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Q62407

- SPEG_MOUSE

UniProt

Q62407 - SPEG_MOUSE

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Protein
Striated muscle-specific serine/threonine-protein kinase
Gene
Speg, Apeg1, Kiaa1297
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1635 – 16351ATP By similarity
Active sitei1724 – 17241Proton acceptor By similarity
Active sitei3080 – 30801Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1612 – 16209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cardiac muscle cell development Source: MGI
  2. cardiovascular system development Source: MGI
  3. in utero embryonic development Source: MGI
  4. respiratory system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
Gene namesi
Name:Speg
Synonyms:Apeg1, Kiaa1297
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109282. Speg.

Subcellular locationi

Isoform 3 : Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32623262Striated muscle-specific serine/threonine-protein kinase
PRO_0000072667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi994 ↔ 1046 By similarity
Modified residuei1177 – 11771Phosphoserine1 Publication
Disulfide bondi1413 ↔ 1469 By similarity
Disulfide bondi2608 ↔ 2660 By similarity

Post-translational modificationi

May be autophosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ62407.
PRIDEiQ62407.

PTM databases

PhosphoSiteiQ62407.

Expressioni

Tissue specificityi

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.2 Publications

Inductioni

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

Gene expression databases

ArrayExpressiQ62407.
BgeeiQ62407.
CleanExiMM_SPEG.
GenevestigatoriQ62407.

Interactioni

Subunit structurei

Isoform 3 is found as a monomer or homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ62407.
SMRiQ62407. Positions 871-966.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682Ig-like 1
Add
BLAST
Domaini727 – 81589Ig-like 2
Add
BLAST
Domaini874 – 96390Ig-like 3
Add
BLAST
Domaini968 – 106295Ig-like 4
Add
BLAST
Domaini1069 – 115789Ig-like 5
Add
BLAST
Domaini1193 – 128391Ig-like 6
Add
BLAST
Domaini1290 – 138798Fibronectin type-III 1
Add
BLAST
Domaini1389 – 148597Ig-like 7
Add
BLAST
Domaini1490 – 157889Ig-like 8
Add
BLAST
Domaini1606 – 1859254Protein kinase 1
Add
BLAST
Domaini2586 – 267691Ig-like 9
Add
BLAST
Domaini2683 – 277795Fibronectin type-III 2
Add
BLAST
Domaini2865 – 2968104Fibronectin type-III 3
Add
BLAST
Domaini2946 – 3213268Protein kinase 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 34872Pro-rich
Add
BLAST
Compositional biasi530 – 639110Pro-rich
Add
BLAST
Compositional biasi1924 – 19296Poly-Ser
Compositional biasi1930 – 19367Poly-Glu
Compositional biasi2180 – 2320141Pro-rich
Add
BLAST
Compositional biasi2775 – 2962188Pro-rich
Add
BLAST
Compositional biasi3241 – 32444Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00750000117320.
HOVERGENiHBG083339.
InParanoidiQ62407.
KOiK08809.
PhylomeDBiQ62407.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 5 hits.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. Align

Isoform 1 (identifier: Q62407-1) [UniParc]FASTAAdd to Basket

Also known as: SPEG-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP     50
LKNAAVCAGS DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC 100
GAQDAGVYSC SAQNERGQAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE 150
LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE 200
AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS 250
LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR 300
PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED 350
ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA 400
GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA 450
WGTPEASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA 500
QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSTPKTS 550
RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ 600
FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT 650
PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR 700
RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII 750
TANPPPQVSW KKDGSMLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT 800
ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE EFPEPGETWP 850
RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE 900
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV 950
NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA 1000
DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST 1050
AKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV 1100
TWTHFGHPVN EGDNLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA 1150
HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ 1200
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL 1250
VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT 1300
GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA 1350
ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK 1400
QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG VYELSQPDDD 1450
QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE 1500
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL 1550
SAGSQDGGVY TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR 1600
RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE 1650
ARLLARLQHG CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE 1700
TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA 1750
QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS 1800
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA 1850
EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE 1900
LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG 1950
SRVSLTDIPT EDEALGTPEA GAATPMDWQE QERTPSKDQE APSPEALPSP 2000
GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS 2050
PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL 2100
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA 2150
GAPLEIPVAR LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS 2200
AVTSRDSPQP PEPQPVPEKV PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY 2250
AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA AVFARVASPP PGVSEKRVPS 2300
ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK FKRSRESPLS 2350
RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL 2400
RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA 2450
SPVLAVRRRL SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE 2500
GESLRRLGVP HNQLGSQTGA TTPSAESLGS EASGTSGSSA PGESRSRHRW 2550
GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP SESDFPPVFH IKLKDQVLLE 2600
GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD GRQLLSIPRA 2650
GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV 2700
WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR 2750
VACSNRAGQG PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP 2800
DSPTSLAPTP ALAPPASQAS TLSPSTSSMS ANQALSSLKA VGPPPATPPR 2850
KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP DTGTLTPTSS PQGVKPAPSS 2900
TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE VVSSPTPEST 2950
TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR 3000
RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF 3050
RYSEDDVATY VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG 3100
SAQPYNPQAL KPLGHRTGTL EFMAPEMVKG DPIGSATDIW GAGVLTYIML 3150
SGYSPFYEPD PQETEARIVG GRFDAFQLYP NTSQSATLFL RKVLSVHPWS 3200
RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ RRRRAEAATR 3250
HKVLLRSYPG SP 3262
Length:3,262
Mass (Da):354,343
Last modified:May 16, 2006 - v2
Checksum:i0387BDD6518B7BB7
GO
Isoform 2 (identifier: Q62407-2) [UniParc]FASTAAdd to Basket

Also known as: BPEG

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     107-131: VYSCSAQNERGQASCEAVLTVLEVR → MKKLWVKKRFQKTGHSRRAFGRLTH
     966-967: AH → GE
     968-3262: Missing.

