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Protein

Apoptosis-stimulating of p53 protein 1

Gene

Ppp1r13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
Gene namesi
Name:Ppp1r13b
Synonyms:Aspp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1336199. Ppp1r13b.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic (By similarity). Some fraction is nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Apoptosis-stimulating of p53 protein 1PRO_0000066963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineBy similarity
Modified residuei679 – 6791PhosphoserineBy similarity
Modified residuei708 – 7081PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ62415.
MaxQBiQ62415.
PaxDbiQ62415.
PRIDEiQ62415.

PTM databases

iPTMnetiQ62415.
PhosphoSiteiQ62415.

Expressioni

Gene expression databases

BgeeiQ62415.
ExpressionAtlasiQ62415. baseline and differential.
GenevisibleiQ62415. MM.

Interactioni

Subunit structurei

Interacts with TP53.By similarity

Protein-protein interaction databases

BioGridi204283. 3 interactions.
STRINGi10090.ENSMUSP00000062464.

Structurei

3D structure databases

ProteinModelPortaliQ62415.
SMRiQ62415. Positions 1-83, 884-1080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati917 – 94933ANK 1Add
BLAST
Repeati950 – 98233ANK 2Add
BLAST
Domaini1016 – 107863SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 292161Gln-richAdd
BLAST
Compositional biasi446 – 857412Pro-richAdd
BLAST

Domaini

The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53.By similarity

Sequence similaritiesi

Belongs to the ASPP family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0515. Eukaryota.
ENOG410Y17W. LUCA.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000034106.
HOVERGENiHBG050596.
InParanoidiQ62415.
KOiK17554.
OMAiLPQNYGT.
OrthoDBiEOG73FQKX.
PhylomeDBiQ62415.
TreeFamiTF105545.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GGCHLAEVWR
60 70 80 90 100
GSERPIPYDH MMYEHLQKWG PRREEVKFFL RHEDSPTESS EQGARQTQEQ
110 120 130 140 150
RTQRSVVNVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV
160 170 180 190 200
AKEQRLHFLK QQERRQQQSV SENEKLQKLK ERVEAQENKL KKIRAMRGQV
210 220 230 240 250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL
260 270 280 290 300
NGFQSYNGRL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
310 320 330 340 350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI
360 370 380 390 400
QVPSTGGFPL PGDPVKPQSL TIASSAAHGR SKSANDGNWP PLKQNSASVK
410 420 430 440 450
STQMTGDWKD SGMEGTLKQG AISSQPLPLS ALGATEKLGI EIGKGPPPIP
460 470 480 490 500
GVGKPLPPSY GTYPSSGPLG PGSTSSLERR KEGSLPRPGA GPPSRQKPAP
510 520 530 540 550
LPPASNAPQP GSSQQIQQRI SVPPSPTYPP AGPPAFPTGD GKPELPLTVA
560 570 580 590 600
IRPFLADKGS RPQSPRKGPQ TVNSSSIYSM YLQQATPPKN YQPPAHGTLN
610 620 630 640 650
KSVKAVYGKP VLPSGSASPS PLPFLHGSLG TGTAQPQPPS DSAEKEPEQE
660 670 680 690 700
GPSVPGEGST VESLPRPLSP TKLTPIVHSP LRYQSDADLE ALRRKLANAP
710 720 730 740 750
RPLKKRSSIT EPEGPGGPNI QKLLYQRFNT LAGGMEGTPF YQPSPSQDFV
760 770 780 790 800
GTLADMDNGN TNANGNLDEP FPPRPTAPLP EELAPSSDAN DNELPSPEPE
810 820 830 840 850
ELICPQTTHQ TAEPTEDNNN NVAPVPSTEQ IPSPVAEAPS EEDQVPPAPL
860 870 880 890 900
SPVIHPPAAS ASKRTNLKKP NSERTGHGLR VRFNPLALLL DASLEGEFDL
910 920 930 940 950
VQRIIYEVED PSKPNDEGIT PLHNAVCAGH HHIVKFLLDF GVNVNAADSD
960 970 980 990 1000
GWTPLHCAAS CNSVHLCKQL VESGAAIFAS TISDIETAAD KCEEMEEGYI
1010 1020 1030 1040 1050
QCSQFLYGVQ EKLGVMNKGT VYALWDYEAQ NSDELSFHEG DAITILRRKD
1060 1070 1080
ENETEWWWAR LGDREGYVPK NLLGLYPRIK PRQRTLA
Length:1,087
Mass (Da):119,170
Last modified:August 15, 2003 - v2
Checksum:i8B3E9CC4B2390F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054788 mRNA. Translation: AAH54788.1.
BC053092 mRNA. Translation: AAH53092.1.
U58881 mRNA. Translation: AAC52638.1.
CCDSiCCDS56866.1.
RefSeqiNP_035755.1. NM_011625.1.
UniGeneiMm.313076.

Genome annotation databases

EnsembliENSMUST00000054815; ENSMUSP00000062464; ENSMUSG00000021285.
GeneIDi21981.
KEGGimmu:21981.
UCSCiuc007ped.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054788 mRNA. Translation: AAH54788.1.
BC053092 mRNA. Translation: AAH53092.1.
U58881 mRNA. Translation: AAC52638.1.
CCDSiCCDS56866.1.
RefSeqiNP_035755.1. NM_011625.1.
UniGeneiMm.313076.

3D structure databases

ProteinModelPortaliQ62415.
SMRiQ62415. Positions 1-83, 884-1080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204283. 3 interactions.
STRINGi10090.ENSMUSP00000062464.

PTM databases

iPTMnetiQ62415.
PhosphoSiteiQ62415.

Proteomic databases

EPDiQ62415.
MaxQBiQ62415.
PaxDbiQ62415.
PRIDEiQ62415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054815; ENSMUSP00000062464; ENSMUSG00000021285.
GeneIDi21981.
KEGGimmu:21981.
UCSCiuc007ped.1. mouse.

Organism-specific databases

CTDi23368.
MGIiMGI:1336199. Ppp1r13b.

Phylogenomic databases

eggNOGiKOG0515. Eukaryota.
ENOG410Y17W. LUCA.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000034106.
HOVERGENiHBG050596.
InParanoidiQ62415.
KOiK17554.
OMAiLPQNYGT.
OrthoDBiEOG73FQKX.
PhylomeDBiQ62415.
TreeFamiTF105545.

Miscellaneous databases

NextBioi301692.
PROiQ62415.
SOURCEiSearch...

Gene expression databases

BgeeiQ62415.
ExpressionAtlasiQ62415. baseline and differential.
GenevisibleiQ62415. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
    Sparks A.B., Hoffman N.G., McConnell S.J., Fowlkes D.M., Kay B.K.
    Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 944-1087.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-708, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney and Lung.

Entry informationi

Entry nameiASPP1_MOUSE
AccessioniPrimary (citable) accession number: Q62415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 15, 2003
Last modified: March 16, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.