Sodium channel protein type 9 subunit alpha - Scn9a

Sequence or UniProt identifier

>sp|Q62205|SCN9A_MOUSE Sodium channel protein type 9 subunit alpha OS=Mus musculus GN=Scn9a PE=1 SV=2 MAMLPPPGPQSFVHFTKQSLALIEQRISEEKAKGHKDEKKDDEEEGPKPSSDLEAGKQLP FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISI KILVHSLFSMLIMCTILTNCIFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCVGE FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQNETLESIMSTAESEEELK RYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTSFDTFGWAFLALFRLMTQ DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE LEFQQMLDRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRR KKKKQKLSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRAREKRLSTPNQSPLSIRG SLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSN ISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTT NQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTF LIWNCSPYWIKFKKFIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTDEFKNVLAVGNL VFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLR VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINE NCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVLN LFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGS KDTKRTADPNNKRENYISNRTLAEISKDHNFLKEKDKISGFSSSLDKSFMDENDYQSFIH NPSLTVTVPIAPGESDLENMNTEELSSDSDSDYSKERRNRSSSSECSTVDNPLPGEEEAE AEPINADEPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMI LLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLD FLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIM NVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRW KNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFII FGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGN KFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTGEC VLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILR LIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFE TFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVS YIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKL SDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQ MEERFMSANPSKVSYEPITTTLKRKQEDVSATIIQRAYRRYRLRQNVKNISSIYIKDGDR DDDLPNKEDIVFDNVNENSSPEKTDATASTISPPSYDSVTKPDQEKYETDKTEKEDKEKD ESRK

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Q62205 (SCN9A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium channel protein type 9 subunit alpha

Alternative name(s):
Peripheral sodium channel 1
Short name=PN1
Sodium channel protein type IX subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.7

Gene names

Name:	Scn9a
Synonyms:	Kiaa4197

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1984 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in pain mechanisms, especially in the development of inflammatory pain. Ref.5
Subunit structure	Interacts with NEDD4 and NEDD4L. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Post-translational modification	Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. Ref.4 Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.
Sequence similarities	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. [View classification] Contains 1 IQ domain.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	Sodium
Molecular function	Ion channel Sodium channel Voltage-gated channel
PTM	Glycoprotein Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to pain Inferred from mutant phenotype Ref.5. Source: MGI inflammatory response Inferred from mutant phenotype Ref.5. Source: MGI post-embryonic development Inferred from mutant phenotype Ref.5. Source: MGI response to toxic substance Inferred from direct assay PubMed 16029194. Source: MGI
Cellular_component	voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1984

