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Q622Z7 (GRK1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein-coupled receptor kinase 1

EC=2.7.11.16
Gene names
Name:grk-1
ORF Names:CBG01947
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors By similarity.

Catalytic activity

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640G protein-coupled receptor kinase 1
PRO_0000226318

Regions

Domain52 – 187136RGS
Domain202 – 469268Protein kinase
Domain479 – 54466AGC-kinase C-terminal
Nucleotide binding208 – 2169ATP By similarity
Region1 – 201201N-terminal By similarity

Sites

Active site3271Proton acceptor By similarity
Binding site2311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q622Z7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 40E5E4D8A78B8252

FASTA64073,412
        10         20         30         40         50         60 
MEIENIVANT VYIKARESGG QKKGKSKKWK NYLQFPHYTE CIPQKKENGE PYAFVVEKQP 

        70         80         90        100        110        120 
IGKLLFHEFC QATNPQYHQC CQFQTKVEEY ETSDDDGQSR RDLASAIVAL LSSKNDQDLS 

       130        140        150        160        170        180 
SSIDEEVWCA FLSDEVISTC ISTADSATHD SEPRSDIFSE PYRLTREYLK QKPFAEFIQT 

       190        200        210        220        230        240 
MYFHRFLQWK WLEKRPVDKH TFRLYRVLGK GGFGEVCACQ VRASGKMYAL KKLEKKRVKK 

       250        260        270        280        290        300 
RHAETLSLNE KQILQKVNSP FVVSLAYAYE TKDALCLVLT LMNGGDLKFH LYNLMPGGFD 

       310        320        330        340        350        360 
EKRVQFYAAE ITLGLQHLHL EHILYRDLKP ENILLDDFGH VRISDLGLAV ELKDNEPIKG 

       370        380        390        400        410        420 
RVGTVGYMAP EIVKNERYTY GVDWWGVGCL IYEMIEGKAP FRQRKEKVKR EEVERRVRED 

       430        440        450        460        470        480 
QEKYSEKFSE AARTLCRGLL HKEPGFRLGC RRVGKPEDGA EEIRAHPFFN TADTATGREP 

       490        500        510        520        530        540 
VPWKKMEAGK VTPPFCPDPR AVYAKDVLDI EQFSTVKGVR LDATDTQFYG KFNTGCVSIP 

       550        560        570        580        590        600 
WQSEMIETEC FAELNTFYEE DGSLVWNLRP DGINMEERRN GTSKPGFFSR LFRKKNIEVT 

       610        620        630        640 
KSLHDLSRLG VDQQQPSTSA KPAAVRSSRA ASASGRTSMI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE601451 Genomic DNA. Translation: CAP23139.3.
RefSeqXP_002643750.1. XM_002643704.1.

3D structure databases

ProteinModelPortalQ622Z7.
SMRQ622Z7. Positions 22-562.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG01947.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG01947; CBG01947; CBG01947.
GeneID8585743.
KEGGcbr:CBG01947.

Organism-specific databases

CTD8585743.
WormBaseCBG01947; CBP00514; WBGene00025109; Cbr-grk-1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000006742.
KOK08291.
OMAEMMETEC.
OrthoDBEOG7V1FQK.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRK1_CAEBR
AccessionPrimary (citable) accession number: Q622Z7
Secondary accession number(s): A8WRN1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: March 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families