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Q623T0

- ODO1_CAEBR

UniProt

Q623T0 - ODO1_CAEBR

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Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
ogdh-1, CBG01737
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

Cofactori

Thiamine pyrophosphate By similarity.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. generation of precursor metabolites and energy Source: UniProtKB
  2. glycolytic process Source: UniProtKB-KW
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:ogdh-1
ORF Names:CBG01737
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG01737; CBP00459; WBGene00024926; Cbr-ogdh-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. mitochondrial membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 10272-oxoglutarate dehydrogenase, mitochondrialPRO_0000234099
Transit peptidei1 – ?Mitochondrion

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG01737.

Structurei

3D structure databases

ProteinModelPortaliQ623T0.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG7FXZXH.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q623T0-1 [UniParc]FASTAAdd to Basket

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MHRASLICRL ASPSRINSIR SASSYGNNTI SATPLVQQRK QSVAASVKHE     50
PFLNGSSSVY IEQMYETWLE NPSSVHTSWD AYFRNVEAGA GPGQAFQAPP 100
SVAYAGSMGV PSAPITSAAP ATRLDTNASV QSISDHLKIQ LLIRSYQTRG 150
HNIADLDPLG INSADLDDTI PPELELSFYG LGERDLDREF LLPPTTFISE 200
KKSLTLREIL QRLKEIYCTS TGVEYMHLNN LEQQDWIRRR FEAPRVTELS 250
HDQKKVLFKR LIRSTKFEEF LAKKWPSEKR FGLEGCEVLI PAIKQVIDSS 300
STLGVDSFVI GMPHRGRLNV LANVCRQPLA TILSQFSTLE PADEGSGDVK 350
YHLGVCIERL NRQSQKNVKI AVVANPSHLE AVDPVVMGKV RAEAFYAGDE 400
KCDRTMAILL HGDAAFAGQG VVLETFNLDD LPSYTTHGAI HIVVNNQIGF 450
TTDPRSSRSS PYCTDVGRVV GCPIFHVNVD DPEAVMHVCN VAADWRKTFK 500
KDVIVDLVCY RRHGHNELDE PMFTQPLMYQ RIKQTKTALE KYQEKILNEG 550
VANEQYVKEE LTKYGAILED AYENAQKVTY VRNRDWLDSP WDDFFKKRDP 600
LKLPSTGIEQ ENIEHIIGKF GSYPEGFNLH RGLERTLKGR QQMLKDNSLD 650
WACGEALAFG SLLKEGIHVR LSGQDVERGT FSHRHHVLHD QKVDQKIYNP 700
LNDLADPQGE YTVCNSSLSE YAVLGFELGY SMVDPNSLVI WEAQFGDFSN 750
TAQCIIDQFV SSGQSKWIRQ SGLVMLLPHG YEGMGPEHSS ARPERFLQMC 800
NEDDEIDLDK IAFGGTFEAQ QLHDTNWIVA NCTTPANIYH LLRRQVTMPF 850
RKPAVVFSPK SLLRHPMARS PVEDFQSGSN FQRIIPETGA PSQNPPNVQR 900
LVFCTGKVYY DMVAARKHVG KENDVALVRV EQLSPFPYDL VQQECRKYQG 950
AEIIWAQEEH KNMGAWSFVQ PRINSLLSID GRATKYAGRL PSSSPATGNK 1000
YTHMQEQKEM MSKVFGVPKS KLEGFKA 1027
Length:1,027
Mass (Da):115,481
Last modified:November 23, 2004 - v1
Checksum:i99584397C5540D7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601298 Genomic DNA. Translation: CAP22897.1.
RefSeqiXP_002634170.1. XM_002634124.1.

Genome annotation databases

EnsemblMetazoaiCBG01737; CBG01737; CBG01737.
GeneIDi8576165.
KEGGicbr:CBG01737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE601298 Genomic DNA. Translation: CAP22897.1 .
RefSeqi XP_002634170.1. XM_002634124.1.

3D structure databases

ProteinModelPortali Q623T0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6238.CBG01737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG01737 ; CBG01737 ; CBG01737 .
GeneIDi 8576165.
KEGGi cbr:CBG01737.

Organism-specific databases

CTDi 8576165.
WormBasei CBG01737 ; CBP00459 ; WBGene00024926 ; Cbr-ogdh-1.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG7FXZXH.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiODO1_CAEBR
AccessioniPrimary (citable) accession number: Q623T0
Secondary accession number(s): A8WQY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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