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Q62255

- SALL3_MOUSE

UniProt

Q62255 - SALL3_MOUSE

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Protein
Sal-like protein 3
Gene
Sall3, Sal
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transcription factor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri427 – 44923C2H2-type 1
Add
BLAST
Zinc fingeri455 – 47723C2H2-type 2
Add
BLAST
Zinc fingeri692 – 71423C2H2-type 3
Add
BLAST
Zinc fingeri720 – 74223C2H2-type 4
Add
BLAST
Zinc fingeri752 – 77423C2H2-type 5
Add
BLAST
Zinc fingeri997 – 101923C2H2-type 6
Add
BLAST
Zinc fingeri1025 – 104723C2H2-type 7
Add
BLAST
Zinc fingeri1133 – 115523C2H2-type 8
Add
BLAST
Zinc fingeri1161 – 118323C2H2-type 9
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. forelimb morphogenesis Source: MGI
  2. hindlimb morphogenesis Source: MGI
  3. negative regulation of smoothened signaling pathway Source: MGI
  4. olfactory bulb interneuron development Source: MGI
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Sal-like protein 3
Alternative name(s):
MSal
Spalt-like protein 3
Gene namesi
Name:Sall3
Synonyms:Sal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:109295. Sall3.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Sal-like protein 3
PRO_0000047025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091Phosphoserine By similarity
Modified residuei932 – 9321Phosphoserine By similarity
Modified residuei1197 – 11971Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62255.

PTM databases

PhosphoSiteiQ62255.

Expressioni

Tissue specificityi

In adult brain, testis and kidney. In lower levels also in adult ovaries and embryonic stem cells. In embryo in developing neuroectoderm of brain, inner ear and spinal chord. Also weakly and transiently expressed in embryonic branchial arches, notochord, limb buds and heart.

Developmental stagei

During embryogenesis detected from 7 dpc onward in tissues derived from mesoderm and ectoderm.

Gene expression databases

BgeeiQ62255.
CleanExiMM_SALL3.
GenevestigatoriQ62255.

Interactioni

Protein-protein interaction databases

BioGridi203420. 3 interactions.
IntActiQ62255. 5 interactions.
STRINGi10090.ENSMUSP00000025457.

Structurei

3D structure databases

ProteinModelPortaliQ62255.
SMRiQ62255. Positions 410-483, 671-806, 994-1184.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi142 – 16019Pro-rich
Add
BLAST
Compositional biasi217 – 2204Poly-Gln
Compositional biasi374 – 3774Poly-Ser
Compositional biasi829 – 932104Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293478.
GeneTreeiENSGT00550000074555.
HOGENOMiHOG000231986.
HOVERGENiHBG058921.
InParanoidiQ62255.
OMAiMEVNGHS.
OrthoDBiEOG7NCV2P.
PhylomeDBiQ62255.
TreeFamiTF317003.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62255-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRRKQAKPQ HLKSDEELPP QDGASEHGVP GDGAEDADSG SESRSGSEET     50
SVCEKCCAEF FKWADFLQHK KTCTKNPLVL IVHDDEPAPP SEDFPEPSPA 100
SSPSDRTESE VAEEVAPTEG SEVKAATKEA EPMDVEVSTD KGPPGPSVPP 150
PPPALPPQPE PAAFSMPSTN VTLETLLSTK VAVAQFSQGA RAGGTTGAGG 200
SVGAVAIPMI LEQLVALQQQ QIHQLQLIEQ IRSQVALMSR QPGPPLKPSA 250
SAPGTASVQL QGLTPHAALQ LSAGPATASA GSGSTLPAAF DGPQHLSQPA 300
SGTSTPCSTS AAPPDSGAHP ACSTGPAPGA VAAASSTVGN AVQPQNASTP 350
PALGPGPLLS SASNLPNPLL PQTSSSSVIF PNPLVSIAAT ANALDPLSAL 400
MKHRKGKPPN VSVFEPKASA EDPFFKHKCR FCAKVFGSDS ALQIHLRSHT 450
GERPFKCNIC GNRFSTKGNL KVHFQRHKEK YPHIQMNPYP VPEYLDNVPT 500
CSGIPYGMSL PPEKPVTTWL DSKPVLPTVP TSVGLQLPPT VPGTHNYTDS 550
PSITPVSRSP QRPSPASSEC TSLSPGLNNT ESGITVRPES PQPLLGGPSL 600
TKAEPVSLPC TSTRTGDAPV VGGQVSGLPT SAATAVTDSA CTSLGSPGLP 650
AVSDQFKAQF PFGGLLDSMQ TSETSKLQQL VENIDKKMTD PNQCVICHRV 700
LSCQSALKMH YRTHTGERPF KCKICGRAFT TKGNLKTHFG VHRAKPPLRV 750
QHSCPICQKK FTNAVVLQQH IRMHMGGQIP NTPLPEGLQE AMDADLPFDE 800
KNAETLSSFD DDIDENSMEE DSELKDTASD SSKPLLSYSG SCPPSPPSVI 850
SSIAALENQM KMIDSVMNCQ QLANLKSVEN GSGESDRLSN DSSSAVGDLE 900
SRSAGSPALS ESSSSQALSP AHSNGESFRS KSPGLGHQED PQEIPLKTER 950
LDSPPPGPGN GGALDLTAGH PGRPLIKEEA PFSLLFLSRE RGKCASTVCG 1000
VCGKPFACKS ALEIHYRSHT KERRFVCTVC RRGCSTMGNL KQHLLTHKLK 1050
ELPSQVFDPN FTLGPSHSTP SLASSPAPTM IKMEVNGHSK AIALGEGPAL 1100
PAGVQVPTGP QTVMSPGLAP MLAPPPRRTP KQHNCQSCGK TFSSASALQI 1150
HERTHTGEKP FGCTICGRAF TTKGNLKVHM GTHMWNNAPA RRGRRLSVEN 1200
PMALLGGDAL KFSEMFQKDL AARAMNVDPS FWNQYAAAIT NGLAMKNNEI 1250
SVIQNGGIPQ LPVSLGGGAI PPLGAMASGV DKARTGSSPP IVSLDKASSE 1300
TGASRPFARF IEDNKEIGIN 1320

Note: No experimental confirmation available.

Length:1,320
Mass (Da):138,760
Last modified:January 9, 2007 - v2
Checksum:i33A19F56C69D5EEB
GO
Isoform 2 (identifier: Q62255-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     993-1064: Missing.

Note: Lacks two zinc finger domains (6 and 7) and is the major isoform.

Show »
Length:1,248
Mass (Da):130,708
Checksum:iC1CFD01A0AB4B3B3
GO

Sequence cautioni

The sequence BAC32197.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei993 – 106472Missing in isoform 2.
VSP_006834Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1322EP → S in CAA66196. 1 Publication
Sequence conflicti236 – 2361A → G in CAA66196. 1 Publication
Sequence conflicti255 – 2562TA → NT in CAA66196. 1 Publication
Sequence conflicti307 – 3071C → CC in CAA66196. 1 Publication
Sequence conflicti497 – 4982NV → KC in CAA66196. 1 Publication
Sequence conflicti744 – 7441A → G in CAA66196. 1 Publication
Sequence conflicti765 – 7651V → I in BAC32197. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC125210 Genomic DNA. No translation available.
BC072631 mRNA. Translation: AAH72631.1.
AK045051 mRNA. Translation: BAC32197.1. Different initiation.
X97581 mRNA. Translation: CAA66196.1. Different termination.
CCDSiCCDS29371.1. [Q62255-2]
PIRiT30253.
RefSeqiNP_840064.2. NM_178280.3. [Q62255-2]
UniGeneiMm.215917.

Genome annotation databases

EnsembliENSMUST00000057950; ENSMUSP00000056967; ENSMUSG00000024565. [Q62255-2]
GeneIDi20689.
KEGGimmu:20689.
UCSCiuc008ftl.2. mouse. [Q62255-1]
uc008ftm.1. mouse. [Q62255-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC125210 Genomic DNA. No translation available.
BC072631 mRNA. Translation: AAH72631.1 .
AK045051 mRNA. Translation: BAC32197.1 . Different initiation.
X97581 mRNA. Translation: CAA66196.1 . Different termination.
CCDSi CCDS29371.1. [Q62255-2 ]
PIRi T30253.
RefSeqi NP_840064.2. NM_178280.3. [Q62255-2 ]
UniGenei Mm.215917.

3D structure databases

ProteinModelPortali Q62255.
SMRi Q62255. Positions 410-483, 671-806, 994-1184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203420. 3 interactions.
IntActi Q62255. 5 interactions.
STRINGi 10090.ENSMUSP00000025457.

PTM databases

PhosphoSitei Q62255.

Proteomic databases

PRIDEi Q62255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057950 ; ENSMUSP00000056967 ; ENSMUSG00000024565 . [Q62255-2 ]
GeneIDi 20689.
KEGGi mmu:20689.
UCSCi uc008ftl.2. mouse. [Q62255-1 ]
uc008ftm.1. mouse. [Q62255-2 ]

Organism-specific databases

CTDi 27164.
MGIi MGI:109295. Sall3.

Phylogenomic databases

eggNOGi NOG293478.
GeneTreei ENSGT00550000074555.
HOGENOMi HOG000231986.
HOVERGENi HBG058921.
InParanoidi Q62255.
OMAi MEVNGHS.
OrthoDBi EOG7NCV2P.
PhylomeDBi Q62255.
TreeFami TF317003.

Miscellaneous databases

NextBioi 299221.
PROi Q62255.
SOURCEi Search...

Gene expression databases

Bgeei Q62255.
CleanExi MM_SALL3.
Genevestigatori Q62255.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1320 (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures."
    Ott T., Kaestner K.H., Monaghan A.P., Schuetz G.
    Mech. Dev. 56:117-128(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-1320 (ISOFORMS 1 AND 2).
    Tissue: Brain and Embryo.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 692-1320.
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiSALL3_MOUSE
AccessioniPrimary (citable) accession number: Q62255
Secondary accession number(s): Q08EB0
, Q52KR5, Q6GQT8, Q8BRD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi