SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62277

- SYPH_MOUSE

UniProt

Q62277 - SYPH_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Synaptophysin
Gene
Syp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane By similarity. Involved in the regulation of short-term and long-term synaptic plasticity.1 Publication

GO - Molecular functioni

  1. SH2 domain binding Source: MGI
  2. cholesterol binding Source: Ensembl
  3. identical protein binding Source: MGI
  4. protein binding Source: MGI
  5. syntaxin-1 binding Source: MGI
  6. transporter activity Source: InterPro

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. endocytosis Source: UniProtKB
  3. regulation of long-term neuronal synaptic plasticity Source: UniProtKB
  4. regulation of opioid receptor signaling pathway Source: UniProtKB
  5. regulation of short-term neuronal synaptic plasticity Source: UniProtKB
  6. synaptic transmission Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin
Alternative name(s):
BM89 antigen
Major synaptic vesicle protein p38
Gene namesi
Name:Syp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:98467. Syp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei26 – 4924Helical; Reviewed prediction
Add
BLAST
Topological domaini50 – 10758Vesicular Reviewed prediction
Add
BLAST
Transmembranei108 – 13124Helical; Reviewed prediction
Add
BLAST
Topological domaini132 – 1387Cytoplasmic Reviewed prediction
Transmembranei139 – 16224Helical; Reviewed prediction
Add
BLAST
Topological domaini163 – 20038Vesicular Reviewed prediction
Add
BLAST
Transmembranei201 – 22424Helical; Reviewed prediction
Add
BLAST
Topological domaini225 – 31490Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. excitatory synapse Source: MGI
  3. integral component of synaptic vesicle membrane Source: RefGenome
  4. membrane Source: MGI
  5. neuron projection Source: ParkinsonsUK-UCL
  6. neuron projection terminus Source: MGI
  7. presynaptic active zone Source: BHF-UCL
  8. presynaptic membrane Source: UniProtKB
  9. protein complex Source: Ensembl
  10. synapse Source: MGI
  11. synaptic vesicle Source: MGI
  12. synaptic vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Disruption phenotypei

Mice lackin both SYNGR1 and SYP show normal brain structure and composition, but impaired short-term and long-term synaptic plasticity.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Synaptophysin
PRO_0000179162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Modified residuei81 – 811Phosphotyrosine1 Publication
Modified residuei227 – 2271Phosphothreonine Reviewed prediction
Modified residuei279 – 2791Phosphotyrosine Reviewed prediction
Modified residuei296 – 2961Phosphotyrosine Reviewed prediction

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ62277.
PaxDbiQ62277.
PRIDEiQ62277.

PTM databases

PhosphoSiteiQ62277.

Expressioni

Gene expression databases

BgeeiQ62277.
CleanExiMM_SYP.
GenevestigatoriQ62277.

Interactioni

Subunit structurei

Homohexamer or homotetramer. Interacts with SRCIN1 By similarity.

Protein-protein interaction databases

BioGridi203609. 11 interactions.
IntActiQ62277. 19 interactions.
MINTiMINT-4136497.

Structurei

3D structure databases

ProteinModelPortaliQ62277.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 228208MARVEL
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni255 – 30551Repeats, Gly-rich
Add
BLAST

Domaini

The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.

Sequence similaritiesi

Contains 1 MARVEL domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82723.
GeneTreeiENSGT00390000010039.
HOGENOMiHOG000252913.
HOVERGENiHBG006681.
InParanoidiQ62277.
OMAiAYGDAGY.
OrthoDBiEOG7WT43S.
PhylomeDBiQ62277.
TreeFamiTF315804.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
IPR028714. SYP.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PTHR10306:SF10. PTHR10306:SF10. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62277-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYTGE    50
LRLSVECANK TESALNIEVE FEYPFRLHQV YFDAPSCVKG GTTKIFLVGD 100
YSSSAEFFVT VAVFAFLYSM GALATYIFLQ NKYRENNKGP MMDFLATAVF 150
AFMWLVSSSA WAKGLSDVKM ATDPENIIKE MPMCRQTGNT CKELRDPVTS 200
GLNTSVVFGF LNLVLWVGNL WFVFKETGWA APFMRAPPGA PEKQPAPGDA 250
YGDAGYGQGP GGYGPQDSYG PQGGYQPDYG QPASGGGGGY GPQGDYGQQG 300
YGQQGAPTSF SNQM 314
Length:314
Mass (Da):34,025
Last modified:October 10, 2003 - v2
Checksum:iF6AC6E30AECE10CE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051A → G in CAA65084. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043756 mRNA. Translation: BAC31642.1.
X95818 mRNA. Translation: CAA65084.1.
BC014823 mRNA. Translation: AAH14823.1.
CCDSiCCDS29967.2.
RefSeqiNP_033331.2. NM_009305.2.
UniGeneiMm.223674.

Genome annotation databases

EnsembliENSMUST00000069520; ENSMUSP00000069429; ENSMUSG00000031144.
GeneIDi20977.
KEGGimmu:20977.
UCSCiuc009slr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK043756 mRNA. Translation: BAC31642.1 .
X95818 mRNA. Translation: CAA65084.1 .
BC014823 mRNA. Translation: AAH14823.1 .
CCDSi CCDS29967.2.
RefSeqi NP_033331.2. NM_009305.2.
UniGenei Mm.223674.

3D structure databases

ProteinModelPortali Q62277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203609. 11 interactions.
IntActi Q62277. 19 interactions.
MINTi MINT-4136497.

PTM databases

PhosphoSitei Q62277.

Proteomic databases

MaxQBi Q62277.
PaxDbi Q62277.
PRIDEi Q62277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069520 ; ENSMUSP00000069429 ; ENSMUSG00000031144 .
GeneIDi 20977.
KEGGi mmu:20977.
UCSCi uc009slr.2. mouse.

Organism-specific databases

CTDi 6855.
MGIi MGI:98467. Syp.

Phylogenomic databases

eggNOGi NOG82723.
GeneTreei ENSGT00390000010039.
HOGENOMi HOG000252913.
HOVERGENi HBG006681.
InParanoidi Q62277.
OMAi AYGDAGY.
OrthoDBi EOG7WT43S.
PhylomeDBi Q62277.
TreeFami TF315804.

Miscellaneous databases

ChiTaRSi SYP. mouse.
NextBioi 299960.
PROi Q62277.
SOURCEi Search...

Gene expression databases

Bgeei Q62277.
CleanExi MM_SYP.
Genevestigatori Q62277.

Family and domain databases

InterProi IPR008253. Marvel.
IPR001285. Synaptophysin/porin.
IPR028714. SYP.
[Graphical view ]
PANTHERi PTHR10306. PTHR10306. 1 hit.
PTHR10306:SF10. PTHR10306:SF10. 1 hit.
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PRINTSi PR00220. SYNAPTOPHYSN.
PROSITEi PS51225. MARVEL. 1 hit.
PS00604. SYNAPTOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex.
  2. "Purification and cDNA cloning of mouse BM89 antigen shows that it is identical with the synaptic vesicle protein synaptophysin."
    Gaitanou M., Mamalaki A., Merkouri E., Matsas R.
    J. Neurosci. Res. 48:507-514(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-314.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-314.
    Tissue: Eye.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 77-89; 170-179 AND 226-235, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I."
    Janz R., Suedhof T.C., Hammer R.E., Unni V., Siegelbaum S.A., Bolshakov V.Y.
    Neuron 24:687-700(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSYPH_MOUSE
AccessioniPrimary (citable) accession number: Q62277
Secondary accession number(s): Q8BRQ0, Q91WI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2003
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi