ID   SALL3_MOUSE             Reviewed;        1320 AA.
AC   Q62255; Q08EB0; Q52KR5; Q6GQT8; Q8BRD9;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 173.
DE   RecName: Full=Sal-like protein 3;
DE   AltName: Full=MSal;
DE   AltName: Full=Spalt-like protein 3;
GN   Name=Sall3; Synonyms=Sal;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1320 (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 30-1320 (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Embryo;
RX   PubMed=8798152; DOI=10.1016/0925-4773(96)00516-3;
RA   Ott T., Kaestner K.H., Monaghan A.P., Schuetz G.;
RT   "The mouse homolog of the region specific homeotic gene spalt of Drosophila
RT   is expressed in the developing nervous system and in mesoderm-derived
RT   structures.";
RL   Mech. Dev. 56:117-128(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 692-1320.
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [5]
RP   DOMAIN.
RX   PubMed=16545361; DOI=10.1016/j.ydbio.2006.02.009;
RA   Sweetman D., Muensterberg A.;
RT   "The vertebrate spalt genes in development and disease.";
RL   Dev. Biol. 293:285-293(2006).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Probable transcription factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q62255-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q62255-2; Sequence=VSP_006834;
CC   -!- TISSUE SPECIFICITY: In adult brain, testis and kidney. In lower levels
CC       also in adult ovaries and embryonic stem cells. In embryo in developing
CC       neuroectoderm of brain, inner ear and spinal chord. Also weakly and
CC       transiently expressed in embryonic branchial arches, notochord, limb
CC       buds and heart.
CC   -!- DEVELOPMENTAL STAGE: During embryogenesis detected from 7 dpc onward in
CC       tissues derived from mesoderm and ectoderm.
CC   -!- MISCELLANEOUS: [Isoform 2]: Lacks two zinc finger domains (6 and 7) and
CC       is the major isoform. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the sal C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC32197.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC125210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC072631; AAH72631.1; -; mRNA.
DR   EMBL; AK045051; BAC32197.1; ALT_INIT; mRNA.
DR   EMBL; X97581; CAA66196.1; ALT_TERM; mRNA.
DR   CCDS; CCDS29371.1; -. [Q62255-2]
DR   CCDS; CCDS89289.1; -. [Q62255-1]
DR   PIR; T30253; T30253.
DR   RefSeq; NP_840064.2; NM_178280.3. [Q62255-2]
DR   AlphaFoldDB; Q62255; -.
DR   BioGRID; 203420; 18.
DR   IntAct; Q62255; 5.
DR   MINT; Q62255; -.
DR   STRING; 10090.ENSMUSP00000056967; -.
DR   GlyGen; Q62255; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q62255; -.
DR   PhosphoSitePlus; Q62255; -.
DR   MaxQB; Q62255; -.
DR   PaxDb; 10090-ENSMUSP00000056967; -.
DR   PeptideAtlas; Q62255; -.
DR   ProteomicsDB; 255454; -. [Q62255-1]
DR   ProteomicsDB; 255455; -. [Q62255-2]
DR   Antibodypedia; 49173; 28 antibodies from 13 providers.
DR   DNASU; 20689; -.
DR   Ensembl; ENSMUST00000057950.9; ENSMUSP00000056967.8; ENSMUSG00000024565.11. [Q62255-2]
DR   GeneID; 20689; -.
DR   KEGG; mmu:20689; -.
DR   UCSC; uc008ftl.2; mouse. [Q62255-1]
DR   UCSC; uc008ftm.1; mouse. [Q62255-2]
DR   AGR; MGI:109295; -.
DR   CTD; 27164; -.
DR   MGI; MGI:109295; Sall3.
DR   VEuPathDB; HostDB:ENSMUSG00000024565; -.
DR   eggNOG; KOG1074; Eukaryota.
DR   GeneTree; ENSGT00940000159356; -.
DR   HOGENOM; CLU_005740_0_0_1; -.
DR   InParanoid; Q62255; -.
DR   OrthoDB; 2880677at2759; -.
DR   PhylomeDB; Q62255; -.
DR   TreeFam; TF317003; -.
DR   BioGRID-ORCS; 20689; 2 hits in 78 CRISPR screens.
DR   PRO; PR:Q62255; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; Q62255; Protein.
DR   Bgee; ENSMUSG00000024565; Expressed in spinal cord mantle layer and 115 other cell types or tissues.
DR   ExpressionAtlas; Q62255; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0035136; P:forelimb morphogenesis; IGI:MGI.
DR   GO; GO:0035137; P:hindlimb morphogenesis; IGI:MGI.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IGI:MGI.
DR   GO; GO:0021891; P:olfactory bulb interneuron development; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; IGI:MGI.
DR   CDD; cd20908; SUF4-like; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23233:SF84; FI23031P1-RELATED; 1.
DR   PANTHER; PTHR23233; SAL-LIKE PROTEIN; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   Pfam; PF12874; zf-met; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
DR   Genevisible; Q62255; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1320
FT                   /note="Sal-like protein 3"
FT                   /id="PRO_0000047025"
FT   ZN_FING         51..73
FT                   /note="C2H2-type 1; atypical"
FT                   /evidence="ECO:0000303|PubMed:16545361"
FT   ZN_FING         427..449
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         455..477
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         692..714
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         720..742
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         752..774
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         997..1019
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1025..1047
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1133..1155
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1161..1183
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          807..846
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          878..972
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..163
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..587
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        605..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        829..846
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        878..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         109
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BXA9"
FT   MOD_RES         932
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BXA9"
FT   MOD_RES         1197
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BXA9"
FT   VAR_SEQ         993..1064
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:8798152"
FT                   /id="VSP_006834"
FT   CONFLICT        131..132
FT                   /note="EP -> S (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        236
FT                   /note="A -> G (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255..256
FT                   /note="TA -> NT (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        307
FT                   /note="C -> CC (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        497..498
FT                   /note="NV -> KC (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        744
FT                   /note="A -> G (in Ref. 3; CAA66196)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        765
FT                   /note="V -> I (in Ref. 4; BAC32197)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1320 AA;  138760 MW;  33A19F56C69D5EEB CRC64;
     MSRRKQAKPQ HLKSDEELPP QDGASEHGVP GDGAEDADSG SESRSGSEET SVCEKCCAEF
     FKWADFLQHK KTCTKNPLVL IVHDDEPAPP SEDFPEPSPA SSPSDRTESE VAEEVAPTEG
     SEVKAATKEA EPMDVEVSTD KGPPGPSVPP PPPALPPQPE PAAFSMPSTN VTLETLLSTK
     VAVAQFSQGA RAGGTTGAGG SVGAVAIPMI LEQLVALQQQ QIHQLQLIEQ IRSQVALMSR
     QPGPPLKPSA SAPGTASVQL QGLTPHAALQ LSAGPATASA GSGSTLPAAF DGPQHLSQPA
     SGTSTPCSTS AAPPDSGAHP ACSTGPAPGA VAAASSTVGN AVQPQNASTP PALGPGPLLS
     SASNLPNPLL PQTSSSSVIF PNPLVSIAAT ANALDPLSAL MKHRKGKPPN VSVFEPKASA
     EDPFFKHKCR FCAKVFGSDS ALQIHLRSHT GERPFKCNIC GNRFSTKGNL KVHFQRHKEK
     YPHIQMNPYP VPEYLDNVPT CSGIPYGMSL PPEKPVTTWL DSKPVLPTVP TSVGLQLPPT
     VPGTHNYTDS PSITPVSRSP QRPSPASSEC TSLSPGLNNT ESGITVRPES PQPLLGGPSL
     TKAEPVSLPC TSTRTGDAPV VGGQVSGLPT SAATAVTDSA CTSLGSPGLP AVSDQFKAQF
     PFGGLLDSMQ TSETSKLQQL VENIDKKMTD PNQCVICHRV LSCQSALKMH YRTHTGERPF
     KCKICGRAFT TKGNLKTHFG VHRAKPPLRV QHSCPICQKK FTNAVVLQQH IRMHMGGQIP
     NTPLPEGLQE AMDADLPFDE KNAETLSSFD DDIDENSMEE DSELKDTASD SSKPLLSYSG
     SCPPSPPSVI SSIAALENQM KMIDSVMNCQ QLANLKSVEN GSGESDRLSN DSSSAVGDLE
     SRSAGSPALS ESSSSQALSP AHSNGESFRS KSPGLGHQED PQEIPLKTER LDSPPPGPGN
     GGALDLTAGH PGRPLIKEEA PFSLLFLSRE RGKCASTVCG VCGKPFACKS ALEIHYRSHT
     KERRFVCTVC RRGCSTMGNL KQHLLTHKLK ELPSQVFDPN FTLGPSHSTP SLASSPAPTM
     IKMEVNGHSK AIALGEGPAL PAGVQVPTGP QTVMSPGLAP MLAPPPRRTP KQHNCQSCGK
     TFSSASALQI HERTHTGEKP FGCTICGRAF TTKGNLKVHM GTHMWNNAPA RRGRRLSVEN
     PMALLGGDAL KFSEMFQKDL AARAMNVDPS FWNQYAAAIT NGLAMKNNEI SVIQNGGIPQ
     LPVSLGGGAI PPLGAMASGV DKARTGSSPP IVSLDKASSE TGASRPFARF IEDNKEIGIN
//