62424. Positions 320-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ62424.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi38 – 5114Poly-AlaAdd
    BLAST
    Compositional biasi52 – 576Poly-Gly
    Compositional biasi62 – 665Poly-Ala
    Compositional biasi73 – 8412Poly-AlaAdd
    BLAST
    Compositional biasi101 – 1044Poly-Ala
    Compositional biasi116 – 13318Poly-AlaAdd
    BLAST
    Compositional biasi198 – 2058Poly-Ala

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG276440.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiQ62424.
    KOiK09298.
    PhylomeDBiQ62424.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62424-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA    50
    AGAGGGGFPH PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG 100
    AAAAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA 150
    KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA 200
    AAAFADKYMD TAGPAAEEFS SRAKEFAFYH QGYAAGPYHH HQPVPGYLDM 250
    PVVPGLGGPG ESRHEPLGLP MESYQPWALP NGWNGQMYCP KEQTQPPHLW 300
    KSTLPDVVSH PSDASSYRRG RKKRVPYTKV QLKELEREYA TNKFITKDKR 350
    RRISATTNLS ERQVTIWFQN RRVKEKKVIN KLKTTS 386
    Length:386
    Mass (Da):39,567
    Last modified:November 1, 1996 - v1
    Checksum:i2B01DCC9B1951324
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59322 Genomic DNA. Translation: AAB03322.1.
    RefSeqiNP_032290.1. NM_008264.1.
    UniGeneiMm.377086.

    Genome annotation databases

    GeneIDi15398.
    KEGGimmu:15398.
    UCSCiuc029vvl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59322 Genomic DNA. Translation: AAB03322.1 .
    RefSeqi NP_032290.1. NM_008264.1.
    UniGenei Mm.377086.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LD5 NMR - A 320-386 [» ]
    ProteinModelPortali Q62424.
    SMRi Q62424. Positions 320-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200366. 4 interactions.
    IntActi Q62424. 3 interactions.

    PTM databases

    PhosphoSitei Q62424.

    Proteomic databases

    PRIDEi Q62424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15398.
    KEGGi mmu:15398.
    UCSCi uc029vvl.1. mouse.

    Organism-specific databases

    CTDi 3209.
    MGIi MGI:96173. Hoxa13.

    Phylogenomic databases

    eggNOGi NOG276440.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi Q62424.
    KOi K09298.
    PhylomeDBi Q62424.

    Miscellaneous databases

    EvolutionaryTracei Q62424.
    NextBioi 288086.
    PROi Q62424.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HOXA13.
    Genevestigatori Q62424.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation."
      Mortlock D.P., Post L.C., Innis J.W.
      Nat. Genet. 13:284-289(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction."
      Williams T.M., Williams M.E., Innis J.W.
      Dev. Biol. 277:457-471(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEIS1; MEIS2 AND MEIS3.
    3. "Structural basis for sequence specific DNA binding and protein dimerization of HOXA13."
      Zhang Y., Larsen C.A., Stadler H.S., Ames J.B.
      PLoS ONE 6:E23069-E23069(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 320-386 IN COMPLEX WITH DNA, SUBUNIT, MUTAGENESIS OF ILE-366; ASN-370 AND VAL-373.

    Entry informationi

    Entry nameiHXA13_MOUSE
    AccessioniPrimary (citable) accession number: Q62424
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3