##gff-version 3 Q62318 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:19131326;Dbxref=PMID:17242355,PMID:19131326 Q62318 UniProtKB Chain 2 834 . . . ID=PRO_0000056393;Note=Transcription intermediary factor 1-beta Q62318 UniProtKB Domain 697 801 . . . Note=Bromo Q62318 UniProtKB Zinc finger 66 122 . . . Note=RING-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00175 Q62318 UniProtKB Zinc finger 149 196 . . . Note=B box-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Zinc finger 205 246 . . . Note=B box-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Zinc finger 625 672 . . . Note=PHD-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00146 Q62318 UniProtKB Region 13 56 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q62318 UniProtKB Region 247 377 . . . Note=Leucine zipper alpha helical coiled-coil region Q62318 UniProtKB Region 248 377 . . . Note=Interaction with MAGEC2;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62318 UniProtKB Region 367 371 . . . Note=Involved in binding PPP1CA;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62318 UniProtKB Region 412 480 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q62318 UniProtKB Region 476 513 . . . Note=HP1 box Q62318 UniProtKB Region 581 602 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q62318 UniProtKB Motif 481 494 . . . Note=PxVxL motif Q62318 UniProtKB Binding site 154 154 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 157 157 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 178 178 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 182 182 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 210 210 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 213 213 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 233 233 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Binding site 238 238 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00024 Q62318 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:19131326;Dbxref=PMID:17242355,PMID:19131326 Q62318 UniProtKB Modified residue 23 23 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19131326;Dbxref=PMID:19131326 Q62318 UniProtKB Modified residue 26 26 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08629 Q62318 UniProtKB Modified residue 30 30 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 51 51 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 139 139 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 267 267 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 Q62318 UniProtKB Modified residue 305 305 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 341 341 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 378 378 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 418 418 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 438 438 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q62318 UniProtKB Modified residue 440 440 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 454 454 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 470 470 . . . Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24463520;Dbxref=PMID:24463520 Q62318 UniProtKB Modified residue 471 471 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 472 472 . . . Note=Citrulline;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24463520;Dbxref=PMID:24463520 Q62318 UniProtKB Modified residue 473 473 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:15345747,ECO:0007744|PubMed:17242355,ECO:0007744|PubMed:19131326,ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:15345747,PMID:17242355,PMID:19131326,PMID:19144319,PMID:21183079 Q62318 UniProtKB Modified residue 479 479 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 489 489 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q62318 UniProtKB Modified residue 498 498 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 501 501 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19131326;Dbxref=PMID:19131326 Q62318 UniProtKB Modified residue 594 594 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q62318 UniProtKB Modified residue 683 683 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 689 689 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 697 697 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 752 752 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q62318 UniProtKB Modified residue 755 755 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q62318 UniProtKB Modified residue 757 757 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 770 770 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 774 774 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 779 779 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 Q62318 UniProtKB Modified residue 784 784 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Modified residue 824 824 . . . Note=Phosphoserine%3B by ATM and ATR and dsDNA kinase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 35 35 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 128 128 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 200 200 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 255 255 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 262 262 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 273 273 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 305 305 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 320 320 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 367 367 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 378 378 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 378 378 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 408 408 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 435 435 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 469 469 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 469 469 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 507 507 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 554 554 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 554 554 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 575 575 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 676 676 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 750 750 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 750 750 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 750 750 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 770 770 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 774 774 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 779 779 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 779 779 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Cross-link 804 804 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q13263 Q62318 UniProtKB Alternative sequence 500 500 . . . ID=VSP_010899;Note=In isoform 2. D->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62318 UniProtKB Alternative sequence 501 834 . . . ID=VSP_010900;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62318 UniProtKB Mutagenesis 713 714 . . . Note=In chatwo%3B hypomorphic mutation with reduced protein stability and impaired transcriptional corepression activity. Embryonic development arrests prior to stage E9%2C with pronounced convergent extention defects and defective morphogenesis of extra-embryonic tissues. The anterior-posterior axis is shortened and embryos fail to undergo gut closure. No effect on interaction with ZFP568. CH->WN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22110054;Dbxref=PMID:22110054 Q62318 UniProtKB Sequence conflict 530 530 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62318 UniProtKB Sequence conflict 821 821 . . . Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62318 UniProtKB Beta strand 155 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Beta strand 165 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Turn 168 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Beta strand 172 174 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Helix 176 183 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Turn 186 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K Q62318 UniProtKB Beta strand 193 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6O5K