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Q62312

- TGFR2_MOUSE

UniProt

Q62312 - TGFR2_MOUSE

Protein

TGF-beta receptor type-2

Gene

Tgfbr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways By similarity.By similarity

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei302 – 3021ATPPROSITE-ProRule annotation
    Active sitei404 – 4041Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi275 – 2839ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glycosaminoglycan binding Source: Ensembl
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. receptor signaling protein serine/threonine kinase activity Source: InterPro
    6. SMAD binding Source: BHF-UCL
    7. transforming growth factor beta-activated receptor activity Source: MGI
    8. transforming growth factor beta binding Source: MGI
    9. transforming growth factor beta receptor activity, type II Source: InterPro

    GO - Biological processi

    1. activation of protein kinase activity Source: MGI
    2. aging Source: Ensembl
    3. brain development Source: BHF-UCL
    4. bronchus development Source: MGI
    5. bronchus morphogenesis Source: MGI
    6. cartilage development Source: UniProtKB
    7. common-partner SMAD protein phosphorylation Source: Ensembl
    8. digestive tract development Source: Ensembl
    9. embryo implantation Source: Ensembl
    10. embryonic cranial skeleton morphogenesis Source: BHF-UCL
    11. embryonic hemopoiesis Source: BHF-UCL
    12. gastrulation Source: MGI
    13. heart development Source: MGI
    14. in utero embryonic development Source: MGI
    15. lens development in camera-type eye Source: MGI
    16. lens fiber cell apoptotic process Source: MGI
    17. lung development Source: MGI
    18. lung lobe morphogenesis Source: MGI
    19. lung morphogenesis Source: MGI
    20. mammary gland morphogenesis Source: MGI
    21. myeloid dendritic cell differentiation Source: MGI
    22. negative regulation of cardiac muscle cell proliferation Source: Ensembl
    23. organ regeneration Source: Ensembl
    24. palate development Source: BHF-UCL
    25. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    26. patterning of blood vessels Source: MGI
    27. peptidyl-serine phosphorylation Source: Ensembl
    28. peptidyl-threonine phosphorylation Source: Ensembl
    29. positive regulation of angiogenesis Source: MGI
    30. positive regulation of B cell tolerance induction Source: MGI
    31. positive regulation of epithelial cell migration Source: MGI
    32. positive regulation of mesenchymal cell proliferation Source: BHF-UCL
    33. positive regulation of NK T cell differentiation Source: MGI
    34. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    35. positive regulation of skeletal muscle tissue regeneration Source: Ensembl
    36. positive regulation of smooth muscle cell proliferation Source: Ensembl
    37. positive regulation of T cell tolerance induction Source: MGI
    38. positive regulation of tolerance induction to self antigen Source: MGI
    39. protein phosphorylation Source: MGI
    40. receptor-mediated endocytosis Source: Ensembl
    41. regulation of cell proliferation Source: MGI
    42. response to cholesterol Source: BHF-UCL
    43. response to drug Source: Ensembl
    44. response to estrogen Source: Ensembl
    45. response to glucose Source: Ensembl
    46. response to mechanical stimulus Source: Ensembl
    47. response to nutrient Source: Ensembl
    48. smoothened signaling pathway Source: MGI
    49. trachea formation Source: MGI
    50. trachea morphogenesis Source: MGI
    51. transforming growth factor beta receptor signaling pathway Source: Ensembl
    52. vasculogenesis Source: BHF-UCL
    53. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Differentiation, Growth regulation

