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Q62270

- SRMS_MOUSE

UniProt

Q62270 - SRMS_MOUSE

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Protein
Tyrosine-protein kinase Srms
Gene
Srms, Srm
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei262 – 2621ATP By similarity
Active sitei354 – 3541Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. peptidyl-tyrosine autophosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Srms (EC:2.7.10.2)
Alternative name(s):
PTK70
Gene namesi
Name:Srms
Synonyms:Srm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:101865. Srms.

Subcellular locationi

Cytoplasm By similarity
Note: Localizes to punctate cytoplasmic structures By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Tyrosine-protein kinase Srms
PRO_0000088161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei384 – 3841Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62270.

PTM databases

PhosphoSiteiQ62270.

Expressioni

Gene expression databases

ArrayExpressiQ62270.
BgeeiQ62270.
CleanExiMM_SRM.
GenevestigatoriQ62270.

Interactioni

Subunit structurei

Interacts (via the SH2 and SH3 domains) with DOK1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ62270.
SMRiQ62270. Positions 60-481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 11662SH3
Add
BLAST
Domaini124 – 21693SH2
Add
BLAST
Domaini234 – 495262Protein kinase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5555N-terminal By similarity
Add
BLAST

Domaini

The N-terminal region regulates its kinase activity By similarity.

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG008761.
InParanoidiQ62270.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62270-1 [UniParc]FASTAAdd to Basket

« Hide

MEPFLRKRLT FLSFFWDKIW PADESEEDIP RIQGHDDNPV PEQAAAVEPC    50
SFPAPRARLF RALYDFTARC AEELSVSRGD RLYALKEEGD YIFAQRLSGP 100
PSTGLVPVTY LAKATPEPPS DQPWYFSGIS RAQAQQLLLS PANAPGAFLI 150
RPSESSIGGY SLSVRAQAKV CHYRICMAPS GSLYLQEGQL FPSLDALLAY 200
YKTNWKLIQN PLLQPCIPQI PLVQDEWERP RSEFVLRRKL GEGFFGEVWE 250
GLWLGSIPVA VKVIKSADMK LADLTKEIEA LKSLRHERLI RLHAICSLGE 300
PVYIVTELMG KGNLQVYLGS SEGKALSLPH LLGFACQVAE GMSYLEERRV 350
VHRDLAARNV LVGDDLTCKV ADFGLARLLK DDVYSPSSGS KIPVKWTAPE 400
AANYRVFSQK SDVWSFGILL YEVFTYGQCP YEGMTNHETL QQISRGYRLP 450
RPAVCPAEVY VLMVECWKGS PEERPTFAIL REKLNAINRR LHLGLT 496
Length:496
Mass (Da):55,758
Last modified:January 17, 2003 - v2
Checksum:i7FE39C9912219BAF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781R → G in BAA05331. 1 Publication
Sequence conflicti236 – 2372LR → FG in BAA05331. 1 Publication
Sequence conflicti238 – 2381R → K in BAA08406. 1 Publication
Sequence conflicti278 – 2781I → N in BAA08406. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49427 mRNA. Translation: BAA08406.1.
D26186 mRNA. Translation: BAA05331.1.
AL450341 Genomic DNA. No translation available.
PIRiA56040.
UniGeneiMm.4752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49427 mRNA. Translation: BAA08406.1 .
D26186 mRNA. Translation: BAA05331.1 .
AL450341 Genomic DNA. No translation available.
PIRi A56040.
UniGenei Mm.4752.

3D structure databases

ProteinModelPortali Q62270.
SMRi Q62270. Positions 60-481.
ModBasei Search...

PTM databases

PhosphoSitei Q62270.

Proteomic databases

PRIDEi Q62270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:101865. Srms.

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG008761.
InParanoidi Q62270.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.

Miscellaneous databases

PROi Q62270.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62270.
Bgeei Q62270.
CleanExi MM_SRM.
Genevestigatori Q62270.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin."
    Kawachi Y., Nakauchi H., Otsuka F.
    Exp. Dermatol. 6:140-146(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Thymus.
  2. "A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption."
    Kohmura N., Yagi T., Tomooka Y., Oyanagi M., Kominami R., Takeda N., Chiba J., Ikawa Y., Aizawa S.
    Mol. Cell. Biol. 14:6915-6925(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. Wall M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiSRMS_MOUSE
AccessioniPrimary (citable) accession number: Q62270
Secondary accession number(s): Q62360, Q923M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 17, 2003
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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