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Protein

Tetraspanin-7

Gene

Tspan7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell proliferation and cell motility.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-416993. Trafficking of GluR2-containing AMPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-7
Short name:
Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
PE31
TALLA homolog
Transmembrane 4 superfamily member 2
CD_antigen: CD231
Gene namesi
Name:Tspan7
Synonyms:Mxs1, Tm4sf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1298407. Tspan7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 40HelicalSequence analysisAdd BLAST24
Topological domaini41 – 56ExtracellularSequence analysisAdd BLAST16
Transmembranei57 – 75HelicalSequence analysisAdd BLAST19
Topological domaini76 – 86CytoplasmicSequence analysisAdd BLAST11
Transmembranei87 – 112HelicalSequence analysisAdd BLAST26
Topological domaini113 – 213ExtracellularSequence analysisAdd BLAST101
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 249CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192491 – 249Tetraspanin-7Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62283.
PaxDbiQ62283.
PeptideAtlasiQ62283.
PRIDEiQ62283.

PTM databases

PhosphoSitePlusiQ62283.
SwissPalmiQ62283.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058254.
CleanExiMM_TSPAN7.
ExpressionAtlasiQ62283. baseline and differential.
GenevisibleiQ62283. MM.

Interactioni

Protein-protein interaction databases

BioGridi204231. 1 interactor.
STRINGi10090.ENSMUSP00000075692.

Structurei

3D structure databases

ProteinModelPortaliQ62283.
SMRiQ62283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiQ62283.
KOiK06571.
OMAiVYSFVFW.
OrthoDBiEOG091G0NJA.
PhylomeDBiQ62283.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQN YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS SSPYFLDHGI PPSCCMNETD CNPLDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Length:249
Mass (Da):27,544
Last modified:November 16, 2001 - v2
Checksum:i04B3A24D16B5DCD3
GO

Sequence cautioni

The sequence AAC34579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA05493 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146R → P in AAC34579 (PubMed:10617319).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
CCDSiCCDS30016.1.
RefSeqiNP_062608.2. NM_019634.2.
UniGeneiMm.18590.

Genome annotation databases

EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneIDi21912.
KEGGimmu:21912.
UCSCiuc009sqm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
CCDSiCCDS30016.1.
RefSeqiNP_062608.2. NM_019634.2.
UniGeneiMm.18590.

3D structure databases

ProteinModelPortaliQ62283.
SMRiQ62283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204231. 1 interactor.
STRINGi10090.ENSMUSP00000075692.

PTM databases

PhosphoSitePlusiQ62283.
SwissPalmiQ62283.

Proteomic databases

MaxQBiQ62283.
PaxDbiQ62283.
PeptideAtlasiQ62283.
PRIDEiQ62283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneIDi21912.
KEGGimmu:21912.
UCSCiuc009sqm.1. mouse.

Organism-specific databases

CTDi7102.
MGIiMGI:1298407. Tspan7.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiQ62283.
KOiK06571.
OMAiVYSFVFW.
OrthoDBiEOG091G0NJA.
PhylomeDBiQ62283.
TreeFamiTF352891.

Enzyme and pathway databases

ReactomeiR-MMU-416993. Trafficking of GluR2-containing AMPA receptors.

Miscellaneous databases

ChiTaRSiTspan7. mouse.
PROiQ62283.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058254.
CleanExiMM_TSPAN7.
ExpressionAtlasiQ62283. baseline and differential.
GenevisibleiQ62283. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN7_MOUSE
AccessioniPrimary (citable) accession number: Q62283
Secondary accession number(s): O88429, Q9DBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 16, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.