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Q62401

- CCL12_MOUSE

UniProt

Q62401 - CCL12_MOUSE

Protein

C-C motif chemokine 12

Gene

Ccl12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

    GO - Molecular functioni

    1. CCR2 chemokine receptor binding Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: BHF-UCL
    2. immune response Source: InterPro
    3. inflammatory response Source: BHF-UCL
    4. monocyte chemotaxis Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 12
    Alternative name(s):
    MCP-1-related chemokine
    Monocyte chemoattractant protein 5
    Monocyte chemotactic protein 5
    Short name:
    MCP-5
    Small-inducible cytokine A12
    Gene namesi
    Name:Ccl12
    Synonyms:Mcp5, Scya12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:108224. Ccl12.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 10482C-C motif chemokine 12PRO_0000005199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 58By similarity
    Disulfide bondi34 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ62401.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

    Inductioni

    By interferon gamma and lipopolysaccharides (LPS).

    Gene expression databases

    ArrayExpressiQ62401.
    BgeeiQ62401.
    CleanExiMM_CCL12.
    GenevestigatoriQ62401.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ62401.
    SMRiQ62401. Positions 30-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ62401.
    KOiK14624.
    OMAiAVIFRTI.
    OrthoDBiEOG7C5MC2.
    PhylomeDBiQ62401.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62401-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISTLLCLL LIATTISPQV LAGPDAVSTP VTCCYNVVKQ KIHVRKLKSY    50
    RRITSSQCPR EAVIFRTILD KEICADPKEK WVKNSINHLD KTSQTFILEP 100
    SCLG 104
    Length:104
    Mass (Da):11,659
    Last modified:November 1, 1997 - v1
    Checksum:i8D102F4FF4CC3DBF
    GO

    Polymorphismi

    The polymorphism in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 10411QTFILEPSCLG → RT in strain: SJL/J.
    Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50712 mRNA. Translation: AAB50053.1.
    U66670 mRNA. Translation: AAB49424.1.
    AF065934 mRNA. Translation: AAF15384.1.
    AF065935 mRNA. Translation: AAF15385.1.
    AF065936 mRNA. Translation: AAF15386.1.
    AF065937 mRNA. Translation: AAF15387.1.
    AF065938 mRNA. Translation: AAF15388.1.
    BC027520 mRNA. Translation: AAH27520.1.
    CCDSiCCDS36247.1.
    RefSeqiNP_035461.2. NM_011331.2.
    XP_006543027.1. XM_006542964.1.
    UniGeneiMm.867.

    Genome annotation databases

    EnsembliENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352.
    GeneIDi102641905.
    20293.
    KEGGimmu:102641905.
    mmu:20293.
    UCSCiuc007kms.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50712 mRNA. Translation: AAB50053.1 .
    U66670 mRNA. Translation: AAB49424.1 .
    AF065934 mRNA. Translation: AAF15384.1 .
    AF065935 mRNA. Translation: AAF15385.1 .
    AF065936 mRNA. Translation: AAF15386.1 .
    AF065937 mRNA. Translation: AAF15387.1 .
    AF065938 mRNA. Translation: AAF15388.1 .
    BC027520 mRNA. Translation: AAH27520.1 .
    CCDSi CCDS36247.1.
    RefSeqi NP_035461.2. NM_011331.2.
    XP_006543027.1. XM_006542964.1.
    UniGenei Mm.867.

    3D structure databases

    ProteinModelPortali Q62401.
    SMRi Q62401. Positions 30-93.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q62401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000194 ; ENSMUSP00000000194 ; ENSMUSG00000035352 .
    GeneIDi 102641905.
    20293.
    KEGGi mmu:102641905.
    mmu:20293.
    UCSCi uc007kms.1. mouse.

    Organism-specific databases

    CTDi 20293.
    MGIi MGI:108224. Ccl12.

    Phylogenomic databases

    eggNOGi NOG46819.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q62401.
    KOi K14624.
    OMAi AVIFRTI.
    OrthoDBi EOG7C5MC2.
    PhylomeDBi Q62401.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 298011.
    PROi Q62401.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62401.
    Bgeei Q62401.
    CleanExi MM_CCL12.
    Genevestigatori Q62401.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation."
      Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C., Wershil B.K., Gutierrez-Ramos J.-C.
      J. Exp. Med. 184:1939-1951(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1."
      Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F., Luster A.D.
      J. Exp. Med. 185:99-109(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
      Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
      J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
      Tissue: Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCCL12_MOUSE
    AccessioniPrimary (citable) accession number: Q62401
    Secondary accession number(s): Q9QYD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3