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Q62371

- DDR2_MOUSE

UniProt

Q62371 - DDR2_MOUSE

Protein

Discoidin domain-containing receptor 2

Gene

Ddr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.5 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei608 – 6081ATPPROSITE-ProRule annotation
    Active sitei709 – 7091Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi569 – 5779ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. collagen binding Source: UniProtKB
    3. protein tyrosine kinase collagen receptor activity Source: UniProtKB
    4. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB
    2. cell adhesion Source: InterPro
    3. chondrocyte proliferation Source: UniProtKB
    4. collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
    5. collagen fibril organization Source: UniProtKB
    6. endochondral bone growth Source: UniProtKB
    7. ossification Source: UniProtKB-KW
    8. peptidyl-tyrosine phosphorylation Source: UniProtKB
    9. positive regulation of cell proliferation Source: MGI
    10. positive regulation of extracellular matrix disassembly Source: UniProtKB
    11. positive regulation of fibroblast migration Source: UniProtKB
    12. positive regulation of fibroblast proliferation Source: UniProtKB
    13. positive regulation of osteoblast differentiation Source: UniProtKB
    14. positive regulation of protein kinase activity Source: UniProtKB
    15. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    16. protein autophosphorylation Source: Ensembl
    17. regulation of bone mineralization Source: UniProtKB
    18. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Osteogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 3474.
    ReactomeiREACT_196607. Non-integrin membrane-ECM interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Discoidin domain-containing receptor 2 (EC:2.7.10.1)
    Short name:
    Discoidin domain receptor 2
    Alternative name(s):
    CD167 antigen-like family member B
    Neurotrophic tyrosine kinase, receptor-related 3
    Receptor protein-tyrosine kinase TKT
    Tyrosine-protein kinase TYRO10
    CD_antigen: CD167b
    Gene namesi
    Name:Ddr2
    Synonyms:Ntrkr3, Tkt, Tyro10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1345277. Ddr2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Ddr2 are the cause of the smallie (sli) phenotype. Smallie mice show distinct dwarfing, with reduced body mass and reduced bone mineral content. Mice also have mild craniofacial deformities, such as protuberant eyes and snub noses. Smallie mice have a reduced life span, with about half of them dying within 6 months. Matings between male and female smallie mice do not yield any offspring. The levels of circulating steroid hormones remain at a level corresponding to prepubertal wild-type mice. Adult testes exhibit much reduced numbers of spermatids with atrophy of spermatogonia, Sertoli and Leydig cells. Ovaries show an absence of corpora lutea.

    Disruption phenotypei

    Mice are born at the expected Mendelian rate, but fail to thrive, resulting in much reduced adult body weight and dwarfing. They exhibit shortening of long bones, irregular growth of flat bones and a shortened snout. Young mice show shortened growth plates in long bones and impaired chondrocyte proliferation. Likewise, cultured fibroblasts from mutant mice show reduced proliferation.1 Publication

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi471 – 4711Y → F: Reduces tyrosine phosphorylation by 90%; when associated with E-608. 1 Publication
    Mutagenesisi608 – 6081K → E: Abolishes kinase activity. Reduces tyrosine phosphorylation by 90%; when associated with F-471. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 854833Discoidin domain-containing receptor 2PRO_0000016747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 185PROSITE-ProRule annotation
    Disulfide bondi73 ↔ 177PROSITE-ProRule annotation
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Modified residuei461 – 4611PhosphoserineBy similarity
    Modified residuei471 – 4711Phosphotyrosine; by SRC and autocatalysis1 Publication
    Modified residuei674 – 6741PhosphoserineBy similarity
    Modified residuei735 – 7351Phosphotyrosine; by SRC and autocatalysisBy similarity
    Modified residuei739 – 7391Phosphotyrosine; by SRC and autocatalysisBy similarity
    Modified residuei740 – 7401Phosphotyrosine; by SRC and autocatalysisBy similarity

    Post-translational modificationi

    N-glycosylated.By similarity
    Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ62371.

    PTM databases

    PhosphoSiteiQ62371.

    Expressioni

    Tissue specificityi

    Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level). Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice.3 Publications

    Inductioni

    Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from mice with osteoarthritis.

    Gene expression databases

    BgeeiQ62371.
    CleanExiMM_DDR2.
    MM_TKT.
    GenevestigatoriQ62371.

    Interactioni

    Subunit structurei

    Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ62371.
    SMRiQ62371. Positions 26-369, 491-850.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 399378ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 854433CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei400 – 42122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 185156F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini563 – 848286Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117362.
    HOGENOMiHOG000043102.
    HOVERGENiHBG005461.
    InParanoidiB2RSD7.
    KOiK05125.
    OMAiASAIKCQ.
    OrthoDBiEOG77Q4W2.
    PhylomeDBiQ62371.
    TreeFamiTF317840.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029553. DDR2.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view]
    PANTHERiPTHR24416:SF297. PTHR24416:SF297. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPIPRMPLV LLLLLLILGS AKAQVNPAIC RYPLGMSGGH IPDEDITASS    50
    QWSESTAAKY GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV 100
    GTQGRHAGGH GIEFAPMYKI NYSRDGSRWI SWRNRHGKQV LDGNSNPYDV 150
    FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV ELYGCVWLDG LVSYNAPAGQ 200
    QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD DFTQTHEYHV 250
    WPGYDYVGWR NESATNGFIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 300
    EVQCYFRSEA SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY 350
    HFADTWMMFS EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTRI 400
    LIGCLVAIIF ILLAIIVIIL WRQFWQKMLE KASRRMLDDE MTVSLSLPSE 450
    SSMFNNNRSS SPSEQESNST YDRIFPLRPD YQEPSRLIRK LPEFAPGEEE 500
    SGCSGVVKPA QPNGPEGVPH YAEADIVNLQ GVTGGNTYCV PAVTMDLLSG 550
    KDVAVEEFPR KLLAFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 600
    QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIRL LAVCITEDPL 650
    CMITEYMENG DLNQFLSRHE PLSSCSSDAT VSYANLKFMA TQIASGMKYL 700
    SSLNFVHRDL ATRNCLVGKN YTIKIADFGM SRNLYSGDYY RIQGRAVLPI 750
    RWMSWESILL GKFTTASDVW AFGVTLWETF TFCQEQPYSQ LSDEQVIENT 800
    GEFFRDQGRQ IYLPQPALCP DSVYKLMLSC WRRETKHRPS FQEIHLLLLQ 850
    QGAE 854
    Length:854
    Mass (Da):96,482
    Last modified:November 1, 1997 - v2
    Checksum:i45CFD2BE9ED524D4
    GO

    Sequence cautioni

    The sequence CAA54040.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76505 mRNA. Translation: CAA54040.1. Different initiation.
    BC138826 mRNA. Translation: AAI38827.1.
    BC138827 mRNA. Translation: AAI38828.1.
    CCDSiCCDS48436.1.
    PIRiI48859.
    RefSeqiNP_072075.2. NM_022563.2.
    XP_006496759.1. XM_006496696.1.
    XP_006496760.1. XM_006496697.1.
    XP_006496761.1. XM_006496698.1.
    UniGeneiMm.229249.

    Genome annotation databases

    EnsembliENSMUST00000027985; ENSMUSP00000027985; ENSMUSG00000026674.
    ENSMUST00000170800; ENSMUSP00000129624; ENSMUSG00000026674.
    GeneIDi18214.
    KEGGimmu:18214.
    UCSCiuc007dlu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76505 mRNA. Translation: CAA54040.1 . Different initiation.
    BC138826 mRNA. Translation: AAI38827.1 .
    BC138827 mRNA. Translation: AAI38828.1 .
    CCDSi CCDS48436.1.
    PIRi I48859.
    RefSeqi NP_072075.2. NM_022563.2.
    XP_006496759.1. XM_006496696.1.
    XP_006496760.1. XM_006496697.1.
    XP_006496761.1. XM_006496698.1.
    UniGenei Mm.229249.

    3D structure databases

    ProteinModelPortali Q62371.
    SMRi Q62371. Positions 26-369, 491-850.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62371.

    Proteomic databases

    PRIDEi Q62371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027985 ; ENSMUSP00000027985 ; ENSMUSG00000026674 .
    ENSMUST00000170800 ; ENSMUSP00000129624 ; ENSMUSG00000026674 .
    GeneIDi 18214.
    KEGGi mmu:18214.
    UCSCi uc007dlu.2. mouse.

    Organism-specific databases

    CTDi 4921.
    MGIi MGI:1345277. Ddr2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117362.
    HOGENOMi HOG000043102.
    HOVERGENi HBG005461.
    InParanoidi B2RSD7.
    KOi K05125.
    OMAi ASAIKCQ.
    OrthoDBi EOG77Q4W2.
    PhylomeDBi Q62371.
    TreeFami TF317840.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 3474.
    Reactomei REACT_196607. Non-integrin membrane-ECM interactions.

    Miscellaneous databases

    NextBioi 293620.
    PROi Q62371.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62371.
    CleanExi MM_DDR2.
    MM_TKT.
    Genevestigatori Q62371.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR029553. DDR2.
    IPR008979. Galactose-bd-like.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR002011. Tyr_kinase_rcpt_2_CS.
    [Graphical view ]
    PANTHERi PTHR24416:SF297. PTHR24416:SF297. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00231. FA58C. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS01285. FA58C_1. 1 hit.
    PS01286. FA58C_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain."
      Karn T., Holtrich U., Braeuninger A., Boehme B., Wolf G., Ruebsamen-Waigmann H., Strebhardt K.
      Oncogene 8:3433-3440(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and expression of the Tyro 10 receptor tyrosine kinase."
      Lai C., Lemke G.E.
      Oncogene 9:877-883(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    4. "The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism."
      Labrador J.P., Azcoitia V., Tuckermann J., Lin C., Olaso E., Manes S., Bruckner K., Goergen J.L., Lemke G., Yancopoulos G., Angel P., Martinez C., Klein R.
      EMBO Rep. 2:446-452(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
    5. "Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2."
      Olaso E., Labrador J.-P., Wang L., Ikeda K., Eng F.J., Klein R., Lovett D.H., Lin H.C., Friedman S.L.
      J. Biol. Chem. 277:3606-3613(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen."
      Ikeda K., Wang L.H., Torres R., Zhao H., Olaso E., Eng F.J., Labrador P., Klein R., Lovett D., Yancopoulos G.D., Friedman S.L., Lin H.C.
      J. Biol. Chem. 277:19206-19212(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SRC AND SHC1, MUTAGENESIS OF TYR-471 AND LYS-608, PHOSPHORYLATION AT TYR-471.
    7. "Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice."
      Xu L., Peng H., Wu D., Hu K., Goldring M.B., Olsen B.R., Li Y.
      J. Biol. Chem. 280:548-555(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN UP-REGULATION OF MMP13.
    8. "A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse."
      Kano K., Marin de Evsikova C., Young J., Wnek C., Maddatu T.P., Nishina P.M., Naggert J.K.
      Mol. Endocrinol. 22:1866-1880(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SLI, TISSUE SPECIFICITY.
    9. "Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice."
      Kano K., Kitamura A., Matsuwaki T., Morimatsu M., Naito K.
      Mol. Reprod. Dev. 77:29-37(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SLI, FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDDR2_MOUSE
    AccessioniPrimary (citable) accession number: Q62371
    Secondary accession number(s): B2RSD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 146 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    According to PubMed:18483174 Ddr2 is required for male and female fertility, since smallie mice with a 150 kb deletion that extends into the Ddr2 gene are sterile. Smallie males have defects in spermatogenesis (PubMed:19681157). On the other hand, the fertility status of mice with a targeted disruption of the Ddr2 gene has not been mentioned (PubMed:11375938). Thus, the infertility of smallie mice may be due to some additional, not yet identified defect.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3