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Q62232 (SIX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein SIX2
Alternative name(s):
Sine oculis homeobox homolog 2
Gene names
Name:Six2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in limb tendon and ligament development.

Subcellular location

Nucleus.

Tissue specificity

Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.

Developmental stage

First expressed at E8.5 of embryo development in a restricted mesodermal subpopulation at the anterior hindbrain level. Expression of SIX2 in the developing limb begins at E11 and is more pronounced ventrally. It progresses into the developing phalanges at E12.5.

Sequence similarities

Belongs to the SIX/Sine oculis homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence CAA56584.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Inferred from mutant phenotype PubMed 20515681. Source: MGI

chondrocyte differentiation

Inferred from mutant phenotype PubMed 20515681. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 20515681. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 15634706. Source: MGI

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from expression pattern PubMed 10322633. Source: UniProtKB

mesodermal cell fate specification

Inferred from direct assay PubMed 17785448. Source: UniProtKB

metanephros development

Inferred from mutant phenotype PubMed 17036046. Source: MGI

middle ear morphogenesis

Inferred from genetic interaction PubMed 15634706. Source: MGI

negative regulation of cell differentiation

Inferred from mutant phenotype PubMed 17036046. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15327782. Source: MGI

protein import into nucleus

Inferred from direct assay PubMed 16024294. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 15327782Ref.2. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 11734542PubMed 20956555. Source: IntAct

protein complex binding

Inferred from direct assay PubMed 17785448. Source: UniProtKB

sequence-specific DNA binding

Inferred from direct assay PubMed 15327782Ref.2. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15327782. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Eya1P977673EBI-1368736,EBI-1368503

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Homeobox protein SIX2
PRO_0000049298

Regions

DNA binding124 – 18360Homeobox

Experimental info

Sequence conflict1 – 66MSMLPT → HVHARH in CAA56584. Ref.1
Sequence conflict1051A → R in CAA56584. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q62232 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 0FFAB002014D8E60

FASTA29632,718
        10         20         30         40         50         60 
MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR 

        70         80         90        100        110        120 
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 

       130        140        150        160        170        180 
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 

       190        200        210        220        230        240 
AAEAKERENS ENSNSSSHNP LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP 

       250        260        270        280        290 
PPPGLPSLHS LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS 

« Hide

References

« Hide 'large scale' references
[1]"Homeobox genes and connective tissue patterning."
Oliver G., Wehr R., Jenkins N.A., Copeland N.G., Cheyette B.N.R., Hartenstein V., Zipursky S.L., Gruss P.
Development 121:693-705(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[2]"Identification and expression of Six family genes in mouse retina."
Kawakami K., Ohto H., Takizawa T., Saito T.
FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80338 mRNA. Translation: CAA56584.1. Different initiation.
D83147 mRNA. Translation: BAA11825.1.
BC068021 mRNA. Translation: AAH68021.1.
CCDSCCDS29007.1.
PIRS74253.
RefSeqNP_035510.1. NM_011380.2.
UniGeneMm.5039.

3D structure databases

ProteinModelPortalQ62232.
SMRQ62232. Positions 1-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203260. 1 interaction.
IntActQ62232. 1 interaction.

PTM databases

PhosphoSiteQ62232.

Proteomic databases

PRIDEQ62232.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024947; ENSMUSP00000024947; ENSMUSG00000024134.
ENSMUST00000163568; ENSMUSP00000125871; ENSMUSG00000024134.
GeneID20472.
KEGGmmu:20472.
UCSCuc008duc.2. mouse.

Organism-specific databases

CTD10736.
MGIMGI:102778. Six2.

Phylogenomic databases

eggNOGNOG289502.
GeneTreeENSGT00540000070251.
HOGENOMHOG000261680.
HOVERGENHBG003609.
InParanoidQ62232.
OMAANSNSHN.
OrthoDBEOG7C5M8Z.
PhylomeDBQ62232.
TreeFamTF315545.

Gene expression databases

BgeeQ62232.
GenevestigatorQ62232.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298583.
PROQ62232.
SOURCESearch...

Entry information

Entry nameSIX2_MOUSE
AccessionPrimary (citable) accession number: Q62232
Secondary accession number(s): P70179
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot