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Protein

Trefoil factor 3

Gene

Tff3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).1 Publication

GO - Biological processi

  • regulation of glucose metabolic process Source: CACAO
  • response to peptide hormone Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 3
Alternative name(s):
Intestinal trefoil factor
Short name:
mITF
Gene namesi
Name:Tff3
Synonyms:Itf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104638. Tff3.

Subcellular locationi

  • Secretedextracellular spaceextracellular matrix By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice lacking this gene show impaired mucosal healing after injury and die from extensive colitis after oral administration of dextran sulfate.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 8159Trefoil factor 3PRO_0000023466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 59PROSITE-ProRule annotation
Disulfide bondi43 ↔ 58PROSITE-ProRule annotation
Disulfide bondi53 ↔ 70PROSITE-ProRule annotation
Disulfide bondi79 – 79InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62395.

Expressioni

Tissue specificityi

Expressed in goblet cells of the intestines and colon (at protein level). Expressed abundantly in goblet cells of intestine and colon, and at low levels in stomach. No expression in brain, lung, spleen, kidney, uterus, pancreas, liver, heart or thymus.2 Publications

Developmental stagei

No expression found in embryos.1 Publication

Gene expression databases

BgeeiQ62395.
CleanExiMM_TFF3.
GenevisibleiQ62395. MM.

Interactioni

Subunit structurei

Monomer. Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024827.

Structurei

3D structure databases

ProteinModelPortaliQ62395.
SMRiQ62395. Positions 24-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 7444P-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 P-type (trefoil) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0FX. Eukaryota.
ENOG41114KR. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ62395.
OMAiTSEQCNN.
OrthoDBiEOG70W3GT.
PhylomeDBiQ62395.
TreeFamiTF336092.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRALWLML LVVLVAGSSG IAADYVGLSP SQCMVPANVR VDCGYPSVTS
60 70 80
EQCNNRGCCF DSSIPNVPWC FKPLQETECT F
Length:81
Mass (Da):8,808
Last modified:July 15, 1998 - v2
Checksum:i655A2E00E390C036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24222, U24220, U24221 Genomic DNA. Translation: AAB92385.1.
D38410 mRNA. Translation: BAA07464.1.
AJ271004 Genomic DNA. Translation: CAB65752.1.
BC011042 mRNA. Translation: AAH11042.1.
U46858 Genomic DNA. Translation: AAC52682.1.
CCDSiCCDS37544.1.
PIRiJC4147.
RefSeqiNP_035705.1. NM_011575.2.
UniGeneiMm.4641.

Genome annotation databases

EnsembliENSMUST00000024827; ENSMUSP00000024827; ENSMUSG00000024029.
GeneIDi21786.
KEGGimmu:21786.
UCSCiuc008buk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24222, U24220, U24221 Genomic DNA. Translation: AAB92385.1.
D38410 mRNA. Translation: BAA07464.1.
AJ271004 Genomic DNA. Translation: CAB65752.1.
BC011042 mRNA. Translation: AAH11042.1.
U46858 Genomic DNA. Translation: AAC52682.1.
CCDSiCCDS37544.1.
PIRiJC4147.
RefSeqiNP_035705.1. NM_011575.2.
UniGeneiMm.4641.

3D structure databases

ProteinModelPortaliQ62395.
SMRiQ62395. Positions 24-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024827.

Proteomic databases

PaxDbiQ62395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024827; ENSMUSP00000024827; ENSMUSG00000024029.
GeneIDi21786.
KEGGimmu:21786.
UCSCiuc008buk.2. mouse.

Organism-specific databases

CTDi7033.
MGIiMGI:104638. Tff3.

Phylogenomic databases

eggNOGiENOG410J0FX. Eukaryota.
ENOG41114KR. LUCA.
GeneTreeiENSGT00840000129881.
HOGENOMiHOG000121778.
HOVERGENiHBG004364.
InParanoidiQ62395.
OMAiTSEQCNN.
OrthoDBiEOG70W3GT.
PhylomeDBiQ62395.
TreeFamiTF336092.

Miscellaneous databases

PROiQ62395.
SOURCEiSearch...

Gene expression databases

BgeeiQ62395.
CleanExiMM_TFF3.
GenevisibleiQ62395. MM.

Family and domain databases

Gene3Di4.10.110.10. 1 hit.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 1 hit.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 1 hit.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 1 hit.
PROSITEiPS00025. P_TREFOIL_1. 1 hit.
PS51448. P_TREFOIL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression."
    Mashimo H., Podolsky D.K., Fishman M.C.
    Biochem. Biophys. Res. Commun. 210:31-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: 129/Sv.
    Tissue: Liver.
  2. "Molecular cloning of mouse intestinal trefoil factor and its expression during goblet cell changes."
    Tomita M., Itoh H., Ishikawa N., Higa A., Ide H., Murakumo Y., Maruyama H., Koga Y., Nawa Y.
    Biochem. J. 311:293-297(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Small intestine.
  3. "Mouse trefoil factor genes: genomic organization, sequences and methylation analyses."
    Ribieras S., Lefebvre O., Tomasetto C., Rio M.C.
    Gene 266:67-75(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "The gene encoding mouse intestinal trefoil factor: structural organization, partial sequence analysis and mapping to murine chromosome 17q."
    Chinery R., Poulsom R., Cox H.M.
    Gene 171:249-253(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77.
  6. "Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor."
    Mashimo H., Wu D.C., Podolsky D.K., Fishman M.C.
    Science 274:262-265(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTFF3_MOUSE
AccessioniPrimary (citable) accession number: Q62395
Secondary accession number(s): Q64352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.