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Q62283 (TSN7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-7

Short name=Tspan-7
Alternative name(s):
Cell surface glycoprotein A15
PE31
TALLA homolog
Transmembrane 4 superfamily member 2
CD_antigen=CD231
Gene names
Name:Tspan7
Synonyms:Mxs1, Tm4sf2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in cell proliferation and cell motility.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence caution

The sequence AAC34579.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA05493.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249Tetraspanin-7
PRO_0000219249

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 4024Helical; Potential
Topological domain41 – 5616Extracellular Potential
Transmembrane57 – 7519Helical; Potential
Topological domain76 – 8611Cytoplasmic Potential
Transmembrane87 – 11226Helical; Potential
Topological domain113 – 213101Extracellular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 24915Cytoplasmic Potential

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1461R → P in AAC34579. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q62283 [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: 04B3A24D16B5DCD3

FASTA24927,544
        10         20         30         40         50         60 
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL IAENSTNAPY 

        70         80         90        100        110        120 
VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL AELVAGISGF VFRHEIKDTF 

       130        140        150        160        170        180 
LRTYTDAMQN YNGNDERSRA VDHVQRSLSC CGVQNYTNWS SSPYFLDHGI PPSCCMNETD 

       190        200        210        220        230        240 
CNPLDLHNLT VAATKVNQKG CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF 


ITANQYEMV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of mouse PE31 (TALLA)."
Nagira M., Ishikawa K., Fujikawa K., Takagi S., Yoshie O.
Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
Strain: BALB/c.
Tissue: Brain.
[2]"Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4 superfamily, and its preferential expression in brain neurons."
Hosokawa Y., Ueyama E., Morikawa Y., Maeda Y., Seto M., Senba E.
Neurosci. Res. 35:281-290(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-249.
Strain: C57BL/6.
Tissue: Spleen.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26483 mRNA. Translation: BAA05493.1. Different initiation.
AF052492 mRNA. Translation: AAC34579.1. Different initiation.
AK004776 mRNA. Translation: BAB23554.1.
RefSeqNP_062608.2. NM_019634.2.
UniGeneMm.18590.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204231. 1 interaction.

PTM databases

PhosphoSiteQ62283.

Proteomic databases

PaxDbQ62283.
PRIDEQ62283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254.
GeneID21912.
KEGGmmu:21912.
UCSCuc009sqm.1. mouse.

Organism-specific databases

CTD7102.
MGIMGI:1298407. Tspan7.

Phylogenomic databases

eggNOGNOG274015.
GeneTreeENSGT00740000115480.
HOGENOMHOG000230656.
HOVERGENHBG107306.
InParanoidQ62283.
KOK06571.
OMAFWITGAI.
OrthoDBEOG73BVDM.
PhylomeDBQ62283.
TreeFamTF352891.

Gene expression databases

ArrayExpressQ62283.
BgeeQ62283.
CleanExMM_TSPAN7.
GenevestigatorQ62283.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTSPAN7. mouse.
NextBio301464.
PROQ62283.
SOURCESearch...

Entry information

Entry nameTSN7_MOUSE
AccessionPrimary (citable) accession number: Q62283
Secondary accession number(s): O88429, Q9DBS3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 16, 2001
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot