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Protein

Pleckstrin homology-like domain family A member 1

Gene

Phlda1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • FasL biosynthetic process Source: MGI

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-8854521 Interaction between PHLDA1 and AURKA

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 1
Alternative name(s):
Proline- and glutamine-rich protein
Short name:
PQ-rich protein
Short name:
PQR protein
T-cell death-associated gene 51 protein
Gene namesi
Name:Phlda1
Synonyms:Tdag51
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1096880 Phlda1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538981 – 405Pleckstrin homology-like domain family A member 1Add BLAST405

Proteomic databases

MaxQBiQ62392
PaxDbiQ62392
PeptideAtlasiQ62392
PRIDEiQ62392

PTM databases

iPTMnetiQ62392
PhosphoSitePlusiQ62392

Expressioni

Tissue specificityi

Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.3 Publications

Inductioni

Induced by IGF-I.1 Publication

Gene expression databases

BgeeiENSMUSG00000020205
GenevisibleiQ62392 MM

Interactioni

Subunit structurei

Interacts with RPL14, EIF3S7 and PABPC4.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ62392, 4 interactors
MINTiQ62392
STRINGi10090.ENSMUSP00000132815

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 277PHAdd BLAST125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni309 – 34416 X 2 AA repeats of P-QAdd BLAST36
Regioni354 – 37711 X 2 AA repeats of P-HAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi189 – 198Poly-Gln10

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXHQ Eukaryota
ENOG4111IXF LUCA
GeneTreeiENSGT00440000039564
HOGENOMiHOG000171183
HOVERGENiHBG108249
InParanoidiQ62392
OMAiQPHGHRL
OrthoDBiEOG091G0FTL
PhylomeDBiQ62392
TreeFamiTF332320

Family and domain databases

InterProiView protein in InterPro
IPR001849 PH_domain
SMARTiView protein in SMART
SM00233 PH, 1 hit

Sequencei

Sequence statusi: Complete.

Q62392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP
60 70 80 90 100
FSERSPEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL
110 120 130 140 150
CALRAGGRGS RWGEDGAGLL LLPPAGASGS LKAERSSSTP YAGRMLENSG
160 170 180 190 200
CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQL QQQQQQQQPG
210 220 230 240 250
QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK GKYMYFTVVM
260 270 280 290 300
TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ
310 320 330 340 350
PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP
360 370 380 390 400
HPHPHPYSHP HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS

TSNSA
Length:405
Mass (Da):45,583
Last modified:May 5, 2009 - v2
Checksum:i87F50D81EFC44C55
GO

Sequence cautioni

The sequence AAC52674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10295 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34715 differs from that shown. Reason: Frameshift at position 176.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209P → R in BAE28322 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44088 mRNA Translation: AAC52674.1 Different initiation.
AK148063 mRNA Translation: BAE28322.1
AK158890 mRNA Translation: BAE34715.1 Sequence problems.
BC010295 mRNA Translation: AAH10295.1 Different initiation.
CCDSiCCDS24167.2
RefSeqiNP_033370.2, NM_009344.3
UniGeneiMm.3117

Genome annotation databases

EnsembliENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205
GeneIDi21664
KEGGimmu:21664
UCSCiuc007haf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPHLA1_MOUSE
AccessioniPrimary (citable) accession number: Q62392
Secondary accession number(s): Q3TY48, Q3UG87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 5, 2009
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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