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Protein

Trefoil factor 3

Gene

Tff3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).1 Publication

GO - Biological processi

  • digestion Source: GO_Central
  • regulation of glucose metabolic process Source: CACAO
  • wound healing Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
mITF
Gene namesi
Name:Tff3
Synonyms:Itf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104638 Tff3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice lacking this gene show impaired mucosal healing after injury and die from extensive colitis after oral administration of dextran sulfate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002346623 – 81Trefoil factor 3Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 59PROSITE-ProRule annotation
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi53 ↔ 70PROSITE-ProRule annotation
Disulfide bondi79InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ62395
PaxDbiQ62395
PeptideAtlasiQ62395
PRIDEiQ62395

Expressioni

Tissue specificityi

Expressed in goblet cells of the intestines and colon (at protein level). Expressed abundantly in goblet cells of intestine and colon, and at low levels in stomach. No expression in brain, lung, spleen, kidney, uterus, pancreas, liver, heart or thymus.2 Publications

Developmental stagei

No expression found in embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000024029
CleanExiMM_TFF3
GenevisibleiQ62395 MM

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024827

Structurei

3D structure databases

ProteinModelPortaliQ62395
SMRiQ62395
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 74P-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0FX Eukaryota
ENOG41114KR LUCA
GeneTreeiENSGT00840000129881
HOGENOMiHOG000121778
HOVERGENiHBG004364
InParanoidiQ62395
KOiK22454
OMAiPLQETEC
OrthoDBiEOG091G0XBT
PhylomeDBiQ62395
TreeFamiTF336092

Family and domain databases

CDDicd00111 Trefoil, 1 hit
InterProiView protein in InterPro
IPR017994 P_trefoil_chordata
IPR017957 P_trefoil_CS
IPR000519 P_trefoil_dom
PfamiView protein in Pfam
PF00088 Trefoil, 1 hit
PRINTSiPR00680 PTREFOIL
SMARTiView protein in SMART
SM00018 PD, 1 hit
PROSITEiView protein in PROSITE
PS00025 P_TREFOIL_1, 1 hit
PS51448 P_TREFOIL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRALWLML LVVLVAGSSG IAADYVGLSP SQCMVPANVR VDCGYPSVTS
60 70 80
EQCNNRGCCF DSSIPNVPWC FKPLQETECT F
Length:81
Mass (Da):8,808
Last modified:July 15, 1998 - v2
Checksum:i655A2E00E390C036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24222, U24220, U24221 Genomic DNA Translation: AAB92385.1
D38410 mRNA Translation: BAA07464.1
AJ271004 Genomic DNA Translation: CAB65752.1
BC011042 mRNA Translation: AAH11042.1
U46858 Genomic DNA Translation: AAC52682.1
CCDSiCCDS37544.1
PIRiJC4147
RefSeqiNP_035705.1, NM_011575.2
UniGeneiMm.4641

Genome annotation databases

EnsembliENSMUST00000024827; ENSMUSP00000024827; ENSMUSG00000024029
GeneIDi21786
KEGGimmu:21786
UCSCiuc008buk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTFF3_MOUSE
AccessioniPrimary (citable) accession number: Q62395
Secondary accession number(s): Q64352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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