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Q62232

- SIX2_MOUSE

UniProt

Q62232 - SIX2_MOUSE

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Protein
Homeobox protein SIX2
Gene
Six2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in limb tendon and ligament development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 18360Homeobox
Add
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein complex binding Source: UniProtKB
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cell proliferation Source: MGI
  2. chondrocyte differentiation Source: MGI
  3. embryonic cranial skeleton morphogenesis Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  6. mesodermal cell fate specification Source: UniProtKB
  7. metanephros development Source: MGI
  8. middle ear morphogenesis Source: MGI
  9. negative regulation of cell differentiation Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  11. protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX2
Alternative name(s):
Sine oculis homeobox homolog 2
Gene namesi
Name:Six2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:102778. Six2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Homeobox protein SIX2
PRO_0000049298Add
BLAST

Proteomic databases

PRIDEiQ62232.

PTM databases

PhosphoSiteiQ62232.

Expressioni

Tissue specificityi

Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.

Developmental stagei

First expressed at E8.5 of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at E11 and is more pronounced ventrally. It progresses into the developing phalanges at E12.5.

Gene expression databases

BgeeiQ62232.
GenevestigatoriQ62232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Eya1P977673EBI-1368736,EBI-1368503

Protein-protein interaction databases

BioGridi203260. 1 interaction.
IntActiQ62232. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ62232.
SMRiQ62232. Positions 1-185.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG289502.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000261680.
HOVERGENiHBG003609.
InParanoidiQ62232.
OMAiANSNSHN.
OrthoDBiEOG7C5M8Z.
PhylomeDBiQ62232.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62232-1 [UniParc]FASTAAdd to Basket

« Hide

MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL    50
KAKAVVAFHR GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG 100
RPLGAVGKYR VRRKFPLPRS IWDGEETSYC FKEKSRSVLR EWYAHNPYPS 150
PREKRELAEA TGLTTTQVSN WFKNRRQRDR AAEAKERENS ENSNSSSHNP 200
LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP PPPGLPSLHS 250
LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS 296
Length:296
Mass (Da):32,718
Last modified:July 15, 1998 - v2
Checksum:i0FFAB002014D8E60
GO

Sequence cautioni

The sequence CAA56584.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 66MSMLPT → HVHARH in CAA56584. 1 Publication
Sequence conflicti105 – 1051A → R in CAA56584. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80338 mRNA. Translation: CAA56584.1. Different initiation.
D83147 mRNA. Translation: BAA11825.1.
BC068021 mRNA. Translation: AAH68021.1.
CCDSiCCDS29007.1.
PIRiS74253.
RefSeqiNP_035510.1. NM_011380.2.
UniGeneiMm.5039.

Genome annotation databases

EnsembliENSMUST00000024947; ENSMUSP00000024947; ENSMUSG00000024134.
ENSMUST00000163568; ENSMUSP00000125871; ENSMUSG00000024134.
GeneIDi20472.
KEGGimmu:20472.
UCSCiuc008duc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80338 mRNA. Translation: CAA56584.1 . Different initiation.
D83147 mRNA. Translation: BAA11825.1 .
BC068021 mRNA. Translation: AAH68021.1 .
CCDSi CCDS29007.1.
PIRi S74253.
RefSeqi NP_035510.1. NM_011380.2.
UniGenei Mm.5039.

3D structure databases

ProteinModelPortali Q62232.
SMRi Q62232. Positions 1-185.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203260. 1 interaction.
IntActi Q62232. 1 interaction.

PTM databases

PhosphoSitei Q62232.

Proteomic databases

PRIDEi Q62232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024947 ; ENSMUSP00000024947 ; ENSMUSG00000024134 .
ENSMUST00000163568 ; ENSMUSP00000125871 ; ENSMUSG00000024134 .
GeneIDi 20472.
KEGGi mmu:20472.
UCSCi uc008duc.2. mouse.

Organism-specific databases

CTDi 10736.
MGIi MGI:102778. Six2.

Phylogenomic databases

eggNOGi NOG289502.
GeneTreei ENSGT00540000070251.
HOGENOMi HOG000261680.
HOVERGENi HBG003609.
InParanoidi Q62232.
OMAi ANSNSHN.
OrthoDBi EOG7C5M8Z.
PhylomeDBi Q62232.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298583.
PROi Q62232.
SOURCEi Search...

Gene expression databases

Bgeei Q62232.
Genevestigatori Q62232.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homeobox genes and connective tissue patterning."
    Oliver G., Wehr R., Jenkins N.A., Copeland N.G., Cheyette B.N.R., Hartenstein V., Zipursky S.L., Gruss P.
    Development 121:693-705(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSIX2_MOUSE
AccessioniPrimary (citable) accession number: Q62232
Secondary accession number(s): P70179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi