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Q62233

- SIX3_MOUSE

UniProt

Q62233 - SIX3_MOUSE

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Protein
Homeobox protein SIX3
Gene
Six3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in visual system development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi207 – 26660Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. brain development Source: MGI
  2. camera-type eye development Source: MGI
  3. circadian behavior Source: MGI
  4. diencephalon development Source: MGI
  5. eye development Source: MGI
  6. forebrain anterior/posterior pattern specification Source: MGI
  7. lens induction in camera-type eye Source: MGI
  8. negative regulation of Wnt signaling pathway Source: MGI
  9. negative regulation of transcription, DNA-templated Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  11. protein import into nucleus Source: MGI
  12. telencephalon development Source: MGI
  13. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX3
Alternative name(s):
Sine oculis homeobox homolog 3
Gene namesi
Name:Six3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:102764. Six3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Homeobox protein SIX3
PRO_0000049300Add
BLAST

Proteomic databases

PRIDEiQ62233.

PTM databases

PhosphoSiteiQ62233.

Expressioni

Developmental stagei

First expressed at E6.5 of embryo development around the anterior border. At E8.5, expression is found over the anterior neural plate. At E9.5, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary.

Gene expression databases

ArrayExpressiQ62233.
BgeeiQ62233.
GenevestigatoriQ62233.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AesP630025EBI-2297327,EBI-646888
groP163712EBI-2297327,EBI-153866From a different organism.
Tle4Q624412EBI-2297327,EBI-2297871

Protein-protein interaction databases

BioGridi203261. 4 interactions.
DIPiDIP-46499N.
IntActiQ62233. 3 interactions.
STRINGi10090.ENSMUSP00000039867.

Structurei

3D structure databases

ProteinModelPortaliQ62233.
SMRiQ62233. Positions 80-268.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 7038Gly-rich
Add
BLAST
Compositional biasi264 – 2674Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244436.
GeneTreeiENSGT00540000070251.
HOVERGENiHBG003609.
InParanoidiQ4QQQ3.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform SIX3B (identifier: Q62233-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVFRSPLDLY SSHFLLPNFA DSHHCSLLLA SSGGGSGASG GGGGAGGGGG    50
GNRAGGGGAG GAGGGSGGGG SRAPPEELSM FQLPTLNFSP EQVASVCETL 100
EETGDIERLG RFLWSLPVAP GACEAINKHE SILRARAVVA FHTGNFRDLY 150
HILENHKFTK ESHGKLQAMW LEAHYQEAEK LRGRPLGPVD KYRVRKKFPL 200
PRTIWDGEQK THCFKERTRS LLREWYLQDP YPNPSKKREL AQATGLTPTQ 250
VGNWFKNRRQ RDRAAAAKNR LQHQAIGPSG MRSLAEPGCP THGSAESPST 300
AASPTTSVSS LTERADTGTS ILSVTSSDSE CDV 333
Length:333
Mass (Da):35,593
Last modified:December 15, 1998 - v2
Checksum:i1AD7D3C4388043B9
GO
Isoform SIX3A (identifier: Q62233-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-286: LQHQAIGPSGMRSLAE → SVAGTAARPPQA
     287-333: Missing.

Show »
Length:282
Mass (Da):30,456
Checksum:iA549F11FB9A48237
GO

Sequence cautioni

The sequence CAA62379.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 28616LQHQA…RSLAE → SVAGTAARPPQA in isoform SIX3A.
VSP_002291Add
BLAST
Alternative sequencei287 – 33347Missing in isoform SIX3A.
VSP_002292Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → GG1 Publication
Sequence conflicti118 – 1192VA → WP in CAA62379. 1 Publication
Sequence conflicti278 – 33356PSGMR…SECDV → ERDALPGRARLPHARLSRVT VHGGQPDHQCVQPDGARGHR HFDPLGNLQRLGM1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90871 mRNA. Translation: CAA62379.1. Different initiation.
D83144 mRNA. Translation: BAA11822.1.
D83145 mRNA. Translation: BAA11823.1.
BC098096 mRNA. Translation: AAH98096.1.
CCDSiCCDS50203.1. [Q62233-1]
PIRiS74255.
RefSeqiNP_035511.2. NM_011381.4. [Q62233-1]
UniGeneiMm.370208.
Mm.391586.

Genome annotation databases

EnsembliENSMUST00000175898; ENSMUSP00000135677; ENSMUSG00000038805. [Q62233-1]
ENSMUST00000176081; ENSMUSP00000135312; ENSMUSG00000038805. [Q62233-1]
GeneIDi20473.
KEGGimmu:20473.
UCSCiuc008dtz.2. mouse. [Q62233-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90871 mRNA. Translation: CAA62379.1 . Different initiation.
D83144 mRNA. Translation: BAA11822.1 .
D83145 mRNA. Translation: BAA11823.1 .
BC098096 mRNA. Translation: AAH98096.1 .
CCDSi CCDS50203.1. [Q62233-1 ]
PIRi S74255.
RefSeqi NP_035511.2. NM_011381.4. [Q62233-1 ]
UniGenei Mm.370208.
Mm.391586.

3D structure databases

ProteinModelPortali Q62233.
SMRi Q62233. Positions 80-268.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203261. 4 interactions.
DIPi DIP-46499N.
IntActi Q62233. 3 interactions.
STRINGi 10090.ENSMUSP00000039867.

PTM databases

PhosphoSitei Q62233.

Proteomic databases

PRIDEi Q62233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000175898 ; ENSMUSP00000135677 ; ENSMUSG00000038805 . [Q62233-1 ]
ENSMUST00000176081 ; ENSMUSP00000135312 ; ENSMUSG00000038805 . [Q62233-1 ]
GeneIDi 20473.
KEGGi mmu:20473.
UCSCi uc008dtz.2. mouse. [Q62233-1 ]

Organism-specific databases

CTDi 6496.
MGIi MGI:102764. Six3.

Phylogenomic databases

eggNOGi NOG244436.
GeneTreei ENSGT00540000070251.
HOVERGENi HBG003609.
InParanoidi Q4QQQ3.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298587.
PROi Q62233.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62233.
Bgeei Q62233.
Genevestigatori Q62233.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development."
    Oliver G., Mailhos A., Wehr R., Copeland N.G., Jenkins N.A., Gruss P.
    Development 121:4045-4055(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Embryonic brain.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SIX3B).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiSIX3_MOUSE
AccessioniPrimary (citable) accession number: Q62233
Secondary accession number(s): P70176, P70177, Q4QQQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: July 9, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi