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Q62277

- SYPH_MOUSE

UniProt

Q62277 - SYPH_MOUSE

Protein

Synaptophysin

Gene

Syp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane By similarity. Involved in the regulation of short-term and long-term synaptic plasticity.By similarity1 Publication

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl
    2. identical protein binding Source: MGI
    3. protein binding Source: MGI
    4. SH2 domain binding Source: MGI
    5. syntaxin-1 binding Source: MGI
    6. transporter activity Source: InterPro

    GO - Biological processi

    1. cellular response to organic substance Source: MGI
    2. endocytosis Source: UniProtKB
    3. regulation of long-term neuronal synaptic plasticity Source: UniProtKB
    4. regulation of opioid receptor signaling pathway Source: UniProtKB
    5. regulation of short-term neuronal synaptic plasticity Source: UniProtKB
    6. synaptic transmission Source: MGI

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptophysin
    Alternative name(s):
    BM89 antigen
    Major synaptic vesicle protein p38
    Gene namesi
    Name:Syp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:98467. Syp.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. excitatory synapse Source: MGI
    3. integral component of synaptic vesicle membrane Source: RefGenome
    4. membrane Source: MGI
    5. neuron projection Source: ParkinsonsUK-UCL
    6. neuron projection terminus Source: MGI
    7. presynaptic active zone Source: BHF-UCL
    8. presynaptic membrane Source: UniProtKB
    9. protein complex Source: Ensembl
    10. synapse Source: MGI
    11. synaptic vesicle Source: MGI
    12. synaptic vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    Pathology & Biotechi

    Disruption phenotypei

    Mice lackin both SYNGR1 and SYP show normal brain structure and composition, but impaired short-term and long-term synaptic plasticity.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314SynaptophysinPRO_0000179162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Modified residuei81 – 811Phosphotyrosine1 Publication
    Modified residuei227 – 2271PhosphothreonineSequence Analysis
    Modified residuei279 – 2791PhosphotyrosineSequence Analysis
    Modified residuei296 – 2961PhosphotyrosineSequence Analysis

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ62277.
    PaxDbiQ62277.
    PRIDEiQ62277.

    PTM databases

    PhosphoSiteiQ62277.

    Expressioni

    Gene expression databases

    BgeeiQ62277.
    CleanExiMM_SYP.
    GenevestigatoriQ62277.

    Interactioni

    Subunit structurei

    Homohexamer or homotetramer. Interacts with SRCIN1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203609. 11 interactions.
    IntActiQ62277. 19 interactions.
    MINTiMINT-4136497.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62277.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini50 – 10758VesicularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 1387CytoplasmicSequence Analysis
    Topological domaini163 – 20038VesicularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 31490CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 13124HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 16224HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22424HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 228208MARVELPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni255 – 30551Repeats, Gly-richAdd
    BLAST

    Domaini

    The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

    Sequence similaritiesi

    Belongs to the synaptophysin/synaptobrevin family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82723.
    GeneTreeiENSGT00390000010039.
    HOGENOMiHOG000252913.
    HOVERGENiHBG006681.
    InParanoidiQ62277.
    OMAiAYGDAGY.
    OrthoDBiEOG7WT43S.
    PhylomeDBiQ62277.
    TreeFamiTF315804.

    Family and domain databases

    InterProiIPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    IPR028714. SYP.
    [Graphical view]
    PANTHERiPTHR10306. PTHR10306. 1 hit.
    PTHR10306:SF10. PTHR10306:SF10. 1 hit.
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PRINTSiPR00220. SYNAPTOPHYSN.
    PROSITEiPS51225. MARVEL. 1 hit.
    PS00604. SYNAPTOP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62277-1 [UniParc]FASTAAdd to Basket

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    MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYTGE    50
    LRLSVECANK TESALNIEVE FEYPFRLHQV YFDAPSCVKG GTTKIFLVGD 100
    YSSSAEFFVT VAVFAFLYSM GALATYIFLQ NKYRENNKGP MMDFLATAVF 150
    AFMWLVSSSA WAKGLSDVKM ATDPENIIKE MPMCRQTGNT CKELRDPVTS 200
    GLNTSVVFGF LNLVLWVGNL WFVFKETGWA APFMRAPPGA PEKQPAPGDA 250
    YGDAGYGQGP GGYGPQDSYG PQGGYQPDYG QPASGGGGGY GPQGDYGQQG 300
    YGQQGAPTSF SNQM 314
    Length:314
    Mass (Da):34,025
    Last modified:October 10, 2003 - v2
    Checksum:iF6AC6E30AECE10CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051A → G in CAA65084. (PubMed:9210520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043756 mRNA. Translation: BAC31642.1.
    X95818 mRNA. Translation: CAA65084.1.
    BC014823 mRNA. Translation: AAH14823.1.
    CCDSiCCDS29967.2.
    RefSeqiNP_033331.2. NM_009305.2.
    UniGeneiMm.223674.

    Genome annotation databases

    EnsembliENSMUST00000069520; ENSMUSP00000069429; ENSMUSG00000031144.
    GeneIDi20977.
    KEGGimmu:20977.
    UCSCiuc009slr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK043756 mRNA. Translation: BAC31642.1 .
    X95818 mRNA. Translation: CAA65084.1 .
    BC014823 mRNA. Translation: AAH14823.1 .
    CCDSi CCDS29967.2.
    RefSeqi NP_033331.2. NM_009305.2.
    UniGenei Mm.223674.

    3D structure databases

    ProteinModelPortali Q62277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203609. 11 interactions.
    IntActi Q62277. 19 interactions.
    MINTi MINT-4136497.

    PTM databases

    PhosphoSitei Q62277.

    Proteomic databases

    MaxQBi Q62277.
    PaxDbi Q62277.
    PRIDEi Q62277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069520 ; ENSMUSP00000069429 ; ENSMUSG00000031144 .
    GeneIDi 20977.
    KEGGi mmu:20977.
    UCSCi uc009slr.2. mouse.

    Organism-specific databases

    CTDi 6855.
    MGIi MGI:98467. Syp.

    Phylogenomic databases

    eggNOGi NOG82723.
    GeneTreei ENSGT00390000010039.
    HOGENOMi HOG000252913.
    HOVERGENi HBG006681.
    InParanoidi Q62277.
    OMAi AYGDAGY.
    OrthoDBi EOG7WT43S.
    PhylomeDBi Q62277.
    TreeFami TF315804.

    Miscellaneous databases

    ChiTaRSi SYP. mouse.
    NextBioi 299960.
    PROi Q62277.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62277.
    CleanExi MM_SYP.
    Genevestigatori Q62277.

    Family and domain databases

    InterProi IPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    IPR028714. SYP.
    [Graphical view ]
    PANTHERi PTHR10306. PTHR10306. 1 hit.
    PTHR10306:SF10. PTHR10306:SF10. 1 hit.
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PRINTSi PR00220. SYNAPTOPHYSN.
    PROSITEi PS51225. MARVEL. 1 hit.
    PS00604. SYNAPTOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    2. "Purification and cDNA cloning of mouse BM89 antigen shows that it is identical with the synaptic vesicle protein synaptophysin."
      Gaitanou M., Mamalaki A., Merkouri E., Matsas R.
      J. Neurosci. Res. 48:507-514(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-314.
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-314.
      Tissue: Eye.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 77-89; 170-179 AND 226-235, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I."
      Janz R., Suedhof T.C., Hammer R.E., Unni V., Siegelbaum S.A., Bolshakov V.Y.
      Neuron 24:687-700(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiSYPH_MOUSE
    AccessioniPrimary (citable) accession number: Q62277
    Secondary accession number(s): Q8BRQ0, Q91WI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3