Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfate transporter

Gene

Slc26a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-427601. Multifunctional anion exchangers.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
ST-OB
Solute carrier family 26 member 2
Gene namesi
Name:Slc26a2
Synonyms:Dtd, Dtdst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:892977. Slc26a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 111CytoplasmicSequence analysisAdd BLAST111
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 136ExtracellularSequence analysis4
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 159CytoplasmicSequence analysis2
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 218ExtracellularSequence analysisAdd BLAST38
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 241CytoplasmicSequence analysis2
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 296ExtracellularSequence analysisAdd BLAST34
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 328CytoplasmicSequence analysisAdd BLAST11
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 377ExtracellularSequence analysisAdd BLAST28
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 420CytoplasmicSequence analysisAdd BLAST22
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 454ExtracellularSequence analysisAdd BLAST13
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Topological domaini476 – 523CytoplasmicSequence analysisAdd BLAST48
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 643ExtracellularSequence analysisAdd BLAST99
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Topological domaini665 – 739CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801591 – 739Sulfate transporterAdd BLAST739

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62273.
PaxDbiQ62273.
PeptideAtlasiQ62273.
PRIDEiQ62273.

PTM databases

iPTMnetiQ62273.
PhosphoSitePlusiQ62273.

Expressioni

Tissue specificityi

Distributed mainly in the thymus, testis and osteoblastic cells.

Gene expression databases

BgeeiENSMUSG00000034320.
ExpressionAtlasiQ62273. baseline and differential.
GenevisibleiQ62273. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997307.
STRINGi10090.ENSMUSP00000119447.

Structurei

3D structure databases

ProteinModelPortaliQ62273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini568 – 719STASPROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ62273.
KOiK14701.
OMAiDTVIWLV.
OrthoDBiEOG091G07RT.
PhylomeDBiQ62273.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030280. SLC26A2.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF16. PTHR11814:SF16. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSENKEQHD LSPRDLPEEA FGFPSELPLE TQRRSGTDLR QSETGHGRRA
60 70 80 90 100
FRRIHMELRE KPDTDIKQFV IRELQKSCQC SAAKVRDGAF DFFPVLRWLP
110 120 130 140 150
KYDLKKNILG DVMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII
160 170 180 190 200
YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDTDAT SSSIAVFSSG
210 220 230 240 250
CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD
260 270 280 290 300
ALLSGFVTGA SFTILTSQAK YLLGLSLPRS HGVGSVITTW IHIFRNIRNT
310 320 330 340 350
NICDLITSLL CLLVLVPSKE LNEHFKDKLK APIPVELIVV VAATLASHFG
360 370 380 390 400
KLNGNYNSSI AGHIPTGFMP PKAPDWSLIP NVAVDAIAIS IIGFAITVSL
410 420 430 440 450
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG
460 470 480 490 500
CQTQLSAIVT ALVLLLVLLV IAPLFYSLQK CVLGVITIVN LRGALLKFRD
510 520 530 540 550
LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQKPK
560 570 580 590 600
NSLLGLEEES ETFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY
610 620 630 640 650
KKALNPVLVK AAWKKAAKRK LKEEMVTFRG DPDEVSMQLS HDPLEVHTIV
660 670 680 690 700
IDCSAIQFLD TAGIHTLKEV RRDYEAVGIQ VLLAQCNPSV RDSLARGEYC
710 720 730
KKEEETLLFY SLSEAVAFAE DSQNQKGVCV VNGLSLSGD
Length:739
Mass (Da):81,604
Last modified:November 1, 1996 - v1
Checksum:iEEDB1DA6278EC6BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31T → A in AAH28345 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42049 mRNA. Translation: BAA07650.1.
AK052942 mRNA. Translation: BAC35214.1.
AK163974 mRNA. Translation: BAE37562.1.
CH466528 Genomic DNA. Translation: EDL09779.1.
BC028345 mRNA. Translation: AAH28345.1.
CCDSiCCDS29282.1.
RefSeqiNP_031911.1. NM_007885.2.
UniGeneiMm.24803.

Genome annotation databases

EnsembliENSMUST00000146409; ENSMUSP00000119447; ENSMUSG00000034320.
GeneIDi13521.
KEGGimmu:13521.
UCSCiuc008fbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42049 mRNA. Translation: BAA07650.1.
AK052942 mRNA. Translation: BAC35214.1.
AK163974 mRNA. Translation: BAE37562.1.
CH466528 Genomic DNA. Translation: EDL09779.1.
BC028345 mRNA. Translation: AAH28345.1.
CCDSiCCDS29282.1.
RefSeqiNP_031911.1. NM_007885.2.
UniGeneiMm.24803.

3D structure databases

ProteinModelPortaliQ62273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997307.
STRINGi10090.ENSMUSP00000119447.

PTM databases

iPTMnetiQ62273.
PhosphoSitePlusiQ62273.

Proteomic databases

MaxQBiQ62273.
PaxDbiQ62273.
PeptideAtlasiQ62273.
PRIDEiQ62273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000146409; ENSMUSP00000119447; ENSMUSG00000034320.
GeneIDi13521.
KEGGimmu:13521.
UCSCiuc008fbu.1. mouse.

Organism-specific databases

CTDi1836.
MGIiMGI:892977. Slc26a2.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
GeneTreeiENSGT00760000119026.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ62273.
KOiK14701.
OMAiDTVIWLV.
OrthoDBiEOG091G07RT.
PhylomeDBiQ62273.
TreeFamiTF313784.

Enzyme and pathway databases

ReactomeiR-MMU-174362. Transport and synthesis of PAPS.
R-MMU-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiQ62273.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034320.
ExpressionAtlasiQ62273. baseline and differential.
GenevisibleiQ62273. MM.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030280. SLC26A2.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PTHR11814:SF16. PTHR11814:SF16. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A2_MOUSE
AccessioniPrimary (citable) accession number: Q62273
Secondary accession number(s): Q543D6, Q8R2L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.