Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62407

- SPEG_MOUSE

UniProt

Q62407 - SPEG_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Striated muscle-specific serine/threonine-protein kinase

Gene

Speg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1635 – 16351ATPPROSITE-ProRule annotation
Active sitei1724 – 17241Proton acceptorBy similarity
Active sitei3080 – 30801Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1612 – 16209ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cardiac muscle cell development Source: MGI
  2. cardiovascular system development Source: MGI
  3. in utero embryonic development Source: MGI
  4. respiratory system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
Gene namesi
Name:Speg
Synonyms:Apeg1, Kiaa1297
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109282. Speg.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lacking SPEG demonstrate dilation of right and left atria and ventricles, cardiac hypertrophy, myofibril degeneration, and a marked decrease in cardiac function. Moreover, mutant mice exhibit significant neonatal mortality.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32623262Striated muscle-specific serine/threonine-protein kinasePRO_0000072667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi994 ↔ 1046PROSITE-ProRule annotation
Modified residuei1177 – 11771Phosphoserine1 Publication
Disulfide bondi1413 ↔ 1469PROSITE-ProRule annotation
Disulfide bondi2608 ↔ 2660PROSITE-ProRule annotation

Post-translational modificationi

May be autophosphorylated.2 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ62407.
PaxDbiQ62407.
PRIDEiQ62407.

PTM databases

PhosphoSiteiQ62407.

Expressioni

Tissue specificityi

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. Isoform 1 and isoform 4 are expressed in cardiomyocytes of the developing heart.3 Publications

Inductioni

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

Gene expression databases

BgeeiQ62407.
CleanExiMM_SPEG.
ExpressionAtlasiQ62407. baseline and differential.
GenevestigatoriQ62407.

Interactioni

Subunit structurei

Interacts with MTM1 (By similarity). Isoform 3 is found as a monomer or homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ62407.
SMRiQ62407. Positions 871-966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682Ig-like 1Add
BLAST
Domaini727 – 81589Ig-like 2Add
BLAST
Domaini874 – 96390Ig-like 3Add
BLAST
Domaini968 – 106295Ig-like 4Add
BLAST
Domaini1069 – 115789Ig-like 5Add
BLAST
Domaini1193 – 128391Ig-like 6Add
BLAST
Domaini1290 – 138798Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1389 – 148597Ig-like 7Add
BLAST
Domaini1490 – 157889Ig-like 8Add
BLAST
Domaini1606 – 1859254Protein kinase 1PROSITE-ProRule annotationAdd
BLAST
Domaini2586 – 267691Ig-like 9Add
BLAST
Domaini2683 – 277795Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini2865 – 2968104Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini2946 – 3213268Protein kinase 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 34872Pro-richAdd
BLAST
Compositional biasi530 – 639110Pro-richAdd
BLAST
Compositional biasi1924 – 19296Poly-Ser
Compositional biasi1930 – 19367Poly-Glu
Compositional biasi2180 – 2320141Pro-richAdd
BLAST
Compositional biasi2775 – 2962188Pro-richAdd
BLAST
Compositional biasi3241 – 32444Poly-Arg

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 protein kinase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118877.
HOVERGENiHBG083339.
InParanoidiQ62407.
KOiK08809.
PhylomeDBiQ62407.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 5 hits.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q62407-1) [UniParc]FASTAAdd to Basket

