Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology-like domain family A member 1

Gene

Phlda1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-8854521. Interaction between PHLDA1 and AURKA.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family A member 1
Alternative name(s):
Proline- and glutamine-rich protein
Short name:
PQ-rich protein
Short name:
PQR protein
T-cell death-associated gene 51 protein
Gene namesi
Name:Phlda1
Synonyms:Tdag51
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1096880. Phlda1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmic vesicle By similarity
  • Nucleusnucleolus By similarity

  • Note: Colocalizes with intracellular vesicles.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Pleckstrin homology-like domain family A member 1PRO_0000053898Add
BLAST

Proteomic databases

MaxQBiQ62392.
PaxDbiQ62392.
PeptideAtlasiQ62392.
PRIDEiQ62392.

PTM databases

iPTMnetiQ62392.
PhosphoSiteiQ62392.

Expressioni

Tissue specificityi

Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.3 Publications

Inductioni

Induced by IGF-I.1 Publication

Gene expression databases

BgeeiENSMUSG00000020205.
GenevisibleiQ62392. MM.

Interactioni

Subunit structurei

Interacts with RPL14, EIF3S7 and PABPC4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJB1P256852EBI-309727,EBI-357034From a different organism.
HSPA1BP081072EBI-309727,EBI-629985From a different organism.
HSPH1Q925982EBI-309727,EBI-356829From a different organism.

Protein-protein interaction databases

IntActiQ62392. 4 interactions.
MINTiMINT-3381520.
STRINGi10090.ENSMUSP00000132815.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 277125PHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni309 – 3443616 X 2 AA repeats of P-QAdd
BLAST
Regioni354 – 3772411 X 2 AA repeats of P-HAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 19810Poly-Gln

Sequence similaritiesi

Contains 1 PH domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXHQ. Eukaryota.
ENOG4111IXF. LUCA.
GeneTreeiENSGT00440000039564.
HOGENOMiHOG000171183.
HOVERGENiHBG108249.
InParanoidiQ62392.
OMAiGRQEPPF.
OrthoDBiEOG091G0FTL.
PhylomeDBiQ62392.
TreeFamiTF332320.

Family and domain databases

InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP
60 70 80 90 100
FSERSPEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL
110 120 130 140 150
CALRAGGRGS RWGEDGAGLL LLPPAGASGS LKAERSSSTP YAGRMLENSG
160 170 180 190 200
CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQL QQQQQQQQPG
210 220 230 240 250
QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK GKYMYFTVVM
260 270 280 290 300
TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ
310 320 330 340 350
PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP
360 370 380 390 400
HPHPHPYSHP HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS

TSNSA
Length:405
Mass (Da):45,583
Last modified:May 5, 2009 - v2
Checksum:i87F50D81EFC44C55
GO

Sequence cautioni

The sequence AAC52674 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH10295 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE34715 differs from that shown. Reason: Frameshift at position 176. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091P → R in BAE28322 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44088 mRNA. Translation: AAC52674.1. Different initiation.
AK148063 mRNA. Translation: BAE28322.1.
AK158890 mRNA. Translation: BAE34715.1. Sequence problems.
BC010295 mRNA. Translation: AAH10295.1. Different initiation.
CCDSiCCDS24167.2.
RefSeqiNP_033370.2. NM_009344.3.
UniGeneiMm.3117.

Genome annotation databases

EnsembliENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205.
GeneIDi21664.
KEGGimmu:21664.
UCSCiuc007haf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44088 mRNA. Translation: AAC52674.1. Different initiation.
AK148063 mRNA. Translation: BAE28322.1.
AK158890 mRNA. Translation: BAE34715.1. Sequence problems.
BC010295 mRNA. Translation: AAH10295.1. Different initiation.
CCDSiCCDS24167.2.
RefSeqiNP_033370.2. NM_009344.3.
UniGeneiMm.3117.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62392. 4 interactions.
MINTiMINT-3381520.
STRINGi10090.ENSMUSP00000132815.

PTM databases

iPTMnetiQ62392.
PhosphoSiteiQ62392.

Proteomic databases

MaxQBiQ62392.
PaxDbiQ62392.
PeptideAtlasiQ62392.
PRIDEiQ62392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205.
GeneIDi21664.
KEGGimmu:21664.
UCSCiuc007haf.2. mouse.

Organism-specific databases

CTDi22822.
MGIiMGI:1096880. Phlda1.

Phylogenomic databases

eggNOGiENOG410IXHQ. Eukaryota.
ENOG4111IXF. LUCA.
GeneTreeiENSGT00440000039564.
HOGENOMiHOG000171183.
HOVERGENiHBG108249.
InParanoidiQ62392.
OMAiGRQEPPF.
OrthoDBiEOG091G0FTL.
PhylomeDBiQ62392.
TreeFamiTF332320.

Enzyme and pathway databases

ReactomeiR-MMU-8854521. Interaction between PHLDA1 and AURKA.

Miscellaneous databases

ChiTaRSiPhlda1. mouse.
PROiQ62392.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020205.
GenevisibleiQ62392. MM.

Family and domain databases

InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPHLA1_MOUSE
AccessioniPrimary (citable) accession number: Q62392
Secondary accession number(s): Q3TY48, Q3UG87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.