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Protein

Pro-thyrotropin-releasing hormone

Gene

Trh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-thyrotropin-releasing hormone
Short name:
Pro-TRH
Alternative name(s):
Prothyroliberin
Cleaved into the following chain:
Alternative name(s):
Protirelin
TSH-releasing factor
Thyroliberin
Thyrotropin-releasing factor
Short name:
TRF
Gene namesi
Name:Trh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98823. Trh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 256232Pro-thyrotropin-releasing hormonePRO_0000022516Add
BLAST
Peptidei77 – 793Thyrotropin-releasing hormoneBy similarityPRO_0000022517
Peptidei109 – 1113Thyrotropin-releasing hormoneBy similarityPRO_0000022518
Peptidei154 – 1563Thyrotropin-releasing hormoneBy similarityPRO_0000022519
Peptidei172 – 1743Thyrotropin-releasing hormoneBy similarityPRO_0000022520
Peptidei203 – 2053Thyrotropin-releasing hormoneBy similarityPRO_0000022521

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791Proline amideBy similarity
Modified residuei111 – 1111Proline amideBy similarity
Modified residuei154 – 1541Pyrrolidone carboxylic acidBy similarity
Modified residuei156 – 1561Proline amideBy similarity
Modified residuei172 – 1721Pyrrolidone carboxylic acidBy similarity
Modified residuei174 – 1741Proline amideBy similarity
Modified residuei205 – 2051Proline amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ62361.
PeptideAtlasiQ62361.
PRIDEiQ62361.

PTM databases

iPTMnetiQ62361.
PhosphoSiteiQ62361.

Expressioni

Tissue specificityi

Specifically expressed in hypothalamus and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000005892.
CleanExiMM_TRH.
GenevisibleiQ62361. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006046.

Structurei

3D structure databases

ProteinModelPortaliQ62361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRH family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IXZK. Eukaryota.
ENOG4111JXZ. LUCA.
GeneTreeiENSGT00390000016951.
HOGENOMiHOG000054194.
HOVERGENiHBG083494.
InParanoidiQ62361.
KOiK05253.
OMAiGRRANQD.
OrthoDBiEOG091G0M01.
PhylomeDBiQ62361.
TreeFamiTF332073.

Family and domain databases

InterProiIPR008857. TRH.
[Graphical view]
PANTHERiPTHR17530. PTHR17530. 1 hit.
PfamiPF05438. TRH. 2 hits.
[Graphical view]
PIRSFiPIRSF001795. TRH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPWLMMAL ALIFVLTGIP KSCALLEAAQ EEGAVTPDLP GLEKVQVRPE
60 70 80 90 100
RRFLRKDLQR VRGDLGAALD SWITKRQHPG KREEKEEDVE AEERGDLGEV
110 120 130 140 150
GAWRPHKRQH PGRRANQDKD SWSDEGDSDW LPPSWLPDFF LDSWFSDAPQ
160 170 180 190 200
VKRQHPGRRS FPWMESDVTK RQHPGRRFID PELQRSWEET EGEEGGLMPE
210 220 230 240 250
KRQHPGKRAV GHPCGPQGIC GQTGLLQLLG DLSRGQETLA KQTPQLEAWV

REPLEE
Length:256
Mass (Da):29,195
Last modified:August 31, 2004 - v2
Checksum:i22ED0AD6A4FC5A2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281A → G in CAA42030 (PubMed:1323011).Curated
Sequence conflicti86 – 861E → L in AAH53493 (PubMed:15489334).Curated
Sequence conflicti89 – 891Missing in AAH53493 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59387 mRNA. Translation: CAA42030.1.
BC053493 mRNA. Translation: AAH53493.1.
CCDSiCCDS20375.1.
PIRiA43955. RTMST.
RefSeqiNP_033452.2. NM_009426.3.
UniGeneiMm.1363.

Genome annotation databases

EnsembliENSMUST00000006046; ENSMUSP00000006046; ENSMUSG00000005892.
GeneIDi22044.
KEGGimmu:22044.
UCSCiuc009cyw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59387 mRNA. Translation: CAA42030.1.
BC053493 mRNA. Translation: AAH53493.1.
CCDSiCCDS20375.1.
PIRiA43955. RTMST.
RefSeqiNP_033452.2. NM_009426.3.
UniGeneiMm.1363.

3D structure databases

ProteinModelPortaliQ62361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006046.

PTM databases

iPTMnetiQ62361.
PhosphoSiteiQ62361.

Proteomic databases

PaxDbiQ62361.
PeptideAtlasiQ62361.
PRIDEiQ62361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006046; ENSMUSP00000006046; ENSMUSG00000005892.
GeneIDi22044.
KEGGimmu:22044.
UCSCiuc009cyw.2. mouse.

Organism-specific databases

CTDi7200.
MGIiMGI:98823. Trh.

Phylogenomic databases

eggNOGiENOG410IXZK. Eukaryota.
ENOG4111JXZ. LUCA.
GeneTreeiENSGT00390000016951.
HOGENOMiHOG000054194.
HOVERGENiHBG083494.
InParanoidiQ62361.
KOiK05253.
OMAiGRRANQD.
OrthoDBiEOG091G0M01.
PhylomeDBiQ62361.
TreeFamiTF332073.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ62361.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005892.
CleanExiMM_TRH.
GenevisibleiQ62361. MM.

Family and domain databases

InterProiIPR008857. TRH.
[Graphical view]
PANTHERiPTHR17530. PTHR17530. 1 hit.
PfamiPF05438. TRH. 2 hits.
[Graphical view]
PIRSFiPIRSF001795. TRH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRH_MOUSE
AccessioniPrimary (citable) accession number: Q62361
Secondary accession number(s): Q7TMT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.