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Protein

T-cell acute lymphocytic leukemia protein 2 homolog

Gene

Tal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. midbrain development Source: MGI
  2. multicellular organism growth Source: MGI
  3. post-embryonic development Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. thalamus development Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 2 homolog
Short name:
TAL-2
Gene namesi
Name:Tal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:99540. Tal2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 108108T-cell acute lymphocytic leukemia protein 2 homologPRO_0000127457Add
BLAST

Proteomic databases

PRIDEiQ62282.

PTM databases

PhosphoSiteiQ62282.

Expressioni

Gene expression databases

BgeeiQ62282.
CleanExiMM_TAL2.
ExpressionAtlasiQ62282. baseline and differential.
GenevestigatoriQ62282.

Interactioni

Protein-protein interaction databases

BioGridi203963. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ62282.
SMRiQ62282. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5453bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256466.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000129920.
HOVERGENiHBG004515.
InParanoidiQ62282.
KOiK09068.
OMAiHLPGLEN.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ62282.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKIFTNTR ERWRQQSVNN AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLHQTGVAA QGNILGLFPP KTRLPDEDDR TLLNDYRVPS

PGPSHGAP
Length:108
Mass (Da):12,315
Last modified:November 1, 1996 - v1
Checksum:i11B8A7711520AF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81077 Genomic DNA. Translation: AAA40162.1.
AK018448 mRNA. Translation: BAB31216.1.
CCDSiCCDS18192.1.
RefSeqiNP_033343.1. NM_009317.3.
UniGeneiMm.56955.

Genome annotation databases

EnsembliENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417.
GeneIDi21350.
KEGGimmu:21350.
UCSCiuc008sxg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81077 Genomic DNA. Translation: AAA40162.1.
AK018448 mRNA. Translation: BAB31216.1.
CCDSiCCDS18192.1.
RefSeqiNP_033343.1. NM_009317.3.
UniGeneiMm.56955.

3D structure databases

ProteinModelPortaliQ62282.
SMRiQ62282. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203963. 3 interactions.

PTM databases

PhosphoSiteiQ62282.

Proteomic databases

PRIDEiQ62282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417.
GeneIDi21350.
KEGGimmu:21350.
UCSCiuc008sxg.1. mouse.

Organism-specific databases

CTDi6887.
MGIiMGI:99540. Tal2.

Phylogenomic databases

eggNOGiNOG256466.
GeneTreeiENSGT00760000119097.
HOGENOMiHOG000129920.
HOVERGENiHBG004515.
InParanoidiQ62282.
KOiK09068.
OMAiHLPGLEN.
OrthoDBiEOG7SN8DF.
PhylomeDBiQ62282.
TreeFamiTF315153.

Miscellaneous databases

NextBioi300540.
PROiQ62282.
SOURCEiSearch...

Gene expression databases

BgeeiQ62282.
CleanExiMM_TAL2.
ExpressionAtlasiQ62282. baseline and differential.
GenevestigatoriQ62282.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
    Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
    Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiTAL2_MOUSE
AccessioniPrimary (citable) accession number: Q62282
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.