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Q623T0

- ODO1_CAEBR

UniProt

Q623T0 - ODO1_CAEBR

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

ogdh-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. generation of precursor metabolites and energy Source: UniProtKB
    2. glycolytic process Source: UniProtKB-KW
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1
    Short name:
    OGDC-E1
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:ogdh-1
    ORF Names:CBG01737
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome IV, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG01737; CBP00459; WBGene00024926; Cbr-ogdh-1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrial membrane Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 10272-oxoglutarate dehydrogenase, mitochondrialPRO_0000234099
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG01737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ623T0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    KOiK00164.
    OMAiGFTTAPH.
    OrthoDBiEOG7FXZXH.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q623T0-1 [UniParc]FASTAAdd to Basket

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    MHRASLICRL ASPSRINSIR SASSYGNNTI SATPLVQQRK QSVAASVKHE     50
    PFLNGSSSVY IEQMYETWLE NPSSVHTSWD AYFRNVEAGA GPGQAFQAPP 100
    SVAYAGSMGV PSAPITSAAP ATRLDTNASV QSISDHLKIQ LLIRSYQTRG 150
    HNIADLDPLG INSADLDDTI PPELELSFYG LGERDLDREF LLPPTTFISE 200
    KKSLTLREIL QRLKEIYCTS TGVEYMHLNN LEQQDWIRRR FEAPRVTELS 250
    HDQKKVLFKR LIRSTKFEEF LAKKWPSEKR FGLEGCEVLI PAIKQVIDSS 300
    STLGVDSFVI GMPHRGRLNV LANVCRQPLA TILSQFSTLE PADEGSGDVK 350
    YHLGVCIERL NRQSQKNVKI AVVANPSHLE AVDPVVMGKV RAEAFYAGDE 400
    KCDRTMAILL HGDAAFAGQG VVLETFNLDD LPSYTTHGAI HIVVNNQIGF 450
    TTDPRSSRSS PYCTDVGRVV GCPIFHVNVD DPEAVMHVCN VAADWRKTFK 500
    KDVIVDLVCY RRHGHNELDE PMFTQPLMYQ RIKQTKTALE KYQEKILNEG 550
    VANEQYVKEE LTKYGAILED AYENAQKVTY VRNRDWLDSP WDDFFKKRDP 600
    LKLPSTGIEQ ENIEHIIGKF GSYPEGFNLH RGLERTLKGR QQMLKDNSLD 650
    WACGEALAFG SLLKEGIHVR LSGQDVERGT FSHRHHVLHD QKVDQKIYNP 700
    LNDLADPQGE YTVCNSSLSE YAVLGFELGY SMVDPNSLVI WEAQFGDFSN 750
    TAQCIIDQFV SSGQSKWIRQ SGLVMLLPHG YEGMGPEHSS ARPERFLQMC 800
    NEDDEIDLDK IAFGGTFEAQ QLHDTNWIVA NCTTPANIYH LLRRQVTMPF 850
    RKPAVVFSPK SLLRHPMARS PVEDFQSGSN FQRIIPETGA PSQNPPNVQR 900
    LVFCTGKVYY DMVAARKHVG KENDVALVRV EQLSPFPYDL VQQECRKYQG 950
    AEIIWAQEEH KNMGAWSFVQ PRINSLLSID GRATKYAGRL PSSSPATGNK 1000
    YTHMQEQKEM MSKVFGVPKS KLEGFKA 1027
    Length:1,027
    Mass (Da):115,481
    Last modified:November 23, 2004 - v1
    Checksum:i99584397C5540D7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601298 Genomic DNA. Translation: CAP22897.1.
    RefSeqiXP_002634170.1. XM_002634124.1.

    Genome annotation databases

    EnsemblMetazoaiCBG01737; CBG01737; CBG01737.
    GeneIDi8576165.
    KEGGicbr:CBG01737.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601298 Genomic DNA. Translation: CAP22897.1 .
    RefSeqi XP_002634170.1. XM_002634124.1.

    3D structure databases

    ProteinModelPortali Q623T0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG01737.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG01737 ; CBG01737 ; CBG01737 .
    GeneIDi 8576165.
    KEGGi cbr:CBG01737.

    Organism-specific databases

    CTDi 8576165.
    WormBasei CBG01737 ; CBP00459 ; WBGene00024926 ; Cbr-ogdh-1.

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    KOi K00164.
    OMAi GFTTAPH.
    OrthoDBi EOG7FXZXH.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiODO1_CAEBR
    AccessioniPrimary (citable) accession number: Q623T0
    Secondary accession number(s): A8WQY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3