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Protein

Apoptosis-stimulating of p53 protein 1

Gene

Ppp1r13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity).By similarity

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6804759 Regulation of TP53 Activity through Association with Co-factors

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
Gene namesi
Name:Ppp1r13b
Synonyms:Aspp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1336199 Ppp1r13b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669631 – 1087Apoptosis-stimulating of p53 protein 1Add BLAST1087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineBy similarity1
Modified residuei335PhosphoserineBy similarity1
Modified residuei552Asymmetric dimethylarginineCombined sources1
Modified residuei679PhosphoserineBy similarity1
Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ62415
MaxQBiQ62415
PaxDbiQ62415
PeptideAtlasiQ62415
PRIDEiQ62415

PTM databases

iPTMnetiQ62415
PhosphoSitePlusiQ62415

Expressioni

Gene expression databases

BgeeiENSMUSG00000021285
ExpressionAtlasiQ62415 baseline and differential
GenevisibleiQ62415 MM

Interactioni

Subunit structurei

Interacts with TP53.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204283, 3 interactors
IntActiQ62415, 1 interactor
STRINGi10090.ENSMUSP00000062464

Structurei

3D structure databases

ProteinModelPortaliQ62415
SMRiQ62415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati917 – 949ANK 1Add BLAST33
Repeati950 – 982ANK 2Add BLAST33
Domaini1016 – 1078SH3PROSITE-ProRule annotationAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 292Gln-richAdd BLAST161
Compositional biasi446 – 857Pro-richAdd BLAST412

Domaini

The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.By similarity

Sequence similaritiesi

Belongs to the ASPP family.Curated

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0515 Eukaryota
ENOG410Y17W LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000034106
HOVERGENiHBG050596
InParanoidiQ62415
KOiK17554
OMAiPPKNYQP
OrthoDBiEOG091G0R1R
PhylomeDBiQ62415
TreeFamiTF105545

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR028319 ASPP_1
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR24131:SF5 PTHR24131:SF5, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q62415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GGCHLAEVWR
60 70 80 90 100
GSERPIPYDH MMYEHLQKWG PRREEVKFFL RHEDSPTESS EQGARQTQEQ
110 120 130 140 150
RTQRSVVNVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV
160 170 180 190 200
AKEQRLHFLK QQERRQQQSV SENEKLQKLK ERVEAQENKL KKIRAMRGQV
210 220 230 240 250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL
260 270 280 290 300
NGFQSYNGRL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
310 320 330 340 350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI
360 370 380 390 400
QVPSTGGFPL PGDPVKPQSL TIASSAAHGR SKSANDGNWP PLKQNSASVK
410 420 430 440 450
STQMTGDWKD SGMEGTLKQG AISSQPLPLS ALGATEKLGI EIGKGPPPIP
460 470 480 490 500
GVGKPLPPSY GTYPSSGPLG PGSTSSLERR KEGSLPRPGA GPPSRQKPAP
510 520 530 540 550
LPPASNAPQP GSSQQIQQRI SVPPSPTYPP AGPPAFPTGD GKPELPLTVA
560 570 580 590 600
IRPFLADKGS RPQSPRKGPQ TVNSSSIYSM YLQQATPPKN YQPPAHGTLN
610 620 630 640 650
KSVKAVYGKP VLPSGSASPS PLPFLHGSLG TGTAQPQPPS DSAEKEPEQE
660 670 680 690 700
GPSVPGEGST VESLPRPLSP TKLTPIVHSP LRYQSDADLE ALRRKLANAP
710 720 730 740 750
RPLKKRSSIT EPEGPGGPNI QKLLYQRFNT LAGGMEGTPF YQPSPSQDFV
760 770 780 790 800
GTLADMDNGN TNANGNLDEP FPPRPTAPLP EELAPSSDAN DNELPSPEPE
810 820 830 840 850
ELICPQTTHQ TAEPTEDNNN NVAPVPSTEQ IPSPVAEAPS EEDQVPPAPL
860 870 880 890 900
SPVIHPPAAS ASKRTNLKKP NSERTGHGLR VRFNPLALLL DASLEGEFDL
910 920 930 940 950
VQRIIYEVED PSKPNDEGIT PLHNAVCAGH HHIVKFLLDF GVNVNAADSD
960 970 980 990 1000
GWTPLHCAAS CNSVHLCKQL VESGAAIFAS TISDIETAAD KCEEMEEGYI
1010 1020 1030 1040 1050
QCSQFLYGVQ EKLGVMNKGT VYALWDYEAQ NSDELSFHEG DAITILRRKD
1060 1070 1080
ENETEWWWAR LGDREGYVPK NLLGLYPRIK PRQRTLA
Length:1,087
Mass (Da):119,170
Last modified:August 15, 2003 - v2
Checksum:i8B3E9CC4B2390F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054788 mRNA Translation: AAH54788.1
BC053092 mRNA Translation: AAH53092.1
U58881 mRNA Translation: AAC52638.1
CCDSiCCDS56866.1
RefSeqiNP_035755.1, NM_011625.1
UniGeneiMm.313076

Genome annotation databases

EnsembliENSMUST00000054815; ENSMUSP00000062464; ENSMUSG00000021285
GeneIDi21981
KEGGimmu:21981
UCSCiuc007ped.1 mouse

Similar proteinsi

Entry informationi

Entry nameiASPP1_MOUSE
AccessioniPrimary (citable) accession number: Q62415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 15, 2003
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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