Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein ZPR1

Gene

Zpr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O(2)-induced neuronal cell death.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB
  • zinc ion binding Source: MGI

GO - Biological processi

  • apoptotic process involved in development Source: UniProtKB
  • axon development Source: UniProtKB
  • Cajal body organization Source: UniProtKB
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • DNA endoreduplication Source: UniProtKB
  • inner cell mass cell proliferation Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • negative regulation of motor neuron apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of growth Source: UniProtKB
  • positive regulation of protein import into nucleus Source: UniProtKB
  • positive regulation of RNA splicing Source: UniProtKB
  • positive regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  • pre-mRNA catabolic process Source: UniProtKB
  • regulation of myelination Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW
  • spinal cord development Source: UniProtKB
  • trophectodermal cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, mRNA processing, mRNA splicing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZPR1
Alternative name(s):
Zinc finger protein 259
Gene namesi
Name:Zpr1
Synonyms:Zfp259, Znf259
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1330262. Zpr1.

Subcellular locationi

  • Nucleus
  • Cytoplasm
  • Nucleusnucleolus
  • Cytoplasmperinuclear region By similarity
  • Nucleusgem
  • NucleusCajal body
  • Cell projectionaxon
  • Cell projectiongrowth cone

  • Note: Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner (By similarity). Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons.By similarity

GO - Cellular componenti

  • axon Source: UniProtKB
  • Cajal body Source: UniProtKB
  • cytoplasm Source: MGI
  • Gemini of coiled bodies Source: UniProtKB
  • growth cone Source: UniProtKB
  • neuronal cell body Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: MGI
  • perikaryon Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • SMN complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration.

Disruption phenotypei

Die during early embryonic development. Embryos show growth delay, failed to form normal trophectoderm and to expand the inner cell mass.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190371 – 459Zinc finger protein ZPR1Add BLAST459

Proteomic databases

EPDiQ62384.
MaxQBiQ62384.
PaxDbiQ62384.
PeptideAtlasiQ62384.
PRIDEiQ62384.

PTM databases

iPTMnetiQ62384.
PhosphoSitePlusiQ62384.

Expressioni

Tissue specificityi

Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebellum.3 Publications

Inductioni

Up-regulated by high fat diet.1 Publication

Gene expression databases

BgeeiENSMUSG00000032078.
CleanExiMM_ZFP259.
ExpressionAtlasiQ62384. baseline and differential.
GenevisibleiQ62384. MM.

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum (By similarity). Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor.By similarity5 Publications

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204651. 1 interactor.
DIPiDIP-46465N.
IntActiQ62384. 3 interactors.
STRINGi10090.ENSMUSP00000117725.

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 50Combined sources3
Turni52 – 54Combined sources3
Beta strandi55 – 67Combined sources13
Turni68 – 70Combined sources3
Beta strandi71 – 79Combined sources9
Turni81 – 83Combined sources3
Beta strandi86 – 96Combined sources11
Beta strandi98 – 107Combined sources10
Helixi110 – 113Combined sources4
Beta strandi116 – 119Combined sources4
Beta strandi124 – 127Combined sources4
Helixi128 – 130Combined sources3
Beta strandi132 – 134Combined sources3
Beta strandi142 – 145Combined sources4
Helixi146 – 158Combined sources13
Helixi161 – 167Combined sources7
Helixi169 – 184Combined sources16
Helixi185 – 187Combined sources3
Beta strandi192 – 198Combined sources7
Turni208 – 211Combined sources4
Beta strandi217 – 222Combined sources6
Helixi226 – 231Combined sources6
Beta strandi252 – 257Combined sources6
Turni260 – 262Combined sources3
Beta strandi268 – 273Combined sources6
Beta strandi281 – 287Combined sources7
Beta strandi289 – 291Combined sources3
Beta strandi294 – 300Combined sources7
Beta strandi302 – 304Combined sources3
Beta strandi308 – 315Combined sources8
Helixi318 – 322Combined sources5
Beta strandi324 – 327Combined sources4
Beta strandi332 – 335Combined sources4
Helixi336 – 338Combined sources3
Beta strandi340 – 342Combined sources3
Turni344 – 347Combined sources4
Beta strandi349 – 353Combined sources5
Helixi354 – 366Combined sources13
Beta strandi372 – 374Combined sources3
Helixi378 – 380Combined sources3
Helixi382 – 395Combined sources14
Beta strandi401 – 407Combined sources7
Turni417 – 420Combined sources4
Beta strandi426 – 431Combined sources6
Turni437 – 439Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QKDX-ray2.00A47-440[»]
ProteinModelPortaliQ62384.
SMRiQ62384.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62384.

Family & Domainsi

Sequence similaritiesi

Belongs to the ZPR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2703. Eukaryota.
COG1779. LUCA.
GeneTreeiENSGT00390000005306.
HOVERGENiHBG002608.
InParanoidiQ62384.
KOiK06874.
OMAiFIMNDPA.
OrthoDBiEOG091G07KC.
TreeFamiTF313084.

Family and domain databases

InterProiIPR004457. Znf_ZPR1.
[Graphical view]
PfamiPF03367. zf-ZPR1. 2 hits.
[Graphical view]
SMARTiSM00709. Zpr1. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00310. ZPR1_znf. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62384-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASGAVQPG HPGAAVGPSP AAAASPATGP LFRPLSAEDE EQQPTEIESL
60 70 80 90 100
CMNCYRNGTT RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG
110 120 130 140 150
VRYTLTVRSQ EDMNREVVKT DSATTRIPEL DFEIPAFSQK GALTTVEGLI
160 170 180 190 200
SRAISGLEQD QPTRRAVEGA IAERIDEFIG KLKDLKQMAS PFTLVIDDPS
210 220 230 240 250
GNSFVENPHA PQKDNALVIT YYDRTPQQAE MLGLQAEAPE EKAEEEDLRN
260 270 280 290 300
EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS
310 320 330 340 350
GGAVEPLGTR ITLHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK
360 370 380 390 400
FTTLEGLLKD IRELVTKNPF TLGDSSNPDQ SEKLQEFSQK LGQIIEGKMK
410 420 430 440 450
AHFIMNDPAG NSYLQNVYAP EDDPEMKVER YKRTFDQNEE LGLNDMKTEG

YEAGLAPQR
Length:459
Mass (Da):50,715
Last modified:November 1, 1996 - v1
Checksum:i771D38C7B806044F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41287 mRNA. Translation: AAC52662.1.
BC021397 mRNA. Translation: AAH21397.1.
CCDSiCCDS23144.1.
RefSeqiNP_035882.1. NM_011752.2.
UniGeneiMm.17519.

Genome annotation databases

EnsembliENSMUST00000156440; ENSMUSP00000117725; ENSMUSG00000032078.
GeneIDi22687.
KEGGimmu:22687.
UCSCiuc009phh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41287 mRNA. Translation: AAC52662.1.
BC021397 mRNA. Translation: AAH21397.1.
CCDSiCCDS23144.1.
RefSeqiNP_035882.1. NM_011752.2.
UniGeneiMm.17519.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QKDX-ray2.00A47-440[»]
ProteinModelPortaliQ62384.
SMRiQ62384.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204651. 1 interactor.
DIPiDIP-46465N.
IntActiQ62384. 3 interactors.
STRINGi10090.ENSMUSP00000117725.

PTM databases

iPTMnetiQ62384.
PhosphoSitePlusiQ62384.

Proteomic databases

EPDiQ62384.
MaxQBiQ62384.
PaxDbiQ62384.
PeptideAtlasiQ62384.
PRIDEiQ62384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156440; ENSMUSP00000117725; ENSMUSG00000032078.
GeneIDi22687.
KEGGimmu:22687.
UCSCiuc009phh.1. mouse.

Organism-specific databases

CTDi8882.
MGIiMGI:1330262. Zpr1.

Phylogenomic databases

eggNOGiKOG2703. Eukaryota.
COG1779. LUCA.
GeneTreeiENSGT00390000005306.
HOVERGENiHBG002608.
InParanoidiQ62384.
KOiK06874.
OMAiFIMNDPA.
OrthoDBiEOG091G07KC.
TreeFamiTF313084.

Miscellaneous databases

EvolutionaryTraceiQ62384.
PROiQ62384.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032078.
CleanExiMM_ZFP259.
ExpressionAtlasiQ62384. baseline and differential.
GenevisibleiQ62384. MM.

Family and domain databases

InterProiIPR004457. Znf_ZPR1.
[Graphical view]
PfamiPF03367. zf-ZPR1. 2 hits.
[Graphical view]
SMARTiSM00709. Zpr1. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00310. ZPR1_znf. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZPR1_MOUSE
AccessioniPrimary (citable) accession number: Q62384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.