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Q62398

- CNGA2_MOUSE

UniProt

Q62398 - CNGA2_MOUSE

Protein

Cyclic nucleotide-gated olfactory channel

Gene

Cnga2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei523 – 5231cAMPSequence Analysis
    Binding sitei538 – 5381cAMPSequence Analysis

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi464 – 586123cAMPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. cGMP binding Source: RefGenome
    3. intracellular cAMP activated cation channel activity Source: RefGenome
    4. intracellular cGMP activated cation channel activity Source: RefGenome
    5. ion channel activity Source: MGI
    6. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. phototransduction, visible light Source: RefGenome
    2. potassium ion transmembrane transport Source: RefGenome
    3. regulation of membrane potential Source: RefGenome
    4. sensory perception of smell Source: MGI

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel

    Keywords - Biological processi

    Ion transport, Olfaction, Sensory transduction, Transport

    Keywords - Ligandi

    Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

    Protein family/group databases

    TCDBi1.A.1.5.4. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic nucleotide-gated olfactory channel
    Alternative name(s):
    Cyclic nucleotide-gated cation channel 2
    Cyclic nucleotide-gated channel alpha-2
    Short name:
    CNG channel alpha-2
    Short name:
    CNG-2
    Short name:
    CNG2
    Gene namesi
    Name:Cnga2
    Synonyms:Cncg2, Cncg4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:108040. Cnga2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 664664Cyclic nucleotide-gated olfactory channelPRO_0000219313Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ62398.

    PTM databases

    PhosphoSiteiQ62398.

    Expressioni

    Gene expression databases

    BgeeiQ62398.
    CleanExiMM_CNGA2.
    GenevestigatoriQ62398.

    Interactioni

    Subunit structurei

    Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000006020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62398.
    SMRiQ62398. Positions 60-87, 325-573, 599-642.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 142142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini195 – 21824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini239 – 27638ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 35152CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini372 – 45584ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini477 – 664188CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei143 – 16321Helical; Name=H1Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19419Helical; Name=H2Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23820Helical; Name=H3Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29923Helical; Name=H4Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37120Helical; Name=H5Sequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621Helical; Name=H6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili599 – 64244By similarityAdd
    BLAST

    Domaini

    The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300025.
    GeneTreeiENSGT00550000074376.
    HOGENOMiHOG000007898.
    HOVERGENiHBG000281.
    InParanoidiQ80XH6.
    KOiK04949.
    OMAiYLSDGMN.
    OrthoDBiEOG771268.
    TreeFamiTF319048.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62398-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSS    50
    ELQRLAEMDT PRRGRGGFRR IVRLVGIIRD WANKNFREEE PRPDSFLERF 100
    RGPELQTVTT HQGDGKGDKD GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA 150
    MPVLYNWCLL VARACFSDLQ RNYFVVWLVL DYFSDTVYIA DLIIRLRTGF 200
    LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV GIHSPEVRFN 250
    RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYAISK 300
    SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE 350
    EYLFVIFDFL IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF 400
    RKVSKDMEAK VIKWFDYLWT NKKTVDEREV LKNLPAKLRA EIAINVHLST 450
    LKKVRIFQDC EAGLLVELVL KLRPQVFSPG DYICRKGDIG KEMYIIKEGK 500
    LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA NIRSLGYSDL 550
    FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ 600
    EKLEQLETNM ETLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY 650
    LSDGINTPEP AVAE 664
    Length:664
    Mass (Da):76,193
    Last modified:July 27, 2011 - v2
    Checksum:i34F8DF3B372C0D9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101T → P in AAC52712. (PubMed:8841933)Curated
    Sequence conflicti355 – 3551V → F in AAC52712. (PubMed:8841933)Curated
    Sequence conflicti540 – 5412AN → GT in AAC52712. (PubMed:8841933)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49391 Genomic DNA. Translation: AAC52712.1.
    AK132574 mRNA. Translation: BAE21237.1.
    CH466624 Genomic DNA. Translation: EDL26564.1.
    BC048775 mRNA. Translation: AAH48775.1.
    CCDSiCCDS30184.1.
    RefSeqiNP_031750.2. NM_007724.2.
    XP_006527824.1. XM_006527761.1.
    XP_006527825.1. XM_006527762.1.
    UniGeneiMm.5097.

    Genome annotation databases

    EnsembliENSMUST00000006020; ENSMUSP00000006020; ENSMUSG00000005864.
    GeneIDi12789.
    KEGGimmu:12789.
    UCSCiuc009tkk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49391 Genomic DNA. Translation: AAC52712.1 .
    AK132574 mRNA. Translation: BAE21237.1 .
    CH466624 Genomic DNA. Translation: EDL26564.1 .
    BC048775 mRNA. Translation: AAH48775.1 .
    CCDSi CCDS30184.1.
    RefSeqi NP_031750.2. NM_007724.2.
    XP_006527824.1. XM_006527761.1.
    XP_006527825.1. XM_006527762.1.
    UniGenei Mm.5097.

    3D structure databases

    ProteinModelPortali Q62398.
    SMRi Q62398. Positions 60-87, 325-573, 599-642.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000006020.

    Protein family/group databases

    TCDBi 1.A.1.5.4. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q62398.

    Proteomic databases

    PRIDEi Q62398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006020 ; ENSMUSP00000006020 ; ENSMUSG00000005864 .
    GeneIDi 12789.
    KEGGi mmu:12789.
    UCSCi uc009tkk.1. mouse.

    Organism-specific databases

    CTDi 1260.
    MGIi MGI:108040. Cnga2.

    Phylogenomic databases

    eggNOGi NOG300025.
    GeneTreei ENSGT00550000074376.
    HOGENOMi HOG000007898.
    HOVERGENi HBG000281.
    InParanoidi Q80XH6.
    KOi K04949.
    OMAi YLSDGMN.
    OrthoDBi EOG771268.
    TreeFami TF319048.

    Miscellaneous databases

    NextBioi 282190.
    PROi Q62398.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62398.
    CleanExi MM_CNGA2.
    Genevestigatori Q62398.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR018488. cNMP-bd_CS.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
    PS00889. CNMP_BINDING_2. 1 hit.
    PS50042. CNMP_BINDING_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart."
      Ruiz M.L., London B., Nadal-Ginard B.
      J. Mol. Cell. Cardiol. 28:1453-1461(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Heart.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCNGA2_MOUSE
    AccessioniPrimary (citable) accession number: Q62398
    Secondary accession number(s): Q80XH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3