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Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPPROSITE-ProRule annotation1
Active sitei327Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 216ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:CBG01947
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG01947a ; CBP30829 ; WBGene00025109 ; Cbr-grk-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002263181 – 640G protein-coupled receptor kinase 1Add BLAST640

Proteomic databases

PRIDEiQ622Z7

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG01947

Structurei

3D structure databases

ProteinModelPortaliQ622Z7
SMRiQ622Z7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 187RGSPROSITE-ProRule annotationAdd BLAST136
Domaini202 – 469Protein kinasePROSITE-ProRule annotationAdd BLAST268
Domaini479 – 544AGC-kinase C-terminalAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 201N-terminalBy similarityAdd BLAST201

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
HOGENOMiHOG000006742
InParanoidiQ622Z7
KOiK08291
OMAiGCFPFRR
OrthoDBiEOG091G062G

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q622Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CIPQKKENGE
60 70 80 90 100
PYAFVVEKQP IGKLLFHEFC QATNPQYHQC CQFQTKVEEY ETSDDDGQSR
110 120 130 140 150
RDLASAIVAL LSSKNDQDLS SSIDEEVWCA FLSDEVISTC ISTADSATHD
160 170 180 190 200
SEPRSDIFSE PYRLTREYLK QKPFAEFIQT MYFHRFLQWK WLEKRPVDKH
210 220 230 240 250
TFRLYRVLGK GGFGEVCACQ VRASGKMYAL KKLEKKRVKK RHAETLSLNE
260 270 280 290 300
KQILQKVNSP FVVSLAYAYE TKDALCLVLT LMNGGDLKFH LYNLMPGGFD
310 320 330 340 350
EKRVQFYAAE ITLGLQHLHL EHILYRDLKP ENILLDDFGH VRISDLGLAV
360 370 380 390 400
ELKDNEPIKG RVGTVGYMAP EIVKNERYTY GVDWWGVGCL IYEMIEGKAP
410 420 430 440 450
FRQRKEKVKR EEVERRVRED QEKYSEKFSE AARTLCRGLL HKEPGFRLGC
460 470 480 490 500
RRVGKPEDGA EEIRAHPFFN TADTATGREP VPWKKMEAGK VTPPFCPDPR
510 520 530 540 550
AVYAKDVLDI EQFSTVKGVR LDATDTQFYG KFNTGCVSIP WQSEMIETEC
560 570 580 590 600
FAELNTFYEE DGSLVWNLRP DGINMEERRN GTSKPGFFSR LFRKKNIEVT
610 620 630 640
KSLHDLSRLG VDQQQPSTSA KPAAVRSSRA ASASGRTSMI
Length:640
Mass (Da):73,412
Last modified:November 23, 2004 - v1
Checksum:i40E5E4D8A78B8252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601451 Genomic DNA Translation: CAP23139.3
RefSeqiXP_002643750.1, XM_002643704.1

Genome annotation databases

GeneIDi8585743
KEGGicbr:CBG01947

Similar proteinsi

Entry informationi

Entry nameiGRK1_CAEBR
AccessioniPrimary (citable) accession number: Q622Z7
Secondary accession number(s): A8WRN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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