Taf6

Functionⁱ

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).By similarity

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding Source: MGI
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 18722179
DNA binding transcription factor activity Source: MGI
protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA-templated transcription, initiation Source: MGI
negative regulation of cell cycle Source: MGI
negative regulation of cell proliferation Source: MGI
regulation of DNA binding transcription factor activity Source: InterPro
transcription initiation from RNA polymerase II promoter Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation

Biological process

Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-674695. RNA Polymerase II Pre-transcription Events. R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation. R-MMU-6807505. RNA polymerase II transcribes snRNA genes. R-MMU-73776. RNA Polymerase II Promoter Escape. R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-MMU-75953. RNA Polymerase II Transcription Initiation. R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Reactomeⁱ

R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 6 Alternative name(s): Transcription initiation factor TFIID 70 kDa subunit Short name: TAF(II)70 Short name: TAFII-70 Short name: TAFII70 Transcription initiation factor TFIID 80 kDa subunit Short name: TAF(II)80 Short name: TAFII-80 Short name: TAFII80 p80
Gene namesⁱ	Name:Taf6 Synonyms:Taf2e
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:109129. Taf6.

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000118874	1 – 678	Transcription initiation factor TFIID subunit 6Add BLAST		678

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	120	PhosphothreonineBy similarity	1
Cross-linkⁱ	196	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	248	PhosphothreonineBy similarity	1
Modified residueⁱ	253	PhosphotyrosineBy similarity	1
Modified residueⁱ	264	PhosphoserineBy similarity	1
Modified residueⁱ	524	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	626	PhosphoserineCombined sources	1
Modified residueⁱ	634	PhosphoserineCombined sources	1
Modified residueⁱ	636	PhosphoserineBy similarity	1
Modified residueⁱ	653	PhosphoserineCombined sources	1
Modified residueⁱ	660	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q62311.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62311.
PaxDbⁱ	Q62311.
PeptideAtlas More...PeptideAtlasⁱ	Q62311.
PRIDEⁱ	Q62311.

PTM databases

iPTMnetⁱ	Q62311.
PhosphoSitePlusⁱ	Q62311.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000036980.
ExpressionAtlasⁱ	Q62311. baseline and differential.
Genevisibleⁱ	Q62311. MM.

Interactionⁱ

Subunit structureⁱ

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SH3KBP1	Q96B97	3	EBI-5744190,EBI-346595	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

SH3KBP1

Q96B97

3

EBI-5744190,EBI-346595

From Homo sapiens.

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding Source: MGI
protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203959. 2 interactors.
CORUMⁱ	Q62311.
Database of interacting proteins More...DIPⁱ	DIP-493N.
IntActⁱ	Q62311. 5 interactors.
Molecular INTeraction database More...MINTⁱ	Q62311.
STRINGⁱ	10090.ENSMUSP00000048016.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62311.
SMRⁱ	Q62311.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2549. Eukaryota. COG5095. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091486.
HOGENOMⁱ	HOG000253001.
HOVERGENⁱ	HBG012489.
InParanoidⁱ	Q62311.
KEGG Orthology (KO) More...KOⁱ	K03131.
OMAⁱ	IQEETCQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05S9.
PhylomeDBⁱ	Q62311.
TreeFamⁱ	TF313632.

Family and domain databases

Gene3Dⁱ	1.10.20.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016024. ARM-type_fold. IPR009072. Histone-fold. IPR037796. TAF6. IPR011442. TAF6_C. IPR004823. TAF_TATA-bd.
PANTHERⁱ	PTHR10221. PTHR10221. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02969. TAF. 1 hit. PF07571. TAF6_C. 1 hit.
SMARTⁱ	View protein in SMART SM00803. TAF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48371. SSF48371. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62311-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI 
        60         70         80         90        100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG 
       110        120        130        140        150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP 
       160        170        180        190        200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGAAAADG KGKEKKAPPL 
       210        220        230        240        250
LEGAPFRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP 
       260        270        280        290        300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY 
       310        320        330        340        350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN 
       360        370        380        390        400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG 
       410        420        430        440        450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRG 
       460        470        480        490        500
EFGSLGPLLC SHVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG 
       510        520        530        540        550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSASST 
       560        570        580        590        600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPAGS 
       610        620        630        640        650
GSVQKYIVVS LPPTGEGKGG PPSHPSPVPP SSSSPSPLGG STLCGGKQEA 
       660        670 
GDSPPPAPGT PKANGSQPTG PGSPQPAL

Length:678

Mass (Da):72,673

Last modified:November 1, 1996 - v1

Checksum:ⁱ2F454DA3A29B410D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49439 mRNA. Translation: BAA08417.1. BC058583 mRNA. Translation: AAH58583.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19795.1.
PIRⁱ	JC4245.
NCBI Reference Sequences More...RefSeqⁱ	NP_033341.1. NM_009315.3. XP_017176274.1. XM_017320785.1. XP_017176275.1. XM_017320786.1.
UniGeneⁱ	Mm.248517.

