Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62273 (S26A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sulfate transporter
Alternative name(s):
Diastrophic dysplasia protein homolog
ST-OB
Solute carrier family 26 member 2
Gene names
Name:Slc26a2
Synonyms:Dtd, Dtdst
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sulfate transporter. May play a role in endochondral bone formation.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Distributed mainly in the thymus, testis and osteoblastic cells.

Sequence similarities

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]

Contains 1 STAS domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processossification

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsecondary active sulfate transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Sulfate transporter
PRO_0000080159

Regions

Topological domain1 – 111111Cytoplasmic Potential
Transmembrane112 – 13221Helical; Potential
Topological domain133 – 1364Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1592Cytoplasmic Potential
Transmembrane160 – 18021Helical; Potential
Topological domain181 – 21838Extracellular Potential
Transmembrane219 – 23921Helical; Potential
Topological domain240 – 2412Cytoplasmic Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 29634Extracellular Potential
Transmembrane297 – 31721Helical; Potential
Topological domain318 – 32811Cytoplasmic Potential
Transmembrane329 – 34921Helical; Potential
Topological domain350 – 37728Extracellular Potential
Transmembrane378 – 39821Helical; Potential
Topological domain399 – 42022Cytoplasmic Potential
Transmembrane421 – 44121Helical; Potential
Topological domain442 – 45413Extracellular Potential
Transmembrane455 – 47521Helical; Potential
Topological domain476 – 52348Cytoplasmic Potential
Transmembrane524 – 54421Helical; Potential
Topological domain545 – 64399Extracellular Potential
Transmembrane644 – 66421Helical; Potential
Topological domain665 – 73975Cytoplasmic Potential
Domain568 – 719152STAS

Amino acid modifications

Modified residue121Phosphoserine By similarity
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict311T → A in AAH28345. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q62273 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EEDB1DA6278EC6BD

FASTA73981,604
        10         20         30         40         50         60 
MSSENKEQHD LSPRDLPEEA FGFPSELPLE TQRRSGTDLR QSETGHGRRA FRRIHMELRE 

        70         80         90        100        110        120 
KPDTDIKQFV IRELQKSCQC SAAKVRDGAF DFFPVLRWLP KYDLKKNILG DVMSGLIVGI 

       130        140        150        160        170        180 
LLVPQSIAYS LLAGQEPIYG LYTSFFASII YFLFGTSRHI SVGIFGILCL MIGEVVDREL 

       190        200        210        220        230        240 
HKACPDTDAT SSSIAVFSSG CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ 

       250        260        270        280        290        300 
VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLSLPRS HGVGSVITTW IHIFRNIRNT 

       310        320        330        340        350        360 
NICDLITSLL CLLVLVPSKE LNEHFKDKLK APIPVELIVV VAATLASHFG KLNGNYNSSI 

       370        380        390        400        410        420 
AGHIPTGFMP PKAPDWSLIP NVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA 

       430        440        450        460        470        480 
IGFCNIIPSF FHCITTSAAL AKTLVKESTG CQTQLSAIVT ALVLLLVLLV IAPLFYSLQK 

       490        500        510        520        530        540 
CVLGVITIVN LRGALLKFRD LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF 

       550        560        570        580        590        600 
CVILRTQKPK NSLLGLEEES ETFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 

       610        620        630        640        650        660 
KKALNPVLVK AAWKKAAKRK LKEEMVTFRG DPDEVSMQLS HDPLEVHTIV IDCSAIQFLD 

       670        680        690        700        710        720 
TAGIHTLKEV RRDYEAVGIQ VLLAQCNPSV RDSLARGEYC KKEEETLLFY SLSEAVAFAE 

       730 
DSQNQKGVCV VNGLSLSGD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse diastrophic dysplasia sulfate transporter gene induced during osteoblast differentiation by bone morphogenetic protein-2."
Kobayashi T., Sugimoto T., Saijoh K., Fukase M., Chihara K.
Gene 198:341-349(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D42049 mRNA. Translation: BAA07650.1.
AK052942 mRNA. Translation: BAC35214.1.
AK163974 mRNA. Translation: BAE37562.1.
CH466528 Genomic DNA. Translation: EDL09779.1.
BC028345 mRNA. Translation: AAH28345.1.
CCDSCCDS29282.1.
RefSeqNP_031911.1. NM_007885.2.
UniGeneMm.24803.

3D structure databases

ProteinModelPortalQ62273.
SMRQ62273. Positions 549-716.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997307.

PTM databases

PhosphoSiteQ62273.

Proteomic databases

MaxQBQ62273.
PaxDbQ62273.
PRIDEQ62273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000146409; ENSMUSP00000119447; ENSMUSG00000034320.
GeneID13521.
KEGGmmu:13521.
UCSCuc008fbu.1. mouse.

Organism-specific databases

CTD1836.
MGIMGI:892977. Slc26a2.

Phylogenomic databases

eggNOGCOG0659.
GeneTreeENSGT00750000117294.
HOGENOMHOG000006546.
HOVERGENHBG000639.
InParanoidQ8R2L9.
KOK14701.
OMAKKTCSCT.
OrthoDBEOG76T9QT.
PhylomeDBQ62273.
TreeFamTF313784.

Gene expression databases

ArrayExpressQ62273.
BgeeQ62273.
GenevestigatorQ62273.

Family and domain databases

Gene3D3.30.750.24. 2 hits.
InterProIPR018045. S04_transporter_CS.
IPR002645. STAS_dom.
IPR001902. SulP_transpt.
IPR011547. Sulph_transpt.
[Graphical view]
PfamPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 2 hits.
TIGRFAMsTIGR00815. sulP. 1 hit.
PROSITEPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio284088.
PROQ62273.
SOURCESearch...

Entry information

Entry nameS26A2_MOUSE
AccessionPrimary (citable) accession number: Q62273
Secondary accession number(s): Q543D6, Q8R2L9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot