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Protein

Sperm surface protein Sp17

Gene

Spa17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm surface protein Sp17
Alternative name(s):
Sperm autoantigenic protein 17
Gene namesi
Name:Spa17
Synonyms:Sp17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1333778. Spa17.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: MGI
  • cytoplasm Source: MGI
  • external side of plasma membrane Source: MGI
  • motile cilium Source: MGI
  • primary cilium Source: MGI
  • sperm fibrous sheath Source: MGI
  • sperm principal piece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Sperm surface protein Sp17PRO_0000181344Add
BLAST

Proteomic databases

MaxQBiQ62252.
PaxDbiQ62252.
PRIDEiQ62252.

2D gel databases

REPRODUCTION-2DPAGEQ62252.

PTM databases

iPTMnetiQ62252.
PhosphoSiteiQ62252.

Expressioni

Tissue specificityi

Testis- and sperm-specific.

Gene expression databases

BgeeiQ62252.
CleanExiMM_SPA17.
ExpressionAtlasiQ62252. baseline and differential.
GenevisibleiQ62252. MM.

Interactioni

Subunit structurei

Homodimer. May interact with ROPN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002013.

Structurei

3D structure databases

ProteinModelPortaliQ62252.
SMRiQ62252. Positions 12-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 14130IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX7J. Eukaryota.
ENOG410XXA6. LUCA.
GeneTreeiENSGT00440000039164.
HOGENOMiHOG000059525.
HOVERGENiHBG003879.
InParanoidiQ62252.
OMAiFKEQEPP.
OrthoDBiEOG7R2BHX.
PhylomeDBiQ62252.
TreeFamiTF332959.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR000048. IQ_motif_EF-hand-BS.
IPR012105. Sp17.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF016533. Sp17. 1 hit.
SMARTiSM00015. IQ. 1 hit.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR
60 70 80 90 100
EKTSFDPAEW GAKVEDRFYN NHAFKEQEQV EKCEQELAKS SGREETPVTP
110 120 130 140
FEESTEEERE QEEAAALKIQ SLFRGHVARE EVKKMKSDKN ENLKEEADN
Length:149
Mass (Da):17,296
Last modified:November 1, 1996 - v1
Checksum:iC7E05D111D6AF0DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46299 mRNA. Translation: CAA86455.1.
BC059727 mRNA. Translation: AAH59727.1.
CCDSiCCDS22982.1.
PIRiS49527.
RefSeqiNP_035579.1. NM_011449.2.
UniGeneiMm.8637.

Genome annotation databases

EnsembliENSMUST00000002013; ENSMUSP00000002013; ENSMUSG00000001948.
GeneIDi20686.
KEGGimmu:20686.
UCSCiuc009ovd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46299 mRNA. Translation: CAA86455.1.
BC059727 mRNA. Translation: AAH59727.1.
CCDSiCCDS22982.1.
PIRiS49527.
RefSeqiNP_035579.1. NM_011449.2.
UniGeneiMm.8637.

3D structure databases

ProteinModelPortaliQ62252.
SMRiQ62252. Positions 12-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002013.

PTM databases

iPTMnetiQ62252.
PhosphoSiteiQ62252.

2D gel databases

REPRODUCTION-2DPAGEQ62252.

Proteomic databases

MaxQBiQ62252.
PaxDbiQ62252.
PRIDEiQ62252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002013; ENSMUSP00000002013; ENSMUSG00000001948.
GeneIDi20686.
KEGGimmu:20686.
UCSCiuc009ovd.2. mouse.

Organism-specific databases

CTDi53340.
MGIiMGI:1333778. Spa17.

Phylogenomic databases

eggNOGiENOG410IX7J. Eukaryota.
ENOG410XXA6. LUCA.
GeneTreeiENSGT00440000039164.
HOGENOMiHOG000059525.
HOVERGENiHBG003879.
InParanoidiQ62252.
OMAiFKEQEPP.
OrthoDBiEOG7R2BHX.
PhylomeDBiQ62252.
TreeFamiTF332959.

Miscellaneous databases

ChiTaRSiSpa17. mouse.
PROiQ62252.
SOURCEiSearch...

Gene expression databases

BgeeiQ62252.
CleanExiMM_SPA17.
ExpressionAtlasiQ62252. baseline and differential.
GenevisibleiQ62252. MM.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR000048. IQ_motif_EF-hand-BS.
IPR012105. Sp17.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF016533. Sp17. 1 hit.
SMARTiSM00015. IQ. 1 hit.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and localization of the mouse sperm autoantigenic protein, Sp17."
    Kong M., Richardson R.T., Widgren E.E., O'Rand M.G.
    Biol. Reprod. 53:579-590(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiSP17_MOUSE
AccessioniPrimary (citable) accession number: Q62252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.