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Q62407 (SPEG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Striated muscle-specific serine/threonine-protein kinase

EC=2.7.11.1
Alternative name(s):
Aortic preferentially expressed protein 1
Short name=APEG-1
Gene names
Name:Speg
Synonyms:Apeg1, Kiaa1297
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length3262 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Isoform 3 is found as a monomer or homodimer By similarity.

Subcellular location

Isoform 3: Nucleus Ref.1.

Tissue specificity

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. Ref.1 Ref.2

Induction

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype. Ref.1

Post-translational modification

May be autophosphorylated. Ref.2

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Contains 3 fibronectin type-III domains.

Contains 9 Ig-like (immunoglobulin-like) domains.

Contains 2 protein kinase domains.

Sequence caution

The sequence AAG34791.1 differs from that shown. Reason: Frameshift at positions 2957 and 2992.

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q62407-1)

Also known as: SPEG-beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q62407-2)

Also known as: BPEG;

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     107-131: VYSCSAQNERGQASCEAVLTVLEVR → MKKLWVKKRFQKTGHSRRAFGRLTH
     966-967: AH → GE
     968-3262: Missing.
Isoform 3 (identifier: Q62407-3)

Also known as: APEG1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE
Note: Produced by alternative promoter usage.
Isoform 4 (identifier: Q62407-4)

Also known as: SPEG-alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
Note: No experimental confirmation available. Produced by alternative promoter usage.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 32623262Striated muscle-specific serine/threonine-protein kinase
PRO_0000072667

Regions

Domain45 – 12682Ig-like 1
Domain727 – 81589Ig-like 2
Domain874 – 96390Ig-like 3
Domain968 – 106295Ig-like 4
Domain1069 – 115789Ig-like 5
Domain1193 – 128391Ig-like 6
Domain1290 – 138798Fibronectin type-III 1
Domain1389 – 148597Ig-like 7
Domain1490 – 157889Ig-like 8
Domain1606 – 1859254Protein kinase 1
Domain2586 – 267691Ig-like 9
Domain2683 – 277795Fibronectin type-III 2
Domain2865 – 2968104Fibronectin type-III 3
Domain2946 – 3213268Protein kinase 2
Nucleotide binding1612 – 16209ATP By similarity
Compositional bias277 – 34872Pro-rich
Compositional bias530 – 639110Pro-rich
Compositional bias1924 – 19296Poly-Ser
Compositional bias1930 – 19367Poly-Glu
Compositional bias2180 – 2320141Pro-rich
Compositional bias2775 – 2962188Pro-rich
Compositional bias3241 – 32444Poly-Arg

Sites

Active site17241Proton acceptor By similarity
Active site30801Proton acceptor By similarity
Binding site16351ATP By similarity

Amino acid modifications

Modified residue11771Phosphoserine Ref.6
Disulfide bond994 ↔ 1046 By similarity
Disulfide bond1413 ↔ 1469 By similarity
Disulfide bond2608 ↔ 2660 By similarity

Natural variations

Alternative sequence1 – 854854Missing in isoform 3 and isoform 4.
VSP_018264
Alternative sequence1 – 106106Missing in isoform 2.
VSP_018265
Alternative sequence107 – 13125VYSCS…VLEVR → MKKLWVKKRFQKTGHSRRAF GRLTH in isoform 2.
VSP_018266
Alternative sequence966 – 9672AH → GE in isoform 2 and isoform 3.
VSP_018267
Alternative sequence968 – 32622295Missing in isoform 2.
VSP_018268

Experimental info

Sequence conflict32371L → R in BAC65770. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (SPEG-beta) [UniParc].

Last modified May 16, 2006. Version 2.
Checksum: 0387BDD6518B7BB7

FASTA3,262354,343
        10         20         30         40         50         60 
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP LKNAAVCAGS 

        70         80         90        100        110        120 
DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC GAQDAGVYSC SAQNERGQAS 

       130        140        150        160        170        180 
CEAVLTVLEV RDSETAEDDI SDVPGTQRLE LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT 

       190        200        210        220        230        240 
GTSEEQVSWW GSGQTVLEQE AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL 

       250        260        270        280        290        300 
VGASWGSEDS LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR 

       310        320        330        340        350        360 
PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED ITTTEEKRGK 

       370        380        390        400        410        420 
KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA GSRILDKLQF FEERRRSLER 

       430        440        450        460        470        480 
SDSPPAPLRP WVPLRKARSL EQPKSEGGAA WGTPEASQEE LRSPRGSVAE RRRLFQQKAA 

       490        500        510        520        530        540 
SLDERTRQRS ATSDLELRFA QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL 

       550        560        570        580        590        600 
FSRPSTPKTS RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ 

       610        620        630        640        650        660 
FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT PGVEDSVLPQ 

       670        680        690        700        710        720 
TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR RARPTSPELE SSDDSYVSAG 

       730        740        750        760        770        780 
EEPLEAPVFE IPLQNMVVAP GADVLLKCII TANPPPQVSW KKDGSMLHSE GRLLIRAEGE 

       790        800        810        820        830        840 
RHTLLLREAQ AADAGSYTAT ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE 

       850        860        870        880        890        900 
EFPEPGETWP RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE 

       910        920        930        940        950        960 
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV NEYGARQCEA 

       970        980        990       1000       1010       1020 
RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA DVEVDWLCRG RLLQPALLKC 

      1030       1040       1050       1060       1070       1080 
KMHFDGRKCK LLLTSVHEDD SGVYTCKLST AKDELTCSAR LTVRPSLAPL FTRLLEDVEV 

      1090       1100       1110       1120       1130       1140 
LEGRAARLDC KISGTPPPSV TWTHFGHPVN EGDNLRLRQD GGLHSLHIAR VGSEDEGLYE 

      1150       1160       1170       1180       1190       1200 
VSATNTHGQA HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ 

      1210       1220       1230       1240       1250       1260 
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL VFPAVGPQHA 

      1270       1280       1290       1300       1310       1320 
GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT GRMVTLSWNP PRSLDMAIDP 

      1330       1340       1350       1360       1370       1380 
DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE 

      1390       1400       1410       1420       1430       1440 
PVQLLEHGPP LEEAPAVLDK QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG 

      1450       1460       1470       1480       1490       1500 
VYELSQPDDD QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE 

      1510       1520       1530       1540       1550       1560 
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL SAGSQDGGVY 

      1570       1580       1590       1600       1610       1620 
TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR RLSDYYDIHQ EIGRGAFSYL 

      1630       1640       1650       1660       1670       1680 
RRVVERSSGL EFAAKFIPSQ AKPKASARRE ARLLARLQHG CVLYFHEAFE RRRGLVIVTE 

      1690       1700       1710       1720       1730       1740 
LCTEELLERM ARKPTVCESE TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE 

      1750       1760       1770       1780       1790       1800 
QVRICDFGNA QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS 

      1810       1820       1830       1840       1850       1860 
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA EETLEHPWFK 

      1870       1880       1890       1900       1910       1920 
TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE LLRAPPERVW VAMPRRQPPS 

      1930       1940       1950       1960       1970       1980 
GGLSSSSDSE EEELEELPSV PRPLQPEFSG SRVSLTDIPT EDEALGTPEA GAATPMDWQE 

      1990       2000       2010       2020       2030       2040 
QERTPSKDQE APSPEALPSP GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA 

      2050       2060       2070       2080       2090       2100 
ASVELPQRRS PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL 

      2110       2120       2130       2140       2150       2160 
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA GAPLEIPVAR 

      2170       2180       2190       2200       2210       2220 
LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS AVTSRDSPQP PEPQPVPEKV 

      2230       2240       2250       2260       2270       2280 
PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA 

      2290       2300       2310       2320       2330       2340 
AVFARVASPP PGVSEKRVPS ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK 

      2350       2360       2370       2380       2390       2400 
FKRSRESPLS RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL 

      2410       2420       2430       2440       2450       2460 
RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA SPVLAVRRRL 

      2470       2480       2490       2500       2510       2520 
SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE GESLRRLGVP HNQLGSQTGA 

      2530       2540       2550       2560       2570       2580 
TTPSAESLGS EASGTSGSSA PGESRSRHRW GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP 

      2590       2600       2610       2620       2630       2640 
SESDFPPVFH IKLKDQVLLE GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD 

      2650       2660       2670       2680       2690       2700 
GRQLLSIPRA GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV 

      2710       2720       2730       2740       2750       2760 
WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR VACSNRAGQG 

      2770       2780       2790       2800       2810       2820 
PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP DSPTSLAPTP ALAPPASQAS 

      2830       2840       2850       2860       2870       2880 
TLSPSTSSMS ANQALSSLKA VGPPPATPPR KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP 

      2890       2900       2910       2920       2930       2940 
DTGTLTPTSS PQGVKPAPSS TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE 

      2950       2960       2970       2980       2990       3000 
VVSSPTPEST TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR 

      3010       3020       3030       3040       3050       3060 
RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF RYSEDDVATY 

      3070       3080       3090       3100       3110       3120 
VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG SAQPYNPQAL KPLGHRTGTL 

      3130       3140       3150       3160       3170       3180 
EFMAPEMVKG DPIGSATDIW GAGVLTYIML SGYSPFYEPD PQETEARIVG GRFDAFQLYP 

      3190       3200       3210       3220       3230       3240 
NTSQSATLFL RKVLSVHPWS RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ 

      3250       3260 
RRRRAEAATR HKVLLRSYPG SP 

« Hide

Isoform 2 (BPEG) [UniParc].

Checksum: EA162A24DDC7C597
Show »

FASTA86193,689
Isoform 3 (APEG1) [UniParc].

Checksum: 639C18C8D114F389
Show »

FASTA2,408262,876
Isoform 4 (SPEG-alpha) [UniParc].

Checksum: 9086EDEF4F90F288
Show »

FASTA2,408262,899

References

« Hide 'large scale' references
[1]"APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury."
Hsieh C.-M., Yoshizumi M., Endege W.O., Kho C.-J., Jain M.K., Kashiki S., de Los Santos R., Lee W.-S., Perrella M.A., Lee M.-E.
J. Biol. Chem. 271:17354-17359(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION.
Strain: C57BL/6.
[2]"Striated muscle preferentially expressed genes alpha and beta are two serine/threonine protein kinases derived from the same gene as the aortic preferentially expressed gene-1."
Hsieh C.-M., Fukumoto S., Layne M.D., Maemura K., Charles H., Patel A., Perrella M.A., Lee M.-E.
J. Biol. Chem. 275:36966-36973(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, PHOSPHORYLATION.
Strain: BALB/c.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Spinal ganglion and Urinary bladder.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 723-3262 (ISOFORM 2).
Strain: C57BL/6.
Tissue: Embryonic brain and Limb.
[5]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2092-3262.
Tissue: Brain.
[6]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57098 mRNA. Translation: AAC52666.1.
AF215896 mRNA. Translation: AAG34791.1. Frameshift.
AK035543 mRNA. Translation: BAC29098.1.
AK164360 mRNA. Translation: BAE37758.1.
BC048698 mRNA. Translation: AAH48698.3.
BC062643 mRNA. Translation: AAH62643.1.
AK122488 mRNA. Translation: BAC65770.1.
CCDSCCDS35626.1. [Q62407-1]
CCDS48292.1. [Q62407-2]
RefSeqNP_001078839.1. NM_001085370.1.
NP_001078840.1. NM_001085371.1. [Q62407-2]
NP_001166948.1. NM_001173477.1.
UniGeneMm.275397.

3D structure databases

ProteinModelPortalQ62407.
SMRQ62407. Positions 871-966.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62407.

Proteomic databases

PaxDbQ62407.
PRIDEQ62407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000113587; ENSMUSP00000109217; ENSMUSG00000026207.
ENSMUST00000113588; ENSMUSP00000109218; ENSMUSG00000026207.
ENSMUST00000113589; ENSMUSP00000109219; ENSMUSG00000026207.
ENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207. [Q62407-2]
ENSMUST00000122266; ENSMUSP00000113646; ENSMUSG00000026207.
GeneID11790.
KEGGmmu:11790.
UCSCuc007bpa.1. mouse. [Q62407-2]

Organism-specific databases

CTD10290.
MGIMGI:109282. Speg.
RougeSearch...

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117320.
HOVERGENHBG083339.
InParanoidQ62407.
KOK08809.
PhylomeDBQ62407.

Gene expression databases

ArrayExpressQ62407.
BgeeQ62407.
CleanExMM_SPEG.
GenevestigatorQ62407.

Family and domain databases

Gene3D2.60.40.10. 11 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF07679. I-set. 8 hits.
PF00069. Pkinase. 2 hits.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 5 hits.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 8 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSPEG. mouse.
NextBio279613.
PROQ62407.
SOURCESearch...

Entry information

Entry nameSPEG_MOUSE
AccessionPrimary (citable) accession number: Q62407
Secondary accession number(s): Q3TPH8 expand/collapse secondary AC list , Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot