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Protein

Zinc finger protein 185

Gene

Znf185

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cellular proliferation and/or differentiation.By similarity

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 185
Alternative name(s):
LIM domain protein Zfp185
P1-A
Gene namesi
Name:Znf185
Synonyms:Zfp185
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108095. Zfp185.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759121 – 352Zinc finger protein 185Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei137PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62394.
PaxDbiQ62394.
PeptideAtlasiQ62394.
PRIDEiQ62394.

PTM databases

iPTMnetiQ62394.
PhosphoSitePlusiQ62394.

Expressioni

Tissue specificityi

Expressed in skin, kidney, ovary, testis. Also expressed in brain, cartilage, heart, lung, spleen and thymus.

Developmental stagei

At E14.5, only expressed in mesenchymal cells. At E16.5 expressed also in cells lining the vertebrae and tendons of the proximal tail. In late embryogenesis, expressed in mesenchymal cells adjacent to the distal limb bones (tibia and calcaneum), in tendons and in the connective tissue sheath (epimysium) surrounding the skeletal muscle. Also expressed in the epithelia of the epididymis of the testis.

Gene expression databases

CleanExiMM_ZFP185.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126066.

Structurei

3D structure databases

ProteinModelPortaliQ62394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 347LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 26Poly-Glu4

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiKOG1704. Eukaryota.
ENOG410XP0W. LUCA.
HOGENOMiHOG000232182.
HOVERGENiHBG071794.
InParanoidiQ62394.

Family and domain databases

InterProiView protein in InterPro
IPR030637. ZNF185.
IPR001781. Znf_LIM.
PANTHERiPTHR15468:SF2. PTHR15468:SF2. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 1 hit.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEDYKKLA PYNIRRSSIS GTEEEEVPFT PDEQKRRSQA ALGVLRKTAP
60 70 80 90 100
REHSYVLSAA KKTTSSPTQE LQSPFLAKRV DVVDEDVLPE KNQEPPALAR
110 120 130 140 150
PDSGLSSSTT EKIAHRQITP PTAELHLVAP DLEALSTPDS CEENNAAPKI
160 170 180 190 200
IKEIPGTLQD GQSDPTVASQ QLADLSILEP LGSPSGAEQQ IKAEDCTNML
210 220 230 240 250
MSPSSCMVTV TVSDTSEQSQ LCVPGVSSKV DSSSTIKGIL FVKEYMNTSE
260 270 280 290 300
VSSGKPVSSH CDSPSSIEDS LDLAKKPPHE GTPSERPTEG VCTYCSHEIQ
310 320 330 340 350
DCPKITLEHL GICCHEYCFK CGICNKPMGD LLDQIFIHRD TIHCGKCYEK

LF
Length:352
Mass (Da):38,322
Last modified:November 1, 1996 - v1
Checksum:i2AB1F833D7AF1A5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46687 mRNA. Translation: AAC52628.1.
RefSeqiNP_001102513.1. NM_001109043.1.
NP_033575.3. NM_009549.3.
UniGeneiMm.1161.

Genome annotation databases

GeneIDi22673.
KEGGimmu:22673.

Similar proteinsi

Entry informationi

Entry nameiZN185_MOUSE
AccessioniPrimary (citable) accession number: Q62394
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot