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Q62273

- S26A2_MOUSE

UniProt

Q62273 - S26A2_MOUSE

Protein

Sulfate transporter

Gene

Slc26a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Sulfate transporter. May play a role in endochondral bone formation.

    GO - Molecular functioni

    1. secondary active sulfate transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. ossification Source: Ensembl

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_214239. Transport and synthesis of PAPS.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfate transporter
    Alternative name(s):
    Diastrophic dysplasia protein homolog
    ST-OB
    Solute carrier family 26 member 2
    Gene namesi
    Name:Slc26a2
    Synonyms:Dtd, Dtdst
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:892977. Slc26a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739Sulfate transporterPRO_0000080159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphoserineBy similarity
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ62273.
    PaxDbiQ62273.
    PRIDEiQ62273.

    PTM databases

    PhosphoSiteiQ62273.

    Expressioni

    Tissue specificityi

    Distributed mainly in the thymus, testis and osteoblastic cells.

    Gene expression databases

    ArrayExpressiQ62273.
    BgeeiQ62273.
    GenevestigatoriQ62273.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62273.
    SMRiQ62273. Positions 549-716.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 111111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 1364ExtracellularSequence Analysis
    Topological domaini158 – 1592CytoplasmicSequence Analysis
    Topological domaini181 – 21838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 2412CytoplasmicSequence Analysis
    Topological domaini263 – 29634ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 32811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 37728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini399 – 42022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini442 – 45413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini476 – 52348CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini545 – 64399ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini665 – 73975CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei112 – 13221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei421 – 44121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei644 – 66421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini568 – 719152STASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 STAS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0659.
    GeneTreeiENSGT00750000117294.
    HOGENOMiHOG000006546.
    HOVERGENiHBG000639.
    InParanoidiQ8R2L9.
    KOiK14701.
    OMAiKKTCSCT.
    OrthoDBiEOG76T9QT.
    PhylomeDBiQ62273.
    TreeFamiTF313784.

    Family and domain databases

    Gene3Di3.30.750.24. 2 hits.
    InterProiIPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view]
    PfamiPF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 2 hits.
    TIGRFAMsiTIGR00815. sulP. 1 hit.
    PROSITEiPS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSENKEQHD LSPRDLPEEA FGFPSELPLE TQRRSGTDLR QSETGHGRRA    50
    FRRIHMELRE KPDTDIKQFV IRELQKSCQC SAAKVRDGAF DFFPVLRWLP 100
    KYDLKKNILG DVMSGLIVGI LLVPQSIAYS LLAGQEPIYG LYTSFFASII 150
    YFLFGTSRHI SVGIFGILCL MIGEVVDREL HKACPDTDAT SSSIAVFSSG 200
    CVVVNHTLDG LCDKSCYAIK IGSTVTFMAG VYQVAMGFFQ VGFVSVYLSD 250
    ALLSGFVTGA SFTILTSQAK YLLGLSLPRS HGVGSVITTW IHIFRNIRNT 300
    NICDLITSLL CLLVLVPSKE LNEHFKDKLK APIPVELIVV VAATLASHFG 350
    KLNGNYNSSI AGHIPTGFMP PKAPDWSLIP NVAVDAIAIS IIGFAITVSL 400
    SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCITTSAAL AKTLVKESTG 450
    CQTQLSAIVT ALVLLLVLLV IAPLFYSLQK CVLGVITIVN LRGALLKFRD 500
    LPKMWRLSRM DTVIWFVTML SSALLSTEIG LLVGVCFSMF CVILRTQKPK 550
    NSLLGLEEES ETFESISTYK NLRSKSGIKV FRFIAPLYYI NKECFKSALY 600
    KKALNPVLVK AAWKKAAKRK LKEEMVTFRG DPDEVSMQLS HDPLEVHTIV 650
    IDCSAIQFLD TAGIHTLKEV RRDYEAVGIQ VLLAQCNPSV RDSLARGEYC 700
    KKEEETLLFY SLSEAVAFAE DSQNQKGVCV VNGLSLSGD 739
    Length:739
    Mass (Da):81,604
    Last modified:November 1, 1996 - v1
    Checksum:iEEDB1DA6278EC6BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311T → A in AAH28345. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42049 mRNA. Translation: BAA07650.1.
    AK052942 mRNA. Translation: BAC35214.1.
    AK163974 mRNA. Translation: BAE37562.1.
    CH466528 Genomic DNA. Translation: EDL09779.1.
    BC028345 mRNA. Translation: AAH28345.1.
    CCDSiCCDS29282.1.
    RefSeqiNP_031911.1. NM_007885.2.
    UniGeneiMm.24803.

    Genome annotation databases

    EnsembliENSMUST00000146409; ENSMUSP00000119447; ENSMUSG00000034320.
    GeneIDi13521.
    KEGGimmu:13521.
    UCSCiuc008fbu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42049 mRNA. Translation: BAA07650.1 .
    AK052942 mRNA. Translation: BAC35214.1 .
    AK163974 mRNA. Translation: BAE37562.1 .
    CH466528 Genomic DNA. Translation: EDL09779.1 .
    BC028345 mRNA. Translation: AAH28345.1 .
    CCDSi CCDS29282.1.
    RefSeqi NP_031911.1. NM_007885.2.
    UniGenei Mm.24803.

    3D structure databases

    ProteinModelPortali Q62273.
    SMRi Q62273. Positions 549-716.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997307.

    PTM databases

    PhosphoSitei Q62273.

    Proteomic databases

    MaxQBi Q62273.
    PaxDbi Q62273.
    PRIDEi Q62273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000146409 ; ENSMUSP00000119447 ; ENSMUSG00000034320 .
    GeneIDi 13521.
    KEGGi mmu:13521.
    UCSCi uc008fbu.1. mouse.

    Organism-specific databases

    CTDi 1836.
    MGIi MGI:892977. Slc26a2.

    Phylogenomic databases

    eggNOGi COG0659.
    GeneTreei ENSGT00750000117294.
    HOGENOMi HOG000006546.
    HOVERGENi HBG000639.
    InParanoidi Q8R2L9.
    KOi K14701.
    OMAi KKTCSCT.
    OrthoDBi EOG76T9QT.
    PhylomeDBi Q62273.
    TreeFami TF313784.

    Enzyme and pathway databases

    Reactomei REACT_214239. Transport and synthesis of PAPS.

    Miscellaneous databases

    NextBioi 284088.
    PROi Q62273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62273.
    Bgeei Q62273.
    Genevestigatori Q62273.

    Family and domain databases

    Gene3Di 3.30.750.24. 2 hits.
    InterProi IPR018045. S04_transporter_CS.
    IPR002645. STAS_dom.
    IPR001902. SulP_transpt.
    IPR011547. Sulph_transpt.
    [Graphical view ]
    Pfami PF01740. STAS. 1 hit.
    PF00916. Sulfate_transp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 2 hits.
    TIGRFAMsi TIGR00815. sulP. 1 hit.
    PROSITEi PS01130. SLC26A. 1 hit.
    PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse diastrophic dysplasia sulfate transporter gene induced during osteoblast differentiation by bone morphogenetic protein-2."
      Kobayashi T., Sugimoto T., Saijoh K., Fukase M., Chihara K.
      Gene 198:341-349(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS26A2_MOUSE
    AccessioniPrimary (citable) accession number: Q62273
    Secondary accession number(s): Q543D6, Q8R2L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3