Reviewed, UniProtKB/Swiss-Prot Q62413 (EPHA6_MOUSE)

Names and origin

Protein names

Recommended name:
    Ephrin type-A receptor 6
    EC=2.7.10.1
Alternative name(s):
    EPH homology kinase 2
      Short name=EHK-2

Gene names

Name:	Epha6
Synonyms:	Ehk-2, Ehk2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1035 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 1035	1013	Ephrin type-A receptor 6		PRO_0000016816
Regions
	Topological domain	23 – 549	527	Extracellular Potential
	Transmembrane	550 – 570	21	Potential
	Topological domain	571 – 1035	465	Cytoplasmic Potential
	Domain	330 – 434	105	Fibronectin type-III 1
	Domain	438 – 533	96	Fibronectin type-III 2
	Domain	630 – 943	314	Protein kinase
	Domain	960 – 1024	65	SAM
	Nucleotide binding	636 – 644	9	ATP By similarity
	Region	33 – 206	174	Ephrin-binding
	Motif	1033 – 1035	3	PDZ-binding Potential
	Compositional bias	193 – 327	135	Cys-rich
Sites
	Active site	797	1	Proton acceptor By similarity
	Binding site	662	1	ATP By similarity
Amino acid modifications
	Modified residue	605	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	611	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	830	1	Phosphotyrosine; by autocatalysis Potential
	Modified residue	977	1	Phosphotyrosine; by autocatalysis Potential
	Glycosylation	342	1	N-linked (GlcNAc...) Potential
	Glycosylation	396	1	N-linked (GlcNAc...) Potential
	Glycosylation	409	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	477	1	T → I in BAC27868. Ref.2
	Sequence conflict	905	1	Q → H in BAC27868. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q62413-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 560B264194A5EF74	FASTA	1,035	116,137
	10 20 30 40 50 60 MGGCEVREFL LQFGFFLPLL TAWTGDCSHV SNQVVLLDTT TVMGELGWKT YPLNGWDAIT 70 80 90 100 110 120 EMDEHNRPIH TYQVCNVMEP NQNNWLRTNW ISRDAAQKIY VEMKFTLRDC NSIPWVLGTC 130 140 150 160 170 180 KETFNLYYIE SDESHGTKFK PSQYIKIDTI AADESFTQMD LGDRILKLNT EIREVGPIER 190 200 210 220 230 240 KGFYLAFQDI GACIALVSVR VFYKKCPFTV RSLAMFPDTI PRVDSSSLVE VRGSCVKSAE 250 260 270 280 290 300 ERDTPKLYCG ADGDWLVPLG RCICSTGYEE IEGSCHACRP GFYKAFAGNT KCSKCPPHSS 310 320 330 340 350 360 TYVEATSVCH CEKGYFRAEK DPPSMACTRP PSAPRNVAFN INETALILEW SPPSDTGGRK 370 380 390 400 410 420 DLTYSVICKK CGLDTTQCED CGGGLRFIPR HTGLINNSVV VLDFVSHVNY TFEIEAMNGV 430 440 450 460 470 480 SELSISPKPF TAITVTTDHD APSLIGMMRK DWASQNSLAL SWQAPAFSNG AILDYETKYY 490 500 510 520 530 540 EKEHEQLTYS STRSKAPSVI VTGLKPATTY IFHIRVRTAT GYSGYSQKFE FETGDETSDM 550 560 570 580 590 600 AAEQGQILVI ATAAVGGFTL LVILTLFFLI TGRCQWYIKA KMKSEEKRRT HLQNGHLRFP 610 620 630 640 650 660 GIKTYIDPDT YEDPSLAVHE FAKEIDPSRI RIERVIGAGE FGEVCSGRLK TPGKREIPVA 670 680 690 700 710 720 IKTLKGGHMD RQRRDFLREA SIMGQFDHPN IIRLEGVVTK RSFPAIGVEA FCPSFLRAGF 730 740 750 760 770 780 LNGIQAPHPV TAGGSLPPRI PAGRPVMIVV EYMENGSLDS FLRKHDGHFT VIQLVGMLRG 790 800 810 820 830 840 IASGMKYLSD MGYVHRDLAA RNILVNSNLV CKVSDFGLSR VLEDDPEAAY TTTGGKIPIR 850 860 870 880 890 900 WTAPEAIAYR KFSSASDAWS YGIVMWEVMS YGERPYWEMS NQDVILSIEE GYRLPAPMGC 910 920 930 940 950 960 PPSLQQLMLH CWQKERNHRP KFTDIVSFLD KLIRNPSALH TLVEDILVMP ESPGDVPEYP 970 980 990 1000 1010 1020 LFVTVGDWLD SIKMGQYKSN FMAAGFTTFD LISRMSIDDI RRIGVILIGH QRRIVSSIQT 1030 LRLHMMHIQE KGFHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea." Lee A.M., Navaratnam D., Ichimiya S., Greene M.I., Davis J.G. DNA Cell Biol. 15:817-825(1996) [PubMed: 8892754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-1035. Strain: C57BL/6J. Tissue: Olfactory bulb.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U58332 mRNA. Translation: AAB53836.1. AK032436 mRNA. Translation: BAC27868.1.
IPI	IPI00125887.
UniGene	Mm.439753 Mm.455790
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q62413.
PTM databases
PhosphoSite	Q62413.
Proteomic databases
PRIDE	Q62413.
Genome annotation databases
Ensembl	ENSMUST00000068860; ENSMUSP00000066734; ENSMUSG00000055540; Mus musculus. [Genome view]
UCSC	uc007zpo.1. mouse.
Organism-specific databases
MGI	MGI:108034. Epha6.
Phylogenomic databases
HOGENOM	HBG755340.
HOVERGEN	Q62413.
InParanoid	Q62413.
Enzyme and pathway databases
BRENDA	2.7.10.1. 244.
Gene expression databases
ArrayExpress	Q62413.
Bgee	Q62413.
CleanEx	MM_EPHA6.
Genevestigator	Q62413.
GermOnline	ENSMUSG00000055540. Mus musculus.
Family and domain databases
InterPro	IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR008979. Galactose-bd-like. IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR010993. SAM_homology. IPR021129. SAM_type1. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits.
PANTHER	PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF00536. SAM_1. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

EPHA6_MOUSE

Accession

Primary (citable) accession number: Q62413
Secondary accession number(s): Q8CCN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)