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Q62232

- SIX2_MOUSE

UniProt

Q62232 - SIX2_MOUSE

Protein

Homeobox protein SIX2

Gene

Six2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    May be involved in limb tendon and ligament development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi124 – 18360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein complex binding Source: UniProtKB
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: UniProtKB
    2. cell proliferation Source: MGI
    3. chondrocyte differentiation Source: MGI
    4. embryonic cranial skeleton morphogenesis Source: MGI
    5. embryonic digestive tract morphogenesis Source: UniProtKB
    6. embryonic skeletal system morphogenesis Source: MGI
    7. kidney development Source: UniProtKB
    8. mesenchymal cell differentiation involved in kidney development Source: UniProtKB
    9. mesenchymal stem cell maintenance involved in nephron morphogenesis Source: UniProtKB
    10. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    11. mesodermal cell fate specification Source: UniProtKB
    12. metanephros development Source: MGI
    13. middle ear morphogenesis Source: MGI
    14. negative regulation of cell differentiation Source: MGI
    15. nephron morphogenesis Source: UniProtKB
    16. positive regulation of chondrocyte proliferation Source: UniProtKB
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. protein import into nucleus Source: MGI
    19. regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    20. regulation of chondrocyte differentiation Source: UniProtKB
    21. regulation of ossification Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein SIX2
    Alternative name(s):
    Sine oculis homeobox homolog 2
    Gene namesi
    Name:Six2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:102778. Six2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Homeobox protein SIX2PRO_0000049298Add
    BLAST

    Proteomic databases

    PRIDEiQ62232.

    PTM databases

    PhosphoSiteiQ62232.

    Expressioni

    Tissue specificityi

    Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.

    Developmental stagei

    First expressed at E8.5 of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at E11 and is more pronounced ventrally. It progresses into the developing phalanges at E12.5.

    Gene expression databases

    BgeeiQ62232.
    GenevestigatoriQ62232.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Eya1P977673EBI-1368736,EBI-1368503

    Protein-protein interaction databases

    BioGridi203260. 1 interaction.
    IntActiQ62232. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62232.
    SMRiQ62232. Positions 1-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SIX/Sine oculis homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289502.
    GeneTreeiENSGT00540000070251.
    HOGENOMiHOG000261680.
    HOVERGENiHBG003609.
    InParanoidiQ62232.
    OMAiANSNSHN.
    OrthoDBiEOG7C5M8Z.
    PhylomeDBiQ62232.
    TreeFamiTF315545.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62232-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL    50
    KAKAVVAFHR GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG 100
    RPLGAVGKYR VRRKFPLPRS IWDGEETSYC FKEKSRSVLR EWYAHNPYPS 150
    PREKRELAEA TGLTTTQVSN WFKNRRQRDR AAEAKERENS ENSNSSSHNP 200
    LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP PPPGLPSLHS 250
    LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS 296
    Length:296
    Mass (Da):32,718
    Last modified:July 15, 1998 - v2
    Checksum:i0FFAB002014D8E60
    GO

    Sequence cautioni

    The sequence CAA56584.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 66MSMLPT → HVHARH in CAA56584. (PubMed:7720577)Curated
    Sequence conflicti105 – 1051A → R in CAA56584. (PubMed:7720577)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80338 mRNA. Translation: CAA56584.1. Different initiation.
    D83147 mRNA. Translation: BAA11825.1.
    BC068021 mRNA. Translation: AAH68021.1.
    CCDSiCCDS29007.1.
    PIRiS74253.
    RefSeqiNP_035510.1. NM_011380.2.
    UniGeneiMm.5039.

    Genome annotation databases

    EnsembliENSMUST00000024947; ENSMUSP00000024947; ENSMUSG00000024134.
    ENSMUST00000163568; ENSMUSP00000125871; ENSMUSG00000024134.
    GeneIDi20472.
    KEGGimmu:20472.
    UCSCiuc008duc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80338 mRNA. Translation: CAA56584.1 . Different initiation.
    D83147 mRNA. Translation: BAA11825.1 .
    BC068021 mRNA. Translation: AAH68021.1 .
    CCDSi CCDS29007.1.
    PIRi S74253.
    RefSeqi NP_035510.1. NM_011380.2.
    UniGenei Mm.5039.

    3D structure databases

    ProteinModelPortali Q62232.
    SMRi Q62232. Positions 1-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203260. 1 interaction.
    IntActi Q62232. 1 interaction.

    PTM databases

    PhosphoSitei Q62232.

    Proteomic databases

    PRIDEi Q62232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024947 ; ENSMUSP00000024947 ; ENSMUSG00000024134 .
    ENSMUST00000163568 ; ENSMUSP00000125871 ; ENSMUSG00000024134 .
    GeneIDi 20472.
    KEGGi mmu:20472.
    UCSCi uc008duc.2. mouse.

    Organism-specific databases

    CTDi 10736.
    MGIi MGI:102778. Six2.

    Phylogenomic databases

    eggNOGi NOG289502.
    GeneTreei ENSGT00540000070251.
    HOGENOMi HOG000261680.
    HOVERGENi HBG003609.
    InParanoidi Q62232.
    OMAi ANSNSHN.
    OrthoDBi EOG7C5M8Z.
    PhylomeDBi Q62232.
    TreeFami TF315545.

    Miscellaneous databases

    NextBioi 298583.
    PROi Q62232.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62232.
    Genevestigatori Q62232.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homeobox genes and connective tissue patterning."
      Oliver G., Wehr R., Jenkins N.A., Copeland N.G., Cheyette B.N.R., Hartenstein V., Zipursky S.L., Gruss P.
      Development 121:693-705(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "Identification and expression of Six family genes in mouse retina."
      Kawakami K., Ohto H., Takizawa T., Saito T.
      FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiSIX2_MOUSE
    AccessioniPrimary (citable) accession number: Q62232
    Secondary accession number(s): P70179
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3