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Q62233

- SIX3_MOUSE

UniProt

Q62233 - SIX3_MOUSE

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Protein

Homeobox protein SIX3

Gene

Six3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon (PubMed:18094027). Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression (PubMed:18775421). In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration (PubMed:22071110). Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2 (PubMed:17576749). During early lens formation plays a role in lens induction and specification by activating directly PAX6 in the presumptive lens ectoderm (PubMed:17066077). In turn PAX6 activates SIX3 resulting in activation of PDGFRA and CCND1 promoting cell proliferation (PubMed:12072567). Also is required for the neuroretina development by directly suppressing WNT8B expression in the anterior neural plate territory (PubMed:20890044). Its action during retina development and lens morphogenesis is AES and TLE4-dependent manner. Furthermore, during eye development regulates several genes expression. Before and during early lens development represses the CRYGF promoter by binding a SIX repressor element (PubMed:11139622). Directly activates RHO transcription, or cooperates with CRX or NRL (PubMed:17666527). Six3 functions also in the formation of the proximodistal axis of the optic cup (PubMed:12163408), and promotes the formation of optic vesicles-like structures (PubMed:11458394). During pituitary development, acts in parallel or alternatively with HESX1 to control cell proliferation through Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye development by suppressing WNT1 expression and in dorsal-ventral patterning by repressing BMP signaling pathway (By similarity).By similarity15 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 26660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. histone deacetylase binding Source: UniProtKB
  3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  6. sequence-specific DNA binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription coactivator activity Source: UniProtKB
  9. transcription corepressor binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process involved in development Source: UniProtKB
  2. brain development Source: MGI
  3. camera-type eye development Source: MGI
  4. cell proliferation in forebrain Source: UniProtKB
  5. circadian behavior Source: MGI
  6. diencephalon development Source: MGI
  7. epithelial cell maturation Source: UniProtKB
  8. eye development Source: MGI
  9. forebrain anterior/posterior pattern specification Source: MGI
  10. lens development in camera-type eye Source: UniProtKB
  11. lens fiber cell apoptotic process Source: UniProtKB
  12. lens fiber cell differentiation Source: UniProtKB
  13. lens induction in camera-type eye Source: MGI
  14. negative regulation of neuron differentiation Source: UniProtKB
  15. negative regulation of transcription, DNA-templated Source: UniProtKB
  16. negative regulation of Wnt signaling pathway Source: MGI
  17. neuroblast differentiation Source: UniProtKB
  18. neuroblast migration Source: UniProtKB
  19. optic vesicle morphogenesis Source: UniProtKB
  20. pituitary gland development Source: UniProtKB
  21. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  22. protein import into nucleus Source: MGI
  23. protein import into nucleus, translocation Source: UniProtKB
  24. proximal/distal axis specification Source: UniProtKB
  25. regulation of cell cycle phase transition Source: UniProtKB
  26. regulation of cell proliferation Source: UniProtKB
  27. regulation of neural precursor cell proliferation Source: UniProtKB
  28. regulation of neural retina development Source: UniProtKB
  29. regulation of neuroblast proliferation Source: UniProtKB
  30. telencephalon development Source: UniProtKB
  31. telencephalon regionalization Source: UniProtKB
  32. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX3
Alternative name(s):
Sine oculis homeobox homolog 3
Gene namesi
Name:Six3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:102764. Six3.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos die at birth and lack most head structures anterior to the midbrain, including the eyes and nose (PubMed:12569128). Embryonic SHH and SIX3 double heterozygous mice exibit a semilobar holoprosencephaly-like phenotype and a dorsoventral patterning defects in telencephalon (PubMed:18694563). Embryonic WNT1 and SIX3 double homozygous mice lack cerebellum and colliculus and have a severely reduced midbrain (PubMed:18094027). Conditional knockout in eye exibit drastically reduced lens size, cataracts, or absence of the lens (PubMed:17066077). Embryo of SIX3 and HESX1 heterozygous mice exhibit severe growth retardation after weaning, with additional gonadal and thyroid gland defects, resulting in a lethal phenotype (PubMed:18775421).5 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi88 – 881F → E: Loss of interaction with AES and TLE4. 1 Publication
Mutagenesisi233 – 2353Missing: Suppression of SIX3-binding to rhodopsin promoter. Impairs the ability of Six3 to stimulate RHO transcription. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Homeobox protein SIX3PRO_0000049300Add
BLAST

Proteomic databases

MaxQBiQ62233.
PRIDEiQ62233.

