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Protein

Spectrin beta chain, non-erythrocytic 1

Gene

Sptbn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6807878. COPI-mediated anterograde transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 1
Alternative name(s):
Beta-II spectrin
Embryonic liver fodrin
Fodrin beta chain
Gene namesi
Name:Sptbn1
Synonyms:Elf, Spnb-2, Spnb2, Sptb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98388. Sptbn1.

Subcellular locationi

Isoform 2 :

GO - Cellular componenti

  • axolemma Source: BHF-UCL
  • cell-cell adherens junction Source: MGI
  • cortical cytoskeleton Source: MGI
  • cuticular plate Source: MGI
  • cytoplasm Source: MGI
  • endomembrane system Source: UniProtKB-SubCell
  • extracellular exosome Source: MGI
  • M band Source: BHF-UCL
  • membrane Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • postsynaptic density Source: MGI
  • protein complex Source: Ensembl
  • spectrin Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000734622 – 2363Spectrin beta chain, non-erythrocytic 1Add BLAST2362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei228PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei1057PhosphoserineBy similarity1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1079PhosphoserineCombined sources1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1388PhosphoserineBy similarity1
Modified residuei1447PhosphoserineBy similarity1
Modified residuei1557PhosphoserineBy similarity1
Modified residuei1805PhosphotyrosineCombined sources1
Modified residuei1815N6-acetyllysineBy similarity1
Modified residuei1913N6-acetyllysineBy similarity1
Modified residuei1989N6-acetyllysineBy similarity1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2127PhosphoserineCombined sources1
Modified residuei2137PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineCombined sources1
Modified residuei2147PhosphoserineCombined sources1
Modified residuei2158PhosphothreonineCombined sources1
Modified residuei2159PhosphoserineBy similarity1
Modified residuei2160PhosphoserineCombined sources1
Modified residuei2163PhosphoserineCombined sources1
Modified residuei2164PhosphoserineCombined sources1
Modified residuei2168PhosphoserineCombined sources1
Modified residuei2170PhosphothreonineCombined sources1
Modified residuei2183PhosphoserineCombined sources1
Modified residuei2186PhosphothreonineCombined sources1
Modified residuei2194PhosphothreonineCombined sources1
Modified residuei2313PhosphoserineBy similarity1
Modified residuei2318PhosphoserineBy similarity1
Modified residuei2319PhosphothreonineBy similarity1
Glycosylationi2323O-linked (GlcNAc)1 Publication1
Modified residuei2327PhosphothreonineBy similarity1
Modified residuei2339PhosphoserineBy similarity1
Modified residuei2340PhosphoserineCombined sources1
Isoform 2 (identifier: Q62261-2)
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ62261.
PaxDbiQ62261.
PeptideAtlasiQ62261.
PRIDEiQ62261.

PTM databases

iPTMnetiQ62261.
PhosphoSitePlusiQ62261.
SwissPalmiQ62261.

Expressioni

Tissue specificityi

Isoform 2 is present in brain, heart, kidney and liver (at protein level).2 Publications

Developmental stagei

Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000020315.
CleanExiMM_SPNB2.
ExpressionAtlasiQ62261. baseline and differential.
GenevisibleiQ62261. MM.

Interactioni

Subunit structurei

Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Interacts with CAMSAP1 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203461. 12 interactors.
DIPiDIP-31558N.
IntActiQ62261. 14 interactors.
MINTiMINT-4135469.
STRINGi10090.ENSMUSP00000006629.

Structurei

Secondary structure

12363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2200 – 2209Combined sources10
Beta strandi2211 – 2213Combined sources3
Beta strandi2222 – 2229Combined sources8
Beta strandi2232 – 2238Combined sources7
Helixi2239 – 2244Combined sources6
Beta strandi2248 – 2250Combined sources3
Beta strandi2253 – 2255Combined sources3
Beta strandi2260 – 2263Combined sources4
Beta strandi2269 – 2277Combined sources9
Beta strandi2283 – 2287Combined sources5
Helixi2291 – 2303Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BTNX-ray2.00A2199-2304[»]
1MPHNMR-A2199-2304[»]
ProteinModelPortaliQ62261.
SMRiQ62261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 275Actin-bindingAdd BLAST274
Domaini54 – 158CH 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 275CH 2PROSITE-ProRule annotationAdd BLAST103
Repeati303 – 411Spectrin 1Add BLAST109
Repeati423 – 525Spectrin 2Add BLAST103
Repeati530 – 636Spectrin 3Add BLAST107
Repeati639 – 742Spectrin 4Add BLAST104
Repeati745 – 847Spectrin 5Add BLAST103
Repeati851 – 952Spectrin 6Add BLAST102
Repeati957 – 1060Spectrin 7Add BLAST104
Repeati1063 – 1166Spectrin 8Add BLAST104
Repeati1169 – 1257Spectrin 9Add BLAST89
Repeati1276 – 1376Spectrin 10Add BLAST101
Repeati1381 – 1482Spectrin 11Add BLAST102
Repeati1486 – 1590Spectrin 12Add BLAST105
Repeati1592 – 1696Spectrin 13Add BLAST105
Repeati1698 – 1801Spectrin 14Add BLAST104
Repeati1805 – 1907Spectrin 15Add BLAST103
Repeati1914 – 2014Spectrin 16Add BLAST101
Repeati2018 – 2097Spectrin 17Add BLAST80
Domaini2196 – 2306PHPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1563 – 2093Interaction with ANK2By similarityAdd BLAST531
Regioni2148 – 2176Mediates interaction with CAMSAP1By similarityAdd BLAST29

Sequence similaritiesi

Belongs to the spectrin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 17 spectrin repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000007281.
HOVERGENiHBG057912.
InParanoidiQ62261.
KOiK06115.
OMAiRWSQFRE.
OrthoDBiEOG091G003V.
PhylomeDBiQ62261.
TreeFamiTF313446.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR016343. Spectrin_bsu.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 17 hits.
[Graphical view]
PIRSFiPIRSF002297. Spectrin_beta_subunit. 1 hit.
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62261-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD
60 70 80 90 100
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL
110 120 130 140 150
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI
160 170 180 190 200
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT
210 220 230 240 250
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL
260 270 280 290 300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
310 320 330 340 350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV
360 370 380 390 400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE
410 420 430 440 450
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF
460 470 480 490 500
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT
510 520 530 540 550
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL
560 570 580 590 600
LLSQDYGKHL LGVEDLLQKH ALVEADIAIQ AERVRGVNAS AQKFATDGEG
610 620 630 640 650
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE
660 670 680 690 700
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE
710 720 730 740 750
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ
760 770 780 790 800
ADADDIDAWM LDILKIVSSN DVGHDEYSTQ SLVKKHKDVA EEITNYRPTI
810 820 830 840 850
DTLHEQASAL PQAHAESPDV KGRLAGIEER CKEMAELTRL RKQALQDTLA
860 870 880 890 900
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
910 920 930 940 950
QASRVAVVNQ IARQLMHNGH PSEKEIRAQQ DKLNTRWSQF RELVDRKKDA
960 970 980 990 1000
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG
1010 1020 1030 1040 1050
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT
1060 1070 1080 1090 1100
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL
1110 1120 1130 1140 1150
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG
1160 1170 1180 1190 1200
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
1210 1220 1230 1240 1250
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV
1260 1270 1280 1290 1300
DSIDDRHRKN REAASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD
1310 1320 1330 1340 1350
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV
1360 1370 1380 1390 1400
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE
1410 1420 1430 1440 1450
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG
1460 1470 1480 1490 1500
KSTDEVDSKR LTVQTKFMEL LEPLSERKHN LLASKEIHQF NRDVEDEILW
1510 1520 1530 1540 1550
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN
1560 1570 1580 1590 1600
IITDSSSLNA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHKAQQYYFD
1610 1620 1630 1640 1650
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ
1660 1670 1680 1690 1700
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL
1710 1720 1730 1740 1750
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI
1760 1770 1780 1790 1800
GQERVDTVNN MADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
1810 1820 1830 1840 1850
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE
1860 1870 1880 1890 1900
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC
1910 1920 1930 1940 1950
EGRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM
1960 1970 1980 1990 2000
NNHQGIKAEI DARNDSFTAC IELGKSLLAR KHYASEEIKE KLLQLTEKRK
2010 2020 2030 2040 2050
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD
2060 2070 2080 2090 2100
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
2110 2120 2130 2140 2150
PSPDPNTKVS EEAESQQWDT SKGDQVSQNG LPAEQGSPRM AGTMETSEMV
2160 2170 2180 2190 2200
NGAAEQRTSS KESSPVPSPT LDRKAKSALP AQSAATLPAR TLETPAAQME
2210 2220 2230 2240 2250
GFLNRKHEWE AHNKKASSRS WHNVYCVINN QEMGFYKDAK SAASGIPYHS
2260 2270 2280 2290 2300
EVPVSLKEAI CEVALDYKKK KHVFKLRLSD GNEYLFQAKD DEEMNTWIQA
2310 2320 2330 2340 2350
ISSAISSDKH DTSASTQSTP ASSRAQTLPT SVVTITSESS PGKREKDKEK
2360
DKEKRFSLFG KKK
Length:2,363
Mass (Da):274,223
Last modified:May 16, 2006 - v2
Checksum:i221362054E64BB8C
GO
Isoform 2 (identifier: Q62261-2) [UniParc]FASTAAdd to basket
Also known as: Elf3

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MTTTVATDYD...FERSRIKALA → MELQRTSSIS...QLEGRFKQLQ
     2140-2246: MAGTMETSEM...KDAKSAASGI → VSYRSQTYQNYKNFNSRRTASDHSWSGM
     2247-2363: Missing.

Show »
Length:2,154
Mass (Da):251,156
Checksum:i5128A840C3FD28AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252D → A in BAE41221 (PubMed:16141072).Curated1
Sequence conflicti309S → T in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti368T → A in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti737K → I in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti796Y → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti846Q → R in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti970W → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti996R → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti1401 – 1403SQI → KPGF in AAC42040 (PubMed:8479293).Curated3
Sequence conflicti1414 – 1455SVNIL…KSTDE → QSQYSSEKGNRRRRIRWKFG RKRSRNCRPSPGSSRGRAQM R in AAC42040 (PubMed:8479293).CuratedAdd BLAST42
Sequence conflicti1508A → R in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti1619 – 1624EKAKDE → KRPRMK in AAC42040 (PubMed:8479293).Curated6
Sequence conflicti1898D → G in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti2171L → S in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti2345 – 2346EK → AE in AAC42040 (PubMed:8479293).Curated2
Sequence conflicti2356 – 2358FSL → STV in AAC42040 (PubMed:8479293).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260571 – 49MTTTV…IKALA → MELQRTSSISGPLSPAYTGQ VPYNYNQLEGRFKQLQ in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0260582140 – 2246MAGTM…AASGI → VSYRSQTYQNYKNFNSRRTA SDHSWSGM in isoform 2. 2 PublicationsAdd BLAST107
Alternative sequenceiVSP_0260592247 – 2363Missing in isoform 2. 2 PublicationsAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74773 mRNA. Translation: AAC42040.1.
AF017112 mRNA. Translation: AAD01616.1.
AL731792, AL672225 Genomic DNA. Translation: CAI24366.1.
AL731792, AL672225 Genomic DNA. Translation: CAI24367.1.
AL672225, AL731792 Genomic DNA. Translation: CAI25429.1.
AL672225, AL731792 Genomic DNA. Translation: CAI25430.1.
AL731792, AL672225 Genomic DNA. Translation: CAM16973.1.
AL672225, AL731792 Genomic DNA. Translation: CAM22716.1.
AK169544 mRNA. Translation: BAE41221.1.
CCDSiCCDS24506.1. [Q62261-2]
CCDS36123.1. [Q62261-1]
RefSeqiNP_033286.2. NM_009260.2. [Q62261-2]
NP_787030.2. NM_175836.2. [Q62261-1]
XP_006514662.1. XM_006514599.3. [Q62261-1]
XP_006514663.1. XM_006514600.3. [Q62261-1]
UniGeneiMm.123110.
Mm.466085.