Also known as: SPEG-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP
60 70 80 90 100
LKNAAVCAGS DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC
110 120 130 140 150
GAQDAGVYSC SAQNERGQAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE
160 170 180 190 200
LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE
210 220 230 240 250
AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS
260 270 280 290 300
LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR
310 320 330 340 350
PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED
360 370 380 390 400
ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA
410 420 430 440 450
GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA
460 470 480 490 500
WGTPEASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA
510 520 530 540 550
QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSTPKTS
560 570 580 590 600
RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ
610 620 630 640 650
FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT
660 670 680 690 700
PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR
710 720 730 740 750
RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII
760 770 780 790 800
TANPPPQVSW KKDGSMLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT
810 820 830 840 850
ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE EFPEPGETWP
860 870 880 890 900
RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE
910 920 930 940 950
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV
960 970 980 990 1000
NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA
1010 1020 1030 1040 1050
DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST
1060 1070 1080 1090 1100
AKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV
1110 1120 1130 1140 1150
TWTHFGHPVN EGDNLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA
1160 1170 1180 1190 1200
HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ
1210 1220 1230 1240 1250
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL
1260 1270 1280 1290 1300
VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT
1310 1320 1330 1340 1350
GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA
1360 1370 1380 1390 1400
ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK
1410 1420 1430 1440 1450
QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG VYELSQPDDD
1460 1470 1480 1490 1500
QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE
1510 1520 1530 1540 1550
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL
1560 1570 1580 1590 1600
SAGSQDGGVY TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR
1610 1620 1630 1640 1650
RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE
1660 1670 1680 1690 1700
ARLLARLQHG CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE
1710 1720 1730 1740 1750
TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA
1760 1770 1780 1790 1800
QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS
1810 1820 1830 1840 1850
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA
1860 1870 1880 1890 1900
EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE
1910 1920 1930 1940 1950
LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG
1960 1970 1980 1990 2000
SRVSLTDIPT EDEALGTPEA GAATPMDWQE QERTPSKDQE APSPEALPSP
2010 2020 2030 2040 2050
GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS
2060 2070 2080 2090 2100
PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL
2110 2120 2130 2140 2150
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA
2160 2170 2180 2190 2200
GAPLEIPVAR LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS
2210 2220 2230 2240 2250
AVTSRDSPQP PEPQPVPEKV PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY
2260 2270 2280 2290 2300
AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA AVFARVASPP PGVSEKRVPS
2310 2320 2330 2340 2350
ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK FKRSRESPLS
2360 2370 2380 2390 2400
RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL
2410 2420 2430 2440 2450
RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA
2460 2470 2480 2490 2500
SPVLAVRRRL SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE
2510 2520 2530 2540 2550
GESLRRLGVP HNQLGSQTGA TTPSAESLGS EASGTSGSSA PGESRSRHRW
2560 2570 2580 2590 2600
GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP SESDFPPVFH IKLKDQVLLE
2610 2620 2630 2640 2650
GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD GRQLLSIPRA
2660 2670 2680 2690 2700
GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV
2710 2720 2730 2740 2750
WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR
2760 2770 2780 2790 2800
VACSNRAGQG PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP
2810 2820 2830 2840 2850
DSPTSLAPTP ALAPPASQAS TLSPSTSSMS ANQALSSLKA VGPPPATPPR
2860 2870 2880 2890 2900
KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP DTGTLTPTSS PQGVKPAPSS
2910 2920 2930 2940 2950
TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE VVSSPTPEST
2960 2970 2980 2990 3000
TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR
3010 3020 3030 3040 3050
RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF
3060 3070 3080 3090 3100
RYSEDDVATY VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG
3110 3120 3130 3140 3150
SAQPYNPQAL KPLGHRTGTL EFMAPEMVKG DPIGSATDIW GAGVLTYIML
3160 3170 3180 3190 3200
SGYSPFYEPD PQETEARIVG GRFDAFQLYP NTSQSATLFL RKVLSVHPWS
3210 3220 3230 3240 3250
RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ RRRRAEAATR
3260
HKVLLRSYPG SP
Length:3,262
Mass (Da):354,343
Last modified:May 16, 2006 - v2
Checksum:i0387BDD6518B7BB7
GO
Isoform 2 (identifier: Q62407-2) [UniParc]FASTAAdd to Basket

Also known as: BPEG

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     107-131: VYSCSAQNERGQASCEAVLTVLEVR → MKKLWVKKRFQKTGHSRRAFGRLTH
     966-967: AH → GE
     968-3262: Missing.

Show »
Length:861
Mass (Da):93,689
Checksum:iEA162A24DDC7C597
GO
Isoform 3 (identifier: Q62407-3) [UniParc]FASTAAdd to Basket

Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE

Note: Produced by alternative promoter usage.

Show »
Length:2,408
Mass (Da):262,876
Checksum:i639C18C8D114F389
GO
Isoform 4 (identifier: Q62407-4) [UniParc]FASTAAdd to Basket

Also known as: SPEG-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.

Note: No experimental confirmation available. Produced by alternative promoter usage.

Show »
Length:2,408
Mass (Da):262,899
Checksum:i9086EDEF4F90F288
GO

Sequence cautioni

The sequence AAG34791.1 differs from that shown. Reason: Frameshift at positions 2957 and 2992. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3237 – 32371L → R in BAC65770. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 854854Missing in isoform 3 and isoform 4. 2 PublicationsVSP_018264Add
BLAST
Alternative sequencei1 – 106106Missing in isoform 2. 3 PublicationsVSP_018265Add
BLAST
Alternative sequencei107 – 13125VYSCS…VLEVR → MKKLWVKKRFQKTGHSRRAF GRLTH in isoform 2. 3 PublicationsVSP_018266Add
BLAST
Alternative sequencei966 – 9672AH → GE in isoform 2 and isoform 3. 4 PublicationsVSP_018267
Alternative sequencei968 – 32622295Missing in isoform 2. 3 PublicationsVSP_018268Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57098 mRNA. Translation: AAC52666.1.
AF215896 mRNA. Translation: AAG34791.1. Frameshift.
AK035543 mRNA. Translation: BAC29098.1.
AK164360 mRNA. Translation: BAE37758.1.
BC048698 mRNA. Translation: AAH48698.3.
BC062643 mRNA. Translation: AAH62643.1.
AK122488 mRNA. Translation: BAC65770.1.
CCDSiCCDS35626.1. [Q62407-1]
CCDS48292.1. [Q62407-2]
RefSeqiNP_001078839.1. NM_001085370.1.
NP_001078840.1. NM_001085371.1. [Q62407-2]
NP_001166948.1. NM_001173477.1.
UniGeneiMm.275397.

Genome annotation databases

EnsembliENSMUST00000113587; ENSMUSP00000109217; ENSMUSG00000026207.
ENSMUST00000113588; ENSMUSP00000109218; ENSMUSG00000026207.
ENSMUST00000113589; ENSMUSP00000109219; ENSMUSG00000026207.
ENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207. [Q62407-2]
ENSMUST00000122266; ENSMUSP00000113646; ENSMUSG00000026207.
GeneIDi11790.
KEGGimmu:11790.
UCSCiuc007bpa.1. mouse. [Q62407-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57098 mRNA. Translation: AAC52666.1 .
AF215896 mRNA. Translation: AAG34791.1 . Frameshift.
AK035543 mRNA. Translation: BAC29098.1 .
AK164360 mRNA. Translation: BAE37758.1 .
BC048698 mRNA. Translation: AAH48698.3 .
BC062643 mRNA. Translation: AAH62643.1 .
AK122488 mRNA. Translation: BAC65770.1 .
CCDSi CCDS35626.1. [Q62407-1 ]
CCDS48292.1. [Q62407-2 ]
RefSeqi NP_001078839.1. NM_001085370.1.
NP_001078840.1. NM_001085371.1. [Q62407-2 ]
NP_001166948.1. NM_001173477.1.
UniGenei Mm.275397.

3D structure databases

ProteinModelPortali Q62407.
SMRi Q62407. Positions 871-966.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62407.

Proteomic databases

MaxQBi Q62407.
PaxDbi Q62407.
PRIDEi Q62407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113587 ; ENSMUSP00000109217 ; ENSMUSG00000026207 .
ENSMUST00000113588 ; ENSMUSP00000109218 ; ENSMUSG00000026207 .
ENSMUST00000113589 ; ENSMUSP00000109219 ; ENSMUSG00000026207 .
ENSMUST00000113590 ; ENSMUSP00000109220 ; ENSMUSG00000026207 . [Q62407-2 ]
ENSMUST00000122266 ; ENSMUSP00000113646 ; ENSMUSG00000026207 .
GeneIDi 11790.
KEGGi mmu:11790.
UCSCi uc007bpa.1. mouse. [Q62407-2 ]

Organism-specific databases

CTDi 10290.
MGIi MGI:109282. Speg.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118877.
HOVERGENi HBG083339.
InParanoidi Q62407.
KOi K08809.
PhylomeDBi Q62407.

Miscellaneous databases

ChiTaRSi Speg. mouse.
NextBioi 279613.
PROi Q62407.
SOURCEi Search...

Gene expression databases

Bgeei Q62407.
CleanExi MM_SPEG.
ExpressionAtlasi Q62407. baseline and differential.
Genevestigatori Q62407.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 5 hits.
SM00220. S_TKc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury."
    Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.
    J. Biol. Chem. 271:17354-17359(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
    Strain: C57BL/6.
  2. "Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1."
    Hsieh C.-M., Fukumoto S., Layne M.D., Maemura K., Charles H., Patel A., Perrella M.A., Lee M.-E.
    J. Biol. Chem. 275:36966-36973(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, PHOSPHORYLATION.
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Spinal ganglion and Urinary bladder.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-3262 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Embryonic brain and Limb.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2092-3262.
    Tissue: Brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. Cited for: TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSPEG_MOUSE
AccessioniPrimary (citable) accession number: Q62407
Secondary accession number(s): Q3TPH8
, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3