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Q62273

- S26A2_MOUSE

UniProt

Q62273 - S26A2_MOUSE

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Protein
Sulfate transporter
Gene
Slc26a2, Dtd, Dtdst
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfate transporter. May play a role in endochondral bone formation.

GO - Molecular functioni

  1. secondary active sulfate transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. ossification Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_214239. Transport and synthesis of PAPS.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
ST-OB
Solute carrier family 26 member 2
Gene namesi
Name:Slc26a2
Synonyms:Dtd, Dtdst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:892977. Slc26a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 111111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Topological domaini133 – 1364Extracellular Reviewed prediction
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 1592Cytoplasmic Reviewed prediction
Transmembranei160 – 18021Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 21838Extracellular Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Topological domaini240 – 2412Cytoplasmic Reviewed prediction
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Topological domaini263 – 29634Extracellular Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Reviewed prediction
Add
BLAST
Topological domaini318 – 32811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei329 – 34921Helical; Reviewed prediction
Add
BLAST
Topological domaini350 – 37728Extracellular Reviewed prediction
Add
BLAST
Transmembranei378 – 39821Helical; Reviewed prediction
Add
BLAST
Topological domaini399 – 42022Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei421 – 44121Helical; Reviewed prediction
Add
BLAST
Topological domaini442 – 45413Extracellular Reviewed prediction
Add
BLAST
Transmembranei455 – 47521Helical; Reviewed prediction
Add
BLAST
Topological domaini476 – 52348Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei524 – 54421Helical; Reviewed prediction
Add
BLAST
Topological domaini545 – 64399Extracellular Reviewed prediction
Add
BLAST
Transmembranei644 – 66421Helical; Reviewed prediction
Add
BLAST
Topological domaini665 – 73975Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Sulfate transporter
PRO_0000080159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphoserine By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62273.
PaxDbiQ62273.
PRIDEiQ62273.

PTM databases

PhosphoSiteiQ62273.

Expressioni

Tissue specificityi

Distributed mainly in the thymus, testis and osteoblastic cells.

Gene expression databases

ArrayExpressiQ62273.
BgeeiQ62273.
GenevestigatoriQ62273.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997307.

Structurei

3D structure databases

ProteinModelPortaliQ62273.
SMRiQ62273. Positions 549-716.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini568 – 719152STAS
Add
BLAST

Sequence similaritiesi

Contains 1 STAS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0659.
GeneTreeiENSGT00750000117294.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ8R2L9.
KOiK14701.
OMAiKKTCSCT.
OrthoDBiEOG76T9QT.
PhylomeDBiQ62273.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62273-1 [UniParc]FASTAAdd to Basket

« Hide

MSSENKEQHD LSPRDLPEEA FGFPSELPLE TQRRSGTDLR QSETGHGRRA    50
FRRIHMELRE KPDTDIKQFV IRELQKSCQC SAAKVRDGAF DFFPVLRWLP 100
KYDLKKNILG DVMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII 150
YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDTDAT SSSIAVFSSG 200
CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD 250
ALLSGFVTGA SFTILTSQAK YLLGLSLPRS HGVGSVITTW IHIFRNIRNT 300
NICDLITSLL CLLVLVPSKE LNEHFKDKLK APIPVELIVV VAATLASHFG 350
KLNGNYNSSI AGHIPTGFMP PKAPDWSLIP NVAVDAIAIS IIGFAITVSL 400
SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG 450
CQTQLSAIVT ALVLLLVLLV IAPLFYSLQK CVLGVITIVN LRGALLKFRD 500
LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQKPK 550
NSLLGLEEES ETFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 600
KKALNPVLVK AAWKKAAKRK LKEEMVTFRG DPDEVSMQLS HDPLEVHTIV 650
IDCSAIQFLD TAGIHTLKEV RRDYEAVGIQ VLLAQCNPSV RDSLARGEYC 700
KKEEETLLFY SLSEAVAFAE DSQNQKGVCV VNGLSLSGD 739
Length:739
Mass (Da):81,604
Last modified:November 1, 1996 - v1
Checksum:iEEDB1DA6278EC6BD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311T → A in AAH28345. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42049 mRNA. Translation: BAA07650.1.
AK052942 mRNA. Translation: BAC35214.1.
AK163974 mRNA. Translation: BAE37562.1.
CH466528 Genomic DNA. Translation: EDL09779.1.
BC028345 mRNA. Translation: AAH28345.1.
CCDSiCCDS29282.1.
RefSeqiNP_031911.1. NM_007885.2.
UniGeneiMm.24803.

Genome annotation databases

EnsembliENSMUST00000146409; ENSMUSP00000119447; ENSMUSG00000034320.
GeneIDi13521.
KEGGimmu:13521.
UCSCiuc008fbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D42049 mRNA. Translation: BAA07650.1 .
AK052942 mRNA. Translation: BAC35214.1 .
AK163974 mRNA. Translation: BAE37562.1 .
CH466528 Genomic DNA. Translation: EDL09779.1 .
BC028345 mRNA. Translation: AAH28345.1 .
CCDSi CCDS29282.1.
RefSeqi NP_031911.1. NM_007885.2.
UniGenei Mm.24803.

3D structure databases

ProteinModelPortali Q62273.
SMRi Q62273. Positions 549-716.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997307.

PTM databases

PhosphoSitei Q62273.

Proteomic databases

MaxQBi Q62273.
PaxDbi Q62273.
PRIDEi Q62273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000146409 ; ENSMUSP00000119447 ; ENSMUSG00000034320 .
GeneIDi 13521.
KEGGi mmu:13521.
UCSCi uc008fbu.1. mouse.

Organism-specific databases

CTDi 1836.
MGIi MGI:892977. Slc26a2.

Phylogenomic databases

eggNOGi COG0659.
GeneTreei ENSGT00750000117294.
HOGENOMi HOG000006546.
HOVERGENi HBG000639.
InParanoidi Q8R2L9.
KOi K14701.
OMAi KKTCSCT.
OrthoDBi EOG76T9QT.
PhylomeDBi Q62273.
TreeFami TF313784.

Enzyme and pathway databases

Reactomei REACT_214239. Transport and synthesis of PAPS.

Miscellaneous databases

NextBioi 284088.
PROi Q62273.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62273.
Bgeei Q62273.
Genevestigatori Q62273.

Family and domain databases

Gene3Di 3.30.750.24. 2 hits.
InterProi IPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view ]
Pfami PF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view ]
SUPFAMi SSF52091. SSF52091. 2 hits.
TIGRFAMsi TIGR00815. sulP. 1 hit.
PROSITEi PS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse diastrophic dysplasia sulfate transporter gene induced during osteoblast differentiation by bone morphogenetic protein-2."
    Kobayashi T., Sugimoto T., Saijoh K., Fukase M., Chihara K.
    Gene 198:341-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS26A2_MOUSE
AccessioniPrimary (citable) accession number: Q62273
Secondary accession number(s): Q543D6, Q8R2L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi