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Protein

U1 small nuclear ribonucleoprotein C

Gene

Snrpc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein CUniRule annotation
Short name:
U1 snRNP CUniRule annotation
Short name:
U1-CUniRule annotation
Short name:
U1CUniRule annotation
Gene namesi
Name:Snrpc
Synonyms:Snrp1c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109489. Snrpc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159U1 small nuclear ribonucleoprotein CPRO_0000097526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphotyrosineBy similarity
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei52 – 521N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ62241.
PaxDbiQ62241.
PRIDEiQ62241.

PTM databases

PhosphoSiteiQ62241.

Expressioni

Tissue specificityi

Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.

Developmental stagei

First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease.

Gene expression databases

BgeeiQ62241.
CleanExiMM_SNRPC.
ExpressionAtlasiQ62241. baseline.
GenevisibleiQ62241. MM.

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi203373. 3 interactions.
IntActiQ62241. 2 interactions.
MINTiMINT-4133349.
STRINGi10090.ENSMUSP00000063976.

Structurei

3D structure databases

ProteinModelPortaliQ62241.
SMRiQ62241. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 15795Met/Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the U1 small nuclear ribonucleoprotein C family.UniRule annotation
Contains 1 matrin-type zinc finger.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 3633Matrin-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5136.
GeneTreeiENSGT00730000110997.
HOGENOMiHOG000238970.
HOVERGENiHBG017764.
InParanoidiQ62241.
KOiK11095.
OMAiGCHLLFL.
OrthoDBiEOG74TX2B.
TreeFamiTF313578.

Family and domain databases

HAMAPiMF_03153. U1_C.
InterProiIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI
60 70 80 90 100
DKTTAAFQQG KIPPAPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP
110 120 130 140 150
PMMPMMGPPP PGMMPVGPAP GMRPPMGGHM PMMPGPPMMR PPARPMMVPT

RPGMTRPDR
Length:159
Mass (Da):17,364
Last modified:November 1, 1996 - v1
Checksum:iF187E13A75B789D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96767 mRNA. Translation: CAA65542.1.
U70315 mRNA. Translation: AAB08894.1.
BC008243 mRNA. Translation: AAH08243.1.
CCDSiCCDS28570.1.
RefSeqiNP_035562.1. NM_011432.2.
UniGeneiMm.103949.
Mm.308514.

Genome annotation databases

EnsembliENSMUST00000071006; ENSMUSP00000063976; ENSMUSG00000024217.
GeneIDi20630.
KEGGimmu:20630.
UCSCiuc008bps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96767 mRNA. Translation: CAA65542.1.
U70315 mRNA. Translation: AAB08894.1.
BC008243 mRNA. Translation: AAH08243.1.
CCDSiCCDS28570.1.
RefSeqiNP_035562.1. NM_011432.2.
UniGeneiMm.103949.
Mm.308514.

3D structure databases

ProteinModelPortaliQ62241.
SMRiQ62241. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203373. 3 interactions.
IntActiQ62241. 2 interactions.
MINTiMINT-4133349.
STRINGi10090.ENSMUSP00000063976.

PTM databases

PhosphoSiteiQ62241.

Proteomic databases

MaxQBiQ62241.
PaxDbiQ62241.
PRIDEiQ62241.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071006; ENSMUSP00000063976; ENSMUSG00000024217.
GeneIDi20630.
KEGGimmu:20630.
UCSCiuc008bps.1. mouse.

Organism-specific databases

CTDi6631.
MGIiMGI:109489. Snrpc.

Phylogenomic databases

eggNOGiCOG5136.
GeneTreeiENSGT00730000110997.
HOGENOMiHOG000238970.
HOVERGENiHBG017764.
InParanoidiQ62241.
KOiK11095.
OMAiGCHLLFL.
OrthoDBiEOG74TX2B.
TreeFamiTF313578.

Miscellaneous databases

NextBioi299027.
PROiQ62241.
SOURCEiSearch...

Gene expression databases

BgeeiQ62241.
CleanExiMM_SNRPC.
ExpressionAtlasiQ62241. baseline.
GenevisibleiQ62241. MM.

Family and domain databases

HAMAPiMF_03153. U1_C.
InterProiIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERiPTHR31148. PTHR31148. 1 hit.
PfamiPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFiPIRSF037969. U1_snRNP-C. 1 hit.
SMARTiSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEiPS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C."
    Nelissen R.L.H., Klein Gunnewiek J.M.T., Lambermon M.H.L., van Venrooij W.J.
    Gene 184:273-278(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphocyte.
  2. "Molecular cloning and developmental expression of a small ribonuclear protein in the mouse testis."
    Morales C.R., Leyne M., El-Alfy M., Oko R.
    Mol. Reprod. Dev. 46:459-470(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Kidney and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiRU1C_MOUSE
AccessioniPrimary (citable) accession number: Q62241
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.