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Q62282

- TAL2_MOUSE

UniProt

Q62282 - TAL2_MOUSE

Protein

T-cell acute lymphocytic leukemia protein 2 homolog

Gene

Tal2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. midbrain development Source: MGI
    2. multicellular organism growth Source: MGI
    3. post-embryonic development Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. thalamus development Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2 homolog
    Short name:
    TAL-2
    Gene namesi
    Name:Tal2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:99540. Tal2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 108108T-cell acute lymphocytic leukemia protein 2 homologPRO_0000127457Add
    BLAST

    Proteomic databases

    PRIDEiQ62282.

    PTM databases

    PhosphoSiteiQ62282.

    Expressioni

    Gene expression databases

    BgeeiQ62282.
    CleanExiMM_TAL2.
    GenevestigatoriQ62282.

    Interactioni

    Protein-protein interaction databases

    BioGridi203963. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62282.
    SMRiQ62282. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 5453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG256466.
    GeneTreeiENSGT00730000110586.
    HOGENOMiHOG000129920.
    HOVERGENiHBG004515.
    InParanoidiQ62282.
    KOiK09068.
    OMAiIENTNIC.
    OrthoDBiEOG7SN8DF.
    PhylomeDBiQ62282.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62282-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRKIFTNTR ERWRQQSVNN AFAKLRKLIP THPPDKKLSK NETLRLAMRY    50
    INFLVKVLGE QSLHQTGVAA QGNILGLFPP KTRLPDEDDR TLLNDYRVPS 100
    PGPSHGAP 108
    Length:108
    Mass (Da):12,315
    Last modified:November 1, 1996 - v1
    Checksum:i11B8A7711520AF13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81077 Genomic DNA. Translation: AAA40162.1.
    AK018448 mRNA. Translation: BAB31216.1.
    CCDSiCCDS18192.1.
    RefSeqiNP_033343.1. NM_009317.3.
    UniGeneiMm.56955.

    Genome annotation databases

    EnsembliENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417.
    GeneIDi21350.
    KEGGimmu:21350.
    UCSCiuc008sxg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81077 Genomic DNA. Translation: AAA40162.1 .
    AK018448 mRNA. Translation: BAB31216.1 .
    CCDSi CCDS18192.1.
    RefSeqi NP_033343.1. NM_009317.3.
    UniGenei Mm.56955.

    3D structure databases

    ProteinModelPortali Q62282.
    SMRi Q62282. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203963. 3 interactions.

    PTM databases

    PhosphoSitei Q62282.

    Proteomic databases

    PRIDEi Q62282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030124 ; ENSMUSP00000030124 ; ENSMUSG00000028417 .
    GeneIDi 21350.
    KEGGi mmu:21350.
    UCSCi uc008sxg.1. mouse.

    Organism-specific databases

    CTDi 6887.
    MGIi MGI:99540. Tal2.

    Phylogenomic databases

    eggNOGi NOG256466.
    GeneTreei ENSGT00730000110586.
    HOGENOMi HOG000129920.
    HOVERGENi HBG004515.
    InParanoidi Q62282.
    KOi K09068.
    OMAi IENTNIC.
    OrthoDBi EOG7SN8DF.
    PhylomeDBi Q62282.
    TreeFami TF315153.

    Miscellaneous databases

    NextBioi 300540.
    PROi Q62282.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62282.
    CleanExi MM_TAL2.
    Genevestigatori Q62282.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia."
      Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III, Le Beau M.M., Baer R.J.
      Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.

    Entry informationi

    Entry nameiTAL2_MOUSE
    AccessioniPrimary (citable) accession number: Q62282
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3