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Q62241

- RU1C_MOUSE

UniProt

Q62241 - RU1C_MOUSE

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Protein

U1 small nuclear ribonucleoprotein C

Gene
Snrpc, Snrp1c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB-HAMAP
  2. single-stranded RNA binding Source: Ensembl
  3. U1 snRNA binding Source: UniProtKB-HAMAP
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA 5'-splice site recognition Source: UniProtKB-HAMAP
  2. spliceosomal snRNP assembly Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein C
Short name:
U1 snRNP C
Short name:
U1-C
Short name:
U1C
Gene namesi
Name:Snrpc
Synonyms:Snrp1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:109489. Snrpc.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. Cajal body Source: Ensembl
  2. commitment complex Source: UniProtKB-HAMAP
  3. U1 snRNP Source: UniProtKB
  4. U2-type prespliceosome Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159U1 small nuclear ribonucleoprotein CUniRule annotationPRO_0000097526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphotyrosine By similarity
Modified residuei17 – 171Phosphoserine By similarity
Modified residuei52 – 521N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ62241.
PaxDbiQ62241.
PRIDEiQ62241.

PTM databases

PhosphoSiteiQ62241.

Expressioni

Tissue specificityi

Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.

Developmental stagei

First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease.UniRule annotation

Gene expression databases

BgeeiQ62241.
CleanExiMM_SNRPC.
GenevestigatoriQ62241.

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA By similarity.

Protein-protein interaction databases

BioGridi203373. 3 interactions.
IntActiQ62241. 1 interaction.
MINTiMINT-4133349.

Structurei

3D structure databases

ProteinModelPortaliQ62241.
SMRiQ62241. Positions 1-61.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 15795Met/Pro-richUniRule annotationAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5136.
GeneTreeiENSGT00730000110997.
HOGENOMiHOG000238970.
HOVERGENiHBG017764.
InParanoidiQ62241.
KOiK11095.
OMAiMLPTPPM.
OrthoDBiEOG74TX2B.
TreeFamiTF313578.

Family and domain databases

HAMAPiMF_03153. U1_C.
InterProiIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62241-1 [UniParc]FASTAAdd to Basket

« Hide

MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI    50
DKTTAAFQQG KIPPAPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP 100
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT 150
RPGMTRPDR 159
Length:159
Mass (Da):17,364
Last modified:November 1, 1996 - v1
Checksum:iF187E13A75B789D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96767 mRNA. Translation: CAA65542.1.
U70315 mRNA. Translation: AAB08894.1.
BC008243 mRNA. Translation: AAH08243.1.
CCDSiCCDS28570.1.
RefSeqiNP_035562.1. NM_011432.2.
UniGeneiMm.103949.
Mm.308514.

Genome annotation databases

EnsembliENSMUST00000071006; ENSMUSP00000063976; ENSMUSG00000024217.
GeneIDi20630.
KEGGimmu:20630.
UCSCiuc008bps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96767 mRNA. Translation: CAA65542.1 .
U70315 mRNA. Translation: AAB08894.1 .
BC008243 mRNA. Translation: AAH08243.1 .
CCDSi CCDS28570.1.
RefSeqi NP_035562.1. NM_011432.2.
UniGenei Mm.103949.
Mm.308514.

3D structure databases

ProteinModelPortali Q62241.
SMRi Q62241. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203373. 3 interactions.
IntActi Q62241. 1 interaction.
MINTi MINT-4133349.

PTM databases

PhosphoSitei Q62241.

Proteomic databases

MaxQBi Q62241.
PaxDbi Q62241.
PRIDEi Q62241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071006 ; ENSMUSP00000063976 ; ENSMUSG00000024217 .
GeneIDi 20630.
KEGGi mmu:20630.
UCSCi uc008bps.1. mouse.

Organism-specific databases

CTDi 6631.
MGIi MGI:109489. Snrpc.

Phylogenomic databases

eggNOGi COG5136.
GeneTreei ENSGT00730000110997.
HOGENOMi HOG000238970.
HOVERGENi HBG017764.
InParanoidi Q62241.
KOi K11095.
OMAi MLPTPPM.
OrthoDBi EOG74TX2B.
TreeFami TF313578.

Miscellaneous databases

NextBioi 299027.
PROi Q62241.
SOURCEi Search...

Gene expression databases

Bgeei Q62241.
CleanExi MM_SNRPC.
Genevestigatori Q62241.

Family and domain databases

HAMAPi MF_03153. U1_C.
InterProi IPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view ]
PANTHERi PTHR31148. PTHR31148. 1 hit.
Pfami PF06220. zf-U1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037969. U1_snRNP-C. 1 hit.
SMARTi SM00451. ZnF_U1. 1 hit.
[Graphical view ]
PROSITEi PS50171. ZF_MATRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C."
    Nelissen R.L.H., Klein Gunnewiek J.M.T., Lambermon M.H.L., van Venrooij W.J.
    Gene 184:273-278(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphocyte.
  2. "Molecular cloning and developmental expression of a small ribonuclear protein in the mouse testis."
    Morales C.R., Leyne M., El-Alfy M., Oko R.
    Mol. Reprod. Dev. 46:459-470(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Kidney and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRU1C_MOUSE
AccessioniPrimary (citable) accession number: Q62241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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