Reviewed,
UniProtKB/Swiss-Prot Q62232 (SIX2_MOUSE)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homeobox protein SIX2 Alternative name(s): Sine oculis homeobox homolog 2 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 296 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May be involved in limb tendon and ligament development. |
| Subcellular location | |
| Tissue specificity | Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme. |
| Developmental stage | First expressed at E8.5 of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at E11 and is more pronounced ventrally. It progresses into the developing phalanges at E12.5. |
| Sequence similarities | Belongs to the SIX/Sine oculis homeobox family. Contains 1 homeobox DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| Gene Ontology (GO) | |
| Biological process | embryonic skeletal system morphogenesis Inferred from genetic interaction. Source: MGI metanephros developmentInferred from mutant phenotype. Source: MGI middle ear morphogenesisInferred from genetic interaction. Source: MGI negative regulation of cell differentiationInferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoterInferred from direct assay. Source: MGI protein import into nucleusInferred from direct assay. Source: MGI |
| Cellular component | nucleus Ref.2 Inferred from direct assay. Source: MGI |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Ref.2Inferred from direct assay. Source: MGI transcription factor activityInferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Homeobox genes and connective tissue patterning." Oliver G., Wehr R., Jenkins N.A., Copeland N.G., Cheyette B.N.R., Hartenstein V., Zipursky S.L., Gruss P. Development 121:693-705(1995) [PubMed: 7720577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Embryo. |
| [2] | "Identification and expression of Six family genes in mouse retina." Kawakami K., Ohto H., Takizawa T., Saito T. FEBS Lett. 393:259-263(1996) [PubMed: 8814301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X80338 mRNA. Translation: CAA56584.1. Different initiation. D83147 mRNA. Translation: BAA11825.1. BC068021 mRNA. Translation: AAH68021.1. | |
| IPI | IPI00123346. |
| PIR | S74253. |
| RefSeq | NP_035510.1. XP_990400.1. |
| UniGene | Mm.5039 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1B72 based on UniProtKB P40424. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q62232. 1 interaction. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000024134. Mus musculus. [Contig view] |
| GeneID | 20472. 675809. |
| KEGG | mmu:20472. mmu:675809. |
Organism-specific databases | |
| MGI | MGI:102778. Six2. |
Phylogenomic databases | |
| HOGENOM | Q62232. |
| HOVERGEN | Q62232. |
| OMA | Q62232. HSLGHPQ. |
Gene expression databases | |
| ArrayExpress | Q62232. |
| Bgee | Q62232. |
| GermOnline | ENSMUSG00000024134. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 298583. |
| SOURCE | Search... |
Entry information
| Entry name | SIX2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q62232 Secondary accession number(s): P70179 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