PTM databases

PhosphoSiteiQ62233.

Expressioni

Tissue specificityi

Expressed in ependymal cells during the formation of the lateral wall.1 Publication

Developmental stagei

Expressed in the developing retina (at protein level). First expressed at E6.5 of embryo development around the anterior border. At E8.5, expression is found over the anterior neural plate. At E9.5, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary. Expression at around E7.5 to E8 is high in the anterior neural ectoderm. Weaker expression is detected in the prechordal plate. At the 5 somite stage (E8.0), expression is maintained in the anterior neural ectoderm. Around the 8 somite stage (E8.0), expression is already restricted to the ventral forebrain and eye field. At the 12 somite stage (E8.5), expression is maintained in the ventral forebrain (PubMed:18694563). At E9.5 strongly expressed throughout the prospective nasal ectoderm. At E10.5 remains expressed throughout the nasal ectoderm (PubMed:16024294). At E7.5 expression is found in the developing anterior neuroectoderm. At E9.0 expression is found in the region of the presumptive lens ectoderm and developing optic vesicle. At E9.5 expression is found in the lens placode, optic vesicles, and ventral forebrain (PubMed:11458394).3 Publications

Inductioni

Represses its own transcription in a TLE4-dependent manner. Induces in lens by PAX6 in a dosage-dependent manner. Activated by SOX2 during forebrain development. Inhibited by MTA1 in mammary glands.3 Publications

Gene expression databases

BgeeiQ62233.
ExpressionAtlasiQ62233. baseline and differential.
GenevestigatoriQ62233.

Interactioni

Subunit structurei

Interacts with EYA4; translocates EYA4 from the cytoplasm to the nucleus and promotes activation of their target genes. Interacts with MTA1 and HDAC2; represses its own transcription. Interacts with MTA1; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with EYA1; promotes EYA1 translocation to the nucleus. Interacts with TLE1 and AES (via Q domain); can act in combination with either TLE1 and/or AES leading to transcriptional repression or activation, respectively (By similarity). Interacts (via homeobox) with NR4A3; differentially regulates the transcriptional activities NR4A3 (By similarity). Interacts with GMNN (By similarity). Interacts with TLE4.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AesP630025EBI-2297327,EBI-646888
groP163712EBI-2297327,EBI-153866From a different organism.
Tle4Q624412EBI-2297327,EBI-2297871

Protein-protein interaction databases

BioGridi203261. 4 interactions.
DIPiDIP-46499N.
IntActiQ62233. 3 interactions.
STRINGi10090.ENSMUSP00000039867.

Structurei

3D structure databases

ProteinModelPortaliQ62233.
SMRiQ62233. Positions 80-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 12048Interaction with AES1 PublicationAdd
BLAST
Regioni233 – 2353Bind to RHO promoter1 Publication

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 7038Gly-richPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244436.
GeneTreeiENSGT00540000070251.
HOVERGENiHBG003609.
InParanoidiQ62233.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform SIX3B1 Publication (identifier: Q62233-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFRSPLDLY SSHFLLPNFA DSHHCSLLLA SSGGGSGASG GGGGAGGGGG
60 70 80 90 100
GNRAGGGGAG GAGGGSGGGG SRAPPEELSM FQLPTLNFSP EQVASVCETL
110 120 130 140 150
EETGDIERLG RFLWSLPVAP GACEAINKHE SILRARAVVA FHTGNFRDLY
160 170 180 190 200
HILENHKFTK ESHGKLQAMW LEAHYQEAEK LRGRPLGPVD KYRVRKKFPL
210 220 230 240 250
PRTIWDGEQK THCFKERTRS LLREWYLQDP YPNPSKKREL AQATGLTPTQ
260 270 280 290 300
VGNWFKNRRQ RDRAAAAKNR LQHQAIGPSG MRSLAEPGCP THGSAESPST
310 320 330
AASPTTSVSS LTERADTGTS ILSVTSSDSE CDV
Length:333
Mass (Da):35,593
Last modified:December 15, 1998 - v2
Checksum:i1AD7D3C4388043B9
GO
Isoform SIX3A1 Publication (identifier: Q62233-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-284: LQHQAIGPSGMRSL → SVAGTAARPPQAPG
     285-333: Missing.

Show »
Length:284
Mass (Da):30,610
Checksum:iB32EB549F11FB9A4
GO

Sequence cautioni

The sequence CAA62379.1 differs from that shown. Reason: Frameshift at positions 117, 119 and 277. Curated
The sequence CAA62379.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → GG in CAA62379. (PubMed:8575305)Curated
Sequence conflicti283 – 2831S → C in CAA62379. (PubMed:8575305)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 28414LQHQA…GMRSL → SVAGTAARPPQAPG in isoform SIX3A. CuratedVSP_002291Add
BLAST
Alternative sequencei285 – 33349Missing in isoform SIX3A. CuratedVSP_002292Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90871 mRNA. Translation: CAA62379.1. Sequence problems.
D83144 mRNA. Translation: BAA11822.1.
D83145 mRNA. Translation: BAA11823.1.
BC098096 mRNA. Translation: AAH98096.1.
CCDSiCCDS50203.1. [Q62233-1]
PIRiS74255.
RefSeqiNP_035511.2. NM_011381.4. [Q62233-1]
UniGeneiMm.370208.
Mm.391586.

Genome annotation databases

EnsembliENSMUST00000175898; ENSMUSP00000135677; ENSMUSG00000038805. [Q62233-1]
ENSMUST00000176081; ENSMUSP00000135312; ENSMUSG00000038805. [Q62233-1]
GeneIDi20473.
KEGGimmu:20473.
UCSCiuc008dtz.2. mouse. [Q62233-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90871 mRNA. Translation: CAA62379.1 . Sequence problems.
D83144 mRNA. Translation: BAA11822.1 .
D83145 mRNA. Translation: BAA11823.1 .
BC098096 mRNA. Translation: AAH98096.1 .
CCDSi CCDS50203.1. [Q62233-1 ]
PIRi S74255.
RefSeqi NP_035511.2. NM_011381.4. [Q62233-1 ]
UniGenei Mm.370208.
Mm.391586.

3D structure databases

ProteinModelPortali Q62233.
SMRi Q62233. Positions 80-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203261. 4 interactions.
DIPi DIP-46499N.
IntActi Q62233. 3 interactions.
STRINGi 10090.ENSMUSP00000039867.

PTM databases

PhosphoSitei Q62233.

Proteomic databases

MaxQBi Q62233.
PRIDEi Q62233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000175898 ; ENSMUSP00000135677 ; ENSMUSG00000038805 . [Q62233-1 ]
ENSMUST00000176081 ; ENSMUSP00000135312 ; ENSMUSG00000038805 . [Q62233-1 ]
GeneIDi 20473.
KEGGi mmu:20473.
UCSCi uc008dtz.2. mouse. [Q62233-1 ]

Organism-specific databases

CTDi 6496.
MGIi MGI:102764. Six3.

Phylogenomic databases

eggNOGi NOG244436.
GeneTreei ENSGT00540000070251.
HOVERGENi HBG003609.
InParanoidi Q62233.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298587.
PROi Q62233.
SOURCEi Search...

Gene expression databases

Bgeei Q62233.
ExpressionAtlasi Q62233. baseline and differential.
Genevestigatori Q62233.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development."
    Oliver G., Mailhos A., Wehr R., Copeland N.G., Jenkins N.A., Gruss P.
    Development 121:4045-4055(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SIX3B).
    Strain: BALB/c.
    Tissue: Embryonic brain.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SIX3A), NUCLEOTIDE SEQUENCE [MRNA] OF 4-333 (ISOFORM SIX3B).
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SIX3B).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos."
    Lagutin O., Zhu C.C., Furuta Y., Rowitch D.H., McMahon A.P., Oliver G.
    Dev. Dyn. 221:342-349(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OPTIC VESICLE MORPHOGENESIS, DEVELOPMENTAL STAGE.
  5. "Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter."
    Lengler J., Krausz E., Tomarev S., Prescott A., Quinlan R.A., Graw J.
    Nucleic Acids Res. 29:515-526(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LENS DEVELOPMENT.
  6. "Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors."
    Zhu C.C., Dyer M.A., Uchikawa M., Kondoh H., Lagutin O.V., Oliver G.
    Development 129:2835-2849(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH AES AND TLE4, MUTAGENESIS OF PHE-88.
  7. "Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye."
    Carl M., Loosli F., Wittbrodt J.
    Development 129:4057-4063(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PROXIMAL/DISTAL AXIS SPECIFICATION.
  8. "Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype."
    Goudreau G., Petrou P., Reneker L.W., Graw J., Loster J., Gruss P.
    Proc. Natl. Acad. Sci. U.S.A. 99:8719-8724(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LENS DEVELOPMENT, INDUCTION.
  9. "Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development."
    Lagutin O.V., Zhu C.C., Kobayashi D., Topczewski J., Shimamura K., Puelles L., Russell H.R., McKinnon P.J., Solnica-Krezel L., Oliver G.
    Genes Dev. 17:368-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN FOREBRAIN DEVELOPMENT, DISRUPTION PHENOTYPE.
  10. "Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction."
    Purcell P., Oliver G., Mardon G., Donner A.L., Maas R.L.
    Gene Expr. Patterns 6:110-118(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA1, DEVELOPMENTAL STAGE.
  11. "Six3 activation of Pax6 expression is essential for mammalian lens induction and specification."
    Liu W., Lagutin O.V., Mende M., Streit A., Oliver G.
    EMBO J. 25:5383-5395(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LENS INDUCTION, DISRUPTION PHENOTYPE.
  12. Cited for: FUNCTION, INTERACTION WITH HDAC2 AND MTA1, MUTAGENESIS OF 233-ASN--SER-235.
  13. "Six3 controls the neural progenitor status in the murine CNS."
    Appolloni I., Calzolari F., Corte G., Perris R., Malatesta P.
    Cereb. Cortex 18:553-562(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PROLIFERATION OF NEURAL PROGENITOR CELLS.
  14. "Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon."
    Lavado A., Lagutin O.V., Oliver G.
    Development 135:441-450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN FOREBRAIN DEVELOPMENT, DISRUPTION PHENOTYPE.
  15. "Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development."
    Gaston-Massuet C., Andoniadou C.L., Signore M., Sajedi E., Bird S., Turner J.M., Martinez-Barbera J.P.
    Dev. Biol. 324:322-333(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PITUITARY DEVELOPMENT, DISRUPTION PHENOTYPE.
  16. "Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly."
    Geng X., Speirs C., Lagutin O., Inbal A., Liu W., Solnica-Krezel L., Jeong Y., Epstein D.J., Oliver G.
    Dev. Cell 15:236-247(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN FOREBRAIN DEVELOPMENT, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  17. "EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally."
    Abe Y., Oka A., Mizuguchi M., Igarashi T., Ishikawa S., Aburatani H., Yokoyama S., Asahara H., Nagao K., Yamada M., Miyashita T.
    Hum. Mutat. 30:E946-E955(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA4.
  18. "Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor."
    Kumar R., Balasenthil S., Manavathi B., Rayala S.K., Pakala S.B.
    Cancer Res. 70:6649-6658(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate."
    Liu W., Lagutin O., Swindell E., Jamrich M., Oliver G.
    J. Clin. Invest. 120:3568-3577(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NEURAL RETINA DEVELOPMENT.
  20. "Six3 is required for ependymal cell maturation."
    Lavado A., Oliver G.
    Development 138:5291-5300(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL MATURATION, TISSUE SPECIFICITY.
  21. "Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain."
    Lee B., Song H., Rizzoti K., Son Y., Yoon J., Baek K., Jeong Y.
    Dev. Biol. 381:491-501(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiSIX3_MOUSE
AccessioniPrimary (citable) accession number: Q62233
Secondary accession number(s): P70176, P70177, Q4QQQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3