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Protein

Son of sevenless homolog 1

Gene

Sos1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.2 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • Ras guanyl-nucleotide exchange factor activity Source: MGI
  • Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  • B cell homeostasis Source: MGI
  • lymphocyte homeostasis Source: MGI
  • neurotrophin TRK receptor signaling pathway Source: Ensembl
  • positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of small GTPase mediated signal transduction Source: Ensembl
  • Ras protein signal transduction Source: Ensembl
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of T cell differentiation in thymus Source: MGI
  • regulation of T cell proliferation Source: MGI
  • small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_271639. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_277280. Activation of Rac.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_301936. DAP12 signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_314186. FCERI mediated MAPK activation.
REACT_320246. Signalling to RAS.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332492. GRB2:SOS provides linkage to MAPK signaling for Integrins.
REACT_333309. SHC-mediated signalling.
REACT_333431. Signal attenuation.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_340694. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_341964. Tie2 Signaling.
REACT_348733. FCERI mediated Ca+2 mobilization.
REACT_354765. Regulation of KIT signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Names & Taxonomyi

Protein namesi
Recommended name:
Son of sevenless homolog 1
Short name:
SOS-1
Short name:
mSOS-1
Gene namesi
Name:Sos1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98354. Sos1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13191319Son of sevenless homolog 1PRO_0000068895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1078 – 10781Phosphoserine1 Publication
Modified residuei1082 – 10821Phosphoserine1 Publication
Modified residuei1120 – 11201PhosphoserineBy similarity
Modified residuei1261 – 12611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62245.
PaxDbiQ62245.
PRIDEiQ62245.

PTM databases

PhosphoSiteiQ62245.

Expressioni

Tissue specificityi

Expressed in most embryonic and adult tissues.

Gene expression databases

BgeeiQ62245.
CleanExiMM_SOS1.
ExpressionAtlasiQ62245. baseline and differential.
GenevestigatoriQ62245.

Interactioni

Subunit structurei

Interacts with GRB2. Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains). Interacts with phosphorylated LAT2. Interacts with NCK1 and NCK2 (By similarity). Part of a complex consisting of ABI1, EPS8 and SOS1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P266632EBI-1693,EBI-6857429From a different organism.
GRB2P6299311EBI-1693,EBI-401755From a different organism.
Grb2Q606317EBI-1693,EBI-1688
sem-5P293552EBI-1693,EBI-315286From a different organism.

Protein-protein interaction databases

BioGridi203394. 6 interactions.
DIPiDIP-29230N.
IntActiQ62245. 17 interactions.
MINTiMINT-158444.

Structurei

Secondary structure

1
1319
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni416 – 4183Combined sources
Helixi419 – 4279Combined sources
Beta strandi437 – 4415Combined sources
Turni443 – 4453Combined sources
Beta strandi446 – 4549Combined sources
Beta strandi459 – 4635Combined sources
Beta strandi465 – 4717Combined sources
Beta strandi481 – 4844Combined sources
Beta strandi490 – 4956Combined sources
Beta strandi500 – 5023Combined sources
Beta strandi514 – 5174Combined sources
Beta strandi519 – 5213Combined sources
Beta strandi523 – 5275Combined sources
Beta strandi529 – 5313Combined sources
Helixi532 – 54514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B07X-ray2.50C1135-1144[»]
1GBQNMR-B1135-1144[»]
1PMSNMR-A414-548[»]
2GBQNMR-B1135-1144[»]
3GBQNMR-B1135-1144[»]
4GBQNMR-B1135-1144[»]
ProteinModelPortaliQ62245.
SMRiQ62245. Positions 6-183, 198-1046.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini200 – 390191DHPROSITE-ProRule annotationAdd
BLAST
Domaini444 – 548105PHPROSITE-ProRule annotationAdd
BLAST
Domaini597 – 741145N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini780 – 1019240Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1244 – 12474Poly-Pro

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG265981.
GeneTreeiENSGT00780000121844.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ62245.
KOiK03099.
OMAiQLPYEFF.
OrthoDBiEOG7XSTD0.
PhylomeDBiQ62245.
TreeFamiTF317296.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE
60 70 80 90 100
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLSLPAERI HHLLREVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR
160 170 180 190 200
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT
210 220 230 240 250
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN DVENIFSRIV
260 270 280 290 300
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
310 320 330 340 350
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC
360 370 380 390 400
LHYFELLKQL EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL
410 420 430 440 450
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL
460 470 480 490 500
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASSAEYRL KEKFFMRKVQ
510 520 530 540 550
INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA LISLQYRSTL
560 570 580 590 600
ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI
610 620 630 640 650
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI
660 670 680 690 700
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH
710 720 730 740 750
FYDFERDADL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH
760 770 780 790 800
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ
810 820 830 840 850
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA
860 870 880 890 900
VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
910 920 930 940 950
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR
960 970 980 990 1000
HGKELINFSK RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS
1010 1020 1030 1040 1050
MEKEFTDYLF NKSLEIEPRH PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM
1060 1070 1080 1090 1100
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGTSSNTD
1110 1120 1130 1140 1150
VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP PRRRPESAPA
1160 1170 1180 1190 1200
ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL
1210 1220 1230 1240 1250
PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP
1260 1270 1280 1290 1300
SPHGTRRHLP SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH
1310
THPSMHRDGP PLLENAHSS
Length:1,319
Mass (Da):150,883
Last modified:July 15, 1999 - v2
Checksum:i3286088A5BA0A4A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11574 mRNA. Translation: CAA77662.1.
Z11578 mRNA. Translation: CAA77665.1.
CCDSiCCDS37704.1.
PIRiS25715.
S25716.
RefSeqiNP_033257.2. NM_009231.2.
UniGeneiMm.360004.
Mm.60975.

Genome annotation databases

EnsembliENSMUST00000068714; ENSMUSP00000067786; ENSMUSG00000024241.
GeneIDi20662.
KEGGimmu:20662.
UCSCiuc008drg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11574 mRNA. Translation: CAA77662.1.
Z11578 mRNA. Translation: CAA77665.1.
CCDSiCCDS37704.1.
PIRiS25715.
S25716.
RefSeqiNP_033257.2. NM_009231.2.
UniGeneiMm.360004.
Mm.60975.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B07X-ray2.50C1135-1144[»]
1GBQNMR-B1135-1144[»]
1PMSNMR-A414-548[»]
2GBQNMR-B1135-1144[»]
3GBQNMR-B1135-1144[»]
4GBQNMR-B1135-1144[»]
ProteinModelPortaliQ62245.
SMRiQ62245. Positions 6-183, 198-1046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203394. 6 interactions.
DIPiDIP-29230N.
IntActiQ62245. 17 interactions.
MINTiMINT-158444.

PTM databases

PhosphoSiteiQ62245.

Proteomic databases

MaxQBiQ62245.
PaxDbiQ62245.
PRIDEiQ62245.

Protocols and materials databases

DNASUi20662.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068714; ENSMUSP00000067786; ENSMUSG00000024241.
GeneIDi20662.
KEGGimmu:20662.
UCSCiuc008drg.1. mouse.

Organism-specific databases

CTDi6654.
MGIiMGI:98354. Sos1.

Phylogenomic databases

eggNOGiNOG265981.
GeneTreeiENSGT00780000121844.
HOGENOMiHOG000013040.
HOVERGENiHBG017831.
InParanoidiQ62245.
KOiK03099.
OMAiQLPYEFF.
OrthoDBiEOG7XSTD0.
PhylomeDBiQ62245.
TreeFamiTF317296.

Enzyme and pathway databases

ReactomeiREACT_271639. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_276076. SHC1 events in ERBB4 signaling.
REACT_277280. Activation of Rac.
REACT_278498. Downstream signal transduction.
REACT_285497. GRB2 events in EGFR signaling.
REACT_286571. SHC1 events in EGFR signaling.
REACT_288801. SOS-mediated signalling.
REACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_301936. DAP12 signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_314186. FCERI mediated MAPK activation.
REACT_320246. Signalling to RAS.
REACT_321592. SHC1 events in ERBB2 signaling.
REACT_325060. EGFR Transactivation by Gastrin.
REACT_327089. GRB2 events in ERBB2 signaling.
REACT_327841. Signaling by SCF-KIT.
REACT_332492. GRB2:SOS provides linkage to MAPK signaling for Integrins.
REACT_333309. SHC-mediated signalling.
REACT_333431. Signal attenuation.
REACT_339798. NCAM signaling for neurite out-growth.
REACT_340694. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_341964. Tie2 Signaling.
REACT_348733. FCERI mediated Ca+2 mobilization.
REACT_354765. Regulation of KIT signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Miscellaneous databases

ChiTaRSiSos1. mouse.
EvolutionaryTraceiQ62245.
NextBioi299109.
PROiQ62245.
SOURCEiSearch...

Gene expression databases

BgeeiQ62245.
CleanExiMM_SOS1.
ExpressionAtlasiQ62245. baseline and differential.
GenevestigatoriQ62245.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
1.10.840.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF00169. PH. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF48366. SSF48366. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras."
    Bowtell D.D., Fu P., Simon M.A., Senior P.V.
    Proc. Natl. Acad. Sci. U.S.A. 89:6511-6515(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
    Tissue: Eye.
  2. Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH ABI1 AND EPS8E.
  3. "An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine."
    Scita G., Tenca P., Areces L.B., Tocchetti A., Frittoli E., Giardina G., Ponzanelli I., Sini P., Innocenti M., Di Fiore P.P.
    J. Cell Biol. 154:1031-1044(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EPS8.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1078 AND SER-1082, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1)."
    Koshiba S., Kigawa T., Kim J.-H., Shirouzu M., Bowtell D., Yokoyama S.
    J. Mol. Biol. 269:579-591(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 415-548.

Entry informationi

Entry nameiSOS1_MOUSE
AccessioniPrimary (citable) accession number: Q62245
Secondary accession number(s): Q62244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: May 27, 2015
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.