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Protein

C-C motif chemokine 12

Gene

Ccl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 12
Alternative name(s):
MCP-1-related chemokine
Monocyte chemoattractant protein 5
Monocyte chemotactic protein 5
Short name:
MCP-5
Small-inducible cytokine A12
Gene namesi
Name:Ccl12
Synonyms:Mcp5, Scya12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108224. Ccl12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 10482C-C motif chemokine 12PRO_0000005199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ62401.

Expressioni

Tissue specificityi

Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiQ62401.
CleanExiMM_CCL12.
ExpressionAtlasiQ62401. baseline and differential.
GenevisibleiQ62401. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000194.

Structurei

3D structure databases

ProteinModelPortaliQ62401.
SMRiQ62401. Positions 30-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ62401.
KOiK14624.
OMAiAVIFRTI.
OrthoDBiEOG7C5MC2.
PhylomeDBiQ62401.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISTLLCLL LIATTISPQV LAGPDAVSTP VTCCYNVVKQ KIHVRKLKSY
60 70 80 90 100
RRITSSQCPR EAVIFRTILD KEICADPKEK WVKNSINHLD KTSQTFILEP

SCLG
Length:104
Mass (Da):11,659
Last modified:November 1, 1997 - v1
Checksum:i8D102F4FF4CC3DBF
GO

Polymorphismi

The polymorphism in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 10411QTFILEPSCLG → RT in strain: SJL/J.
Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50712 mRNA. Translation: AAB50053.1.
U66670 mRNA. Translation: AAB49424.1.
AF065934 mRNA. Translation: AAF15384.1.
AF065935 mRNA. Translation: AAF15385.1.
AF065936 mRNA. Translation: AAF15386.1.
AF065937 mRNA. Translation: AAF15387.1.
AF065938 mRNA. Translation: AAF15388.1.
BC027520 mRNA. Translation: AAH27520.1.
CCDSiCCDS36247.1.
RefSeqiNP_035461.2. NM_011331.2.
XP_011238879.1. XM_011240577.1.
UniGeneiMm.867.

Genome annotation databases

EnsembliENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352.
GeneIDi105242482.
20293.
KEGGimmu:20293.
UCSCiuc007kms.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50712 mRNA. Translation: AAB50053.1.
U66670 mRNA. Translation: AAB49424.1.
AF065934 mRNA. Translation: AAF15384.1.
AF065935 mRNA. Translation: AAF15385.1.
AF065936 mRNA. Translation: AAF15386.1.
AF065937 mRNA. Translation: AAF15387.1.
AF065938 mRNA. Translation: AAF15388.1.
BC027520 mRNA. Translation: AAH27520.1.
CCDSiCCDS36247.1.
RefSeqiNP_035461.2. NM_011331.2.
XP_011238879.1. XM_011240577.1.
UniGeneiMm.867.

3D structure databases

ProteinModelPortaliQ62401.
SMRiQ62401. Positions 30-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000194.

Proteomic databases

PRIDEiQ62401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352.
GeneIDi105242482.
20293.
KEGGimmu:20293.
UCSCiuc007kms.1. mouse.

Organism-specific databases

CTDi20293.
MGIiMGI:108224. Ccl12.

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ62401.
KOiK14624.
OMAiAVIFRTI.
OrthoDBiEOG7C5MC2.
PhylomeDBiQ62401.
TreeFamiTF334888.

Miscellaneous databases

NextBioi298011.
PROiQ62401.
SOURCEiSearch...

Gene expression databases

BgeeiQ62401.
CleanExiMM_CCL12.
ExpressionAtlasiQ62401. baseline and differential.
GenevisibleiQ62401. MM.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation."
    Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C., Wershil B.K., Gutierrez-Ramos J.-C.
    J. Exp. Med. 184:1939-1951(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1."
    Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F., Luster A.D.
    J. Exp. Med. 185:99-109(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
    Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.
    J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J.
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiCCL12_MOUSE
AccessioniPrimary (citable) accession number: Q62401
Secondary accession number(s): Q9QYD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.