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Q62270

- SRMS_MOUSE

UniProt

Q62270 - SRMS_MOUSE

Protein

Tyrosine-protein kinase Srms

Gene

Srms

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei262 – 2621ATPPROSITE-ProRule annotation
    Active sitei354 – 3541Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine autophosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Srms (EC:2.7.10.2)
    Alternative name(s):
    PTK70
    Gene namesi
    Name:Srms
    Synonyms:Srm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:101865. Srms.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Localizes to punctate cytoplasmic structures.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Tyrosine-protein kinase SrmsPRO_0000088161Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei384 – 3841Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62270.

    PTM databases

    PhosphoSiteiQ62270.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62270.
    BgeeiQ62270.
    CleanExiMM_SRM.
    GenevestigatoriQ62270.

    Interactioni

    Subunit structurei

    Interacts (via the SH2 and SH3 domains) with DOK1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ62270.
    SMRiQ62270. Positions 60-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 11662SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini124 – 21693SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini234 – 495262Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5555N-terminalBy similarityAdd
    BLAST

    Domaini

    The N-terminal region regulates its kinase activity.By similarity

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG008761.
    InParanoidiQ62270.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62270-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPFLRKRLT FLSFFWDKIW PADESEEDIP RIQGHDDNPV PEQAAAVEPC    50
    SFPAPRARLF RALYDFTARC AEELSVSRGD RLYALKEEGD YIFAQRLSGP 100
    PSTGLVPVTY LAKATPEPPS DQPWYFSGIS RAQAQQLLLS PANAPGAFLI 150
    RPSESSIGGY SLSVRAQAKV CHYRICMAPS GSLYLQEGQL FPSLDALLAY 200
    YKTNWKLIQN PLLQPCIPQI PLVQDEWERP RSEFVLRRKL GEGFFGEVWE 250
    GLWLGSIPVA VKVIKSADMK LADLTKEIEA LKSLRHERLI RLHAICSLGE 300
    PVYIVTELMG KGNLQVYLGS SEGKALSLPH LLGFACQVAE GMSYLEERRV 350
    VHRDLAARNV LVGDDLTCKV ADFGLARLLK DDVYSPSSGS KIPVKWTAPE 400
    AANYRVFSQK SDVWSFGILL YEVFTYGQCP YEGMTNHETL QQISRGYRLP 450
    RPAVCPAEVY VLMVECWKGS PEERPTFAIL REKLNAINRR LHLGLT 496
    Length:496
    Mass (Da):55,758
    Last modified:January 17, 2003 - v2
    Checksum:i7FE39C9912219BAF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781R → G in BAA05331. (PubMed:7935409)Curated
    Sequence conflicti236 – 2372LR → FG in BAA05331. (PubMed:7935409)Curated
    Sequence conflicti238 – 2381R → K in BAA08406. (PubMed:9226137)Curated
    Sequence conflicti278 – 2781I → N in BAA08406. (PubMed:9226137)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49427 mRNA. Translation: BAA08406.1.
    D26186 mRNA. Translation: BAA05331.1.
    AL450341 Genomic DNA. No translation available.
    PIRiA56040.
    UniGeneiMm.4752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49427 mRNA. Translation: BAA08406.1 .
    D26186 mRNA. Translation: BAA05331.1 .
    AL450341 Genomic DNA. No translation available.
    PIRi A56040.
    UniGenei Mm.4752.

    3D structure databases

    ProteinModelPortali Q62270.
    SMRi Q62270. Positions 60-481.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62270.

    Proteomic databases

    PRIDEi Q62270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:101865. Srms.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG008761.
    InParanoidi Q62270.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.

    Miscellaneous databases

    PROi Q62270.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62270.
    Bgeei Q62270.
    CleanExi MM_SRM.
    Genevestigatori Q62270.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin."
      Kawachi Y., Nakauchi H., Otsuka F.
      Exp. Dermatol. 6:140-146(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Thymus.
    2. "A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption."
      Kohmura N., Yagi T., Tomooka Y., Oyanagi M., Kominami R., Takeda N., Chiba J., Ikawa Y., Aizawa S.
      Mol. Cell. Biol. 14:6915-6925(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. Wall M.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiSRMS_MOUSE
    AccessioniPrimary (citable) accession number: Q62270
    Secondary accession number(s): Q62360, Q923M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3