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Q62407

- SPEG_MOUSE

UniProt

Q62407 - SPEG_MOUSE

Protein

Striated muscle-specific serine/threonine-protein kinase

Gene

Speg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1635 – 16351ATPPROSITE-ProRule annotation
    Active sitei1724 – 17241Proton acceptorBy similarity
    Active sitei3080 – 30801Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1612 – 16209ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cardiac muscle cell development Source: MGI
    2. cardiovascular system development Source: MGI
    3. in utero embryonic development Source: MGI
    4. respiratory system development Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
    Alternative name(s):
    Aortic preferentially expressed protein 1
    Short name:
    APEG-1
    Gene namesi
    Name:Speg
    Synonyms:Apeg1, Kiaa1297
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109282. Speg.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 32623262Striated muscle-specific serine/threonine-protein kinasePRO_0000072667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi994 ↔ 1046PROSITE-ProRule annotation
    Modified residuei1177 – 11771Phosphoserine2 Publications
    Disulfide bondi1413 ↔ 1469PROSITE-ProRule annotation
    Disulfide bondi2608 ↔ 2660PROSITE-ProRule annotation

    Post-translational modificationi

    May be autophosphorylated.2 Publications

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiQ62407.
    PRIDEiQ62407.

    PTM databases

    PhosphoSiteiQ62407.

    Expressioni

    Tissue specificityi

    Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.2 Publications

    Inductioni

    Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

    Gene expression databases

    ArrayExpressiQ62407.
    BgeeiQ62407.
    CleanExiMM_SPEG.
    GenevestigatoriQ62407.

    Interactioni

    Subunit structurei

    Isoform 3 is found as a monomer or homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ62407.
    SMRiQ62407. Positions 871-966.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 12682Ig-like 1Add
    BLAST
    Domaini727 – 81589Ig-like 2Add
    BLAST
    Domaini874 – 96390Ig-like 3Add
    BLAST
    Domaini968 – 106295Ig-like 4Add
    BLAST
    Domaini1069 – 115789Ig-like 5Add
    BLAST
    Domaini1193 – 128391Ig-like 6Add
    BLAST
    Domaini1290 – 138798Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1389 – 148597Ig-like 7Add
    BLAST
    Domaini1490 – 157889Ig-like 8Add
    BLAST
    Domaini1606 – 1859254Protein kinase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2586 – 267691Ig-like 9Add
    BLAST
    Domaini2683 – 277795Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2865 – 2968104Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2946 – 3213268Protein kinase 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi277 – 34872Pro-richAdd
    BLAST
    Compositional biasi530 – 639110Pro-richAdd
    BLAST
    Compositional biasi1924 – 19296Poly-Ser
    Compositional biasi1930 – 19367Poly-Glu
    Compositional biasi2180 – 2320141Pro-richAdd
    BLAST
    Compositional biasi2775 – 2962188Pro-richAdd
    BLAST
    Compositional biasi3241 – 32444Poly-Arg

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 protein kinase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117320.
    HOVERGENiHBG083339.
    InParanoidiQ62407.
    KOiK08809.
    PhylomeDBiQ62407.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07679. I-set. 8 hits.
    PF00069. Pkinase. 2 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    SM00409. IG. 4 hits.
    SM00408. IGc2. 5 hits.
    SM00220. S_TKc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 8 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00108. PROTEIN_KINASE_ST. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q62407-1) [UniParc]FASTAAdd to Basket

    Also known as: SPEG-beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP     50
    LKNAAVCAGS DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC 100
    GAQDAGVYSC SAQNERGQAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE 150
    LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE 200
    AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS 250
    LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR 300
    PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED 350
    ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA 400
    GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA 450
    WGTPEASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA 500
    QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSTPKTS 550
    RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ 600
    FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT 650
    PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR 700
    RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII 750
    TANPPPQVSW KKDGSMLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT 800
    ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE EFPEPGETWP 850
    RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE 900
    PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV 950
    NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA 1000
    DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST 1050
    AKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV 1100
    TWTHFGHPVN EGDNLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA 1150
    HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ 1200
    DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL 1250
    VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT 1300
    GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA 1350
    ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK 1400
    QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG VYELSQPDDD 1450
    QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE 1500
    VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL 1550
    SAGSQDGGVY TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR 1600
    RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE 1650
    ARLLARLQHG CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE 1700
    TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA 1750
    QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS 1800
    PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA 1850
    EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE 1900
    LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG 1950
    SRVSLTDIPT EDEALGTPEA GAATPMDWQE QERTPSKDQE APSPEALPSP 2000
    GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS 2050
    PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL 2100
    GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA 2150
    GAPLEIPVAR LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS 2200
    AVTSRDSPQP PEPQPVPEKV PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY 2250
    AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA AVFARVASPP PGVSEKRVPS 2300
    ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK FKRSRESPLS 2350
    RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL 2400
    RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA 2450
    SPVLAVRRRL SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE 2500
    GESLRRLGVP HNQLGSQTGA TTPSAESLGS EASGTSGSSA PGESRSRHRW 2550
    GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP SESDFPPVFH IKLKDQVLLE 2600
    GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD GRQLLSIPRA 2650
    GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV 2700
    WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR 2750
    VACSNRAGQG PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP 2800
    DSPTSLAPTP ALAPPASQAS TLSPSTSSMS ANQALSSLKA VGPPPATPPR 2850
    KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP DTGTLTPTSS PQGVKPAPSS 2900
    TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE VVSSPTPEST 2950
    TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR 3000
    RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF 3050
    RYSEDDVATY VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG 3100
    SAQPYNPQAL KPLGHRTGTL EFMAPEMVKG DPIGSATDIW GAGVLTYIML 3150
    SGYSPFYEPD PQETEARIVG GRFDAFQLYP NTSQSATLFL RKVLSVHPWS 3200
    RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ RRRRAEAATR 3250
    HKVLLRSYPG SP 3262
    Length:3,262
    Mass (Da):354,343
    Last modified:May 16, 2006 - v2
    Checksum:i0387BDD6518B7BB7
    GO
    Isoform 2 (identifier: Q62407-2) [UniParc]FASTAAdd to Basket

    Also known as: BPEG

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.
         107-131: VYSCSAQNERGQASCEAVLTVLEVR → MKKLWVKKRFQKTGHSRRAFGRLTH
         966-967: AH → GE
         968-3262: Missing.

    Show »
    Length:861
    Mass (Da):93,689
    Checksum:iEA162A24DDC7C597
    GO
    Isoform 3 (identifier: Q62407-3) [UniParc]FASTAAdd to Basket

    Also known as: APEG1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-854: Missing.
         966-967: AH → GE

    Note: Produced by alternative promoter usage.

    Show »
    Length:2,408
    Mass (Da):262,876
    Checksum:i639C18C8D114F389
    GO
    Isoform 4 (identifier: Q62407-4) [UniParc]FASTAAdd to Basket

    Also known as: SPEG-alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-854: Missing.

    Note: No experimental confirmation available. Produced by alternative promoter usage.

    Show »
    Length:2,408
    Mass (Da):262,899
    Checksum:i9086EDEF4F90F288
    GO

    Sequence cautioni

    The sequence AAG34791.1 differs from that shown. Reason: Frameshift at positions 2957 and 2992.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3237 – 32371L → R in BAC65770. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 854854Missing in isoform 3 and isoform 4. 2 PublicationsVSP_018264Add
    BLAST
    Alternative sequencei1 – 106106Missing in isoform 2. 3 PublicationsVSP_018265Add
    BLAST
    Alternative sequencei107 – 13125VYSCS…VLEVR → MKKLWVKKRFQKTGHSRRAF GRLTH in isoform 2. 3 PublicationsVSP_018266Add
    BLAST
    Alternative sequencei966 – 9672AH → GE in isoform 2 and isoform 3. 4 PublicationsVSP_018267
    Alternative sequencei968 – 32622295Missing in isoform 2. 3 PublicationsVSP_018268Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57098 mRNA. Translation: AAC52666.1.
    AF215896 mRNA. Translation: AAG34791.1. Frameshift.
    AK035543 mRNA. Translation: BAC29098.1.
    AK164360 mRNA. Translation: BAE37758.1.
    BC048698 mRNA. Translation: AAH48698.3.
    BC062643 mRNA. Translation: AAH62643.1.
    AK122488 mRNA. Translation: BAC65770.1.
    CCDSiCCDS35626.1. [Q62407-1]
    CCDS48292.1. [Q62407-2]
    RefSeqiNP_001078839.1. NM_001085370.1.
    NP_001078840.1. NM_001085371.1. [Q62407-2]
    NP_001166948.1. NM_001173477.1.
    UniGeneiMm.275397.

    Genome annotation databases

    EnsembliENSMUST00000113587; ENSMUSP00000109217; ENSMUSG00000026207.
    ENSMUST00000113588; ENSMUSP00000109218; ENSMUSG00000026207.
    ENSMUST00000113589; ENSMUSP00000109219; ENSMUSG00000026207.
    ENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207. [Q62407-2]
    ENSMUST00000122266; ENSMUSP00000113646; ENSMUSG00000026207.
    GeneIDi11790.
    KEGGimmu:11790.
    UCSCiuc007bpa.1. mouse. [Q62407-2]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57098 mRNA. Translation: AAC52666.1 .
    AF215896 mRNA. Translation: AAG34791.1 . Frameshift.
    AK035543 mRNA. Translation: BAC29098.1 .
    AK164360 mRNA. Translation: BAE37758.1 .
    BC048698 mRNA. Translation: AAH48698.3 .
    BC062643 mRNA. Translation: AAH62643.1 .
    AK122488 mRNA. Translation: BAC65770.1 .
    CCDSi CCDS35626.1. [Q62407-1 ]
    CCDS48292.1. [Q62407-2 ]
    RefSeqi NP_001078839.1. NM_001085370.1.
    NP_001078840.1. NM_001085371.1. [Q62407-2 ]
    NP_001166948.1. NM_001173477.1.
    UniGenei Mm.275397.

    3D structure databases

    ProteinModelPortali Q62407.
    SMRi Q62407. Positions 871-966.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62407.

    Proteomic databases

    PaxDbi Q62407.
    PRIDEi Q62407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113587 ; ENSMUSP00000109217 ; ENSMUSG00000026207 .
    ENSMUST00000113588 ; ENSMUSP00000109218 ; ENSMUSG00000026207 .
    ENSMUST00000113589 ; ENSMUSP00000109219 ; ENSMUSG00000026207 .
    ENSMUST00000113590 ; ENSMUSP00000109220 ; ENSMUSG00000026207 . [Q62407-2 ]
    ENSMUST00000122266 ; ENSMUSP00000113646 ; ENSMUSG00000026207 .
    GeneIDi 11790.
    KEGGi mmu:11790.
    UCSCi uc007bpa.1. mouse. [Q62407-2 ]

    Organism-specific databases

    CTDi 10290.
    MGIi MGI:109282. Speg.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117320.
    HOVERGENi HBG083339.
    InParanoidi Q62407.
    KOi K08809.
    PhylomeDBi Q62407.

    Miscellaneous databases

    ChiTaRSi SPEG. mouse.
    NextBioi 279613.
    PROi Q62407.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62407.
    Bgeei Q62407.
    CleanExi MM_SPEG.
    Genevestigatori Q62407.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07679. I-set. 8 hits.
    PF00069. Pkinase. 2 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    SM00409. IG. 4 hits.
    SM00408. IGc2. 5 hits.
    SM00220. S_TKc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 8 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 2 hits.
    PS00108. PROTEIN_KINASE_ST. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury."
      Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.
      J. Biol. Chem. 271:17354-17359(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
      Strain: C57BL/6.
    2. "Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1."
      Hsieh C.-M., Fukumoto S., Layne M.D., Maemura K., Charles H., Patel A., Perrella M.A., Lee M.-E.
      J. Biol. Chem. 275:36966-36973(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, PHOSPHORYLATION.
      Strain: BALB/c.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Spinal ganglion and Urinary bladder.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-3262 (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Embryonic brain and Limb.
    5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2092-3262.
      Tissue: Brain.
    6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiSPEG_MOUSE
    AccessioniPrimary (citable) accession number: Q62407
    Secondary accession number(s): Q3TPH8
    , Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Expression is under the tight control of the locus control region (LCRs).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3