Genome annotation databases

Ensemblⁱ	ENSMUST00000048698; ENSMUSP00000048016; ENSMUSG00000036980. ENSMUST00000110936; ENSMUSP00000106561; ENSMUSG00000036980.
GeneIDⁱ	21343.
KEGGⁱ	mmu:21343.
UCSC genome browser More...UCSCⁱ	uc009aew.1. mouse.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q62311	P49848 J3KR72 UPI0007A6EC6F UPI0007A720EB A0A2K5KRH5 A0A2K6N7F5 A0A2K6LFY4 A0A2K6N7D3 C9JTY6 A0A2J8Q0L8 +186	Homo sapiens (Human) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Pan troglodytes (Chimpanzee) Papio anubis (Olive baboon) Colobus angolensis palliatus (Peters' Angolan colobus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	677	UniRef90_P49848	Cluster: Transcription initiation factor TFIID subunit 6	197

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q62311	P49848 J3KR72 UPI0007A6EC6F UPI0007A720EB A0A2K5KRH5 A0A2K5J9D1 A0A2K5XA02 A0A096NQ81 A0A2K6N7F5 A0A2K6LFY4 +313	Homo sapiens (Human) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Colobus angolensis palliatus (Peters' Angolan colobus) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Papio anubis (Olive baboon) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) And more	677	UniRef50_P49848	Cluster: Transcription initiation factor TFIID subunit 6	324

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D49439 mRNA. Translation: BAA08417.1. BC058583 mRNA. Translation: AAH58583.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19795.1.
PIRⁱ	JC4245.
NCBI Reference Sequences More...RefSeqⁱ	NP_033341.1. NM_009315.3. XP_017176274.1. XM_017320785.1. XP_017176275.1. XM_017320786.1.
UniGeneⁱ	Mm.248517.

3D structure databases

ProteinModelPortalⁱ	Q62311.
SMRⁱ	Q62311.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203959. 2 interactors.
CORUMⁱ	Q62311.
Database of interacting proteins More...DIPⁱ	DIP-493N.
IntActⁱ	Q62311. 5 interactors.
Molecular INTeraction database More...MINTⁱ	Q62311.
STRINGⁱ	10090.ENSMUSP00000048016.

PTM databases

iPTMnetⁱ	Q62311.
PhosphoSitePlusⁱ	Q62311.

Proteomic databases

EPDⁱ	Q62311.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62311.
PaxDbⁱ	Q62311.
PeptideAtlas More...PeptideAtlasⁱ	Q62311.
PRIDEⁱ	Q62311.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000048698; ENSMUSP00000048016; ENSMUSG00000036980. ENSMUST00000110936; ENSMUSP00000106561; ENSMUSG00000036980.
GeneIDⁱ	21343.
KEGGⁱ	mmu:21343.
UCSC genome browser More...UCSCⁱ	uc009aew.1. mouse.

Organism-specific databases

CTDⁱ	6878.
MGIⁱ	MGI:109129. Taf6.

Phylogenomic databases

eggNOGⁱ	KOG2549. Eukaryota. COG5095. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091486.
HOGENOMⁱ	HOG000253001.
HOVERGENⁱ	HBG012489.
InParanoidⁱ	Q62311.
KEGG Orthology (KO) More...KOⁱ	K03131.
OMAⁱ	IQEETCQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05S9.
PhylomeDBⁱ	Q62311.
TreeFamⁱ	TF313632.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-674695. RNA Polymerase II Pre-transcription Events. R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation. R-MMU-6807505. RNA polymerase II transcribes snRNA genes. R-MMU-73776. RNA Polymerase II Promoter Escape. R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-MMU-75953. RNA Polymerase II Transcription Initiation. R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Reactomeⁱ

R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q62311.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000036980.
ExpressionAtlasⁱ	Q62311. baseline and differential.
Genevisibleⁱ	Q62311. MM.

Family and domain databases

Gene3Dⁱ	1.10.20.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016024. ARM-type_fold. IPR009072. Histone-fold. IPR037796. TAF6. IPR011442. TAF6_C. IPR004823. TAF_TATA-bd.
PANTHERⁱ	PTHR10221. PTHR10221. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02969. TAF. 1 hit. PF07571. TAF6_C. 1 hit.
SMARTⁱ	View protein in SMART SM00803. TAF. 1 hit.
SUPFAMⁱ	SSF47113. SSF47113. 1 hit. SSF48371. SSF48371. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF6_MOUSE
Accessionⁱ	Q62311Primary (citable) accession number: Q62311
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	November 1, 1996
	Last modified:	March 28, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62311 (TAF6_MOUSE)

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Transcription initiation factor TFIID subunit 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