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Protein

Cornifin-A

Gene

Sprr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-A
Alternative name(s):
Small proline-rich protein 1A
Short name:
SPR1 A
Short name:
SPR1A
Gene namesi
Name:Sprr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106660. Sprr1a.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: MGI
  • cornified envelope Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Cornifin-APRO_0000149998Add
BLAST

Proteomic databases

MaxQBiQ62266.
PaxDbiQ62266.
PRIDEiQ62266.

PTM databases

iPTMnetiQ62266.

Expressioni

Tissue specificityi

Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus.1 Publication

Developmental stagei

First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages.1 Publication

Gene expression databases

BgeeiQ62266.
CleanExiMM_SPRR1A.
GenevisibleiQ62266. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053751.

Structurei

3D structure databases

ProteinModelPortaliQ62266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 3481
Repeati35 – 4282
Repeati43 – 4973
Repeati50 – 5784
Repeati58 – 6585
Repeati66 – 7386
Repeati74 – 8187
Repeati82 – 8988
Repeati90 – 9789
Repeati98 – 105810
Repeati106 – 113811
Repeati114 – 121812
Repeati122 – 129813

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 12910313 X 8 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiQ62266.
OMAiPEPCNPK.
OrthoDBiEOG773XKP.
PhylomeDBiQ62266.
TreeFamiTF338205.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF47. PTHR23263:SF47. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHQQKQPC TVPPQLHQQQ VKQPCQPPPQ EPCAPKTKDP CHPVPEPCNP
60 70 80 90 100
KGPEPCHPKA PEPCHPKAPE PCNPKVPEPC QPKVPEPCQP KVPEPCNPKV
110 120 130 140
PEPCQPKAPE PCHPKAPEPC HPVVPEPCPS TVTPSPYQQK TKQK
Length:144
Mass (Da):15,765
Last modified:November 1, 1996 - v1
Checksum:iA7D591678E5823AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91824 mRNA. Translation: CAA62933.1.
AF057156 Genomic DNA. Translation: AAD10126.1.
AK144782 mRNA. Translation: BAE26064.1.
CH466656 Genomic DNA. Translation: EDL00695.1.
BC027534 mRNA. Translation: AAH27534.1.
CCDSiCCDS17559.1.
RefSeqiNP_033290.1. NM_009264.2.
UniGeneiMm.331191.

Genome annotation databases

EnsembliENSMUST00000054599; ENSMUSP00000053751; ENSMUSG00000050359.
GeneIDi20753.
KEGGimmu:20753.
UCSCiuc008qed.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91824 mRNA. Translation: CAA62933.1.
AF057156 Genomic DNA. Translation: AAD10126.1.
AK144782 mRNA. Translation: BAE26064.1.
CH466656 Genomic DNA. Translation: EDL00695.1.
BC027534 mRNA. Translation: AAH27534.1.
CCDSiCCDS17559.1.
RefSeqiNP_033290.1. NM_009264.2.
UniGeneiMm.331191.

3D structure databases

ProteinModelPortaliQ62266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053751.

PTM databases

iPTMnetiQ62266.

Proteomic databases

MaxQBiQ62266.
PaxDbiQ62266.
PRIDEiQ62266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054599; ENSMUSP00000053751; ENSMUSG00000050359.
GeneIDi20753.
KEGGimmu:20753.
UCSCiuc008qed.1. mouse.

Organism-specific databases

CTDi6698.
MGIiMGI:106660. Sprr1a.

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiQ62266.
OMAiPEPCNPK.
OrthoDBiEOG773XKP.
PhylomeDBiQ62266.
TreeFamiTF338205.

Miscellaneous databases

ChiTaRSiSprr1a. mouse.
PROiQ62266.
SOURCEiSearch...

Gene expression databases

BgeeiQ62266.
CleanExiMM_SPRR1A.
GenevisibleiQ62266. MM.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF47. PTHR23263:SF47. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression patterns of mouse SPR1: correlation of expression with epithelial function."
    Kartasova T., Darwiche N., Kohno Y., Koizumi H., Osada S., Huh N.-H., Lichti U., Steinert P.M., Kuroki T.
    J. Invest. Dermatol. 106:294-304(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
  2. "Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B."
    Reddy S.P., Konkin T., Wu R.
    Gene 224:59-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiSPR1A_MOUSE
AccessioniPrimary (citable) accession number: Q62266
Secondary accession number(s): Q3UMN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.