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Protein

G protein-coupled receptor kinase 1

Gene

grk-1

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors.By similarity

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei231 – 2311ATPPROSITE-ProRule annotation
Active sitei327 – 3271Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2169ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 1 (EC:2.7.11.16)
Gene namesi
Name:grk-1
ORF Names:CBG01947
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG01947; CBP00514; WBGene00025109; Cbr-grk-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640G protein-coupled receptor kinase 1PRO_0000226318Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG01947.

Structurei

3D structure databases

ProteinModelPortaliQ622Z7.
SMRiQ622Z7. Positions 22-562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 187136RGSPROSITE-ProRule annotationAdd
BLAST
Domaini202 – 469268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini479 – 54466AGC-kinase C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 201201N-terminalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000006742.
InParanoidiQ622Z7.
KOiK08291.
OMAiNFYTKFN.
OrthoDBiEOG7V1FQK.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q622Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CIPQKKENGE
60 70 80 90 100
PYAFVVEKQP IGKLLFHEFC QATNPQYHQC CQFQTKVEEY ETSDDDGQSR
110 120 130 140 150
RDLASAIVAL LSSKNDQDLS SSIDEEVWCA FLSDEVISTC ISTADSATHD
160 170 180 190 200
SEPRSDIFSE PYRLTREYLK QKPFAEFIQT MYFHRFLQWK WLEKRPVDKH
210 220 230 240 250
TFRLYRVLGK GGFGEVCACQ VRASGKMYAL KKLEKKRVKK RHAETLSLNE
260 270 280 290 300
KQILQKVNSP FVVSLAYAYE TKDALCLVLT LMNGGDLKFH LYNLMPGGFD
310 320 330 340 350
EKRVQFYAAE ITLGLQHLHL EHILYRDLKP ENILLDDFGH VRISDLGLAV
360 370 380 390 400
ELKDNEPIKG RVGTVGYMAP EIVKNERYTY GVDWWGVGCL IYEMIEGKAP
410 420 430 440 450
FRQRKEKVKR EEVERRVRED QEKYSEKFSE AARTLCRGLL HKEPGFRLGC
460 470 480 490 500
RRVGKPEDGA EEIRAHPFFN TADTATGREP VPWKKMEAGK VTPPFCPDPR
510 520 530 540 550
AVYAKDVLDI EQFSTVKGVR LDATDTQFYG KFNTGCVSIP WQSEMIETEC
560 570 580 590 600
FAELNTFYEE DGSLVWNLRP DGINMEERRN GTSKPGFFSR LFRKKNIEVT
610 620 630 640
KSLHDLSRLG VDQQQPSTSA KPAAVRSSRA ASASGRTSMI
Length:640
Mass (Da):73,412
Last modified:November 23, 2004 - v1
Checksum:i40E5E4D8A78B8252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601451 Genomic DNA. Translation: CAP23139.3.
RefSeqiXP_002643750.1. XM_002643704.1.

Genome annotation databases

EnsemblMetazoaiCBG01947; CBG01947; CBG01947.
GeneIDi8585743.
KEGGicbr:CBG01947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601451 Genomic DNA. Translation: CAP23139.3.
RefSeqiXP_002643750.1. XM_002643704.1.

3D structure databases

ProteinModelPortaliQ622Z7.
SMRiQ622Z7. Positions 22-562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6238.CBG01947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiCBG01947; CBG01947; CBG01947.
GeneIDi8585743.
KEGGicbr:CBG01947.

Organism-specific databases

CTDi8585743.
WormBaseiCBG01947; CBP00514; WBGene00025109; Cbr-grk-1.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000006742.
InParanoidiQ622Z7.
KOiK08291.
OMAiNFYTKFN.
OrthoDBiEOG7V1FQK.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiGRK1_CAEBR
AccessioniPrimary (citable) accession number: Q622Z7
Secondary accession number(s): A8WRN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.