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.
    ReactomeiREACT_196549. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_203510. TGF-beta receptor signaling activates SMADs.
    REACT_209370. TGFBR2 MSI Frameshift Mutants in Cancer.
    REACT_215733. Downregulation of TGF-beta receptor signaling.
    REACT_216792. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_217958. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_224217. TGFBR1 LBD Mutants in Cancer.
    REACT_224787. TGFBR2 Kinase Domain Mutants in Cancer.
    REACT_224802. TGFBR1 KD Mutants in Cancer.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TGF-beta receptor type-2 (EC:2.7.11.30)
    Short name:
    TGFR-2
    Alternative name(s):
    TGF-beta type II receptor
    Transforming growth factor-beta receptor type II
    Short name:
    TGF-beta receptor type II
    Short name:
    TbetaR-II
    Gene namesi
    Name:Tgfbr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:98729. Tgfbr2.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. cytosol Source: Ensembl
    3. external side of plasma membrane Source: MGI
    4. integral component of plasma membrane Source: Ensembl
    5. membrane raft Source: MGI
    6. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 592569TGF-beta receptor type-2PRO_0000024427Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi76 ↔ 109By similarity
    Disulfide bondi79 ↔ 96By similarity
    Disulfide bondi86 ↔ 92By similarity
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi102 ↔ 126By similarity
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 161By similarity
    Disulfide bondi163 ↔ 168By similarity
    Modified residuei573 – 5731PhosphoserineBy similarity
    Modified residuei578 – 5781Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ62312.
    PRIDEiQ62312.

    PTM databases

    PhosphoSiteiQ62312.

    Expressioni

    Tissue specificityi

    Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.

    Gene expression databases

    ArrayExpressiQ62312.
    BgeeiQ62312.
    CleanExiMM_TGFBR2.
    GenevestigatoriQ62312.

    Interactioni

    Subunit structurei

    Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor By similarity. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2 By similarity. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cdh5P552844EBI-2899332,EBI-7087433
    DLG5Q8TDM63EBI-2899332,EBI-715138From a different organism.
    Shc1P98083-12EBI-2899332,EBI-7533258
    Shc1P98083-23EBI-2899332,EBI-1019301

    Protein-protein interaction databases

    BioGridi204164. 2 interactions.
    DIPiDIP-44605N.
    IntActiQ62312. 8 interactions.
    MINTiMINT-5181700.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62312.
    SMRiQ62312. Positions 73-178, 269-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 184161ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini215 – 592378CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei185 – 21430HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 569301Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000231495.
    HOVERGENiHBG104975.
    InParanoidiQ62312.
    KOiK04388.
    OMAiWETSKPR.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiQ62312.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    IPR017194. Transform_growth_fac-b_typ-2.
    IPR015013. Transforming_GF_b_rcpt_2_ecto.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF08917. ecTbetaR2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037393. TGFRII. 1 hit.
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform RII-2 (identifier: Q62312-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT    50
    IHPLKHFNSD VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA 100
    ICEKPHEVCV AVWRKNDKNI TLETVCHDPK LTYHGFTLED AASPKCVMKE 150
    KKRAGETFFM CACNMEECND YIIFSEEYTT SSPDLLLVII QVTGVSLLPP 200
    LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN CAIILEDDRS 250
    DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA 300
    VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT 350
    AFHAKGNLQE YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI 400
    VHRDLKSSNI LVKNDLTCCL CDFGLSLRLD PTLSVDDLAN SGQVGTARYM 450
    APEVLESRMN LENVESFKQT DVYSMALVLW EMTSRCNAVG EVKDYEPPFG 500
    SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE TLTECWDHDP 550
    EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK 592
    Length:592
    Mass (Da):67,122
    Last modified:November 1, 1996 - v1
    Checksum:i1A12D58550921F5E
    GO
    Isoform RII-1 (identifier: Q62312-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-56: Missing.
         57-57: F → V

    Show »
    Length:567
    Mass (Da):64,219
    Checksum:i4C66067ADA84F986
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81G → A in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti117 – 1171D → N in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti354 – 3541A → R in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti440 – 4434NSGQ → KQRE in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti486 – 4861C → W in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti506 – 5061H → P in AAB30100. (PubMed:8119124)Curated
    Sequence conflicti569 – 5702PE → MD in AAB30100. (PubMed:8119124)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 5625Missing in isoform RII-1. CuratedVSP_004955Add
    BLAST
    Alternative sequencei57 – 571F → V in isoform RII-1. CuratedVSP_004956

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32072 mRNA. Translation: BAA06840.1.
    S69114 mRNA. Translation: AAB30100.2.
    BC052629 mRNA. No translation available.
    CCDSiCCDS23601.1. [Q62312-1]
    CCDS23602.1. [Q62312-2]
    PIRiS51371.
    RefSeqiNP_033397.3. NM_009371.3. [Q62312-1]
    UniGeneiMm.172346.

