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Q62283

- TSN7_MOUSE

UniProt

Q62283 - TSN7_MOUSE

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Protein

Tetraspanin-7

Gene

Tspan7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in cell proliferation and cell motility.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-7
Short name:
Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
PE31
TALLA homolog
Transmembrane 4 superfamily member 2
CD_antigen: CD231
Gene namesi
Name:Tspan7
Synonyms:Mxs1, Tm4sf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1298407. Tspan7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 4024HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 5616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 7519HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 8611CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei87 – 11226HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 213101ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 24915CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Tetraspanin-7PRO_0000219249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62283.
PaxDbiQ62283.
PRIDEiQ62283.

PTM databases

PhosphoSiteiQ62283.

Expressioni

Gene expression databases

BgeeiQ62283.
CleanExiMM_TSPAN7.
ExpressionAtlasiQ62283. baseline and differential.
GenevestigatoriQ62283.

Interactioni

Protein-protein interaction databases

BioGridi204231. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ62283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230656.
HOVERGENiHBG107306.
InParanoidiQ62283.
KOiK06571.
OMAiFWITGAI.
OrthoDBiEOG73BVDM.
PhylomeDBiQ62283.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQN YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS SSPYFLDHGI PPSCCMNETD CNPLDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Length:249
Mass (Da):27,544
Last modified:November 16, 2001 - v2
Checksum:i04B3A24D16B5DCD3
GO

Sequence cautioni

The sequence AAC34579.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA05493.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461R → P in AAC34579. (PubMed:10617319)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
CCDSiCCDS30016.1.
RefSeqiNP_062608.2. NM_019634.2.
UniGeneiMm.18590.

Genome annotation databases

EnsembliENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneIDi21912.
KEGGimmu:21912.
UCSCiuc009sqm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26483 mRNA. Translation: BAA05493.1 . Different initiation.
AF052492 mRNA. Translation: AAC34579.1 . Different initiation.
AK004776 mRNA. Translation: BAB23554.1 .
CCDSi CCDS30016.1.
RefSeqi NP_062608.2. NM_019634.2.
UniGenei Mm.18590.

3D structure databases

ProteinModelPortali Q62283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204231. 1 interaction.

PTM databases

PhosphoSitei Q62283.

Proteomic databases

MaxQBi Q62283.
PaxDbi Q62283.
PRIDEi Q62283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076354 ; ENSMUSP00000075692 ; ENSMUSG00000058254 .
GeneIDi 21912.
KEGGi mmu:21912.
UCSCi uc009sqm.1. mouse.

Organism-specific databases

CTDi 7102.
MGIi MGI:1298407. Tspan7.

Phylogenomic databases

eggNOGi NOG274015.
GeneTreei ENSGT00760000118875.
HOGENOMi HOG000230656.
HOVERGENi HBG107306.
InParanoidi Q62283.
KOi K06571.
OMAi FWITGAI.
OrthoDBi EOG73BVDM.
PhylomeDBi Q62283.
TreeFami TF352891.

Miscellaneous databases

ChiTaRSi Tspan7. mouse.
NextBioi 301464.
PROi Q62283.
SOURCEi Search...

Gene expression databases

Bgeei Q62283.
CleanExi MM_TSPAN7.
ExpressionAtlasi Q62283. baseline and differential.
Genevestigatori Q62283.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of mouse PE31 (TALLA)."
    Nagira M., Ishikawa K., Fujikawa K., Takagi S., Yoshie O.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
    Strain: BALB/c.
    Tissue: Brain.
  2. "Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons."
    Hosokawa Y., Ueyama E., Morikawa Y., Maeda Y., Seto M., Senba E.
    Neurosci. Res. 35:281-290(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
    Strain: C57BL/6.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiTSN7_MOUSE
AccessioniPrimary (citable) accession number: Q62283
Secondary accession number(s): O88429, Q9DBS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 16, 2001
Last modified: November 26, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3