SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62398

- CNGA2_MOUSE

UniProt

Q62398 - CNGA2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cyclic nucleotide-gated olfactory channel
Gene
Cnga2, Cncg2, Cncg4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei523 – 5231cAMP Reviewed prediction
Binding sitei538 – 5381cAMP Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi464 – 586123cAMP By similarity
Add
BLAST

GO - Molecular functioni

  1. cAMP binding Source: UniProtKB-KW
  2. cGMP binding Source: RefGenome
  3. intracellular cAMP activated cation channel activity Source: RefGenome
  4. intracellular cGMP activated cation channel activity Source: RefGenome
  5. ion channel activity Source: MGI
  6. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. phototransduction, visible light Source: RefGenome
  2. potassium ion transmembrane transport Source: RefGenome
  3. regulation of membrane potential Source: RefGenome
  4. sensory perception of smell Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel

Keywords - Biological processi

Ion transport, Olfaction, Sensory transduction, Transport

Keywords - Ligandi

Calmodulin-binding, cAMP, cAMP-binding, Nucleotide-binding

Protein family/group databases

TCDBi1.A.1.5.4. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:Cnga2
Synonyms:Cncg2, Cncg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:108040. Cnga2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 142142Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Name=H1; Reviewed prediction
Add
BLAST
Topological domaini164 – 17512Extracellular Reviewed prediction
Add
BLAST
Transmembranei176 – 19419Helical; Name=H2; Reviewed prediction
Add
BLAST
Topological domaini195 – 21824Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei219 – 23820Helical; Name=H3; Reviewed prediction
Add
BLAST
Topological domaini239 – 27638Extracellular Reviewed prediction
Add
BLAST
Transmembranei277 – 29923Helical; Name=H4; Reviewed prediction
Add
BLAST
Topological domaini300 – 35152Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei352 – 37120Helical; Name=H5; Reviewed prediction
Add
BLAST
Topological domaini372 – 45584Extracellular Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Name=H6; Reviewed prediction
Add
BLAST
Topological domaini477 – 664188Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Cyclic nucleotide-gated olfactory channel
PRO_0000219313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ62398.

PTM databases

PhosphoSiteiQ62398.

Expressioni

Gene expression databases

BgeeiQ62398.
CleanExiMM_CNGA2.
GenevestigatoriQ62398.

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006020.

Structurei

3D structure databases

ProteinModelPortaliQ62398.
SMRiQ62398. Positions 60-87, 325-573, 599-642.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili599 – 64244 By similarity
Add
BLAST

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300025.
GeneTreeiENSGT00550000074376.
HOGENOMiHOG000007898.
HOVERGENiHBG000281.
InParanoidiQ80XH6.
KOiK04949.
OMAiYLSDGMN.
OrthoDBiEOG771268.
TreeFamiTF319048.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62398-1 [UniParc]FASTAAdd to Basket

« Hide

MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSS    50
ELQRLAEMDT PRRGRGGFRR IVRLVGIIRD WANKNFREEE PRPDSFLERF 100
RGPELQTVTT HQGDGKGDKD GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA 150
MPVLYNWCLL VARACFSDLQ RNYFVVWLVL DYFSDTVYIA DLIIRLRTGF 200
LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV GIHSPEVRFN 250
RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYAISK 300
SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE 350
EYLFVIFDFL IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF 400
RKVSKDMEAK VIKWFDYLWT NKKTVDEREV LKNLPAKLRA EIAINVHLST 450
LKKVRIFQDC EAGLLVELVL KLRPQVFSPG DYICRKGDIG KEMYIIKEGK 500
LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA NIRSLGYSDL 550
FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ 600
EKLEQLETNM ETLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY 650
LSDGINTPEP AVAE 664
Length:664
Mass (Da):76,193
Last modified:July 27, 2011 - v2
Checksum:i34F8DF3B372C0D9C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101T → P in AAC52712. 1 Publication
Sequence conflicti355 – 3551V → F in AAC52712. 1 Publication
Sequence conflicti540 – 5412AN → GT in AAC52712. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49391 Genomic DNA. Translation: AAC52712.1.
AK132574 mRNA. Translation: BAE21237.1.
CH466624 Genomic DNA. Translation: EDL26564.1.
BC048775 mRNA. Translation: AAH48775.1.
CCDSiCCDS30184.1.
RefSeqiNP_031750.2. NM_007724.2.
XP_006527824.1. XM_006527761.1.
XP_006527825.1. XM_006527762.1.
UniGeneiMm.5097.

Genome annotation databases

EnsembliENSMUST00000006020; ENSMUSP00000006020; ENSMUSG00000005864.
GeneIDi12789.
KEGGimmu:12789.
UCSCiuc009tkk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49391 Genomic DNA. Translation: AAC52712.1 .
AK132574 mRNA. Translation: BAE21237.1 .
CH466624 Genomic DNA. Translation: EDL26564.1 .
BC048775 mRNA. Translation: AAH48775.1 .
CCDSi CCDS30184.1.
RefSeqi NP_031750.2. NM_007724.2.
XP_006527824.1. XM_006527761.1.
XP_006527825.1. XM_006527762.1.
UniGenei Mm.5097.

3D structure databases

ProteinModelPortali Q62398.
SMRi Q62398. Positions 60-87, 325-573, 599-642.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000006020.

Protein family/group databases

TCDBi 1.A.1.5.4. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q62398.

Proteomic databases

PRIDEi Q62398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006020 ; ENSMUSP00000006020 ; ENSMUSG00000005864 .
GeneIDi 12789.
KEGGi mmu:12789.
UCSCi uc009tkk.1. mouse.

Organism-specific databases

CTDi 1260.
MGIi MGI:108040. Cnga2.

Phylogenomic databases

eggNOGi NOG300025.
GeneTreei ENSGT00550000074376.
HOGENOMi HOG000007898.
HOVERGENi HBG000281.
InParanoidi Q80XH6.
KOi K04949.
OMAi YLSDGMN.
OrthoDBi EOG771268.
TreeFami TF319048.

Miscellaneous databases

NextBioi 282190.
PROi Q62398.
SOURCEi Search...

Gene expression databases

Bgeei Q62398.
CleanExi MM_CNGA2.
Genevestigatori Q62398.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS00888. CNMP_BINDING_1. 1 hit.
PS00889. CNMP_BINDING_2. 1 hit.
PS50042. CNMP_BINDING_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart."
    Ruiz M.L., London B., Nadal-Ginard B.
    J. Mol. Cell. Cardiol. 28:1453-1461(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCNGA2_MOUSE
AccessioniPrimary (citable) accession number: Q62398
Secondary accession number(s): Q80XH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi