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Protein

Trans-Golgi network integral membrane protein 1

Gene

Tgoln1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in regulating membrane traffic to and from trans-Golgi network.

Miscellaneous

Also found in strains BALB/c, C57BL/6 and DBA/2.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-Golgi network integral membrane protein 1
Alternative name(s):
TGN38A
Gene namesi
Name:Tgoln1
Synonyms:Ttgn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:105080 Tgoln1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 298ExtracellularSequence analysisAdd BLAST281
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 353CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002248518 – 353Trans-Golgi network integral membrane protein 1Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ62313
MaxQBiQ62313
PaxDbiQ62313
PRIDEiQ62313

PTM databases

iPTMnetiQ62313
PhosphoSitePlusiQ62313

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000056429
CleanExiMM_TGOLN1
ExpressionAtlasiQ62313 baseline and differential
GenevisibleiQ62313 MM

Interactioni

Protein-protein interaction databases

IntActiQ62313, 1 interactor
STRINGi10090.ENSMUSP00000068487

Structurei

3D structure databases

ProteinModelPortaliQ62313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati131 – 13818
Repeati139 – 14628
Repeati147 – 15438
Repeati155 – 16248
Repeati163 – 17058
Repeati171 – 17868

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 1786 X 8 AA tandem repeatsAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi346 – 349Endocytosis signalBy similarity4

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXPE Eukaryota
ENOG410XUUR LUCA
GeneTreeiENSGT00530000064712
HOVERGENiHBG060160
InParanoidiQ62313
OMAiINDECID
OrthoDBiEOG091G02UO
TreeFamiTF332514

Family and domain databases

InterProiView protein in InterPro
IPR026084 TGN38
PANTHERiPTHR23211 PTHR23211, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFQVALLLL SVAVARALPS VYKRDADSGD SQNPPNQPSK QSSTPLPSSN
60 70 80 90 100
QVKTTRPTDG QGQKSDKKDQ DKTTLAAVSS KAESGPRTAA TDHSLGDSRR
110 120 130 140 150
QPEKTDAELN ETARPLSPVN PKLEKSDQSS TEDSGKPTGG NSGKPTGGDS
160 170 180 190 200
GKPTEAGSNK ATEDDSGKST KVDLDKPTSK ISPDTETSKT DKVQPTEKGQ
210 220 230 240 250
KPTLTSKTES GETLAGDSDF SLKPEKGDKS SEPTEDVETK EIEEGDTEPE
260 270 280 290 300
EGSPLEEENE KVPGPSSSEN QEGTLTDSMK NEKDDLYKDS SGNTSAESSH
310 320 330 340 350
FFAYLVTAAV LVAVLYIAYH NKRKIIAFAL EGKRSKVTRR PKASDYQRLN

LKL
Length:353
Mass (Da):37,848
Last modified:November 1, 1996 - v1
Checksum:i95C340C2F4A21EB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50031 mRNA Translation: BAA08757.1
AK041302 mRNA Translation: BAC30896.1
AK076586 mRNA Translation: BAC36404.1
BC009143 mRNA Translation: AAH09143.1
CCDSiCCDS51811.1
PIRiB56940
RefSeqiNP_033469.1, NM_009443.3
UniGeneiMm.246563

Genome annotation databases

EnsembliENSMUST00000070524; ENSMUSP00000068487; ENSMUSG00000056429
GeneIDi22134
KEGGimmu:22134

Similar proteinsi

Entry informationi

Entry nameiTGON1_MOUSE
AccessioniPrimary (citable) accession number: Q62313
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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