Reviewed, UniProtKB/Swiss-Prot Q62393 (TPD52_MOUSE)

Names and origin

Protein names

Recommended name:
    Tumor protein D52
      Short name=mD52

Gene names

Name:

Tpd52

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Forms homodimer or heterodimer with other members of the family By similarity.
Tissue specificity	Isoform 2 is expressed at higher levels in kidney and brain than in liver, lung, testis and heart. Within the brain, isoform 2 is highly expressed in the granular layer of the cerebellum, the cortex and the hippocampus. In embryos, isoform 2 is expressed in the epithelium of the developing intestine, stomach, olfactory epithelium, neuronal layers of the retina, salivary gland, kidney and dorsal root ganglion. Ref.7
Sequence similarities	Belongs to the TPD52 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	B cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	endoplasmic reticulum Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB protein heterodimerization activity Inferred from direct assay. Source: UniProtKB protein homodimerization activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-782591,EBI-782591
TPD52	P55327	1	EBI-782591,EBI-782581	From a different organism.
TPD52L2	O43399-2	1	EBI-782591,EBI-782616	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q62393-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q62393-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MECRDMELADDYQSPFDFDSGVNKNYLYLSPSGNTSPPGSPTQNV → MDRGEQ

Isoform 3 (identifier: Q62393-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MECRDMELADDYQSPFDFDSGVNKNYLYLSPSGNTSPPGSPTQNV → MDRGEQ
     168-168: K → NIRSIQHSISMPAMR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Tumor protein D52		PRO_0000185739
Regions
	Coiled coil	61 – 113	53	Potential
Amino acid modifications
	Modified residue	170	1	Phosphoserine By similarity
	Modified residue	172	1	Phosphothreonine By similarity
	Modified residue	175	1	Phosphoserine By similarity
	Modified residue	223	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 45	45	MECRD…PTQNV → MDRGEQ in isoform 2 and isoform 3.		VSP_037379
	Alternative sequence	168	1	K → NIRSIQHSISMPAMR in isoform 3.		VSP_037380
Experimental info
	Sequence conflict	129	1	V → L in AAH04068. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 26, 2009. Version 2. Checksum: C80D8AB9038B0D73	FASTA	224	24,313
	10 20 30 40 50 60 MECRDMELAD DYQSPFDFDS GVNKNYLYLS PSGNTSPPGS PTQNVGLLKT EPVAEEGEDA 70 80 90 100 110 120 VTMLSAPEAL TEEEQEELRR ELTKVEEEIQ TLSQVLAAKE KHLAELKRKL GISSLQEFKQ 130 140 150 160 170 180 NIAKGWQDVT ATNAYKKTSE TLSQAGQKAS AAFSSVGSVI TKKLEDVKNS PTFKSFEEKV 190 200 210 220 ENLKSKVGGA KPAGGDFGEV LNSTANATST MTTEPPPEQM TESP
	Isoform 2. Checksum: 345B487842135D33	FASTA	185	20,059
	10 20 30 40 50 60 MDRGEQGLLK TEPVAEEGED AVTMLSAPEA LTEEEQEELR RELTKVEEEI QTLSQVLAAK 70 80 90 100 110 120 EKHLAELKRK LGISSLQEFK QNIAKGWQDV TATNAYKKTS ETLSQAGQKA SAAFSSVGSV 130 140 150 160 170 180 ITKKLEDVKN SPTFKSFEEK VENLKSKVGG AKPAGGDFGE VLNSTANATS TMTTEPPPEQ MTESP
	Isoform 3. Checksum: 7E81DF05305EEB51	FASTA	199	21,654
	10 20 30 40 50 60 MDRGEQGLLK TEPVAEEGED AVTMLSAPEA LTEEEQEELR RELTKVEEEI QTLSQVLAAK 70 80 90 100 110 120 EKHLAELKRK LGISSLQEFK QNIAKGWQDV TATNAYKKTS ETLSQAGQKA SAAFSSVGSV 130 140 150 160 170 180 ITKKLEDVNI RSIQHSISMP AMRNSPTFKS FEEKVENLKS KVGGAKPAGG DFGEVLNSTA 190 NATSTMTTEP PPEQMTESP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)." Byrne J.A., Mattei M.-G., Basset P. Genomics 35:523-532(1996) [PubMed: 8812487] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Mammary gland.
[2]	"Cloning and characterization of PC-1 homolog in Mouse (mPC-1)." Zhou J.-G., Huang C.-F. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J and NOD. Tissue: Amnion, Bone marrow macrophage, Dendritic cell, Medulla oblongata, Placenta and Thymus.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: Czech II and FVB/N. Tissue: Mammary gland.
[6]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 110-123, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[7]	"Isolation and characterization of a novel gene expressed in multiple cancers." Chen S.-L., Maroulakou I.G., Green J.E., Romano-Spica V., Modi W., Lautenberger J., Bhat N.K. Oncogene 12:741-751(1996) [PubMed: 8632896] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U44426 mRNA. Translation: AAB40897.1. AY048852 mRNA. Translation: AAL05266.1. AK005456 mRNA. Translation: BAB24048.1. AK032111 mRNA. Translation: BAC27709.1. AK151471 mRNA. Translation: BAE30428.1. AK151744 mRNA. Translation: BAE30655.1. AK152543 mRNA. Translation: BAE31298.1. AK153266 mRNA. Translation: BAE31856.1. AK153292 mRNA. Translation: BAE31875.1. AK161753 mRNA. Translation: BAE36558.1. AK168379 mRNA. Translation: BAE40308.1. AK168817 mRNA. Translation: BAE40644.1. AK169751 mRNA. Translation: BAE41345.1. AK170725 mRNA. Translation: BAE41982.1. AK171050 mRNA. Translation: BAE42212.1. CH466577 Genomic DNA. Translation: EDL05193.1. BC002036 mRNA. Translation: AAH02036.1. BC004068 mRNA. Translation: AAH04068.1. BC094018 mRNA. Translation: AAH94018.1.
IPI	IPI00408626. IPI00473743. IPI00622833.
RefSeq	NP_001020432.1. NP_001020433.1. NP_001020434.1. NP_001020435.1. NP_033438.1.
UniGene	Mm.371590
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62393. 6 interactions.
STRING	Q62393.
PTM databases
PhosphoSite	Q62393.
Proteomic databases
PRIDE	Q62393.
Genome annotation databases
Ensembl	ENSMUST00000094381; ENSMUSP00000091943; ENSMUSG00000027506; Mus musculus. [Genome view]
GeneID	21985.
KEGG	mmu:21985.
UCSC	uc008oov.1. mouse.
Organism-specific databases
CTD	21985.
MGI	MGI:107749. Tpd52.
Phylogenomic databases
HOVERGEN	Q62393.
OrthoDB	EOG9J13TJ.
Gene expression databases
ArrayExpress	Q62393.
Bgee	Q62393.
CleanEx	MM_TPD52.
Genevestigator	Q62393.
GermOnline	ENSMUSG00000027506. Mus musculus.
Family and domain databases
InterPro	IPR007327. TPD52. [Graphical view]
PANTHER	PTHR19307. TPD52. 1 hit.
Pfam	PF04201. TPD52. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	301708.
SOURCE	Search...

Entry information

Entry name

TPD52_MOUSE

Accession

Primary (citable) accession number: Q62393
Secondary accession number(s): Q545M5 , Q8CCU1, Q8K564, Q99KP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 26, 2009
Last modified:	November 24, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)