Q622Z7 (GRK1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G protein-coupled receptor kinase 1
EC=2.7.11.16

Gene names

Name:	grk-1
ORF Names:	CBG01947

Organism

Caenorhabditis briggsae [Reference proteome]

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.
Catalytic activity	ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from electronic annotation. Source: InterPro termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	G protein-coupled receptor kinase 1		PRO_0000226318
Regions
	Domain	52 – 187	136	RGS
	Domain	202 – 469	268	Protein kinase
	Domain	479 – 544	66	AGC-kinase C-terminal
	Nucleotide binding	208 – 216	9	ATP By similarity
	Region	1 – 201	201	N-terminal By similarity
Sites
	Active site	327	1	Proton acceptor By similarity
	Binding site	231	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q622Z7 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 40E5E4D8A78B8252	FASTA	640	73,412
	10 20 30 40 50 60 MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CIPQKKENGE PYAFVVEKQP 70 80 90 100 110 120 IGKLLFHEFC QATNPQYHQC CQFQTKVEEY ETSDDDGQSR RDLASAIVAL LSSKNDQDLS 130 140 150 160 170 180 SSIDEEVWCA FLSDEVISTC ISTADSATHD SEPRSDIFSE PYRLTREYLK QKPFAEFIQT 190 200 210 220 230 240 MYFHRFLQWK WLEKRPVDKH TFRLYRVLGK GGFGEVCACQ VRASGKMYAL KKLEKKRVKK 250 260 270 280 290 300 RHAETLSLNE KQILQKVNSP FVVSLAYAYE TKDALCLVLT LMNGGDLKFH LYNLMPGGFD 310 320 330 340 350 360 EKRVQFYAAE ITLGLQHLHL EHILYRDLKP ENILLDDFGH VRISDLGLAV ELKDNEPIKG 370 380 390 400 410 420 RVGTVGYMAP EIVKNERYTY GVDWWGVGCL IYEMIEGKAP FRQRKEKVKR EEVERRVRED 430 440 450 460 470 480 QEKYSEKFSE AARTLCRGLL HKEPGFRLGC RRVGKPEDGA EEIRAHPFFN TADTATGREP 490 500 510 520 530 540 VPWKKMEAGK VTPPFCPDPR AVYAKDVLDI EQFSTVKGVR LDATDTQFYG KFNTGCVSIP 550 560 570 580 590 600 WQSEMIETEC FAELNTFYEE DGSLVWNLRP DGINMEERRN GTSKPGFFSR LFRKKNIEVT 610 620 630 640 KSLHDLSRLG VDQQQPSTSA KPAAVRSSRA ASASGRTSMI

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HE601451 Genomic DNA. Translation: CAP23139.1.
RefSeq	XP_002643750.1. XM_002643704.1.
3D structure databases
ProteinModelPortal	Q622Z7.
SMR	Q622Z7. Positions 22-562.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	CBG01947; CBG01947; CBG01947.
GeneID	8585743.
KEGG	cbr:CBG01947.
Organism-specific databases
CTD	8585743.
WormBase	CBG01947; CBP00514; WBGene00025109; Cbr-grk-1.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000006742.
KO	K08291.
OMA	EMMETEC.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR00717. GPCRKINASE.
SMART	SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRK1_CAEBR

Accession

Primary (citable) accession number: Q622Z7
Secondary accession number(s): A8WRN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 23, 2004
Last modified:	October 3, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project