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Protein

Protein SSXT

Gene

Ss18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Appears to function synergistically with RBM14 as transcription coactivator.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell morphogenesis Source: MGI
  • cytoskeleton organization Source: MGI
  • ephrin receptor signaling pathway Source: MGI
  • intracellular signal transduction Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • neuronal stem cell population maintenance Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • response to drug Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSXT
Alternative name(s):
Protein SYT
Synovial sarcoma-associated Ss18-alpha
Gene namesi
Name:Ss18
Synonyms:Ssxt, Syt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:107708 Ss18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001818242 – 418Protein SSXTAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ62280
PaxDbiQ62280
PeptideAtlasiQ62280
PRIDEiQ62280

PTM databases

iPTMnetiQ62280
PhosphoSitePlusiQ62280

Expressioni

Developmental stagei

Ubiquitously expressed in early embryogenesis (12.5 days). In later stages (14.5 days), the expression is restricted to cartilage forming cells, to specific neuronal cells and some epithelial derived tissues. In adults, SSXT is expressed in heart, kidney, testis and also in muscle, brain and liver. In mature testis, expression is specifically observed in primary spermatocytes.

Gene expression databases

BgeeiENSMUSG00000037013
CleanExiMM_SS18
ExpressionAtlasiQ62280 baseline and differential
GenevisibleiQ62280 MM

Interactioni

Subunit structurei

Interacts with MLLT10.By similarity

Protein-protein interaction databases

BioGridi234592, 4 interactors
DIPiDIP-60230N
IntActiQ62280, 4 interactors
MINTiQ62280
STRINGi10090.ENSMUSP00000046320

Structurei

3D structure databases

ProteinModelPortaliQ62280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati344 – 3561Add BLAST13
Repeati357 – 3692Add BLAST13

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 3692 X 13 AA imperfect tandem repeatsAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 53SH2-bindingSequence analysis4
Motifi374 – 377SH2-bindingSequence analysis4
Motifi392 – 401SH3-bindingSequence analysis10
Motifi413 – 416SH2-bindingSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 99Poly-Pro5
Compositional biasi175 – 418Gln-richAdd BLAST244

Sequence similaritiesi

Belongs to the SS18 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3227 Eukaryota
ENOG41128HA LUCA
GeneTreeiENSGT00500000044808
HOGENOMiHOG000048717
HOVERGENiHBG003892
InParanoidiQ62280
KOiK15623
OMAiPRAHNMP
OrthoDBiEOG091G0O10
TreeFamiTF330999

Family and domain databases

InterProiView protein in InterPro
IPR007726 SS18_fam
PfamiView protein in Pfam
PF05030 SSXT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAFAAPRQ RGKGEITPAA IQKMLDENNH LIQCIMDYQN KGKASECSQY
60 70 80 90 100
QQILHTNLVY LATIADSNQN MQSLLPAPPT QTMPMGPGGM SQSGPPPPPR
110 120 130 140 150
SHNMPSDGMV GGGPPAPHMQ NQMNGQMPGP NHMPMQGPGP SQLSMTNSSM
160 170 180 190 200
NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT MSQGQPMGNY GPRPNMNMQP
210 220 230 240 250
NQGPMMHQQP PSQQYNMPPG GAQHYQGQQA PMGLMGQVNQ GSHMMGQRQM
260 270 280 290 300
PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGHNDYGY
310 320 330 340 350
QQPSYPEQGY DRPYEDSSQH YYEGGNSQYG QQQDAYQGPP PQQGYPPQQQ
360 370 380 390 400
QYPGQQGYPG QQQSYGPSQG GPGPQYPNYP QGQGQQYGGY RPTQPGPPQP
410
PQQRPYGYDQ GQYGNYQQ
Length:418
Mass (Da):45,864
Last modified:July 27, 2011 - v2
Checksum:iFE2BE95EA7396888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156S → N in CAA63733 (PubMed:8760306).Curated1
Sequence conflicti156S → N in AAL17746 (PubMed:11435705).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93357 mRNA Translation: CAA63733.1
AY055726 Genomic DNA Translation: AAL17746.1
AK166053 mRNA Translation: BAE38546.1
CCDSiCCDS29070.1
RefSeqiNP_033306.2, NM_009280.2
UniGeneiMm.31761

Genome annotation databases

EnsembliENSMUST00000040924; ENSMUSP00000046320; ENSMUSG00000037013
GeneIDi268996
KEGGimmu:268996
UCSCiuc008ede.1 mouse

Entry informationi

Entry nameiSSXT_MOUSE
AccessioniPrimary (citable) accession number: Q62280
Secondary accession number(s): Q3TM96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health