Q62396 (ZFP92_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 92
Short name=Zfp-92

Gene names

Name:

Zfp92

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 9 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Zinc finger protein 92		PRO_0000047314
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	141 – 163	23	C2H2-type 1
	Zinc finger	169 – 191	23	C2H2-type 2
	Zinc finger	197 – 219	23	C2H2-type 3
	Zinc finger	225 – 247	23	C2H2-type 4
	Zinc finger	253 – 275	23	C2H2-type 5
	Zinc finger	281 – 303	23	C2H2-type 6
	Zinc finger	309 – 331	23	C2H2-type 7; degenerate
	Zinc finger	337 – 359	23	C2H2-type 8
	Zinc finger	410 – 432	23	C2H2-type 9
Experimental info
	Sequence conflict	296	1	L → V in AAC52629. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q62396 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: E163773E0903D68C	FASTA	488	55,976
	10 20 30 40 50 60 MAATLLRAKP KVTVSFEDVS VYFTKTEWRL LDLKQRTLYK QVMLENYSHL VSVGFAFSKP 70 80 90 100 110 120 NLVSQLERGE KPWIRDDGME SAARSCAGNR IKTKTLTSKP KLFGRGLLRN TSRSSLQRRP 130 140 150 160 170 180 HDFRPNPIVR YQHSRIADKR YLCQQCGKSF SRSFNLIKHR IIHSREKPYE CSECGKQFQR 190 200 210 220 230 240 SLALLEHQRI HSGDKPYECG ECGKTFTRSS NLVKHQVIHS SEMPFVCRMC GKVFRRSFAL 250 260 270 280 290 300 LEHTRIHSGE RPFECTECGK AFSRSSNLIE HQRIHSGQKP YICKECGKAF KGVSQLIHHQ 310 320 330 340 350 360 LIHRGDKPFT CHEYGKAFRG LSGLSQHQRV HRGEKPYECS ECGRAFGRRA NLFKHQVVHG 370 380 390 400 410 420 GVRLQHRTRG KGFQRKLLEH LRDLHGQQPQ EAGEGSSAEP QPIDTNEKPQ VCERCGQVFE 430 440 450 460 470 480 NKLLLCRHLR IHDDEDDKKQ KPVISSTSVL EDKSLLSQHL EAQPTEESDS EGSVVFVYAE KPHGPSSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28." Levin M.L., Chatterjee A., Pragliola A., Worley K.C., Wehnert M., Zhuchenko O., Smith R.F., Lee C.C., Herman G.E. Genome Res. 6:465-477(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129/Sv.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U47104 mRNA. Translation: AAC52629.1. AK141522 mRNA. Translation: BAE24717.1. AL049866 Genomic DNA. Translation: CAB88276.1. AL732461 Genomic DNA. Translation: CAM27428.1. CH466650 Genomic DNA. Translation: EDL29901.1.
IPI	IPI00124843.
RefSeq	NP_033592.2. NM_009566.4.
UniGene	Mm.5060.
3D structure databases
ProteinModelPortal	Q62396.
SMR	Q62396. Positions 14-55, 138-439.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000033740.
PTM databases
PhosphoSite	Q62396.
Proteomic databases
PRIDE	Q62396.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033740; ENSMUSP00000033740; ENSMUSG00000031374.
GeneID	22754.
KEGG	mmu:22754.
Organism-specific databases
CTD	139735.
MGI	MGI:108094. Zfp92.
Phylogenomic databases
eggNOG	COG5048.
GeneTree	ENSGT00700000104462.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9JJR0.
KO	K09228.
OrthoDB	EOG4F1X3D.
Gene expression databases
ArrayExpress	Q62396.
Bgee	Q62396.
CleanEx	MM_ZFP92.
Genevestigator	Q62396.
GermOnline	ENSMUSG00000031374. Mus musculus.
Family and domain databases
Gene3D	3.30.160.60. 9 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 9 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	303253.
SOURCE	Search...

Entry information

Entry name

ZFP92_MOUSE

Accession

Primary (citable) accession number: Q62396
Secondary accession number(s): Q9JJR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program