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Protein

Protein SSXT

Gene

Ss18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to function synergistically with RBM14 as transcription coactivator.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell morphogenesis Source: MGI
  • cytoskeleton organization Source: MGI
  • ephrin receptor signaling pathway Source: MGI
  • intracellular signal transduction Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • neuronal stem cell population maintenance Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to drug Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSXT
Alternative name(s):
Protein SYT
Synovial sarcoma-associated Ss18-alpha
Gene namesi
Name:Ss18
Synonyms:Ssxt, Syt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:107708. Ss18.

Subcellular locationi

GO - Cellular componenti

  • npBAF complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 418417Protein SSXTPRO_0000181824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ62280.
PaxDbiQ62280.
PRIDEiQ62280.

PTM databases

iPTMnetiQ62280.
PhosphoSiteiQ62280.

Expressioni

Developmental stagei

Ubiquitously expressed in early embryogenesis (12.5 days). In later stages (14.5 days), the expression is restricted to cartilage forming cells, to specific neuronal cells and some epithelial derived tissues. In adults, SSXT is expressed in heart, kidney, testis and also in muscle, brain and liver. In mature testis, expression is specifically observed in primary spermatocytes.

Gene expression databases

BgeeiQ62280.
CleanExiMM_SS18.
ExpressionAtlasiQ62280. baseline and differential.
GenevisibleiQ62280. MM.

Interactioni

Subunit structurei

Interacts with MLLT10.By similarity

Protein-protein interaction databases

BioGridi234592. 4 interactions.
DIPiDIP-60230N.
IntActiQ62280. 3 interactions.
STRINGi10090.ENSMUSP00000046320.

Structurei

3D structure databases

ProteinModelPortaliQ62280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati344 – 356131Add
BLAST
Repeati357 – 369132Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 369262 X 13 AA imperfect tandem repeatsAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 534SH2-bindingSequence analysis
Motifi374 – 3774SH2-bindingSequence analysis
Motifi392 – 40110SH3-bindingSequence analysis
Motifi413 – 4164SH2-bindingSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 995Poly-Pro
Compositional biasi175 – 418244Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SS18 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3227. Eukaryota.
ENOG41128HA. LUCA.
GeneTreeiENSGT00500000044808.
HOGENOMiHOG000048717.
HOVERGENiHBG003892.
InParanoidiQ62280.
KOiK15623.
OMAiIMDFQSK.
TreeFamiTF330999.

Family and domain databases

InterProiIPR007726. SS18_fam.
[Graphical view]
PANTHERiPTHR23107. PTHR23107. 1 hit.
PfamiPF05030. SSXT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAFAAPRQ RGKGEITPAA IQKMLDENNH LIQCIMDYQN KGKASECSQY
60 70 80 90 100
QQILHTNLVY LATIADSNQN MQSLLPAPPT QTMPMGPGGM SQSGPPPPPR
110 120 130 140 150
SHNMPSDGMV GGGPPAPHMQ NQMNGQMPGP NHMPMQGPGP SQLSMTNSSM
160 170 180 190 200
NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT MSQGQPMGNY GPRPNMNMQP
210 220 230 240 250
NQGPMMHQQP PSQQYNMPPG GAQHYQGQQA PMGLMGQVNQ GSHMMGQRQM
260 270 280 290 300
PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGHNDYGY
310 320 330 340 350
QQPSYPEQGY DRPYEDSSQH YYEGGNSQYG QQQDAYQGPP PQQGYPPQQQ
360 370 380 390 400
QYPGQQGYPG QQQSYGPSQG GPGPQYPNYP QGQGQQYGGY RPTQPGPPQP
410
PQQRPYGYDQ GQYGNYQQ
Length:418
Mass (Da):45,864
Last modified:July 27, 2011 - v2
Checksum:iFE2BE95EA7396888
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561S → N in CAA63733 (PubMed:8760306).Curated
Sequence conflicti156 – 1561S → N in AAL17746 (PubMed:11435705).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93357 mRNA. Translation: CAA63733.1.
AY055726 Genomic DNA. Translation: AAL17746.1.
AK166053 mRNA. Translation: BAE38546.1.
CCDSiCCDS29070.1.
RefSeqiNP_033306.2. NM_009280.2.
UniGeneiMm.31761.

Genome annotation databases

EnsembliENSMUST00000040924; ENSMUSP00000046320; ENSMUSG00000037013.
GeneIDi268996.
KEGGimmu:268996.
UCSCiuc008ede.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93357 mRNA. Translation: CAA63733.1.
AY055726 Genomic DNA. Translation: AAL17746.1.
AK166053 mRNA. Translation: BAE38546.1.
CCDSiCCDS29070.1.
RefSeqiNP_033306.2. NM_009280.2.
UniGeneiMm.31761.

3D structure databases

ProteinModelPortaliQ62280.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234592. 4 interactions.
DIPiDIP-60230N.
IntActiQ62280. 3 interactions.
STRINGi10090.ENSMUSP00000046320.

PTM databases

iPTMnetiQ62280.
PhosphoSiteiQ62280.

Proteomic databases

MaxQBiQ62280.
PaxDbiQ62280.
PRIDEiQ62280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040924; ENSMUSP00000046320; ENSMUSG00000037013.
GeneIDi268996.
KEGGimmu:268996.
UCSCiuc008ede.1. mouse.

Organism-specific databases

CTDi6760.
MGIiMGI:107708. Ss18.

Phylogenomic databases

eggNOGiKOG3227. Eukaryota.
ENOG41128HA. LUCA.
GeneTreeiENSGT00500000044808.
HOGENOMiHOG000048717.
HOVERGENiHBG003892.
InParanoidiQ62280.
KOiK15623.
OMAiIMDFQSK.
TreeFamiTF330999.

Miscellaneous databases

PROiQ62280.
SOURCEiSearch...

Gene expression databases

BgeeiQ62280.
CleanExiMM_SS18.
ExpressionAtlasiQ62280. baseline and differential.
GenevisibleiQ62280. MM.

Family and domain databases

InterProiIPR007726. SS18_fam.
[Graphical view]
PANTHERiPTHR23107. PTHR23107. 1 hit.
PfamiPF05030. SSXT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the mouse homolog of SYT, a gene implicated in the development of human synovial sarcomas."
    de Bruijn D.R.H., Baats E., Zechner U., de Leeuw B., Balemans M., Olde Weghuis D., Hirning-Folz U., Geurts van Kessel A.G.
    Oncogene 13:643-648(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
    Tissue: Fetal brain.
  2. "Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene."
    de Bruijn D.R., Kater-Baats E., Eleveld M., Merkx G., Geurts Van Kessel A.
    Cytogenet. Cell Genet. 92:310-319(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiSSXT_MOUSE
AccessioniPrimary (citable) accession number: Q62280
Secondary accession number(s): Q3TM96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.