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Protein

Ephrin type-A receptor 6

Gene

Epha6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei662ATPPROSITE-ProRule annotation1
Active sitei797Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi636 – 644ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 6 (EC:2.7.10.1)
Alternative name(s):
EPH homology kinase 2
Short name:
EHK-2
Gene namesi
Name:Epha6
Synonyms:Ehk-2, Ehk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108034. Epha6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 549ExtracellularSequence analysisAdd BLAST527
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Topological domaini571 – 1035CytoplasmicSequence analysisAdd BLAST465

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi1826.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001681623 – 1035Ephrin type-A receptor 6Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei605Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei611Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei830Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei977Phosphotyrosine; by autocatalysisSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62413.
PaxDbiQ62413.
PRIDEiQ62413.

PTM databases

iPTMnetiQ62413.
PhosphoSitePlusiQ62413.

Expressioni

Gene expression databases

CleanExiMM_EPHA6.

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066734.

Structurei

3D structure databases

ProteinModelPortaliQ62413.
SMRiQ62413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 211Eph LBDPROSITE-ProRule annotationAdd BLAST179
Domaini330 – 440Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST111
Domaini441 – 536Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini630 – 943Protein kinasePROSITE-ProRule annotationAdd BLAST314
Domaini960 – 1024SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1033 – 1035PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 327Cys-richAdd BLAST135

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiQ62413.

Family and domain databases

CDDicd10484. EphR_LBD_A6. 1 hit.
cd00063. FN3. 2 hits.
Gene3Di2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR027936. Eph_TM.
IPR034280. EphA6_rcpt_lig-bd.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
PfamiView protein in Pfam
PF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 2 hits.
PF00536. SAM_1. 1 hit.
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCEVREFL LQFGFFLPLL TAWTGDCSHV SNQVVLLDTT TVMGELGWKT
60 70 80 90 100
YPLNGWDAIT EMDEHNRPIH TYQVCNVMEP NQNNWLRTNW ISRDAAQKIY
110 120 130 140 150
VEMKFTLRDC NSIPWVLGTC KETFNLYYIE SDESHGTKFK PSQYIKIDTI
160 170 180 190 200
AADESFTQMD LGDRILKLNT EIREVGPIER KGFYLAFQDI GACIALVSVR
210 220 230 240 250
VFYKKCPFTV RNLAMFPDTI PRVDSSSLVE VRGSCVKSAE ERDTPKLYCG
260 270 280 290 300
ADGDWLVPLG RCICSTGYEE IEGSCHACRP GFYKAFAGNT KCSKCPPHSS
310 320 330 340 350
TYVEATSVCH CEKGYFRAEK DPPSMACTRP PSAPRNVAFN INETALILEW
360 370 380 390 400
SPPSDTGGRK DLTYSVICKK CGLDTTQCED CGGGLRFIPR HTGLINNSVV
410 420 430 440 450
VLDFVSHVNY TFEIEAMNGV SELSISPKPF TAITVTTDHD APSLIGMMRK
460 470 480 490 500
DWASQNSLAL SWQAPAFSNG AILDYEIKYY EKEHEQLTYS STRSKAPSVI
510 520 530 540 550
VTGLKPATTY IFHIRVRTAT GYSGYSQKFE FETGDETSDM AAEQGQILVI
560 570 580 590 600
ATAAVGGFTL LVILTLFFLI TGRCQWYIKA KMKSEEKRRT HLQNGHLRFP
610 620 630 640 650
GIKTYIDPDT YEDPSLAVHE FAKEIDPSRI RIERVIGAGE FGEVCSGRLK
660 670 680 690 700
TPGKREIPVA IKTLKGGHMD RQRRDFLREA SIMGQFDHPN IIRLEGVVTK
710 720 730 740 750
RSFPAIGVEA FCPSFLRAGF LNGIQAPHPV TAGGSLPPRI PAGRPVMIVV
760 770 780 790 800
EYMENGSLDS FLRKHDGHFT VIQLVGMLRG IASGMKYLSD MGYVHRDLAA
810 820 830 840 850
RNILVNSNLV CKVSDFGLSR VLEDDPEAAY TTTGGKIPIR WTAPEAIAYR
860 870 880 890 900
KFSSASDAWS YGIVMWEVMS YGERPYWEMS NQDVILSIEE GYRLPAPMGC
910 920 930 940 950
PPSLHQLMLH CWQKERNHRP KFTDIVSFLD KLIRNPSALH TLVEDILVMP
960 970 980 990 1000
ESPGDVPEYP LFVTVGDWLD SIKMGQYKSN FMAAGFTTFD LISRMSIDDI
1010 1020 1030
RRIGVILIGH QRRIVSSIQT LRLHMMHIQE KGFHV
Length:1,035
Mass (Da):116,185
Last modified:July 27, 2011 - v2
Checksum:i9886E5A92B146E44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212N → S in AAB53836 (PubMed:8892754).Curated1
Sequence conflicti477I → T in AAB53836 (PubMed:8892754).Curated1
Sequence conflicti905H → Q in AAB53836 (PubMed:8892754).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58332 mRNA. Translation: AAB53836.1.
CH466521 Genomic DNA. Translation: EDK98232.1.
BC141090 mRNA. Translation: AAI41091.1.
AK032436 mRNA. Translation: BAC27868.1.
UniGeneiMm.455790.

Genome annotation databases

UCSCiuc012agy.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiEPHA6_MOUSE
AccessioniPrimary (citable) accession number: Q62413
Secondary accession number(s): B9EIV2, Q8CCN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families