Reviewed, UniProtKB/Swiss-Prot Q62371 (DDR2_MOUSE)

Names and origin

Protein names

Recommended name:
    Discoidin domain-containing receptor 2
      Short name=Discoidin domain receptor 2
    EC=2.7.10.1
Alternative name(s):
    Receptor protein-tyrosine kinase TKT
    Tyrosine-protein kinase TYRO10
    Neurotrophic tyrosine kinase, receptor-related 3
    CD167 antigen-like family member B
    CD_antigen=CD167b

Gene names

Name:	Ddr2
Synonyms:	Ntrkr3, Tkt, Tyro10

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	854 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing. Ref.3
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Widely expressed; high levels in skeletal muscle, heart, CNS, and kidney; less in other tissues. The major 10 kDa transcript is expressed in high levels in heart and lung, less in brain and testis.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 F5/8 type C domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro positive regulation of cell proliferation Ref.3 Inferred from mutant phenotype. Source: MGI protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Ref.3 Inferred from direct assay. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 854	833	Discoidin domain-containing receptor 2		PRO_0000016747
Regions
	Topological domain	22 – 399	378	Extracellular Potential
	Transmembrane	400 – 421	22	Potential
	Topological domain	422 – 854	433	Cytoplasmic Potential
	Domain	30 – 185	156	F5/8 type C
	Domain	563 – 848	286	Protein kinase
	Nucleotide binding	569 – 577	9	ATP By similarity
Sites
	Active site	709	1	Proton acceptor By similarity
	Binding site	608	1	ATP By similarity
Amino acid modifications
	Modified residue	735	1	Phosphotyrosine By similarity
	Modified residue	739	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	213	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Glycosylation	280	1	N-linked (GlcNAc...) Potential
	Glycosylation	372	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 185		By similarity
	Disulfide bond	73 ↔ 177		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62371-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 45CFD2BE9ED524D4	FASTA	854	96,482
	10 20 30 40 50 60 MIPIPRMPLV LLLLLLILGS AKAQVNPAIC RYPLGMSGGH IPDEDITASS QWSESTAAKY 70 80 90 100 110 120 GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV GTQGRHAGGH GIEFAPMYKI 130 140 150 160 170 180 NYSRDGSRWI SWRNRHGKQV LDGNSNPYDV FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV 190 200 210 220 230 240 ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 250 260 270 280 290 300 DFTQTHEYHV WPGYDYVGWR NESATNGFIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 310 320 330 340 350 360 EVQCYFRSEA SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 370 380 390 400 410 420 EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 430 440 450 460 470 480 WRQFWQKMLE KASRRMLDDE MTVSLSLPSE SSMFNNNRSS SPSEQESNST YDRIFPLRPD 490 500 510 520 530 540 YQEPSRLIRK LPEFAPGEEE SGCSGVVKPA QPNGPEGVPH YAEADIVNLQ GVTGGNTYCV 550 560 570 580 590 600 PAVTMDLLSG KDVAVEEFPR KLLAFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 610 620 630 640 650 660 QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIRL LAVCITEDPL CMITEYMENG 670 680 690 700 710 720 DLNQFLSRHE PLSSCSSDAT VSYANLKFMA TQIASGMKYL SSLNFVHRDL ATRNCLVGKN 730 740 750 760 770 780 YTIKIADFGM SRNLYSGDYY RIQGRAVLPI RWMSWESILL GKFTTASDVW AFGVTLWETF 790 800 810 820 830 840 TFCQEQPYSQ LSDEQVIENT GEFFRDQGRQ IYLPQPALCP DSVYKLMLSC WRRETKHRPS 850 FQEIHLLLLQ QGAE

References

[1]	"Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain." Karn T., Holtrich U., Braeuninger A., Boehme B., Wolf G., Ruebsamen-Waigmann H., Strebhardt K. Oncogene 8:3433-3440(1993) [PubMed: 8247548] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and expression of the Tyro 10 receptor tyrosine kinase." Lai C., Lemke G.E. Oncogene 9:877-883(1994) [PubMed: 8108131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Brain.
[3]	"Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2." Olaso E., Labrador J.-P., Wang L., Ikeda K., Eng F.J., Klein R., Lovett D.H., Lin H.C., Friedman S.L. J. Biol. Chem. 277:3606-3613(2002) [PubMed: 11723120] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76505 mRNA. Translation: CAA54040.1. Different initiation.
IPI	IPI00124761.
PIR	I48859.
RefSeq	NP_072075.2.
UniGene	Mm.229249
3D structure databases
HSSP	HSSP built from PDB template 1LUF based on UniProtKB Q62838.
ModBase	Search...
PTM databases
PhosphoSite	Q62371.
Genome annotation databases
Ensembl	ENSMUSG00000026674. Mus musculus. [Contig view]
GeneID	18214.
KEGG	mmu:18214.
Organism-specific databases
MGI	MGI:1345277. Ddr2.
Phylogenomic databases
HOGENOM	Q62371.
HOVERGEN	Q62371.
OMA	Q62371. TRWISWR.
Enzyme and pathway databases
BRENDA	2.7.10.1. 244.
Gene expression databases
ArrayExpress	Q62371.
Bgee	Q62371.
CleanEx	MM_DDR2. MM_TKT.
GermOnline	ENSMUSG00000026674. Mus musculus.
Family and domain databases
InterPro	IPR000421. Coagulation_factor_5/8-type_C. IPR000719. Prot_kinase_core. IPR002011. Recept_tyr_kinase-II_CS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Pfam	PF00754. F5_F8_type_C. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00231. FA58C. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01285. FA58C_1. 1 hit. PS01286. FA58C_2. 1 hit. PS50022. FA58C_3. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	293620.
SOURCE	Search...

Entry information

Entry name

DDR2_MOUSE

Accession

Primary (citable) accession number: Q62371

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)