Q62401 (CCL12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-C motif chemokine 12

Alternative name(s):
MCP-1-related chemokine
Monocyte chemoattractant protein 5
Monocyte chemotactic protein 5
Short name=MCP-5
Small-inducible cytokine A12

Gene names

Name:	Ccl12
Synonyms:	Mcp5, Scya12

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted.
Tissue specificity	Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.
Induction	By interferon gamma and lipopolysaccharides (LPS).
Polymorphism	The polymorphism in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from direct assay PubMed 18334747. Source: BHF-UCL immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from direct assay Ref.2. Source: BHF-UCL monocyte chemotaxis Inferred from direct assay Ref.2. Source: BHF-UCL
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 104	82	C-C motif chemokine 12		PRO_0000005199
Amino acid modifications
	Disulfide bond	33 ↔ 58		By similarity
	Disulfide bond	34 ↔ 74		By similarity
Natural variations
	Natural variant	94 – 104	11	QTFILEPSCLG → RT in strain: SJL/J.

Sequences

	Sequence		Length	Mass (Da)
	Q62401 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 8D102F4FF4CC3DBF	FASTA	104	11,659
	10 20 30 40 50 60 MKISTLLCLL LIATTISPQV LAGPDAVSTP VTCCYNVVKQ KIHVRKLKSY RRITSSQCPR 70 80 90 100 EAVIFRTILD KEICADPKEK WVKNSINHLD KTSQTFILEP SCLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation." Jia G.-Q., Gonzalo J.A., Lloyd C., Kremer L., Lu L., Martinez A.C., Wershil B.K., Gutierrez-Ramos J.-C. J. Exp. Med. 184:1939-1951(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1." Sarafi M.N., Garcia-Zepeda E.A., McLean J.A., Charo I.F., Luster A.D. J. Exp. Med. 185:99-109(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis." Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P. J. Immunol. 163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10.S/J, BALB/c, DBA/2J, NOD/LtJ and SJL/J. Tissue: Spleen.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50712 mRNA. Translation: AAB50053.1. U66670 mRNA. Translation: AAB49424.1. AF065934 mRNA. Translation: AAF15384.1. AF065935 mRNA. Translation: AAF15385.1. AF065936 mRNA. Translation: AAF15386.1. AF065937 mRNA. Translation: AAF15387.1. AF065938 mRNA. Translation: AAF15388.1. BC027520 mRNA. Translation: AAH27520.1.
IPI	IPI00125860.
RefSeq	NP_035461.2. NM_011331.2. XP_003689314.1. XM_003689266.1.
UniGene	Mm.867.
3D structure databases
ProteinModelPortal	Q62401.
SMR	Q62401. Positions 30-93.
ModBase	Search...
Proteomic databases
PRIDE	Q62401.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352.
GeneID	100862578. 20293.
KEGG	mmu:100862578. mmu:20293.
Organism-specific databases
CTD	20293.
MGI	MGI:108224. Ccl12.
Phylogenomic databases
eggNOG	NOG46819.
GeneTree	ENSGT00560000076972.
HOGENOM	HOG000036686.
HOVERGEN	HBG017871.
InParanoid	Q62401.
KO	K14624.
OMA	AVIFRTI.
OrthoDB	EOG45DWR1.
Gene expression databases
ArrayExpress	Q62401.
Bgee	Q62401.
CleanEx	MM_CCL12.
Genevestigator	Q62401.
GermOnline	ENSMUSG00000035352. Mus musculus.
Family and domain databases
InterPro	IPR000827. Chemokine_CC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
Pfam	PF00048. IL8. 1 hit. [Graphical view]
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00472. SMALL_CYTOKINES_CC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298011.
SOURCE	Search...

Entry information

Entry name

CCL12_MOUSE

Accession

Primary (citable) accession number: Q62401
Secondary accession number(s): Q9QYD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program