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Protein

Cornifin-B

Gene

Sprr1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: MGI

GO - Biological processi

  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: GO_Central
  • regulation of cell shape Source: MGI

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-B
Alternative name(s):
Small proline-rich protein 1B
Short name:
SPR1 B
Short name:
SPR1B
Gene namesi
Name:Sprr1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106659. Sprr1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500001 – 153Cornifin-BAdd BLAST153

Proteomic databases

MaxQBiQ62267.
PaxDbiQ62267.
PeptideAtlasiQ62267.
PRIDEiQ62267.

PTM databases

PhosphoSitePlusiQ62267.

Expressioni

Tissue specificityi

Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus.

Developmental stagei

First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages.

Gene expression databases

BgeeiENSMUSG00000048455.
CleanExiMM_SPRR1B.
GenevisibleiQ62267. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058617.

Structurei

3D structure databases

ProteinModelPortaliQ62267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 3418
Repeati35 – 4228
Repeati43 – 5038
Repeati51 – 5848
Repeati59 – 6658
Repeati67 – 7468
Repeati75 – 8278
Repeati83 – 9088
Repeati91 – 9898
Repeati99 – 106108
Repeati107 – 114118
Repeati115 – 122128
Repeati123 – 130138
Repeati131 – 138148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 13814 X 8 AA approximate tandem repeatsAdd BLAST112

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiQ62267.
OMAiKLPEPCH.
OrthoDBiEOG091G0QRS.
PhylomeDBiQ62267.
TreeFamiTF338205.

Family and domain databases

InterProiView protein in InterPro
IPR026075. SPRR/LCE.
PANTHERiPTHR23263. PTHR23263. 3 hits.

Sequencei

Sequence statusi: Complete.

Q62267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHQQKQPC TAPPQLHEQQ VKQPCQPPPP EPCVSQVKTP CDTKVPEPCH
60 70 80 90 100
PKAPEPCHPK APEPCHPKAP EPCHPKAPEP CHPKAPEPCH PKAPEPCHPK
110 120 130 140 150
APEPCHPKAP EPCHPKVPEP CLPKAPEPCQ PIVPEPCPST VTPILAQQKT

KQK
Length:153
Mass (Da):16,636
Last modified:November 1, 1996 - v1
Checksum:i2B4ACD31FAF69A54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91825 mRNA. Translation: CAA62934.1.
U66820 Genomic DNA. Translation: AAD10127.1.
AK003398 mRNA. Translation: BAB22763.1.
AK009752 mRNA. Translation: BAB26478.1.
BC119288 mRNA. Translation: AAI19289.1.
BC119290 mRNA. Translation: AAI19291.1.
CCDSiCCDS17557.1.
RefSeqiNP_033291.1. NM_009265.3.
UniGeneiMm.140151.

Genome annotation databases

EnsembliENSMUST00000062160; ENSMUSP00000058617; ENSMUSG00000048455.
GeneIDi20754.
KEGGimmu:20754.
UCSCiuc008qeb.1. mouse.

Entry informationi

Entry nameiSPR1B_MOUSE
AccessioniPrimary (citable) accession number: Q62267
Secondary accession number(s): Q0VEC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families