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Q62351

- TFR1_MOUSE

UniProt

Q62351 - TFR1_MOUSE

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Protein
Transferrin receptor protein 1
Gene
Tfrc, Trfr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity.1 Publication

GO - Molecular functioni

  1. double-stranded RNA binding Source: MGI
  2. iron ion transmembrane transporter activity Source: MGI
  3. peptidase activity Source: InterPro
  4. protein binding Source: MGI
  5. transferrin receptor activity Source: MGI

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. iron ion transmembrane transport Source: GOC
  3. osteoclast differentiation Source: DFLAT
  4. positive regulation of bone resorption Source: DFLAT
  5. receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

ReactomeiREACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

MEROPSiM28.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Transferrin receptor protein 1
Short name:
TR
Short name:
TfR
Short name:
TfR1
Short name:
Trfr
Alternative name(s):
CD_antigen: CD71
Gene namesi
Name:Tfrc
Synonyms:Trfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:98822. Tfrc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei68 – 8821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini89 – 763675Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. coated pit Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. endosome Source: MGI
  5. external side of plasma membrane Source: MGI
  6. extracellular vesicular exosome Source: MGI
  7. integral component of membrane Source: UniProtKB-KW
  8. melanosome Source: UniProtKB-SubCell
  9. perinuclear region of cytoplasm Source: MGI
  10. plasma membrane Source: MGI
  11. recycling endosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Transferrin receptor protein 1
PRO_0000174133Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphotyrosine2 Publications
Modified residuei21 – 211Phosphothreonine By similarity
Modified residuei24 – 241Phosphoserine By similarity
Lipidationi67 – 671S-palmitoyl cysteine By similarity
Disulfide bondi89 – 89Interchain By similarity
Disulfide bondi98 – 98Interchain By similarity
Glycosylationi104 – 1041O-linked (GalNAc...) By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...) By similarity
Glycosylationi319 – 3191N-linked (GlcNAc...) By similarity
Glycosylationi725 – 7251N-linked (GlcNAc...)1 Publication
Glycosylationi730 – 7301N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N- and O-glycosylated, phosphorylated and palmitoylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ62351.
PaxDbiQ62351.
PRIDEiQ62351.

PTM databases

PhosphoSiteiQ62351.

Expressioni

Gene expression databases

ArrayExpressiQ62351.
BgeeiQ62351.
CleanExiMM_TFRC.
GenevestigatoriQ62351.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 By similarity.

Protein-protein interaction databases

BioGridi204314. 2 interactions.
IntActiQ62351. 3 interactions.
MINTiMINT-1858479.

Structurei

3D structure databases

ProteinModelPortaliQ62351.
SMRiQ62351. Positions 123-762.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 31591PA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6767Mediates interaction with SH3BP4 By similarity
Add
BLAST
Regioni572 – 763192Ligand-binding By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 234Endocytosis signal
Motifi58 – 614Stop-transfer sequence
Motifi649 – 6513Cell attachment site Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG74799.
GeneTreeiENSGT00550000074421.
HOGENOMiHOG000124067.
HOVERGENiHBG023177.
InParanoidiQ62351.
KOiK06503.
OMAiDNSHVEM.
OrthoDBiEOG780RKW.
PhylomeDBiQ62351.
TreeFamiTF312981.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiIPR007484. Peptidase_M28.
IPR003137. Protease-assoc_domain.
IPR029513. TfR.
IPR007365. TFR-like_dimer_dom.
[Graphical view]
PANTHERiPTHR10404:SF26. PTHR10404:SF26. 1 hit.
PfamiPF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62351-1 [UniParc]FASTAAdd to Basket

« Hide

MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENADN    50
NMKASVRKPK RFNGRLCFAA IALVIFFLIG FMSGYLGYCK RVEQKEECVK 100
LAETEETDKS ETMETEDVPT SSRLYWADLK TLLSEKLNSI EFADTIKQLS 150
QNTYTPREAG SQKDESLAYY IENQFHEFKF SKVWRDEHYV KIQVKSSIGQ 200
NMVTIVQSNG NLDPVESPEG YVAFSKPTEV SGKLVHANFG TKKDFEELSY 250
SVNGSLVIVR AGEITFAEKV ANAQSFNAIG VLIYMDKNKF PVVEADLALF 300
GHAHLGTGDP YTPGFPSFNH TQFPPSQSSG LPNIPVQTIS RAAAEKLFGK 350
MEGSCPARWN IDSSCKLELS QNQNVKLIVK NVLKERRILN IFGVIKGYEE 400
PDRYVVVGAQ RDALGAGVAA KSSVGTGLLL KLAQVFSDMI SKDGFRPSRS 450
IIFASWTAGD FGAVGATEWL EGYLSSLHLK AFTYINLDKV VLGTSNFKVS 500
ASPLLYTLMG KIMQDVKHPV DGKSLYRDSN WISKVEKLSF DNAAYPFLAY 550
SGIPAVSFCF CEDADYPYLG TRLDTYEALT QKVPQLNQMV RTAAEVAGQL 600
IIKLTHDVEL NLDYEMYNSK LLSFMKDLNQ FKTDIRDMGL SLQWLYSARG 650
DYFRATSRLT TDFHNAEKTN RFVMREINDR IMKVEYHFLS PYVSPRESPF 700
RHIFWGSGSH TLSALVENLK LRQKNITAFN ETLFRNQLAL ATWTIQGVAN 750
ALSGDIWNID NEF 763
Length:763
Mass (Da):85,731
Last modified:November 1, 1996 - v1
Checksum:i832A148CC26CE489
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 262LA → AL in AAA37616. 1 Publication
Sequence conflicti743 – 7431W → H AA sequence 1 Publication
Sequence conflicti757 – 7571W → I AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57349 mRNA. Translation: CAA40624.1.
BC054522 mRNA. Translation: AAH54522.1.
M29618 mRNA. Translation: AAA37616.1.
CCDSiCCDS28123.1.
PIRiS29548.
RefSeqiNP_035768.1. NM_011638.4.
XP_006522062.1. XM_006521999.1.
UniGeneiMm.28683.

Genome annotation databases

EnsembliENSMUST00000023486; ENSMUSP00000023486; ENSMUSG00000022797.
GeneIDi22042.
KEGGimmu:22042.
UCSCiuc007yza.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57349 mRNA. Translation: CAA40624.1 .
BC054522 mRNA. Translation: AAH54522.1 .
M29618 mRNA. Translation: AAA37616.1 .
CCDSi CCDS28123.1.
PIRi S29548.
RefSeqi NP_035768.1. NM_011638.4.
XP_006522062.1. XM_006521999.1.
UniGenei Mm.28683.

3D structure databases

ProteinModelPortali Q62351.
SMRi Q62351. Positions 123-762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204314. 2 interactions.
IntActi Q62351. 3 interactions.
MINTi MINT-1858479.

Protein family/group databases

MEROPSi M28.972.

PTM databases

PhosphoSitei Q62351.

Proteomic databases

MaxQBi Q62351.
PaxDbi Q62351.
PRIDEi Q62351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023486 ; ENSMUSP00000023486 ; ENSMUSG00000022797 .
GeneIDi 22042.
KEGGi mmu:22042.
UCSCi uc007yza.2. mouse.

Organism-specific databases

CTDi 7037.
MGIi MGI:98822. Tfrc.

Phylogenomic databases

eggNOGi NOG74799.
GeneTreei ENSGT00550000074421.
HOGENOMi HOG000124067.
HOVERGENi HBG023177.
InParanoidi Q62351.
KOi K06503.
OMAi DNSHVEM.
OrthoDBi EOG780RKW.
PhylomeDBi Q62351.
TreeFami TF312981.

Enzyme and pathway databases

Reactomei REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

NextBioi 301828.
PROi Q62351.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62351.
Bgeei Q62351.
CleanExi MM_TFRC.
Genevestigatori Q62351.

Family and domain databases

Gene3Di 1.20.930.40. 1 hit.
InterProi IPR007484. Peptidase_M28.
IPR003137. Protease-assoc_domain.
IPR029513. TfR.
IPR007365. TFR-like_dimer_dom.
[Graphical view ]
PANTHERi PTHR10404:SF26. PTHR10404:SF26. 1 hit.
Pfami PF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
[Graphical view ]
SUPFAMi SSF47672. SSF47672. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Trowbridge I.S., Domingo D.L., Thomas M.L., Chain A.
    Submitted (JAN-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
    Tissue: Hematopoietic.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "cDNA cloning of the murine transferrin receptor: sequence of trans-membrane and adjacent regions."
    Stearne P.A., Pietersz G.A., Goding J.W.
    J. Immunol. 134:3474-3479(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-301.
    Tissue: Myeloma.
  4. "The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence."
    van Driel I.R., Stearne P.A., Grego B., Simpson R.J., Goding J.W.
    J. Immunol. 133:3220-3224(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 7-19; 158-179; 196-208; 450-467 AND 736-759.
    Tissue: Myeloma.
  5. "Transferrin receptor is necessary for development of erythrocytes and the nervous system."
    Levy J.E., Jin O., Fujiwara Y., Kuo F., Andrews N.C.
    Nat. Genet. 21:396-399(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-20, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-725 AND ASN-730.

Entry informationi

Entry nameiTFR1_MOUSE
AccessioniPrimary (citable) accession number: Q62351
Secondary accession number(s): Q61560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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