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Protein

Cyclic nucleotide-gated olfactory channel

Gene

Cnga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei523cAMPSequence analysis1
Binding sitei538cAMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi464 – 586cAMPBy similarityAdd BLAST123

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Ion channel, Ligand-gated ion channel
Biological processIon transport, Olfaction, Sensory transduction, Transport
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.A.1.5.4 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic nucleotide-gated olfactory channel
Alternative name(s):
Cyclic nucleotide-gated cation channel 2
Cyclic nucleotide-gated channel alpha-2
Short name:
CNG channel alpha-2
Short name:
CNG-2
Short name:
CNG2
Gene namesi
Name:Cnga2
Synonyms:Cncg2, Cncg4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:108040 Cnga2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 142CytoplasmicSequence analysisAdd BLAST142
Transmembranei143 – 163Helical; Name=H1Sequence analysisAdd BLAST21
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 194Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini195 – 218CytoplasmicSequence analysisAdd BLAST24
Transmembranei219 – 238Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini239 – 276ExtracellularSequence analysisAdd BLAST38
Transmembranei277 – 299Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini300 – 351CytoplasmicSequence analysisAdd BLAST52
Transmembranei352 – 371Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini372 – 455ExtracellularSequence analysisAdd BLAST84
Transmembranei456 – 476Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini477 – 664CytoplasmicSequence analysisAdd BLAST188

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193131 – 664Cyclic nucleotide-gated olfactory channelAdd BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62398
PRIDEiQ62398

PTM databases

PhosphoSitePlusiQ62398

Expressioni

Gene expression databases

BgeeiENSMUSG00000005864
CleanExiMM_CNGA2
ExpressionAtlasiQ62398 baseline and differential
GenevisibleiQ62398 MM

Interactioni

Subunit structurei

Heterotetramer composed of two subunits of CNGA2, one of CNGA4 and one of CNGB1b. The complex forms the cyclic nucleotide-gated (CNG) channel of olfactory sensory neurons (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006020

Structurei

3D structure databases

ProteinModelPortaliQ62398
SMRiQ62398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili599 – 642By similarityAdd BLAST44

Domaini

The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.By similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0500 Eukaryota
ENOG410YWWI LUCA
GeneTreeiENSGT00900000140801
HOGENOMiHOG000007898
HOVERGENiHBG000281
InParanoidiQ62398
KOiK04949
OMAiEAKVIRW
OrthoDBiEOG091G03EW
TreeFamiTF319048

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032406 CLZ_dom
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF16526 CLZ, 1 hit
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 1 hit
PS00889 CNMP_BINDING_2, 1 hit
PS50042 CNMP_BINDING_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q62398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTEKSNGVK SSPANNHNHH PPPSIKANGK DDHRAGSRPQ SVAADDDTSS
60 70 80 90 100
ELQRLAEMDT PRRGRGGFRR IVRLVGIIRD WANKNFREEE PRPDSFLERF
110 120 130 140 150
RGPELQTVTT HQGDGKGDKD GEGKGTKKKF ELFVLDPAGD WYYRWLFVIA
160 170 180 190 200
MPVLYNWCLL VARACFSDLQ RNYFVVWLVL DYFSDTVYIA DLIIRLRTGF
210 220 230 240 250
LEQGLLVKDP KKLRDNYIHT LQFKLDVASI IPTDLIYFAV GIHSPEVRFN
260 270 280 290 300
RLLHFARMFE FFDRTETRTS YPNIFRISNL VLYILVIIHW NACIYYAISK
310 320 330 340 350
SIGFGVDTWV YPNITDPEYG YLAREYIYCL YWSTLTLTTI GETPPPVKDE
360 370 380 390 400
EYLFVIFDFL IGVLIFATIV GNVGSMISNM NATRAEFQAK IDAVKHYMQF
410 420 430 440 450
RKVSKDMEAK VIKWFDYLWT NKKTVDEREV LKNLPAKLRA EIAINVHLST
460 470 480 490 500
LKKVRIFQDC EAGLLVELVL KLRPQVFSPG DYICRKGDIG KEMYIIKEGK
510 520 530 540 550
LAVVADDGVT QYALLSAGSC FGEISILNIK GSKMGNRRTA NIRSLGYSDL
560 570 580 590 600
FCLSKDDLME AVTEYPDAKK VLEERGREIL MKEGLLDENE VAASMEVDVQ
610 620 630 640 650
EKLEQLETNM ETLYTRFARL LAEYTGAQQK LKQRITVLET KMKQNHEDDY
660
LSDGINTPEP AVAE
Length:664
Mass (Da):76,193
Last modified:July 27, 2011 - v2
Checksum:i34F8DF3B372C0D9C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110T → P in AAC52712 (PubMed:8841933).Curated1
Sequence conflicti355V → F in AAC52712 (PubMed:8841933).Curated1
Sequence conflicti540 – 541AN → GT in AAC52712 (PubMed:8841933).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49391 Genomic DNA Translation: AAC52712.1
AK132574 mRNA Translation: BAE21237.1
CH466624 Genomic DNA Translation: EDL26564.1
BC048775 mRNA Translation: AAH48775.1
CCDSiCCDS30184.1
RefSeqiNP_031750.2, NM_007724.3
XP_006527824.1, XM_006527761.1
UniGeneiMm.5097

Genome annotation databases

EnsembliENSMUST00000006020; ENSMUSP00000006020; ENSMUSG00000005864
GeneIDi12789
KEGGimmu:12789
UCSCiuc009tkk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCNGA2_MOUSE
AccessioniPrimary (citable) accession number: Q62398
Secondary accession number(s): Q80XH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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