Genome annotation databases

EnsembliENSMUST00000006629; ENSMUSP00000006629; ENSMUSG00000020315. [Q62261-1]
ENSMUST00000011877; ENSMUSP00000011877; ENSMUSG00000020315. [Q62261-1]
ENSMUST00000102838; ENSMUSP00000099902; ENSMUSG00000020315. [Q62261-2]
GeneIDi20742.
KEGGimmu:20742.
UCSCiuc007ihs.1. mouse. [Q62261-1]
uc007iht.1. mouse. [Q62261-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74773 mRNA. Translation: AAC42040.1.
AF017112 mRNA. Translation: AAD01616.1.
AL731792, AL672225 Genomic DNA. Translation: CAI24366.1.
AL731792, AL672225 Genomic DNA. Translation: CAI24367.1.
AL672225, AL731792 Genomic DNA. Translation: CAI25429.1.
AL672225, AL731792 Genomic DNA. Translation: CAI25430.1.
AL731792, AL672225 Genomic DNA. Translation: CAM16973.1.
AL672225, AL731792 Genomic DNA. Translation: CAM22716.1.
AK169544 mRNA. Translation: BAE41221.1.
CCDSiCCDS24506.1. [Q62261-2]
CCDS36123.1. [Q62261-1]
RefSeqiNP_033286.2. NM_009260.2. [Q62261-2]
NP_787030.2. NM_175836.2. [Q62261-1]
XP_006514662.1. XM_006514599.3. [Q62261-1]
XP_006514663.1. XM_006514600.3. [Q62261-1]
UniGeneiMm.123110.
Mm.466085.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BTNX-ray2.00A2199-2304[»]
1MPHNMR-A2199-2304[»]
ProteinModelPortaliQ62261.
SMRiQ62261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203461. 12 interactors.
DIPiDIP-31558N.
IntActiQ62261. 14 interactors.
MINTiMINT-4135469.
STRINGi10090.ENSMUSP00000006629.

PTM databases

iPTMnetiQ62261.
PhosphoSitePlusiQ62261.
SwissPalmiQ62261.

Proteomic databases

EPDiQ62261.
PaxDbiQ62261.
PeptideAtlasiQ62261.
PRIDEiQ62261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006629; ENSMUSP00000006629; ENSMUSG00000020315. [Q62261-1]
ENSMUST00000011877; ENSMUSP00000011877; ENSMUSG00000020315. [Q62261-1]
ENSMUST00000102838; ENSMUSP00000099902; ENSMUSG00000020315. [Q62261-2]
GeneIDi20742.
KEGGimmu:20742.
UCSCiuc007ihs.1. mouse. [Q62261-1]
uc007iht.1. mouse. [Q62261-2]

Organism-specific databases

CTDi6711.
MGIiMGI:98388. Sptbn1.

Phylogenomic databases

eggNOGiKOG0035. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOGENOMiHOG000007281.
HOVERGENiHBG057912.
InParanoidiQ62261.
KOiK06115.
OMAiRWSQFRE.
OrthoDBiEOG091G003V.
PhylomeDBiQ62261.
TreeFamiTF313446.

Enzyme and pathway databases

ReactomeiR-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-445095. Interaction between L1 and Ankyrins.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6807878. COPI-mediated anterograde transport.

Miscellaneous databases

EvolutionaryTraceiQ62261.
PROiQ62261.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020315.
CleanExiMM_SPNB2.
ExpressionAtlasiQ62261. baseline and differential.
GenevisibleiQ62261. MM.

Family and domain databases

CDDicd00014. CH. 2 hits.
Gene3Di1.10.418.10. 2 hits.
2.30.29.30. 1 hit.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR016343. Spectrin_bsu.
IPR002017. Spectrin_repeat.
[Graphical view]
PfamiPF00307. CH. 2 hits.
PF00435. Spectrin. 17 hits.
[Graphical view]
PIRSFiPIRSF002297. Spectrin_beta_subunit. 1 hit.
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00033. CH. 2 hits.
SM00233. PH. 1 hit.
SM00150. SPEC. 17 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPTB2_MOUSE
AccessioniPrimary (citable) accession number: Q62261
Secondary accession number(s): A2AFU1
, Q3TEM7, Q5SQL8, Q5SQL9, Q9QWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2006
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.