Homeobox protein SIX2 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

Q62232 (SIX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Homeobox protein SIX2

Alternative name(s):
Sine oculis homeobox homolog 2

Gene names

Name:

Six2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in limb tendon and ligament development.
Subcellular location	Nucleus.
Tissue specificity	Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.
Developmental stage	First expressed at E8.5 of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at E11 and is more pronounced ventrally. It progresses into the developing phalanges at E12.5.
Sequence similarities	Belongs to the SIX/Sine oculis homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence CAA56584.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Inferred from mutant phenotype. Source: MGI chondrocyte differentiation Inferred from mutant phenotype. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype. Source: MGI mesenchymal to epithelial transition involved in metanephros morphogenesis Inferred from expression pattern. Source: UniProtKB mesodermal cell fate specification Inferred from direct assay. Source: UniProtKB middle ear morphogenesis Inferred from genetic interaction. Source: MGI negative regulation of cell differentiation Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: MGI protein import into nucleus Inferred from direct assay. Source: MGI
Cellular component	nucleus Inferred from direct assay Ref.2. Source: MGI
Molecular function	protein complex binding Inferred from direct assay. Source: UniProtKB sequence-specific DNA binding Inferred from direct assay Ref.2. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Eya1	P97767	2	EBI-1368736,EBI-1368503

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 296

296

Homeobox protein SIX2

PRO_0000049298

Regions

DNA binding

124 – 183

Homeobox

Experimental info

Sequence conflict

1 – 6

MSMLPT → HVHARH in CAA56584. Ref.1

Sequence conflict

105

A → R in CAA56584. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q62232 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 0FFAB002014D8E60
Show »

FASTA

296

32,718

        10         20         30         40         50         60 
MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR 

        70         80         90        100        110        120 
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 

       130        140        150        160        170        180 
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 

       190        200        210        220        230        240 
AAEAKERENS ENSNSSSHNP LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP 

       250        260        270        280        290 
PPPGLPSLHS LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homeobox genes and connective tissue patterning." Oliver G., Wehr R., Jenkins N.A., Copeland N.G., Cheyette B.N.R., Hartenstein V., Zipursky S.L., Gruss P. Development 121:693-705(1995) [PubMed: 7720577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Embryo.
[2]	"Identification and expression of Six family genes in mouse retina." Kawakami K., Ohto H., Takizawa T., Saito T. FEBS Lett. 393:259-263(1996) [PubMed: 8814301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80338 mRNA. Translation: CAA56584.1. Different initiation. D83147 mRNA. Translation: BAA11825.1. BC068021 mRNA. Translation: AAH68021.1.
IPI	IPI00123346.
PIR	S74253.
RefSeq	NP_035510.1. NM_011380.2.
UniGene	Mm.5039.
3D structure databases
ProteinModelPortal	Q62232.
SMR	Q62232. Positions 25-186.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62232. 1 interaction.
STRING	Q62232.
PTM databases
PhosphoSite	Q62232.
Proteomic databases
PRIDE	Q62232.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000024947; ENSMUSP00000024947; ENSMUSG00000024134. ENSMUST00000163568; ENSMUSP00000125871; ENSMUSG00000024134.
GeneID	20472.
KEGG	mmu:20472.
Organism-specific databases
CTD	10736.
MGI	MGI:102778. Six2.
Phylogenomic databases
eggNOG	maNOG06745.
GeneTree	ENSGT00540000070251.
HOGENOM	HBG443955.
HOVERGEN	HBG003609.
InParanoid	Q62232.
OMA	SSNSHNP.
OrthoDB	EOG4RJG27.
Gene expression databases
ArrayExpress	Q62232.
Bgee	Q62232.
Genevestigator	Q62232.
GermOnline	ENSMUSG00000024134. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	298583.
SOURCE	Search...

Entry information

Entry name

SIX2_MOUSE

Accession

Primary (citable) accession number: Q62232
Secondary accession number(s): P70179

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	September 21, 2011
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents