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Protein

U1 small nuclear ribonucleoprotein C

Gene

Snrpc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
Gene namesi
Name:SnrpcUniRule annotation
Synonyms:Snrp1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109489 Snrpc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975261 – 159U1 small nuclear ribonucleoprotein CAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphotyrosineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei52N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62241
MaxQBiQ62241
PaxDbiQ62241
PRIDEiQ62241

PTM databases

iPTMnetiQ62241
PhosphoSitePlusiQ62241

Expressioni

Tissue specificityi

Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.

Developmental stagei

First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease.

Gene expression databases

BgeeiENSMUSG00000024217
CleanExiMM_SNRPC
ExpressionAtlasiQ62241 baseline and differential
GenevisibleiQ62241 MM

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203373, 4 interactors
IntActiQ62241, 2 interactors
MINTiQ62241
STRINGi10090.ENSMUSP00000063976

Structurei

3D structure databases

ProteinModelPortaliQ62241
SMRiQ62241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 157Met/Pro-richAdd BLAST95

Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 36Matrin-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3454 Eukaryota
COG5136 LUCA
GeneTreeiENSGT00730000110997
HOGENOMiHOG000238970
HOVERGENiHBG017764
InParanoidiQ62241
KOiK11095
OMAiFRFYCDY
OrthoDBiEOG091G13HV
TreeFamiTF313578

Family and domain databases

HAMAPiMF_03153 U1_C, 1 hit
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR013085 U1-CZ_Znf_C2H2
IPR017340 U1_snRNP-C
IPR036236 Znf_C2H2_sf
PANTHERiPTHR31148 PTHR31148, 1 hit
PfamiView protein in Pfam
PF06220 zf-U1, 1 hit
PIRSFiPIRSF037969 U1_snRNP-C, 1 hit
SMARTiView protein in SMART
SM00451 ZnF_U1, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50171 ZF_MATRIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q62241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPAPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT

RPGMTRPDR
Length:159
Mass (Da):17,364
Last modified:November 1, 1996 - v1
Checksum:iF187E13A75B789D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96767 mRNA Translation: CAA65542.1
U70315 mRNA Translation: AAB08894.1
BC008243 mRNA Translation: AAH08243.1
CCDSiCCDS28570.1
RefSeqiNP_035562.1, NM_011432.2
UniGeneiMm.103949
Mm.308514

Genome annotation databases

EnsembliENSMUST00000071006; ENSMUSP00000063976; ENSMUSG00000024217
GeneIDi20630
KEGGimmu:20630
UCSCiuc008bps.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRU1C_MOUSE
AccessioniPrimary (citable) accession number: Q62241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health