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Q62283

- TSN7_MOUSE

UniProt

Q62283 - TSN7_MOUSE

Protein

Tetraspanin-7

Gene

Tspan7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (16 Nov 2001)
      Previous versions | rss
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    Functioni

    May be involved in cell proliferation and cell motility.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-7
    Short name:
    Tspan-7
    Alternative name(s):
    Cell surface glycoprotein A15
    PE31
    TALLA homolog
    Transmembrane 4 superfamily member 2
    CD_antigen: CD231
    Gene namesi
    Name:Tspan7
    Synonyms:Mxs1, Tm4sf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1298407. Tspan7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Tetraspanin-7PRO_0000219249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ62283.
    PRIDEiQ62283.

    PTM databases

    PhosphoSiteiQ62283.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62283.
    BgeeiQ62283.
    CleanExiMM_TSPAN7.
    GenevestigatoriQ62283.

    Interactioni

    Protein-protein interaction databases

    BioGridi204231. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62283.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5616ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 8611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 213101ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 24915CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 4024HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 11226HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274015.
    GeneTreeiENSGT00740000115480.
    HOGENOMiHOG000230656.
    HOVERGENiHBG107306.
    InParanoidiQ62283.
    KOiK06571.
    OMAiFWITGAI.
    OrthoDBiEOG73BVDM.
    PhylomeDBiQ62283.
    TreeFamiTF352891.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL    50
    IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL 100
    AELVAGISGF VFRHEIKDTF LRTYTDAMQN YNGNDERSRA VDHVQRSLSC 150
    CGVQNYTNWS SSPYFLDHGI PPSCCMNETD CNPLDLHNLT VAATKVNQKG 200
    CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV 249
    Length:249
    Mass (Da):27,544
    Last modified:November 16, 2001 - v2
    Checksum:i04B3A24D16B5DCD3
    GO

    Sequence cautioni

    The sequence AAC34579.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA05493.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461R → P in AAC34579. (PubMed:10617319)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26483 mRNA. Translation: BAA05493.1. Different initiation.
    AF052492 mRNA. Translation: AAC34579.1. Different initiation.
    AK004776 mRNA. Translation: BAB23554.1.
    CCDSiCCDS30016.1.
    RefSeqiNP_062608.2. NM_019634.2.
    UniGeneiMm.18590.

    Genome annotation databases

    EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
    GeneIDi21912.
    KEGGimmu:21912.
    UCSCiuc009sqm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26483 mRNA. Translation: BAA05493.1 . Different initiation.
    AF052492 mRNA. Translation: AAC34579.1 . Different initiation.
    AK004776 mRNA. Translation: BAB23554.1 .
    CCDSi CCDS30016.1.
    RefSeqi NP_062608.2. NM_019634.2.
    UniGenei Mm.18590.

    3D structure databases

    ProteinModelPortali Q62283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204231. 1 interaction.

    PTM databases

    PhosphoSitei Q62283.

    Proteomic databases

    PaxDbi Q62283.
    PRIDEi Q62283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076354 ; ENSMUSP00000075692 ; ENSMUSG00000058254 .
    GeneIDi 21912.
    KEGGi mmu:21912.
    UCSCi uc009sqm.1. mouse.

    Organism-specific databases

    CTDi 7102.
    MGIi MGI:1298407. Tspan7.

    Phylogenomic databases

    eggNOGi NOG274015.
    GeneTreei ENSGT00740000115480.
    HOGENOMi HOG000230656.
    HOVERGENi HBG107306.
    InParanoidi Q62283.
    KOi K06571.
    OMAi FWITGAI.
    OrthoDBi EOG73BVDM.
    PhylomeDBi Q62283.
    TreeFami TF352891.

    Miscellaneous databases

    ChiTaRSi TSPAN7. mouse.
    NextBioi 301464.
    PROi Q62283.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62283.
    Bgeei Q62283.
    CleanExi MM_TSPAN7.
    Genevestigatori Q62283.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of mouse PE31 (TALLA)."
      Nagira M., Ishikawa K., Fujikawa K., Takagi S., Yoshie O.
      Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
      Strain: BALB/c.
      Tissue: Brain.
    2. "Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons."
      Hosokawa Y., Ueyama E., Morikawa Y., Maeda Y., Seto M., Senba E.
      Neurosci. Res. 35:281-290(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
      Strain: C57BL/6.
      Tissue: Spleen.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.

    Entry informationi

    Entry nameiTSN7_MOUSE
    AccessioniPrimary (citable) accession number: Q62283
    Secondary accession number(s): O88429, Q9DBS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3