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Q62270 (SRMS_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase Srms

EC=2.7.10.2
Alternative name(s):
PTK70
Gene names
Name:Srms
Synonyms:Srm
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts (via the SH2 and SH3 domains) with DOK1 By similarity.

Subcellular location

Cytoplasm By similarity. Note: Localizes to punctate cytoplasmic structures By similarity.

Domain

The N-terminal region regulates its kinase activity By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Tyrosine-protein kinase Srms
PRO_0000088161

Regions

Domain55 – 11662SH3
Domain124 – 21693SH2
Domain234 – 495262Protein kinase
Nucleotide binding240 – 2489ATP By similarity
Region1 – 5555N-terminal By similarity

Sites

Active site3541Proton acceptor By similarity
Binding site2621ATP By similarity

Amino acid modifications

Modified residue3841Phosphotyrosine; by autocatalysis By similarity

Experimental info

Sequence conflict781R → G in BAA05331. Ref.2
Sequence conflict236 – 2372LR → FG in BAA05331. Ref.2
Sequence conflict2381R → K in BAA08406. Ref.1
Sequence conflict2781I → N in BAA08406. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q62270 [UniParc].

Last modified January 17, 2003. Version 2.
Checksum: 7FE39C9912219BAF

FASTA49655,758
        10         20         30         40         50         60 
MEPFLRKRLT FLSFFWDKIW PADESEEDIP RIQGHDDNPV PEQAAAVEPC SFPAPRARLF 

        70         80         90        100        110        120 
RALYDFTARC AEELSVSRGD RLYALKEEGD YIFAQRLSGP PSTGLVPVTY LAKATPEPPS 

       130        140        150        160        170        180 
DQPWYFSGIS RAQAQQLLLS PANAPGAFLI RPSESSIGGY SLSVRAQAKV CHYRICMAPS 

       190        200        210        220        230        240 
GSLYLQEGQL FPSLDALLAY YKTNWKLIQN PLLQPCIPQI PLVQDEWERP RSEFVLRRKL 

       250        260        270        280        290        300 
GEGFFGEVWE GLWLGSIPVA VKVIKSADMK LADLTKEIEA LKSLRHERLI RLHAICSLGE 

       310        320        330        340        350        360 
PVYIVTELMG KGNLQVYLGS SEGKALSLPH LLGFACQVAE GMSYLEERRV VHRDLAARNV 

       370        380        390        400        410        420 
LVGDDLTCKV ADFGLARLLK DDVYSPSSGS KIPVKWTAPE AANYRVFSQK SDVWSFGILL 

       430        440        450        460        470        480 
YEVFTYGQCP YEGMTNHETL QQISRGYRLP RPAVCPAEVY VLMVECWKGS PEERPTFAIL 

       490 
REKLNAINRR LHLGLT 

« Hide

References

[1]"Isolation of a cDNA encoding a tyrosine kinase expressed in murine skin."
Kawachi Y., Nakauchi H., Otsuka F.
Exp. Dermatol. 6:140-146(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Thymus.
[2]"A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption."
Kohmura N., Yagi T., Tomooka Y., Oyanagi M., Kominami R., Takeda N., Chiba J., Ikawa Y., Aizawa S.
Mol. Cell. Biol. 14:6915-6925(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]Wall M.
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49427 mRNA. Translation: BAA08406.1.
D26186 mRNA. Translation: BAA05331.1.
AL450341 Genomic DNA. No translation available.
PIRA56040.
UniGeneMm.4752.

3D structure databases

ProteinModelPortalQ62270.
SMRQ62270. Positions 60-481.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62270.

Proteomic databases

PRIDEQ62270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:101865. Srms.

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG008761.
InParanoidQ62270.

Enzyme and pathway databases

BRENDA2.7.10.2. 3474.

Gene expression databases

ArrayExpressQ62270.
BgeeQ62270.
CleanExMM_SRM.
GenevestigatorQ62270.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ62270.
SOURCESearch...

Entry information

Entry nameSRMS_MOUSE
AccessionPrimary (citable) accession number: Q62270
Secondary accession number(s): Q62360, Q923M5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 17, 2003
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot