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Protein

Tetraspanin-7

Gene

Tspan7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in cell proliferation and cell motility.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-7
Short name:
Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
PE31
TALLA homolog
Transmembrane 4 superfamily member 2
CD_antigen: CD231
Gene namesi
Name:Tspan7
Synonyms:Mxs1, Tm4sf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1298407. Tspan7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 4024HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 5616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 7519HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 8611CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei87 – 11226HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 213101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 24915CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Tetraspanin-7PRO_0000219249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62283.
PaxDbiQ62283.
PRIDEiQ62283.

PTM databases

PhosphoSiteiQ62283.

Expressioni

Gene expression databases

BgeeiQ62283.
CleanExiMM_TSPAN7.
ExpressionAtlasiQ62283. baseline and differential.
GenevestigatoriQ62283.

Interactioni

Protein-protein interaction databases

BioGridi204231. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiQ62283.
KOiK06571.
OMAiFWITGAI.
OrthoDBiEOG73BVDM.
PhylomeDBiQ62283.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQN YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS SSPYFLDHGI PPSCCMNETD CNPLDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Length:249
Mass (Da):27,544
Last modified:November 15, 2001 - v2
Checksum:i04B3A24D16B5DCD3
GO

Sequence cautioni

The sequence AAC34579.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA05493.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461R → P in AAC34579 (PubMed:10617319).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
CCDSiCCDS30016.1.
RefSeqiNP_062608.2. NM_019634.2.
UniGeneiMm.18590.

Genome annotation databases

EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneIDi21912.
KEGGimmu:21912.
UCSCiuc009sqm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
CCDSiCCDS30016.1.
RefSeqiNP_062608.2. NM_019634.2.
UniGeneiMm.18590.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204231. 1 interaction.

PTM databases

PhosphoSiteiQ62283.

Proteomic databases

MaxQBiQ62283.
PaxDbiQ62283.
PRIDEiQ62283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneIDi21912.
KEGGimmu:21912.
UCSCiuc009sqm.1. mouse.

Organism-specific databases

CTDi7102.
MGIiMGI:1298407. Tspan7.

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiQ62283.
KOiK06571.
OMAiFWITGAI.
OrthoDBiEOG73BVDM.
PhylomeDBiQ62283.
TreeFamiTF352891.

Miscellaneous databases

ChiTaRSiTspan7. mouse.
NextBioi301464.
PROiQ62283.
SOURCEiSearch...

Gene expression databases

BgeeiQ62283.
CleanExiMM_TSPAN7.
ExpressionAtlasiQ62283. baseline and differential.
GenevestigatoriQ62283.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of mouse PE31 (TALLA)."
    Nagira M., Ishikawa K., Fujikawa K., Takagi S., Yoshie O.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
    Strain: BALB/c.
    Tissue: Brain.
  2. "Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons."
    Hosokawa Y., Ueyama E., Morikawa Y., Maeda Y., Seto M., Senba E.
    Neurosci. Res. 35:281-290(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
    Strain: C57BL/6.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiTSN7_MOUSE
AccessioniPrimary (citable) accession number: Q62283
Secondary accession number(s): O88429, Q9DBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: November 15, 2001
Last modified: March 31, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.