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Q623T0 (ODO1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase, mitochondrial

EC=1.2.4.2
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene names
ORF Names:CBG01737
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1027 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB Q02218

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. UniProtKB Q02218

Cofactor

Thiamine pyrophosphate By similarity. UniProtKB Q02218

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 10272-oxoglutarate dehydrogenase, mitochondrialPRO_0000234099

Sequences

Sequence LengthMass (Da)Tools
Q623T0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 99584397C5540D7B

FASTA1,027115,481
        10         20         30         40         50         60 
MHRASLICRL ASPSRINSIR SASSYGNNTI SATPLVQQRK QSVAASVKHE PFLNGSSSVY 

        70         80         90        100        110        120 
IEQMYETWLE NPSSVHTSWD AYFRNVEAGA GPGQAFQAPP SVAYAGSMGV PSAPITSAAP 

       130        140        150        160        170        180 
ATRLDTNASV QSISDHLKIQ LLIRSYQTRG HNIADLDPLG INSADLDDTI PPELELSFYG 

       190        200        210        220        230        240 
LGERDLDREF LLPPTTFISE KKSLTLREIL QRLKEIYCTS TGVEYMHLNN LEQQDWIRRR 

       250        260        270        280        290        300 
FEAPRVTELS HDQKKVLFKR LIRSTKFEEF LAKKWPSEKR FGLEGCEVLI PAIKQVIDSS 

       310        320        330        340        350        360 
STLGVDSFVI GMPHRGRLNV LANVCRQPLA TILSQFSTLE PADEGSGDVK YHLGVCIERL 

       370        380        390        400        410        420 
NRQSQKNVKI AVVANPSHLE AVDPVVMGKV RAEAFYAGDE KCDRTMAILL HGDAAFAGQG 

       430        440        450        460        470        480 
VVLETFNLDD LPSYTTHGAI HIVVNNQIGF TTDPRSSRSS PYCTDVGRVV GCPIFHVNVD 

       490        500        510        520        530        540 
DPEAVMHVCN VAADWRKTFK KDVIVDLVCY RRHGHNELDE PMFTQPLMYQ RIKQTKTALE 

       550        560        570        580        590        600 
KYQEKILNEG VANEQYVKEE LTKYGAILED AYENAQKVTY VRNRDWLDSP WDDFFKKRDP 

       610        620        630        640        650        660 
LKLPSTGIEQ ENIEHIIGKF GSYPEGFNLH RGLERTLKGR QQMLKDNSLD WACGEALAFG 

       670        680        690        700        710        720 
SLLKEGIHVR LSGQDVERGT FSHRHHVLHD QKVDQKIYNP LNDLADPQGE YTVCNSSLSE 

       730        740        750        760        770        780 
YAVLGFELGY SMVDPNSLVI WEAQFGDFSN TAQCIIDQFV SSGQSKWIRQ SGLVMLLPHG 

       790        800        810        820        830        840 
YEGMGPEHSS ARPERFLQMC NEDDEIDLDK IAFGGTFEAQ QLHDTNWIVA NCTTPANIYH 

       850        860        870        880        890        900 
LLRRQVTMPF RKPAVVFSPK SLLRHPMARS PVEDFQSGSN FQRIIPETGA PSQNPPNVQR 

       910        920        930        940        950        960 
LVFCTGKVYY DMVAARKHVG KENDVALVRV EQLSPFPYDL VQQECRKYQG AEIIWAQEEH 

       970        980        990       1000       1010       1020 
KNMGAWSFVQ PRINSLLSID GRATKYAGRL PSSSPATGNK YTHMQEQKEM MSKVFGVPKS 


KLEGFKA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601298 Genomic DNA. Translation: CAP22897.1.
RefSeqXP_002634170.1. XM_002634124.1.

3D structure databases

ProteinModelPortalQ623T0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG01737.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG01737; CBG01737; CBG01737.
GeneID8576165.
KEGGcbr:CBG01737.

Organism-specific databases

CTD8576165.
WormBaseCBG01737; CBP00459; WBGene00024926.

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259586.
KOK00164.
OMANEGVANE.
OrthoDBEOG7FXZXH.

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_CAEBR
AccessionPrimary (citable) accession number: Q623T0
Secondary accession number(s): A8WQY9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: November 13, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families