UniProtKB - Q62311 (TAF6_MOUSE)
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Protein
Transcription initiation factor TFIID subunit 6
Gene
Taf6
Organism
Mus musculus (Mouse)
Status
Functioni
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).By similarity
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- DNA binding Source: MGI
- DNA binding transcription factor activity Source: MGI
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- DNA-templated transcription, initiation Source: MGI
- negative regulation of cell cycle Source: MGI
- negative regulation of cell proliferation Source: MGI
- regulation of DNA binding transcription factor activity Source: InterPro
- transcription initiation from RNA polymerase II promoter Source: MGI
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-674695. RNA Polymerase II Pre-transcription Events. R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation. R-MMU-6807505. RNA polymerase II transcribes snRNA genes. R-MMU-73776. RNA Polymerase II Promoter Escape. R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening. R-MMU-75953. RNA Polymerase II Transcription Initiation. R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance. |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 6Alternative name(s): Transcription initiation factor TFIID 70 kDa subunit Short name: TAF(II)70 Short name: TAFII-70 Short name: TAFII70 Transcription initiation factor TFIID 80 kDa subunit Short name: TAF(II)80 Short name: TAFII-80 Short name: TAFII80 p80 |
Gene namesi | Name:Taf6 Synonyms:Taf2e |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109129. Taf6. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118874 | 1 – 678 | Transcription initiation factor TFIID subunit 6Add BLAST | 678 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 120 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 196 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 248 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 253 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 524 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 626 | PhosphoserineCombined sources | 1 | |
Modified residuei | 634 | PhosphoserineCombined sources | 1 | |
Modified residuei | 636 | PhosphoserineBy similarity | 1 | |
Modified residuei | 653 | PhosphoserineCombined sources | 1 | |
Modified residuei | 660 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q62311. |
MaxQBi | Q62311. |
PaxDbi | Q62311. |
PeptideAtlasi | Q62311. |
PRIDEi | Q62311. |
PTM databases
iPTMneti | Q62311. |
PhosphoSitePlusi | Q62311. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000036980. |
ExpressionAtlasi | Q62311. baseline and differential. |
Genevisiblei | Q62311. MM. |
Interactioni
Subunit structurei
TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
SH3KBP1 | Q96B97 | 3 | EBI-5744190,EBI-346595 | From Homo sapiens. |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: MGI
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
BioGridi | 203959. 2 interactors. |
CORUMi | Q62311. |
DIPi | DIP-493N. |
IntActi | Q62311. 5 interactors. |
MINTi | Q62311. |
STRINGi | 10090.ENSMUSP00000048016. |
Structurei
3D structure databases
ProteinModelPortali | Q62311. |
SMRi | Q62311. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TAF6 family.Curated
Phylogenomic databases
eggNOGi | KOG2549. Eukaryota. COG5095. LUCA. |
GeneTreei | ENSGT00640000091486. |
HOGENOMi | HOG000253001. |
HOVERGENi | HBG012489. |
InParanoidi | Q62311. |
KOi | K03131. |
OMAi | IQEETCQ. |
OrthoDBi | EOG091G05S9. |
PhylomeDBi | Q62311. |
TreeFami | TF313632. |
Family and domain databases
Gene3Di | 1.10.20.10. 1 hit. |
InterProi | View protein in InterPro IPR016024. ARM-type_fold. IPR009072. Histone-fold. IPR037796. TAF6. IPR011442. TAF6_C. IPR004823. TAF_TATA-bd. |
PANTHERi | PTHR10221. PTHR10221. 1 hit. |
Pfami | View protein in Pfam PF02969. TAF. 1 hit. PF07571. TAF6_C. 1 hit. |
SMARTi | View protein in SMART SM00803. TAF. 1 hit. |
SUPFAMi | SSF47113. SSF47113. 1 hit. SSF48371. SSF48371. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q62311-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
60 70 80 90 100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
110 120 130 140 150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
160 170 180 190 200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGAAAADG KGKEKKAPPL
210 220 230 240 250
LEGAPFRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
260 270 280 290 300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
310 320 330 340 350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
360 370 380 390 400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
410 420 430 440 450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRG
460 470 480 490 500
EFGSLGPLLC SHVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
510 520 530 540 550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSASST
560 570 580 590 600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPAGS
610 620 630 640 650
GSVQKYIVVS LPPTGEGKGG PPSHPSPVPP SSSSPSPLGG STLCGGKQEA
660 670
GDSPPPAPGT PKANGSQPTG PGSPQPAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D49439 mRNA. Translation: BAA08417.1. BC058583 mRNA. Translation: AAH58583.1. |
CCDSi | CCDS19795.1. |
PIRi | JC4245. |
RefSeqi | NP_033341.1. NM_009315.3. XP_017176274.1. XM_017320785.1. XP_017176275.1. XM_017320786.1. |
UniGenei | Mm.248517. |
Genome annotation databases
Ensembli | ENSMUST00000048698; ENSMUSP00000048016; ENSMUSG00000036980. ENSMUST00000110936; ENSMUSP00000106561; ENSMUSG00000036980. |
GeneIDi | 21343. |
KEGGi | mmu:21343. |
UCSCi | uc009aew.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | TAF6_MOUSE | |
Accessioni | Q62311Primary (citable) accession number: Q62311 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |