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Q622Z7

- GRK1_CAEBR

UniProt

Q622Z7 - GRK1_CAEBR

Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

    Catalytic activityi

    ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei231 – 2311ATPPROSITE-ProRule annotation
    Active sitei327 – 3271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi208 – 2169ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. G-protein coupled receptor kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. signal transduction Source: InterPro
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-coupled receptor kinase 1 (EC:2.7.11.16)
    Gene namesi
    Name:grk-1
    ORF Names:CBG01947
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG01947; CBP00514; WBGene00025109; Cbr-grk-1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640G protein-coupled receptor kinase 1PRO_0000226318Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG01947.

    Structurei

    3D structure databases

    ProteinModelPortaliQ622Z7.
    SMRiQ622Z7. Positions 22-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 187136RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini202 – 469268Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini479 – 54466AGC-kinase C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 201201N-terminalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000006742.
    KOiK08291.
    OMAiEMMETEC.
    OrthoDBiEOG7V1FQK.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR00717. GPCRKINASE.
    SMARTiSM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q622Z7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CIPQKKENGE    50
    PYAFVVEKQP IGKLLFHEFC QATNPQYHQC CQFQTKVEEY ETSDDDGQSR 100
    RDLASAIVAL LSSKNDQDLS SSIDEEVWCA FLSDEVISTC ISTADSATHD 150
    SEPRSDIFSE PYRLTREYLK QKPFAEFIQT MYFHRFLQWK WLEKRPVDKH 200
    TFRLYRVLGK GGFGEVCACQ VRASGKMYAL KKLEKKRVKK RHAETLSLNE 250
    KQILQKVNSP FVVSLAYAYE TKDALCLVLT LMNGGDLKFH LYNLMPGGFD 300
    EKRVQFYAAE ITLGLQHLHL EHILYRDLKP ENILLDDFGH VRISDLGLAV 350
    ELKDNEPIKG RVGTVGYMAP EIVKNERYTY GVDWWGVGCL IYEMIEGKAP 400
    FRQRKEKVKR EEVERRVRED QEKYSEKFSE AARTLCRGLL HKEPGFRLGC 450
    RRVGKPEDGA EEIRAHPFFN TADTATGREP VPWKKMEAGK VTPPFCPDPR 500
    AVYAKDVLDI EQFSTVKGVR LDATDTQFYG KFNTGCVSIP WQSEMIETEC 550
    FAELNTFYEE DGSLVWNLRP DGINMEERRN GTSKPGFFSR LFRKKNIEVT 600
    KSLHDLSRLG VDQQQPSTSA KPAAVRSSRA ASASGRTSMI 640
    Length:640
    Mass (Da):73,412
    Last modified:November 23, 2004 - v1
    Checksum:i40E5E4D8A78B8252
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601451 Genomic DNA. Translation: CAP23139.3.
    RefSeqiXP_002643750.1. XM_002643704.1.

    Genome annotation databases

    EnsemblMetazoaiCBG01947; CBG01947; CBG01947.
    GeneIDi8585743.
    KEGGicbr:CBG01947.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE601451 Genomic DNA. Translation: CAP23139.3 .
    RefSeqi XP_002643750.1. XM_002643704.1.

    3D structure databases

    ProteinModelPortali Q622Z7.
    SMRi Q622Z7. Positions 22-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG01947.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG01947 ; CBG01947 ; CBG01947 .
    GeneIDi 8585743.
    KEGGi cbr:CBG01947.

    Organism-specific databases

    CTDi 8585743.
    WormBasei CBG01947 ; CBP00514 ; WBGene00025109 ; Cbr-grk-1.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000006742.
    KOi K08291.
    OMAi EMMETEC.
    OrthoDBi EOG7V1FQK.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR000239. GPCR_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR00717. GPCRKINASE.
    SMARTi SM00315. RGS. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiGRK1_CAEBR
    AccessioniPrimary (citable) accession number: Q622Z7
    Secondary accession number(s): A8WRN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3