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Q62419

- SH3G1_MOUSE

UniProt

Q62419 - SH3G1_MOUSE

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Protein
Endophilin-A2
Gene
Sh3gl1, Sh3d2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in endocytosis. May recruit other proteins to membranes with high curvature By similarity.

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. endocytosis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-A2
Alternative name(s):
Endophilin-2
SH3 domain protein 2B
SH3 domain-containing GRB2-like protein 1
SH3p8
Gene namesi
Name:Sh3gl1
Synonyms:Sh3d2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:700010. Sh3gl1.

Subcellular locationi

Cytoplasm By similarity. Early endosome membrane; Peripheral membrane protein By similarity. Cell projectionpodosome By similarity
Note: Associated with postsynaptic endosomes in hippocampal neurons By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB-KW
  3. early endosome membrane Source: UniProtKB-SubCell
  4. podosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Endophilin-A2
PRO_0000146745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881Phosphoserine1 Publication
Modified residuei315 – 3151Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62419.
PaxDbiQ62419.
PRIDEiQ62419.

PTM databases

PhosphoSiteiQ62419.

Expressioni

Gene expression databases

BgeeiQ62419.
CleanExiMM_SH3GL1.
GenevestigatoriQ62419.

Interactioni

Subunit structurei

Interacts with ARC, SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
FauP355453EBI-642935,EBI-309546

Protein-protein interaction databases

BioGridi203207. 4 interactions.
IntActiQ62419. 8 interactions.
MINTiMINT-238674.
STRINGi10090.ENSMUSP00000003268.

Structurei

3D structure databases

ProteinModelPortaliQ62419.
SMRiQ62419. Positions 30-252, 305-368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 249232BAR
Add
BLAST
Domaini306 – 36560SH3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2121Membrane-binding amphipathic helix By similarity
Add
BLAST
Regioni60 – 8728Required for dimerization upon membrane association By similarity
Add
BLAST
Regioni218 – 25437Interaction with ARC By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili180 – 25071 Reviewed prediction
Add
BLAST

Domaini

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes By similarity.

Sequence similaritiesi

Belongs to the endophilin family.
Contains 1 BAR domain.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG307129.
GeneTreeiENSGT00550000074464.
HOGENOMiHOG000231641.
HOVERGENiHBG052866.
InParanoidiQ62419.
KOiK11247.
OMAiGGFSCNP.
OrthoDBiEOG7G1V6H.
PhylomeDBiQ62419.
TreeFamiTF313281.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10661:SF125. PTHR10661:SF125. 1 hit.
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62419-1 [UniParc]FASTAAdd to Basket

« Hide

MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKDMEKKV DVTSKAVAEV    50
LVRTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMVRH 100
GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCDKD 150
LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS 200
MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILEELADKL KRRVREASSR 250
PKREFKPRPR EPFELGELEQ PNGGFPCAPA PKITASSSFR SSDKPIRMPS 300
KSMPPLDQPS CKALYDFEPE NDGELGFREG DLITLTNQID ENWYEGMLHG 350
QSGFFPLSYV QVLVPLPQ 368
Length:368
Mass (Da):41,518
Last modified:November 1, 1996 - v1
Checksum:i3F753B1669086353
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58885 mRNA. Translation: AAC71775.1.
CCDSiCCDS28891.1.
RefSeqiNP_038692.1. NM_013664.3.
UniGeneiMm.1773.

Genome annotation databases

EnsembliENSMUST00000003268; ENSMUSP00000003268; ENSMUSG00000003200.
GeneIDi20405.
KEGGimmu:20405.
UCSCiuc008daq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58885 mRNA. Translation: AAC71775.1 .
CCDSi CCDS28891.1.
RefSeqi NP_038692.1. NM_013664.3.
UniGenei Mm.1773.

3D structure databases

ProteinModelPortali Q62419.
SMRi Q62419. Positions 30-252, 305-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203207. 4 interactions.
IntActi Q62419. 8 interactions.
MINTi MINT-238674.
STRINGi 10090.ENSMUSP00000003268.

PTM databases

PhosphoSitei Q62419.

Proteomic databases

MaxQBi Q62419.
PaxDbi Q62419.
PRIDEi Q62419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003268 ; ENSMUSP00000003268 ; ENSMUSG00000003200 .
GeneIDi 20405.
KEGGi mmu:20405.
UCSCi uc008daq.2. mouse.

Organism-specific databases

CTDi 6455.
MGIi MGI:700010. Sh3gl1.

Phylogenomic databases

eggNOGi NOG307129.
GeneTreei ENSGT00550000074464.
HOGENOMi HOG000231641.
HOVERGENi HBG052866.
InParanoidi Q62419.
KOi K11247.
OMAi GGFSCNP.
OrthoDBi EOG7G1V6H.
PhylomeDBi Q62419.
TreeFami TF313281.

Miscellaneous databases

ChiTaRSi SH3GL1. mouse.
NextBioi 298376.
PROi Q62419.
SOURCEi Search...

Gene expression databases

Bgeei Q62419.
CleanExi MM_SH3GL1.
Genevestigatori Q62419.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR028501. Endophilin-A.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR10661:SF125. PTHR10661:SF125. 1 hit.
Pfami PF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
    Sparks A.B., Hoffman N.G., McConnell S.J., Fowlkes D.M., Kay B.K.
    Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 228-239, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSH3G1_MOUSE
AccessioniPrimary (citable) accession number: Q62419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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