Q62386 (IL17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17A
Short name=IL-17
Short name=IL-17A

Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name=CTLA-8

Gene names

Name:	Il17a
Synonyms:	Ctla8, Il17

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces stromal cells to produce proinflammatory and hematopoietic cytokines By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted.
Tissue specificity	Restricted to a subset of activated T-cells.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to interleukin-1 Inferred from direct assay. Source: MGI inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI extracellular space Inferred from direct assay. Source: MGI
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 158	133	Interleukin-17A		PRO_0000015424
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 147		By similarity
	Disulfide bond	102 ↔ 149		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62386 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3505C143435F4653	FASTA	158	17,490
	10 20 30 40 50 60 MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN LKVFNSLGAK 70 80 90 100 110 120 VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ RCVNAEGKLD HHMNSVLIQQ 130 140 150 EILVLKREPE SCPFTFRVEK MLVGVGCTCV ASIVRQAA

References

[1]	"Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A. J. Interferon Cytokine Res. 16:611-617(1996) [PubMed: 8877732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Thymocyte.
[2]	"Complete nucleotide sequence of the mouse CTLA8 gene." Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K. Gene 168:223-225(1996) [PubMed: 8654948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-158. Strain: 129/Sv. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43088 mRNA. Translation: AAB05222.1. U35108 Genomic DNA. Translation: AAA93253.1.
IPI	IPI00124807.
PIR	JC4628.
RefSeq	NP_034682.1. NM_010552.3.
UniGene	Mm.5419.
3D structure databases
ProteinModelPortal	Q62386.
SMR	Q62386. Positions 29-154.
ModBase	Search...
Protein-protein interaction databases
STRING	Q62386.
Proteomic databases
PRIDE	Q62386.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929.
GeneID	16171.
KEGG	mmu:16171.
Organism-specific databases
CTD	3605.
MGI	MGI:107364. Il17a.
Phylogenomic databases
GeneTree	ENSGT00530000063175.
HOGENOM	HBG279620.
HOVERGEN	HBG006143.
InParanoid	Q62386.
OMA	WNLHRNE.
OrthoDB	EOG40S0H2.
PhylomeDB	Q62386.
Gene expression databases
ArrayExpress	Q62386.
Bgee	Q62386.
CleanEx	MM_IL17A.
Genevestigator	Q62386.
GermOnline	ENSMUSG00000025929. Mus musculus.
Family and domain databases
InterPro	IPR020440. Interleukin-17_chordata. IPR010345. Interleukin-17_met. [Graphical view]
KO	K05489.
PANTHER	PTHR21295. IL17. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
PRINTS	PR01932. INTRLEUKIN17.
ProtoNet	Search...
Other
NextBio	289017.
SOURCE	Search...

Entry information

Entry name

IL17_MOUSE

Accession

Primary (citable) accession number: Q62386
Secondary accession number(s): Q60971

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program