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Protein

Follistatin-related protein 1

Gene

Fstl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • response to starvation Source: UniProtKB

Keywordsi

Molecular functionHeparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI01.967

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
TGF-beta-inducible protein TSC-36
Gene namesi
Name:Fstl1
Synonyms:Frp, Fstl, Tsc36
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:102793 Fstl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001011319 – 306Follistatin-related protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
Glycosylationi142N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei163PhosphoserineBy similarity1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62356
PaxDbiQ62356
PeptideAtlasiQ62356
PRIDEiQ62356

PTM databases

iPTMnetiQ62356
PhosphoSitePlusiQ62356

Expressioni

Gene expression databases

BgeeiENSMUSG00000022816
CleanExiMM_FSTL1
GenevisibleiQ62356 MM

Interactioni

Subunit structurei

Interacts with SCN10A.

Binary interactionsi

WithEntry#Exp.IntActNotes
DIP2AQ146893EBI-2564326,EBI-2564275From Homo sapiens.

Protein-protein interaction databases

DIPiDIP-56414N
IntActiQ62356, 4 interactors
STRINGi10090.ENSMUSP00000110411

Structurei

3D structure databases

ProteinModelPortaliQ62356
SMRiQ62356
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 51Follistatin-likeAdd BLAST24
Domaini46 – 98Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini142 – 176EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini191 – 226EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini231 – 285VWFCAdd BLAST55

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIPU Eukaryota
ENOG410ZJ7W LUCA
GeneTreeiENSGT00530000063333
HOGENOMiHOG000007780
HOVERGENiHBG051665
InParanoidiQ62356
OMAiTTYADQE
OrthoDBiEOG091G0YXX
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKRWLALSL VTIALVHGEE EPRSKSKICA NVFCGAGREC AVTEKGEPTC
60 70 80 90 100
LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK
110 120 130 140 150
SASPSASPVV CYQANRDELR RRLIQWLEAE IIPDGWFSKG SNYSEILDKY
160 170 180 190 200
FKSFDNGDSH LDSSEFLKFV EQNETAINIT TYADQENNKL LRSLCVDALI
210 220 230 240 250
ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR
260 270 280 290 300
CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE KTGYVQELQK HQGTAEKTKK

VNTKEI
Length:306
Mass (Da):34,554
Last modified:July 27, 2011 - v2
Checksum:i0AEB11C6321E8FDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235D → V in AAC37633 (PubMed:7901004).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91380 mRNA Translation: AAC37633.1
AK049440 mRNA Translation: BAC33751.1
AK147117 mRNA Translation: BAE27689.1
CH466521 Genomic DNA Translation: EDK97964.1
BC028921 mRNA Translation: AAH28921.1
BC006185 mRNA No translation available.
CCDSiCCDS37339.1
PIRiS38251
RefSeqiNP_032073.2, NM_008047.5
UniGeneiMm.182434

Genome annotation databases

EnsembliENSMUST00000114763; ENSMUSP00000110411; ENSMUSG00000022816
GeneIDi14314
KEGGimmu:14314
UCSCiuc007zej.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFSTL1_MOUSE
AccessioniPrimary (citable) accession number: Q62356
Secondary accession number(s): Q6GTX2, Q99JI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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