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Q62241 (RU1C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U1 small nuclear ribonucleoprotein C

Short name=U1 snRNP C
Short name=U1-C
Short name=U1C
Gene names
Name:Snrpc
Synonyms:Snrp1c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region By similarity. HAMAP-Rule MF_03153

Subunit structure

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA By similarity.

Subcellular location

Nucleus HAMAP-Rule MF_03153.

Tissue specificity

Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.

Developmental stage

First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease. HAMAP-Rule MF_03153

Sequence similarities

Belongs to the U1 small nuclear ribonucleoprotein C family.

Contains 1 matrin-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159U1 small nuclear ribonucleoprotein C HAMAP-Rule MF_03153
PRO_0000097526

Regions

Zinc finger4 – 3633Matrin-type HAMAP-Rule MF_03153
Compositional bias63 – 15795Met/Pro-rich HAMAP-Rule MF_03153

Amino acid modifications

Modified residue81Phosphotyrosine By similarity
Modified residue171Phosphoserine By similarity
Modified residue521N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62241 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F187E13A75B789D0

FASTA15917,364
        10         20         30         40         50         60 
MPKFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI DKTTAAFQQG 

        70         80         90        100        110        120 
KIPPAPFSAP PPAGAMIPPP PSLPGPPRPG MMPAPHMGGP PMMPMMGPPP PGMMPVGPAP 

       130        140        150 
GMRPPMGGHM PMMPGPPMMR PPARPMMVPT RPGMTRPDR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C."
Nelissen R.L.H., Klein Gunnewiek J.M.T., Lambermon M.H.L., van Venrooij W.J.
Gene 184:273-278(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphocyte.
[2]"Molecular cloning and developmental expression of a small ribonuclear protein in the mouse testis."
Morales C.R., Leyne M., El-Alfy M., Oko R.
Mol. Reprod. Dev. 46:459-470(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Kidney and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96767 mRNA. Translation: CAA65542.1.
U70315 mRNA. Translation: AAB08894.1.
BC008243 mRNA. Translation: AAH08243.1.
CCDSCCDS28570.1.
RefSeqNP_035562.1. NM_011432.2.
UniGeneMm.103949.
Mm.308514.

3D structure databases

ProteinModelPortalQ62241.
SMRQ62241. Positions 1-61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203373. 3 interactions.
IntActQ62241. 1 interaction.
MINTMINT-4133349.

PTM databases

PhosphoSiteQ62241.

Proteomic databases

MaxQBQ62241.
PaxDbQ62241.
PRIDEQ62241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000071006; ENSMUSP00000063976; ENSMUSG00000024217.
GeneID20630.
KEGGmmu:20630.
UCSCuc008bps.1. mouse.

Organism-specific databases

CTD6631.
MGIMGI:109489. Snrpc.

Phylogenomic databases

eggNOGCOG5136.
GeneTreeENSGT00730000110997.
HOGENOMHOG000238970.
HOVERGENHBG017764.
InParanoidQ62241.
KOK11095.
OMAMLPTPPM.
OrthoDBEOG74TX2B.
TreeFamTF313578.

Gene expression databases

BgeeQ62241.
CleanExMM_SNRPC.
GenevestigatorQ62241.

Family and domain databases

HAMAPMF_03153. U1_C.
InterProIPR017340. U1_snRNP-C.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
IPR013085. Znf_U1-C.
[Graphical view]
PANTHERPTHR31148. PTHR31148. 1 hit.
PfamPF06220. zf-U1. 1 hit.
[Graphical view]
PIRSFPIRSF037969. U1_snRNP-C. 1 hit.
SMARTSM00451. ZnF_U1. 1 hit.
[Graphical view]
PROSITEPS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299027.
PROQ62241.
SOURCESearch...

Entry information

Entry nameRU1C_MOUSE
AccessionPrimary (citable) accession number: Q62241
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot