Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62356

- FSTL1_MOUSE

UniProt

Q62356 - FSTL1_MOUSE

Protein

Follistatin-related protein 1

Gene

Fstl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. response to starvation Source: UniProt

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_220505. Signaling by BMP.

    Protein family/group databases

    MEROPSiI01.967.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    TGF-beta-inducible protein TSC-36
    Gene namesi
    Name:Fstl1
    Synonyms:Frp, Fstl, Tsc36
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:102793. Fstl1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 306288Follistatin-related protein 1PRO_0000010113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
    Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
    Glycosylationi142 – 1421N-linked (GlcNAc...)1 Publication
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ62356.
    PaxDbiQ62356.
    PRIDEiQ62356.

    PTM databases

    PhosphoSiteiQ62356.

    Expressioni

    Gene expression databases

    BgeeiQ62356.
    CleanExiMM_FSTL1.
    GenevestigatoriQ62356.

    Interactioni

    Subunit structurei

    Interacts with SCN10A.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DIP2AQ146893EBI-2564326,EBI-2564275From a different organism.

    Protein-protein interaction databases

    DIPiDIP-56414N.
    IntActiQ62356. 1 interaction.
    STRINGi10090.ENSMUSP00000110411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62356.
    SMRiQ62356. Positions 27-97, 145-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 5124Follistatin-likeAdd
    BLAST
    Domaini46 – 9853Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 17635EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 22636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 28555VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG148907.
    GeneTreeiENSGT00530000063333.
    HOGENOMiHOG000007780.
    HOVERGENiHBG051665.
    InParanoidiQ6GTX2.
    OMAiRGLCIDA.
    OrthoDBiEOG7WT427.
    TreeFamiTF106409.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKRWLALSL VTIALVHGEE EPRSKSKICA NVFCGAGREC AVTEKGEPTC    50
    LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK 100
    SASPSASPVV CYQANRDELR RRLIQWLEAE IIPDGWFSKG SNYSEILDKY 150
    FKSFDNGDSH LDSSEFLKFV EQNETAINIT TYADQENNKL LRSLCVDALI 200
    ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR 250
    CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE KTGYVQELQK HQGTAEKTKK 300
    VNTKEI 306
    Length:306
    Mass (Da):34,554
    Last modified:July 27, 2011 - v2
    Checksum:i0AEB11C6321E8FDC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351D → V in AAC37633. (PubMed:7901004)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91380 mRNA. Translation: AAC37633.1.
    AK049440 mRNA. Translation: BAC33751.1.
    AK147117 mRNA. Translation: BAE27689.1.
    CH466521 Genomic DNA. Translation: EDK97964.1.
    BC028921 mRNA. Translation: AAH28921.1.
    BC006185 mRNA. No translation available.
    CCDSiCCDS37339.1.
    PIRiS38251.
    RefSeqiNP_032073.2. NM_008047.5.
    UniGeneiMm.182434.

    Genome annotation databases

    EnsembliENSMUST00000114763; ENSMUSP00000110411; ENSMUSG00000022816.
    GeneIDi14314.
    KEGGimmu:14314.
    UCSCiuc007zej.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91380 mRNA. Translation: AAC37633.1 .
    AK049440 mRNA. Translation: BAC33751.1 .
    AK147117 mRNA. Translation: BAE27689.1 .
    CH466521 Genomic DNA. Translation: EDK97964.1 .
    BC028921 mRNA. Translation: AAH28921.1 .
    BC006185 mRNA. No translation available.
    CCDSi CCDS37339.1.
    PIRi S38251.
    RefSeqi NP_032073.2. NM_008047.5.
    UniGenei Mm.182434.

    3D structure databases

    ProteinModelPortali Q62356.
    SMRi Q62356. Positions 27-97, 145-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-56414N.
    IntActi Q62356. 1 interaction.
    STRINGi 10090.ENSMUSP00000110411.

    Protein family/group databases

    MEROPSi I01.967.

    PTM databases

    PhosphoSitei Q62356.

    Proteomic databases

    MaxQBi Q62356.
    PaxDbi Q62356.
    PRIDEi Q62356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114763 ; ENSMUSP00000110411 ; ENSMUSG00000022816 .
    GeneIDi 14314.
    KEGGi mmu:14314.
    UCSCi uc007zej.1. mouse.

    Organism-specific databases

    CTDi 11167.
    MGIi MGI:102793. Fstl1.

    Phylogenomic databases

    eggNOGi NOG148907.
    GeneTreei ENSGT00530000063333.
    HOGENOMi HOG000007780.
    HOVERGENi HBG051665.
    InParanoidi Q6GTX2.
    OMAi RGLCIDA.
    OrthoDBi EOG7WT427.
    TreeFami TF106409.

    Enzyme and pathway databases

    Reactomei REACT_220505. Signaling by BMP.

    Miscellaneous databases

    NextBioi 285749.
    PROi Q62356.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62356.
    CleanExi MM_FSTL1.
    Genevestigatori Q62356.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide."
      Shibanuma M., Mashimo J., Mita A., Kuroki T., Nose K.
      Eur. J. Biochem. 217:13-19(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
    5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiFSTL1_MOUSE
    AccessioniPrimary (citable) accession number: Q62356
    Secondary accession number(s): Q6GTX2, Q99JI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3