Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q623T0

- ODO1_CAEBR

UniProt

Q623T0 - ODO1_CAEBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

Cofactori

thiamine diphosphateBy similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh-1
ORF Names:CBG01737
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG01737; CBP00459; WBGene00024926; Cbr-ogdh-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 10272-oxoglutarate dehydrogenase, mitochondrialPRO_0000234099
Transit peptidei1 – ?MitochondrionSequence Analysis

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG01737.

Structurei

3D structure databases

ProteinModelPortaliQ623T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
InParanoidiQ623T0.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG7FXZXH.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q623T0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRASLICRL ASPSRINSIR SASSYGNNTI SATPLVQQRK QSVAASVKHE
60 70 80 90 100
PFLNGSSSVY IEQMYETWLE NPSSVHTSWD AYFRNVEAGA GPGQAFQAPP
110 120 130 140 150
SVAYAGSMGV PSAPITSAAP ATRLDTNASV QSISDHLKIQ LLIRSYQTRG
160 170 180 190 200
HNIADLDPLG INSADLDDTI PPELELSFYG LGERDLDREF LLPPTTFISE
210 220 230 240 250
KKSLTLREIL QRLKEIYCTS TGVEYMHLNN LEQQDWIRRR FEAPRVTELS
260 270 280 290 300
HDQKKVLFKR LIRSTKFEEF LAKKWPSEKR FGLEGCEVLI PAIKQVIDSS
310 320 330 340 350
STLGVDSFVI GMPHRGRLNV LANVCRQPLA TILSQFSTLE PADEGSGDVK
360 370 380 390 400
YHLGVCIERL NRQSQKNVKI AVVANPSHLE AVDPVVMGKV RAEAFYAGDE
410 420 430 440 450
KCDRTMAILL HGDAAFAGQG VVLETFNLDD LPSYTTHGAI HIVVNNQIGF
460 470 480 490 500
TTDPRSSRSS PYCTDVGRVV GCPIFHVNVD DPEAVMHVCN VAADWRKTFK
510 520 530 540 550
KDVIVDLVCY RRHGHNELDE PMFTQPLMYQ RIKQTKTALE KYQEKILNEG
560 570 580 590 600
VANEQYVKEE LTKYGAILED AYENAQKVTY VRNRDWLDSP WDDFFKKRDP
610 620 630 640 650
LKLPSTGIEQ ENIEHIIGKF GSYPEGFNLH RGLERTLKGR QQMLKDNSLD
660 670 680 690 700
WACGEALAFG SLLKEGIHVR LSGQDVERGT FSHRHHVLHD QKVDQKIYNP
710 720 730 740 750
LNDLADPQGE YTVCNSSLSE YAVLGFELGY SMVDPNSLVI WEAQFGDFSN
760 770 780 790 800
TAQCIIDQFV SSGQSKWIRQ SGLVMLLPHG YEGMGPEHSS ARPERFLQMC
810 820 830 840 850
NEDDEIDLDK IAFGGTFEAQ QLHDTNWIVA NCTTPANIYH LLRRQVTMPF
860 870 880 890 900
RKPAVVFSPK SLLRHPMARS PVEDFQSGSN FQRIIPETGA PSQNPPNVQR
910 920 930 940 950
LVFCTGKVYY DMVAARKHVG KENDVALVRV EQLSPFPYDL VQQECRKYQG
960 970 980 990 1000
AEIIWAQEEH KNMGAWSFVQ PRINSLLSID GRATKYAGRL PSSSPATGNK
1010 1020
YTHMQEQKEM MSKVFGVPKS KLEGFKA
Length:1,027
Mass (Da):115,481
Last modified:November 23, 2004 - v1
Checksum:i99584397C5540D7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601298 Genomic DNA. Translation: CAP22897.1.
RefSeqiXP_002634170.1. XM_002634124.1.

Genome annotation databases

EnsemblMetazoaiCBG01737; CBG01737; CBG01737.
GeneIDi8576165.
KEGGicbr:CBG01737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601298 Genomic DNA. Translation: CAP22897.1 .
RefSeqi XP_002634170.1. XM_002634124.1.

3D structure databases

ProteinModelPortali Q623T0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG01737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG01737 ; CBG01737 ; CBG01737 .
GeneIDi 8576165.
KEGGi cbr:CBG01737.

Organism-specific databases

CTDi 8576165.
WormBasei CBG01737 ; CBP00459 ; WBGene00024926 ; Cbr-ogdh-1.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
InParanoidi Q623T0.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG7FXZXH.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiODO1_CAEBR
AccessioniPrimary (citable) accession number: Q623T0
Secondary accession number(s): A8WQY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3