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Q62419

- SH3G1_MOUSE

UniProt

Q62419 - SH3G1_MOUSE

Protein

Endophilin-A2

Gene

Sh3gl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Implicated in endocytosis. May recruit other proteins to membranes with high curvature By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW

    Keywords - Biological processi

    Endocytosis

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endophilin-A2
    Alternative name(s):
    Endophilin-2
    SH3 domain protein 2B
    SH3 domain-containing GRB2-like protein 1
    SH3p8
    Gene namesi
    Name:Sh3gl1
    Synonyms:Sh3d2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:700010. Sh3gl1.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity. Cell projectionpodosome By similarity
    Note: Associated with postsynaptic endosomes in hippocampal neurons.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell projection Source: UniProtKB-KW
    3. early endosome membrane Source: UniProtKB-SubCell
    4. podosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell projection, Cytoplasm, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 368368Endophilin-A2PRO_0000146745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei288 – 2881Phosphoserine1 Publication
    Modified residuei315 – 3151Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ62419.
    PaxDbiQ62419.
    PRIDEiQ62419.

    PTM databases

    PhosphoSiteiQ62419.

    Expressioni

    Gene expression databases

    BgeeiQ62419.
    CleanExiMM_SH3GL1.
    GenevestigatoriQ62419.

    Interactioni

    Subunit structurei

    Interacts with ARC, SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FauP355453EBI-642935,EBI-309546

    Protein-protein interaction databases

    BioGridi203207. 4 interactions.
    IntActiQ62419. 8 interactions.
    MINTiMINT-238674.
    STRINGi10090.ENSMUSP00000003268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62419.
    SMRiQ62419. Positions 30-252, 305-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 249232BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 36560SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2121Membrane-binding amphipathic helixBy similarityAdd
    BLAST
    Regioni60 – 8728Required for dimerization upon membrane associationBy similarityAdd
    BLAST
    Regioni218 – 25437Interaction with ARCBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili180 – 25071Sequence AnalysisAdd
    BLAST

    Domaini

    An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.By similarity

    Sequence similaritiesi

    Belongs to the endophilin family.Curated
    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG307129.
    GeneTreeiENSGT00550000074464.
    HOGENOMiHOG000231641.
    HOVERGENiHBG052866.
    InParanoidiQ62419.
    KOiK11247.
    OMAiGGFSCNP.
    OrthoDBiEOG7G1V6H.
    PhylomeDBiQ62419.
    TreeFamiTF313281.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10661:SF125. PTHR10661:SF125. 1 hit.
    PfamiPF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVAGLKKQF YKASQLVSEK VGGAEGTKLD DDFKDMEKKV DVTSKAVAEV    50
    LVRTIEYLQP NPASRAKLTM LNTVSKIRGQ VKNPGYPQSE GLLGECMVRH 100
    GKELGGESNF GDALLDAGES MKRLAEVKDS LDIEVKQNFI DPLQNLCDKD 150
    LKEIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF EESKEVAETS 200
    MHNLLETDIE QVSQLSALVD AQLDYHRQAV QILEELADKL KRRVREASSR 250
    PKREFKPRPR EPFELGELEQ PNGGFPCAPA PKITASSSFR SSDKPIRMPS 300
    KSMPPLDQPS CKALYDFEPE NDGELGFREG DLITLTNQID ENWYEGMLHG 350
    QSGFFPLSYV QVLVPLPQ 368
    Length:368
    Mass (Da):41,518
    Last modified:November 1, 1996 - v1
    Checksum:i3F753B1669086353
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58885 mRNA. Translation: AAC71775.1.
    CCDSiCCDS28891.1.
    RefSeqiNP_038692.1. NM_013664.3.
    UniGeneiMm.1773.

    Genome annotation databases

    EnsembliENSMUST00000003268; ENSMUSP00000003268; ENSMUSG00000003200.
    GeneIDi20405.
    KEGGimmu:20405.
    UCSCiuc008daq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58885 mRNA. Translation: AAC71775.1 .
    CCDSi CCDS28891.1.
    RefSeqi NP_038692.1. NM_013664.3.
    UniGenei Mm.1773.

    3D structure databases

    ProteinModelPortali Q62419.
    SMRi Q62419. Positions 30-252, 305-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203207. 4 interactions.
    IntActi Q62419. 8 interactions.
    MINTi MINT-238674.
    STRINGi 10090.ENSMUSP00000003268.

    PTM databases

    PhosphoSitei Q62419.

    Proteomic databases

    MaxQBi Q62419.
    PaxDbi Q62419.
    PRIDEi Q62419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003268 ; ENSMUSP00000003268 ; ENSMUSG00000003200 .
    GeneIDi 20405.
    KEGGi mmu:20405.
    UCSCi uc008daq.2. mouse.

    Organism-specific databases

    CTDi 6455.
    MGIi MGI:700010. Sh3gl1.

    Phylogenomic databases

    eggNOGi NOG307129.
    GeneTreei ENSGT00550000074464.
    HOGENOMi HOG000231641.
    HOVERGENi HBG052866.
    InParanoidi Q62419.
    KOi K11247.
    OMAi GGFSCNP.
    OrthoDBi EOG7G1V6H.
    PhylomeDBi Q62419.
    TreeFami TF313281.

    Miscellaneous databases

    ChiTaRSi SH3GL1. mouse.
    NextBioi 298376.
    PROi Q62419.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62419.
    CleanExi MM_SH3GL1.
    Genevestigatori Q62419.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR028501. Endophilin-A.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10661:SF125. PTHR10661:SF125. 1 hit.
    Pfami PF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
      Sparks A.B., Hoffman N.G., McConnell S.J., Fowlkes D.M., Kay B.K.
      Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 228-239, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    3. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSH3G1_MOUSE
    AccessioniPrimary (citable) accession number: Q62419
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3