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Q62255

- SALL3_MOUSE

UniProt

Q62255 - SALL3_MOUSE

Protein

Sal-like protein 3

Gene

Sall3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Probable transcription factor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri427 – 44923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri752 – 77423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri997 – 101923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1025 – 104723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. forelimb morphogenesis Source: MGI
    2. hindlimb morphogenesis Source: MGI
    3. negative regulation of smoothened signaling pathway Source: MGI
    4. olfactory bulb interneuron development Source: MGI
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sal-like protein 3
    Alternative name(s):
    MSal
    Spalt-like protein 3
    Gene namesi
    Name:Sall3
    Synonyms:Sal
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:109295. Sall3.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13201320Sal-like protein 3PRO_0000047025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei109 – 1091PhosphoserineBy similarity
    Modified residuei932 – 9321PhosphoserineBy similarity
    Modified residuei1197 – 11971PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62255.

    PTM databases

    PhosphoSiteiQ62255.

    Expressioni

    Tissue specificityi

    In adult brain, testis and kidney. In lower levels also in adult ovaries and embryonic stem cells. In embryo in developing neuroectoderm of brain, inner ear and spinal chord. Also weakly and transiently expressed in embryonic branchial arches, notochord, limb buds and heart.

    Developmental stagei

    During embryogenesis detected from 7 dpc onward in tissues derived from mesoderm and ectoderm.

    Gene expression databases

    BgeeiQ62255.
    CleanExiMM_SALL3.
    GenevestigatoriQ62255.

    Interactioni

    Protein-protein interaction databases

    BioGridi203420. 3 interactions.
    IntActiQ62255. 5 interactions.
    STRINGi10090.ENSMUSP00000025457.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62255.
    SMRiQ62255. Positions 410-483, 671-806, 994-1184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi142 – 16019Pro-richAdd
    BLAST
    Compositional biasi217 – 2204Poly-Gln
    Compositional biasi374 – 3774Poly-Ser
    Compositional biasi829 – 932104Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri427 – 44923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri455 – 47723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri692 – 71423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri720 – 74223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri752 – 77423C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri997 – 101923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1025 – 104723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1133 – 115523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1161 – 118323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG293478.
    GeneTreeiENSGT00550000074555.
    HOGENOMiHOG000231986.
    HOVERGENiHBG058921.
    InParanoidiQ62255.
    OMAiMEVNGHS.
    OrthoDBiEOG7NCV2P.
    PhylomeDBiQ62255.
    TreeFamiTF317003.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q62255-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRRKQAKPQ HLKSDEELPP QDGASEHGVP GDGAEDADSG SESRSGSEET     50
    SVCEKCCAEF FKWADFLQHK KTCTKNPLVL IVHDDEPAPP SEDFPEPSPA 100
    SSPSDRTESE VAEEVAPTEG SEVKAATKEA EPMDVEVSTD KGPPGPSVPP 150
    PPPALPPQPE PAAFSMPSTN VTLETLLSTK VAVAQFSQGA RAGGTTGAGG 200
    SVGAVAIPMI LEQLVALQQQ QIHQLQLIEQ IRSQVALMSR QPGPPLKPSA 250
    SAPGTASVQL QGLTPHAALQ LSAGPATASA GSGSTLPAAF DGPQHLSQPA 300
    SGTSTPCSTS AAPPDSGAHP ACSTGPAPGA VAAASSTVGN AVQPQNASTP 350
    PALGPGPLLS SASNLPNPLL PQTSSSSVIF PNPLVSIAAT ANALDPLSAL 400
    MKHRKGKPPN VSVFEPKASA EDPFFKHKCR FCAKVFGSDS ALQIHLRSHT 450
    GERPFKCNIC GNRFSTKGNL KVHFQRHKEK YPHIQMNPYP VPEYLDNVPT 500
    CSGIPYGMSL PPEKPVTTWL DSKPVLPTVP TSVGLQLPPT VPGTHNYTDS 550
    PSITPVSRSP QRPSPASSEC TSLSPGLNNT ESGITVRPES PQPLLGGPSL 600
    TKAEPVSLPC TSTRTGDAPV VGGQVSGLPT SAATAVTDSA CTSLGSPGLP 650
    AVSDQFKAQF PFGGLLDSMQ TSETSKLQQL VENIDKKMTD PNQCVICHRV 700
    LSCQSALKMH YRTHTGERPF KCKICGRAFT TKGNLKTHFG VHRAKPPLRV 750
    QHSCPICQKK FTNAVVLQQH IRMHMGGQIP NTPLPEGLQE AMDADLPFDE 800
    KNAETLSSFD DDIDENSMEE DSELKDTASD SSKPLLSYSG SCPPSPPSVI 850
    SSIAALENQM KMIDSVMNCQ QLANLKSVEN GSGESDRLSN DSSSAVGDLE 900
    SRSAGSPALS ESSSSQALSP AHSNGESFRS KSPGLGHQED PQEIPLKTER 950
    LDSPPPGPGN GGALDLTAGH PGRPLIKEEA PFSLLFLSRE RGKCASTVCG 1000
    VCGKPFACKS ALEIHYRSHT KERRFVCTVC RRGCSTMGNL KQHLLTHKLK 1050
    ELPSQVFDPN FTLGPSHSTP SLASSPAPTM IKMEVNGHSK AIALGEGPAL 1100
    PAGVQVPTGP QTVMSPGLAP MLAPPPRRTP KQHNCQSCGK TFSSASALQI 1150
    HERTHTGEKP FGCTICGRAF TTKGNLKVHM GTHMWNNAPA RRGRRLSVEN 1200
    PMALLGGDAL KFSEMFQKDL AARAMNVDPS FWNQYAAAIT NGLAMKNNEI 1250
    SVIQNGGIPQ LPVSLGGGAI PPLGAMASGV DKARTGSSPP IVSLDKASSE 1300
    TGASRPFARF IEDNKEIGIN 1320

    Note: No experimental confirmation available.

    Length:1,320
    Mass (Da):138,760
    Last modified:January 9, 2007 - v2
    Checksum:i33A19F56C69D5EEB
    GO
    Isoform 2 (identifier: Q62255-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         993-1064: Missing.

    Note: Lacks two zinc finger domains (6 and 7) and is the major isoform.

    Show »
    Length:1,248
    Mass (Da):130,708
    Checksum:iC1CFD01A0AB4B3B3
    GO

    Sequence cautioni

    The sequence BAC32197.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti131 – 1322EP → S in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti236 – 2361A → G in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti255 – 2562TA → NT in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti307 – 3071C → CC in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti497 – 4982NV → KC in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti744 – 7441A → G in CAA66196. (PubMed:8798152)Curated
    Sequence conflicti765 – 7651V → I in BAC32197. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei993 – 106472Missing in isoform 2. 2 PublicationsVSP_006834Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC125210 Genomic DNA. No translation available.
    BC072631 mRNA. Translation: AAH72631.1.
    AK045051 mRNA. Translation: BAC32197.1. Different initiation.
    X97581 mRNA. Translation: CAA66196.1. Different termination.
    CCDSiCCDS29371.1. [Q62255-2]
    PIRiT30253.
    RefSeqiNP_840064.2. NM_178280.3. [Q62255-2]
    UniGeneiMm.215917.

    Genome annotation databases

    EnsembliENSMUST00000057950; ENSMUSP00000056967; ENSMUSG00000024565. [Q62255-2]
    GeneIDi20689.
    KEGGimmu:20689.
    UCSCiuc008ftl.2. mouse. [Q62255-1]
    uc008ftm.1. mouse. [Q62255-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC125210 Genomic DNA. No translation available.
    BC072631 mRNA. Translation: AAH72631.1 .
    AK045051 mRNA. Translation: BAC32197.1 . Different initiation.
    X97581 mRNA. Translation: CAA66196.1 . Different termination.
    CCDSi CCDS29371.1. [Q62255-2 ]
    PIRi T30253.
    RefSeqi NP_840064.2. NM_178280.3. [Q62255-2 ]
    UniGenei Mm.215917.

    3D structure databases

    ProteinModelPortali Q62255.
    SMRi Q62255. Positions 410-483, 671-806, 994-1184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203420. 3 interactions.
    IntActi Q62255. 5 interactions.
    STRINGi 10090.ENSMUSP00000025457.

    PTM databases

    PhosphoSitei Q62255.

    Proteomic databases

    PRIDEi Q62255.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057950 ; ENSMUSP00000056967 ; ENSMUSG00000024565 . [Q62255-2 ]
    GeneIDi 20689.
    KEGGi mmu:20689.
    UCSCi uc008ftl.2. mouse. [Q62255-1 ]
    uc008ftm.1. mouse. [Q62255-2 ]

    Organism-specific databases

    CTDi 27164.
    MGIi MGI:109295. Sall3.

    Phylogenomic databases

    eggNOGi NOG293478.
    GeneTreei ENSGT00550000074555.
    HOGENOMi HOG000231986.
    HOVERGENi HBG058921.
    InParanoidi Q62255.
    OMAi MEVNGHS.
    OrthoDBi EOG7NCV2P.
    PhylomeDBi Q62255.
    TreeFami TF317003.

    Miscellaneous databases

    NextBioi 299221.
    PROi Q62255.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62255.
    CleanExi MM_SALL3.
    Genevestigatori Q62255.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1320 (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures."
      Ott T., Kaestner K.H., Monaghan A.P., Schuetz G.
      Mech. Dev. 56:117-128(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-1320 (ISOFORMS 1 AND 2).
      Tissue: Brain and Embryo.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 692-1320.
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiSALL3_MOUSE
    AccessioniPrimary (citable) accession number: Q62255
    Secondary accession number(s): Q08EB0
    , Q52KR5, Q6GQT8, Q8BRD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3