Show »
Length:861
Mass (Da):93,689
Checksum:iEA162A24DDC7C597
GO
Isoform 3 (identifier: Q62407-3) [UniParc]FASTAAdd to Basket

Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE

Note: Produced by alternative promoter usage.

Show »
Length:2,408
Mass (Da):262,876
Checksum:i639C18C8D114F389
GO
Isoform 4 (identifier: Q62407-4) [UniParc]FASTAAdd to Basket

Also known as: SPEG-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.

Note: No experimental confirmation available. Produced by alternative promoter usage.

Show »
Length:2,408
Mass (Da):262,899
Checksum:i9086EDEF4F90F288
GO

Sequence cautioni

The sequence AAG34791.1 differs from that shown. Reason: Frameshift at positions 2957 and 2992.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 854854Missing in isoform 3 and isoform 4.
VSP_018264Add
BLAST
Alternative sequencei1 – 106106Missing in isoform 2.
VSP_018265Add
BLAST
Alternative sequencei107 – 13125VYSCS…VLEVR → MKKLWVKKRFQKTGHSRRAF GRLTH in isoform 2.
VSP_018266Add
BLAST
Alternative sequencei966 – 9672AH → GE in isoform 2 and isoform 3.
VSP_018267
Alternative sequencei968 – 32622295Missing in isoform 2.
VSP_018268Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3237 – 32371L → R in BAC65770. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57098 mRNA. Translation: AAC52666.1.
AF215896 mRNA. Translation: AAG34791.1. Frameshift.
AK035543 mRNA. Translation: BAC29098.1.
AK164360 mRNA. Translation: BAE37758.1.
BC048698 mRNA. Translation: AAH48698.3.
BC062643 mRNA. Translation: AAH62643.1.
AK122488 mRNA. Translation: BAC65770.1.
CCDSiCCDS35626.1. [Q62407-1]
CCDS48292.1. [Q62407-2]
RefSeqiNP_001078839.1. NM_001085370.1.
NP_001078840.1. NM_001085371.1. [Q62407-2]
NP_001166948.1. NM_001173477.1.
UniGeneiMm.275397.

Genome annotation databases

EnsembliENSMUST00000113587; ENSMUSP00000109217; ENSMUSG00000026207.
ENSMUST00000113588; ENSMUSP00000109218; ENSMUSG00000026207.
ENSMUST00000113589; ENSMUSP00000109219; ENSMUSG00000026207.
ENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207. [Q62407-2]
ENSMUST00000122266; ENSMUSP00000113646; ENSMUSG00000026207.
GeneIDi11790.
KEGGimmu:11790.
UCSCiuc007bpa.1. mouse. [Q62407-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57098 mRNA. Translation: AAC52666.1 .
AF215896 mRNA. Translation: AAG34791.1 . Frameshift.
AK035543 mRNA. Translation: BAC29098.1 .
AK164360 mRNA. Translation: BAE37758.1 .
BC048698 mRNA. Translation: AAH48698.3 .
BC062643 mRNA. Translation: AAH62643.1 .
AK122488 mRNA. Translation: BAC65770.1 .
CCDSi CCDS35626.1. [Q62407-1 ]
CCDS48292.1. [Q62407-2 ]
RefSeqi NP_001078839.1. NM_001085370.1.
NP_001078840.1. NM_001085371.1. [Q62407-2 ]
NP_001166948.1. NM_001173477.1.
UniGenei Mm.275397.

3D structure databases

ProteinModelPortali Q62407.
SMRi Q62407. Positions 871-966.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62407.

Proteomic databases

PaxDbi Q62407.
PRIDEi Q62407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113587 ; ENSMUSP00000109217 ; ENSMUSG00000026207 .
ENSMUST00000113588 ; ENSMUSP00000109218 ; ENSMUSG00000026207 .
ENSMUST00000113589 ; ENSMUSP00000109219 ; ENSMUSG00000026207 .
ENSMUST00000113590 ; ENSMUSP00000109220 ; ENSMUSG00000026207 . [Q62407-2 ]
ENSMUST00000122266 ; ENSMUSP00000113646 ; ENSMUSG00000026207 .
GeneIDi 11790.
KEGGi mmu:11790.
UCSCi uc007bpa.1. mouse. [Q62407-2 ]

Organism-specific databases

CTDi 10290.
MGIi MGI:109282. Speg.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00750000117320.
HOVERGENi HBG083339.
InParanoidi Q62407.
KOi K08809.
PhylomeDBi Q62407.

Miscellaneous databases

ChiTaRSi SPEG. mouse.
NextBioi 279613.
PROi Q62407.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62407.
Bgeei Q62407.
CleanExi MM_SPEG.
Genevestigatori Q62407.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 5 hits.
SM00220. S_TKc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury."
    Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.
    J. Biol. Chem. 271:17354-17359(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
    Strain: C57BL/6.
  2. "Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1."
    Hsieh C.-M., Fukumoto S., Layne M.D., Maemura K., Charles H., Patel A., Perrella M.A., Lee M.-E.
    J. Biol. Chem. 275:36966-36973(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, PHOSPHORYLATION.
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Spinal ganglion and Urinary bladder.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-3262 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Embryonic brain and Limb.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2092-3262.
    Tissue: Brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSPEG_MOUSE
AccessioniPrimary (citable) accession number: Q62407
Secondary accession number(s): Q3TPH8
, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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