    Genome annotation databases

    EnsembliENSMUST00000035014; ENSMUSP00000035014; ENSMUSG00000032440. [Q62312-2]
    ENSMUST00000061101; ENSMUSP00000062333; ENSMUSG00000032440. [Q62312-1]
    GeneIDi21813.
    KEGGimmu:21813.
    UCSCiuc009rys.2. mouse. [Q62312-1]
    uc009ryt.2. mouse. [Q62312-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32072 mRNA. Translation: BAA06840.1 .
    S69114 mRNA. Translation: AAB30100.2 .
    BC052629 mRNA. No translation available.
    CCDSi CCDS23601.1. [Q62312-1 ]
    CCDS23602.1. [Q62312-2 ]
    PIRi S51371.
    RefSeqi NP_033397.3. NM_009371.3. [Q62312-1 ]
    UniGenei Mm.172346.

    3D structure databases

    ProteinModelPortali Q62312.
    SMRi Q62312. Positions 73-178, 269-564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204164. 2 interactions.
    DIPi DIP-44605N.
    IntActi Q62312. 8 interactions.
    MINTi MINT-5181700.

    PTM databases

    PhosphoSitei Q62312.

    Proteomic databases

    PaxDbi Q62312.
    PRIDEi Q62312.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035014 ; ENSMUSP00000035014 ; ENSMUSG00000032440 . [Q62312-2 ]
    ENSMUST00000061101 ; ENSMUSP00000062333 ; ENSMUSG00000032440 . [Q62312-1 ]
    GeneIDi 21813.
    KEGGi mmu:21813.
    UCSCi uc009rys.2. mouse. [Q62312-1 ]
    uc009ryt.2. mouse. [Q62312-2 ]

    Organism-specific databases

    CTDi 7048.
    MGIi MGI:98729. Tgfbr2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000231495.
    HOVERGENi HBG104975.
    InParanoidi Q62312.
    KOi K04388.
    OMAi WETSKPR.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi Q62312.
    TreeFami TF314724.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.
    Reactomei REACT_196549. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_203510. TGF-beta receptor signaling activates SMADs.
    REACT_209370. TGFBR2 MSI Frameshift Mutants in Cancer.
    REACT_215733. Downregulation of TGF-beta receptor signaling.
    REACT_216792. SMAD2/3 MH2 Domain Mutants in Cancer.
    REACT_217958. SMAD2/3 Phosphorylation Motif Mutants in Cancer.
    REACT_224217. TGFBR1 LBD Mutants in Cancer.
    REACT_224787. TGFBR2 Kinase Domain Mutants in Cancer.
    REACT_224802. TGFBR1 KD Mutants in Cancer.

    Miscellaneous databases

    ChiTaRSi TGFBR2. mouse.
    NextBioi 301206.
    PROi Q62312.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62312.
    Bgeei Q62312.
    CleanExi MM_TGFBR2.
    Genevestigatori Q62312.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    IPR017194. Transform_growth_fac-b_typ-2.
    IPR015013. Transforming_GF_b_rcpt_2_ecto.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF08917. ecTbetaR2. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037393. TGFRII. 1 hit.
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of an isoform of mouse TGF-beta type II receptor gene."
      Suzuki A., Shioda N., Maeda T., Tada M., Ueno N.
      FEBS Lett. 355:19-22(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Tissue: Brain.
    2. "The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1."
      Lawler S., Candia A.F., Ebner R., Shum L., Lopez A.R., Moses H.L., Wright C.V., Derynck R.
      Development 120:165-175(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM RII-2).
      Tissue: Olfactory epithelium.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTGFR2_MOUSE
    AccessioniPrimary (citable) accession number: Q62312
    Secondary accession number(s): Q63947
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3