Reviewed,
UniProtKB/Swiss-Prot Q62233 (SIX3_MOUSE)
Last modified
March 24, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homeobox protein SIX3 Alternative name(s): Sine oculis homeobox homolog 3 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 333 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May be involved in visual system development. |
| Subcellular location | |
| Developmental stage | First expressed at E6.5 of embryo development around the anterior border. At E8.5, expression is found over the anterior neural plate. At E9.5, in the diencephalic part of the ventral forebrain, optic vesicles, olfactory placodes and Rathke pouch. In later stages, present in hypothalamus, eyes and pituitary. |
| Sequence similarities | Belongs to the SIX/Sine oculis homeobox family. Contains 1 homeobox DNA-binding domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform SIX3B (identifier: Q62233-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform SIX3A (identifier: Q62233-2) The sequence of this isoform differs from the canonical sequence as follows: 271-286: LQHQAIGPSGMRSLAE → SVAGTAARPPQA 287-333: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 333 | 333 | Homeobox protein SIX3 | PRO_0000049300 | |||||
Regions | |||||||||
| DNA binding | 207 – 266 | 60 | Homeobox | ||||||
| Compositional bias | 33 – 70 | 38 | Gly-rich | ||||||
| Compositional bias | 264 – 267 | 4 | Poly-Ala | ||||||
Natural variations | |||||||||
| Alternative sequence | 271 – 286 | 16 | LQHQA…RSLAE → SVAGTAARPPQA in isoform SIX3A. | VSP_002291 | |||||
| Alternative sequence | 287 – 333 | 47 | Missing in isoform SIX3A. | VSP_002292 | |||||
Experimental info | |||||||||
| Sequence conflict | 44 | 1 | G → GG Ref.1 | ||||||
| Sequence conflict | 118 – 119 | 2 | VA → WP in CAA62379. Ref.1 | ||||||
| Sequence conflict | 278 – 333 | 56 | PSGMR…SECDV → ERDALPGRARLPHARLSRVT VHGGQPDHQCVQPDGARGHR HFDPLGNLQRLGM Ref.1 | ||||||
Sequences
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References
| [1] | "Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development." Oliver G., Mailhos A., Wehr R., Copeland N.G., Jenkins N.A., Gruss P. Development 121:4045-4055(1995) [PubMed: 8575305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Embryonic brain. |
| [2] | "Identification and expression of Six family genes in mouse retina." Kawakami K., Ohto H., Takizawa T., Saito T. FEBS Lett. 393:259-263(1996) [PubMed: 8814301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X90871 mRNA. Translation: CAA62379.1. Different initiation. D83144 mRNA. Translation: BAA11822.1. D83145 mRNA. Translation: BAA11823.1. | |
| IPI | IPI00123350. IPI00230578. |
| PIR | S74255. |
| RefSeq | NP_035511.2. |
| UniGene | Mm.370208 Mm.391586 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DU6 based on UniProtKB P41778. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000038805. Mus musculus. [Contig view] |
| GeneID | 20473. |
| KEGG | mmu:20473. |
Organism-specific databases | |
| MGI | MGI:102764. Six3. |
Phylogenomic databases | |
| HOVERGEN | Q62233. |
Gene expression databases | |
| ArrayExpress | Q62233. |
| Bgee | Q62233. |
| GermOnline | ENSMUSG00000038805. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 298587. |
| SOURCE | Search... |
Entry information
| Entry name | SIX3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62233 Secondary accession number(s): P70176, P70177 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


