Reviewed,
UniProtKB/Swiss-Prot Q62371 (DDR2_MOUSE)
Last modified
February 9, 2010.
Version 101.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Discoidin domain-containing receptor 2 Short name=Discoidin domain receptor 2 EC=2.7.10.1 Alternative name(s): Receptor protein-tyrosine kinase TKT Tyrosine-protein kinase TYRO10 Neurotrophic tyrosine kinase, receptor-related 3 CD167 antigen-like family member B CD_antigen=CD167b | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 854 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Ref.4 |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | |
| Tissue specificity | Widely expressed; high levels in skeletal muscle, heart, CNS, and kidney; less in other tissues. The major 10 kDa transcript is expressed in high levels in heart and lung, less in brain and testis. |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 F5/8 type C domain. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Transferase Tyrosine-protein kinase |
| PTM | Disulfide bond Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Ref.4Inferred from mutant phenotype. Source: MGI protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Ref.4Inferred from direct assay. Source: MGI |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 854 | 833 | Discoidin domain-containing receptor 2 | PRO_0000016747 | |||||||
Regions | |||||||||||
| Topological domain | 22 – 399 | 378 | Extracellular Potential | ||||||||
| Transmembrane | 400 – 421 | 22 | Potential | ||||||||
| Topological domain | 422 – 854 | 433 | Cytoplasmic Potential | ||||||||
| Domain | 30 – 185 | 156 | F5/8 type C | ||||||||
| Domain | 563 – 848 | 286 | Protein kinase | ||||||||
| Nucleotide binding | 569 – 577 | 9 | ATP By similarity | ||||||||
Sites | |||||||||||
| Active site | 709 | 1 | Proton acceptor By similarity | ||||||||
| Binding site | 608 | 1 | ATP By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 461 | 1 | Phosphoserine By similarity | ||||||||
| Modified residue | 674 | 1 | Phosphoserine By similarity | ||||||||
| Modified residue | 735 | 1 | Phosphotyrosine By similarity | ||||||||
| Modified residue | 739 | 1 | Phosphotyrosine; by autocatalysis By similarity | ||||||||
| Glycosylation | 121 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 213 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 261 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 280 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 372 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 30 ↔ 185 | By similarity | |||||||||
| Disulfide bond | 73 ↔ 177 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain." Karn T., Holtrich U., Braeuninger A., Boehme B., Wolf G., Ruebsamen-Waigmann H., Strebhardt K. Oncogene 8:3433-3440(1993) [PubMed: 8247548] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Structure and expression of the Tyro 10 receptor tyrosine kinase." Lai C., Lemke G.E. Oncogene 9:877-883(1994) [PubMed: 8108131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Brain. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
| [4] | "Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2." Olaso E., Labrador J.-P., Wang L., Ikeda K., Eng F.J., Klein R., Lovett D.H., Lin H.C., Friedman S.L. J. Biol. Chem. 277:3606-3613(2002) [PubMed: 11723120] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X76505 mRNA. Translation: CAA54040.1. Different initiation. BC138826 mRNA. Translation: AAI38827.1. BC138827 mRNA. Translation: AAI38828.1. |
| IPI | IPI00124761. |
| PIR | I48859. |
| RefSeq | NP_072075.2. |
| UniGene | Mm.229249 Mm.477411 |
3D structure databases | |
| SMR | Q62371. Positions 26-186. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q62371. |
PTM databases | |
| PhosphoSite | Q62371. |
Proteomic databases | |
| PRIDE | Q62371. |
Genome annotation databases | |
| Ensembl | ENSMUST00000027985; ENSMUSP00000027985; ENSMUSG00000026674; Mus musculus. [Genome view] |
| GeneID | 18214. |
| KEGG | mmu:18214. |
| UCSC | uc007dlu.1. mouse. |
Organism-specific databases | |
| CTD | 18214. |
| MGI | MGI:1345277. Ddr2. |
Phylogenomic databases | |
| eggNOG | roNOG09256. |
| HOGENOM | HBG387802. |
| HOVERGEN | Q62371. |
| InParanoid | Q62371. |
| OMA | TRWISWR. |
| OrthoDB | EOG9X9B2Z. |
| PhylomeDB | Q62371. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 244. |
Gene expression databases | |
| ArrayExpress | Q62371. |
| Bgee | Q62371. |
| CleanEx | MM_DDR2. MM_TKT. |
| Genevestigator | Q62371. |
| GermOnline | ENSMUSG00000026674. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000421. Coagulation_factor_5/8-type_C. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR002011. Tyr_prot_kinase_rcpt_2_CS. [Graphical view] |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF00754. F5_F8_type_C. 1 hit. [Graphical view] |
| SMART | SM00231. FA58C. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS01285. FA58C_1. 1 hit. PS01286. FA58C_2. 1 hit. PS50022. FA58C_3. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 293620. |
| SOURCE | Search... |
Entry information
| Entry name | DDR2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62371 Secondary accession number(s): B2RSD7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


