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Reviewed, UniProtKB/Swiss-Prot Q62371 (DDR2_MOUSE)

Last modified February 9, 2010. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Discoidin domain-containing receptor 2
      Short name=Discoidin domain receptor 2
    EC=2.7.10.1
Alternative name(s):
    Receptor protein-tyrosine kinase TKT
    Tyrosine-protein kinase TYRO10
    Neurotrophic tyrosine kinase, receptor-related 3
    CD167 antigen-like family member B
    CD_antigen=CD167b
Gene names
Name: Ddr2
Synonyms: Ntrkr3, Tkt, Tyro10
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length854 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Ref.4

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Widely expressed; high levels in skeletal muscle, heart, CNS, and kidney; less in other tissues. The major 10 kDa transcript is expressed in high levels in heart and lung, less in brain and testis.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 1 F5/8 type C domain.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 854833Discoidin domain-containing receptor 2
PRO_0000016747

Regions

Topological domain22 – 399378Extracellular Potential
Transmembrane400 – 42122 Potential
Topological domain422 – 854433Cytoplasmic Potential
Domain30 – 185156F5/8 type C
Domain563 – 848286Protein kinase
Nucleotide binding569 – 5779ATP By similarity

Sites

Active site7091Proton acceptor By similarity
Binding site6081ATP By similarity

Amino acid modifications

Modified residue4611Phosphoserine By similarity
Modified residue6741Phosphoserine By similarity
Modified residue7351Phosphotyrosine By similarity
Modified residue7391Phosphotyrosine; by autocatalysis By similarity
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation2801N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 185 By similarity
Disulfide bond73 ↔ 177 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q62371-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 45CFD2BE9ED524D4

FASTA85496,482
        10         20         30         40         50         60 
MIPIPRMPLV LLLLLLILGS AKAQVNPAIC RYPLGMSGGH IPDEDITASS QWSESTAAKY 

        70         80         90        100        110        120 
GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV GTQGRHAGGH GIEFAPMYKI 

       130        140        150        160        170        180 
NYSRDGSRWI SWRNRHGKQV LDGNSNPYDV FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV 

       190        200        210        220        230        240 
ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 

       250        260        270        280        290        300 
DFTQTHEYHV WPGYDYVGWR NESATNGFIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 

       310        320        330        340        350        360 
EVQCYFRSEA SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 

       370        380        390        400        410        420 
EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 

       430        440        450        460        470        480 
WRQFWQKMLE KASRRMLDDE MTVSLSLPSE SSMFNNNRSS SPSEQESNST YDRIFPLRPD 

       490        500        510        520        530        540 
YQEPSRLIRK LPEFAPGEEE SGCSGVVKPA QPNGPEGVPH YAEADIVNLQ GVTGGNTYCV 

       550        560        570        580        590        600 
PAVTMDLLSG KDVAVEEFPR KLLAFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 

       610        620        630        640        650        660 
QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIRL LAVCITEDPL CMITEYMENG 

       670        680        690        700        710        720 
DLNQFLSRHE PLSSCSSDAT VSYANLKFMA TQIASGMKYL SSLNFVHRDL ATRNCLVGKN 

       730        740        750        760        770        780 
YTIKIADFGM SRNLYSGDYY RIQGRAVLPI RWMSWESILL GKFTTASDVW AFGVTLWETF 

       790        800        810        820        830        840 
TFCQEQPYSQ LSDEQVIENT GEFFRDQGRQ IYLPQPALCP DSVYKLMLSC WRRETKHRPS 

       850 
FQEIHLLLLQ QGAE

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References

« Hide 'large scale' references
[1]"Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain."
Karn T., Holtrich U., Braeuninger A., Boehme B., Wolf G., Ruebsamen-Waigmann H., Strebhardt K.
Oncogene 8:3433-3440(1993) [PubMed: 8247548] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and expression of the Tyro 10 receptor tyrosine kinase."
Lai C., Lemke G.E.
Oncogene 9:877-883(1994) [PubMed: 8108131] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[4]"Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2."
Olaso E., Labrador J.-P., Wang L., Ikeda K., Eng F.J., Klein R., Lovett D.H., Lin H.C., Friedman S.L.
J. Biol. Chem. 277:3606-3613(2002) [PubMed: 11723120] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X76505 mRNA. Translation: CAA54040.1. Different initiation.
BC138826 mRNA. Translation: AAI38827.1.
BC138827 mRNA. Translation: AAI38828.1.
IPIIPI00124761.
PIRI48859.
RefSeqNP_072075.2.
UniGeneMm.229249
Mm.477411

3D structure databases

SMRQ62371. Positions 26-186.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ62371.

PTM databases

PhosphoSiteQ62371.

Proteomic databases

PRIDEQ62371.

Genome annotation databases

EnsemblENSMUST00000027985; ENSMUSP00000027985; ENSMUSG00000026674; Mus musculus. [Genome view]
GeneID18214.
KEGGmmu:18214.
UCSCuc007dlu.1. mouse.

Organism-specific databases

CTD18214.
MGIMGI:1345277. Ddr2.

Phylogenomic databases

eggNOGroNOG09256.
HOGENOMHBG387802.
HOVERGENQ62371.
InParanoidQ62371.
OMATRWISWR.
OrthoDBEOG9X9B2Z.
PhylomeDBQ62371.

Enzyme and pathway databases

BRENDA2.7.10.1. 244.

Gene expression databases

ArrayExpressQ62371.
BgeeQ62371.
CleanExMM_DDR2.
MM_TKT.
GenevestigatorQ62371.
GermOnlineENSMUSG00000026674. Mus musculus.

Family and domain databases

InterProIPR000421. Coagulation_factor_5/8-type_C.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR002011. Tyr_prot_kinase_rcpt_2_CS.
[Graphical view]
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF00754. F5_F8_type_C. 1 hit.
[Graphical view]
SMARTSM00231. FA58C. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS01285. FA58C_1. 1 hit.
PS01286. FA58C_2. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio293620.
SOURCESearch...

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Entry information

Entry nameDDR2_MOUSE
AccessionPrimary (citable) accession number: Q62371
Secondary accession number(s): B2RSD7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 9, 2010
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents