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Protein

Interleukin-17A

Gene

Il17a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:Il17a
Synonyms:Ctla8, Il17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107364. Il17a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • external side of plasma membrane Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 158133Interleukin-17APRO_0000015424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 147By similarity
Disulfide bondi102 ↔ 149By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62386.
PRIDEiQ62386.

PTM databases

PhosphoSiteiQ62386.

Expressioni

Tissue specificityi

Restricted to a subset of activated T-cells.1 Publication

Inductioni

Induced upon antigen receptor ligation in the presence of IL6 and TGB1.1 Publication

Gene expression databases

BgeeiQ62386.
CleanExiMM_IL17A.
ExpressionAtlasiQ62386. baseline and differential.
GenevisibleiQ62386. MM.

Interactioni

Subunit structurei

Homodimer. Heterodimer with IL17F.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62386. 2 interactions.
STRINGi10090.ENSMUSP00000027061.

Structurei

3D structure databases

ProteinModelPortaliQ62386.
SMRiQ62386. Positions 71-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ62386.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG70089V.
PhylomeDBiQ62386.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN
60 70 80 90 100
LKVFNSLGAK VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ
110 120 130 140 150
RCVNAEGKLD HHMNSVLIQQ EILVLKREPE SCPFTFRVEK MLVGVGCTCV

ASIVRQAA
Length:158
Mass (Da):17,490
Last modified:November 1, 1996 - v1
Checksum:i3505C143435F4653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43088 mRNA. Translation: AAB05222.1.
U35108 Genomic DNA. Translation: AAA93253.1.
CCDSiCCDS14842.1.
PIRiJC4628.
RefSeqiNP_034682.1. NM_010552.3.
UniGeneiMm.5419.

Genome annotation databases

EnsembliENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929.
GeneIDi16171.
KEGGimmu:16171.
UCSCiuc007aky.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43088 mRNA. Translation: AAB05222.1.
U35108 Genomic DNA. Translation: AAA93253.1.
CCDSiCCDS14842.1.
PIRiJC4628.
RefSeqiNP_034682.1. NM_010552.3.
UniGeneiMm.5419.

3D structure databases

ProteinModelPortaliQ62386.
SMRiQ62386. Positions 71-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62386. 2 interactions.
STRINGi10090.ENSMUSP00000027061.

PTM databases

PhosphoSiteiQ62386.

Proteomic databases

PaxDbiQ62386.
PRIDEiQ62386.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929.
GeneIDi16171.
KEGGimmu:16171.
UCSCiuc007aky.1. mouse.

Organism-specific databases

CTDi3605.
MGIiMGI:107364. Il17a.

Phylogenomic databases

eggNOGiENOG410J12P. Eukaryota.
ENOG410YS4N. LUCA.
GeneTreeiENSGT00730000110824.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ62386.
KOiK05489.
OMAiHMNSVPI.
OrthoDBiEOG70089V.
PhylomeDBiQ62386.
TreeFamiTF314701.

Enzyme and pathway databases

ReactomeiR-MMU-448424. Interleukin-17 signaling.

Miscellaneous databases

PROiQ62386.
SOURCEiSearch...

Gene expression databases

BgeeiQ62386.
CleanExiMM_IL17A.
ExpressionAtlasiQ62386. baseline and differential.
GenevisibleiQ62386. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells."
    Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A.
    J. Interferon Cytokine Res. 16:611-617(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Thymocyte.
  2. "Complete nucleotide sequence of the mouse CTLA8 gene."
    Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.
    Gene 168:223-225(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-158.
    Strain: 129/Sv.
    Tissue: T-cell.
  3. "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
    Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R.
    Cell 126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY IL6 AND TGFB1, TISSUE SPECIFICITY.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiIL17_MOUSE
AccessioniPrimary (citable) accession number: Q62386
Secondary accession number(s): Q60971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.