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Q62424

- HXA13_MOUSE

UniProt

Q62424 - HXA13_MOUSE

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Protein
Homeobox protein Hox-A13
Gene
Hoxa13, Hox-1.10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi320 – 37960Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: MGI
  5. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. artery morphogenesis Source: MGI
  3. branching involved in prostate gland morphogenesis Source: MGI
  4. embryonic forelimb morphogenesis Source: MGI
  5. endothelial cell fate specification Source: MGI
  6. endothelial cell morphogenesis Source: MGI
  7. inner ear development Source: MGI
  8. male genitalia development Source: MGI
  9. organ morphogenesis Source: MGI
  10. positive regulation of mesenchymal cell apoptotic process Source: MGI
  11. positive regulation of mitosis Source: MGI
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. regulation of BMP signaling pathway Source: MGI
  14. tissue homeostasis Source: MGI
  15. transcription, DNA-templated Source: UniProtKB-KW
  16. vasculogenesis Source: MGI
  17. ventricular septum development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A13
Alternative name(s):
Homeobox protein Hox-1.10
Gene namesi
Name:Hoxa13
Synonyms:Hox-1.10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96173. Hoxa13.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Hoxa13 are the cause of hypodactyly (Hd), a condition characterized by profound deficiency of digital arch structures.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi366 – 3661I → A: Decreased DNA binding and transcriptional activity. 1 Publication
Mutagenesisi370 – 3701N → A: Decreased DNA binding and transcriptional activity. 1 Publication
Mutagenesisi373 – 3731V → A: Decreased DNA binding and transcriptional activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386Homeobox protein Hox-A13
PRO_0000200102Add
BLAST

Proteomic databases

PRIDEiQ62424.

PTM databases

PhosphoSiteiQ62424.

Expressioni

Gene expression databases

CleanExiMM_HOXA13.
GenevestigatoriQ62424.

Interactioni

Subunit structurei

Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Meis1Q60954-23EBI-925160,EBI-445723

Protein-protein interaction databases

BioGridi200366. 4 interactions.
IntActiQ62424. 3 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi329 – 34113
Helixi347 – 35711
Helixi362 – 38120

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LD5NMR-A320-386[»]
ProteinModelPortaliQ62424.
SMRiQ62424. Positions 320-386.

Miscellaneous databases

EvolutionaryTraceiQ62424.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 5114Poly-Ala
Add
BLAST
Compositional biasi52 – 576Poly-Gly
Compositional biasi62 – 665Poly-Ala
Compositional biasi73 – 8412Poly-Ala
Add
BLAST
Compositional biasi101 – 1044Poly-Ala
Compositional biasi116 – 13318Poly-Ala
Add
BLAST
Compositional biasi198 – 2058Poly-Ala

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG276440.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiQ62424.
KOiK09298.
PhylomeDBiQ62424.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62424-1 [UniParc]FASTAAdd to Basket

« Hide

MTASVLLHPR WIEPTVMFLY DNGGGLVADE LNKNMEGAAA AAAAAAAAAA    50
AGAGGGGFPH PAAAAAGGNF SVAAAAAAAA AAAANQCRNL MAHPAPLAPG 100
AAAAYSSAPG EAPPSAAAAA AAAAAAAAAA AAASSSGGPG PAGPAGAEAA 150
KQCSPCSAAA QSSSGPAALP YGYFGSGYYP CARMGPHPNA IKSCAQPASA 200
AAAFADKYMD TAGPAAEEFS SRAKEFAFYH QGYAAGPYHH HQPVPGYLDM 250
PVVPGLGGPG ESRHEPLGLP MESYQPWALP NGWNGQMYCP KEQTQPPHLW 300
KSTLPDVVSH PSDASSYRRG RKKRVPYTKV QLKELEREYA TNKFITKDKR 350
RRISATTNLS ERQVTIWFQN RRVKEKKVIN KLKTTS 386
Length:386
Mass (Da):39,567
Last modified:November 1, 1996 - v1
Checksum:i2B01DCC9B1951324
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59322 Genomic DNA. Translation: AAB03322.1.
RefSeqiNP_032290.1. NM_008264.1.
UniGeneiMm.377086.

Genome annotation databases

GeneIDi15398.
KEGGimmu:15398.
UCSCiuc029vvl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59322 Genomic DNA. Translation: AAB03322.1 .
RefSeqi NP_032290.1. NM_008264.1.
UniGenei Mm.377086.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LD5 NMR - A 320-386 [» ]
ProteinModelPortali Q62424.
SMRi Q62424. Positions 320-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200366. 4 interactions.
IntActi Q62424. 3 interactions.

PTM databases

PhosphoSitei Q62424.

Proteomic databases

PRIDEi Q62424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15398.
KEGGi mmu:15398.
UCSCi uc029vvl.1. mouse.

Organism-specific databases

CTDi 3209.
MGIi MGI:96173. Hoxa13.

Phylogenomic databases

eggNOGi NOG276440.
HOGENOMi HOG000231176.
HOVERGENi HBG106958.
InParanoidi Q62424.
KOi K09298.
PhylomeDBi Q62424.

Miscellaneous databases

EvolutionaryTracei Q62424.
NextBioi 288086.
PROi Q62424.
SOURCEi Search...

Gene expression databases

CleanExi MM_HOXA13.
Genevestigatori Q62424.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation."
    Mortlock D.P., Post L.C., Innis J.W.
    Nat. Genet. 13:284-289(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction."
    Williams T.M., Williams M.E., Innis J.W.
    Dev. Biol. 277:457-471(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEIS1; MEIS2 AND MEIS3.
  3. "Structural basis for sequence specific DNA binding and protein dimerization of HOXA13."
    Zhang Y., Larsen C.A., Stadler H.S., Ames J.B.
    PLoS ONE 6:E23069-E23069(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 320-386 IN COMPLEX WITH DNA, SUBUNIT, MUTAGENESIS OF ILE-366; ASN-370 AND VAL-373.

Entry informationi

Entry nameiHXA13_MOUSE
AccessioniPrimary (citable) accession number: Q62424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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