1984

Sodium channel protein type 9 subunit alpha

PRO_0000048503

Regions

Transmembrane

122 – 145

Helical; Name=S1 of repeat I; Potential

Transmembrane

154 – 173

Helical; Name=S2 of repeat I; Potential

Transmembrane

187 – 205

Helical; Name=S3 of repeat I; Potential

Transmembrane

212 – 231

Helical; Voltage-sensor; Name=S4 of repeat I; Potential

Transmembrane

248 – 271

Helical; Name=S5 of repeat I; Potential

Transmembrane

379 – 404

Helical; Name=S6 of repeat I; Potential

Transmembrane

738 – 762

Helical; Name=S1 of repeat II; Potential

Transmembrane

774 – 797

Helical; Name=S2 of repeat II; Potential

Transmembrane

806 – 825

Helical; Name=S3 of repeat II; Potential

Transmembrane

832 – 851

Helical; Voltage-sensor; Name=S4 of repeat II; Potential

Transmembrane

868 – 888

Helical; Name=S5 of repeat II; Potential

Transmembrane

942 – 967

Helical; Name=S6 of repeat II; Potential

Transmembrane

1186 – 1209

Helical; Name=S1 of repeat III; Potential

Transmembrane

1223 – 1248

Helical; Name=S2 of repeat III; Potential

Transmembrane

1255 – 1276

Helical; Name=S3 of repeat III; Potential

Transmembrane

1281 – 1302

Helical; Voltage-sensor; Name=S4 of repeat III; Potential

Transmembrane

1322 – 1349

Helical; Name=S5 of repeat III; Potential

Transmembrane

1429 – 1455

Helical; Name=S6 of repeat III; Potential

Transmembrane

1509 – 1532

Helical; Name=S1 of repeat IV; Potential

Transmembrane

1544 – 1567

Helical; Name=S2 of repeat IV; Potential

Transmembrane

1574 – 1597

Helical; Name=S3 of repeat IV; Potential

Transmembrane

1608 – 1629

Helical; Voltage-sensor; Name=S4 of repeat IV; Potential

Transmembrane

1645 – 1667

Helical; Name=S5 of repeat IV; Potential

Transmembrane

1734 – 1758

Helical; Name=S6 of repeat IV; Potential

Repeat

121 – 405

285

Repeat

737 – 968

232

Repeat

1185 – 1456

272

III

Repeat

1508 – 1759

252

Domain

1887 – 1916

Coiled coil

402 – 449

Potential

Coiled coil

684 – 708

Potential

Amino acid modifications

Modified residue

1488

Phosphoserine; by PKC By similarity

Glycosylation

867

N-linked (GlcNAc...) Potential

Glycosylation

974

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q62205 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 51A8DBA38EC7EF38
Show »

FASTA

1,984

225,813

        10         20         30         40         50         60 
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS SDLEAGKQLP 

        70         80         90        100        110        120 
FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 

       130        140        150        160        170        180 
KILVHSLFSM LIMCTILTNC IFMTMSNPPD WTKNVEYTFT GIYTFESLIK ILARGFCVGE 

       190        200        210        220        230        240 
FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 

       250        260        270        280        290        300 
SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 

       310        320        330        340        350        360 
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA FLALFRLMTQ 

       370        380        390        400        410        420 
DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE 

       430        440        450        460        470        480 
LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL GRSRIMGLSE SSSETSRLSS KSAKERRNRR 

       490        500        510        520        530        540 
KKKKQKLSSG EEKGDDEKLS KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG 

       550        560        570        580        590        600 
SLFSARRSSR TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 

       610        620        630        640        650        660 
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID KATSDDSGTT 

       670        680        690        700        710        720 
NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHTF 

       730        740        750        760        770        780 
LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL 

       790        800        810        820        830        840 
VFTGIFAAEM VLKLIAMDPY EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR 

       850        860        870        880        890        900 
VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE 

       910        920        930        940        950        960 
NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV MVIGNLVVLN 

       970        980        990       1000       1010       1020 
LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY VKQTLREFIL KSFSKKPKGS 

      1030       1040       1050       1060       1070       1080 
KDTKRTADPN NKRENYISNR TLAEISKDHN FLKEKDKISG FSSSLDKSFM DENDYQSFIH 

      1090       1100       1110       1120       1130       1140 
NPSLTVTVPI APGESDLENM NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE 

      1150       1160       1170       1180       1190       1200 
AEPINADEPE ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 

      1210       1220       1230       1240       1250       1260 
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT YFTNAWCWLD 

      1270       1280       1290       1300       1310       1320 
FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS RFEGMRVVVN ALIGAIPSIM 

      1330       1340       1350       1360       1370       1380 
NVLLVCLIFW LIFSIMGVNL FAGKFYECVN TTDGSRFSVS QVANRSECFA LMNVSGNVRW 

      1390       1400       1410       1420       1430       1440 
KNLKVNFDNV GLGYLSLLQV ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII 

      1450       1460       1470       1480       1490       1500 
FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 

      1510       1520       1530       1540       1550       1560 
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV VFIILFTGEC 

      1570       1580       1590       1600       1610       1620 
VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY FVSPTLFRVI RLARIGRILR 

      1630       1640       1650       1660       1670       1680 
LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKKE AGINDMFNFE 

      1690       1700       1710       1720       1730       1740 
TFGNSMICLF QITTSAGWDG LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS 

      1750       1760       1770       1780       1790       1800 
YIIISFLVVV NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 

      1810       1820       1830       1840       1850       1860 
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE SGEMDSLRSQ 

      1870       1880       1890       1900       1910       1920 
MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR YRLRQNVKNI SSIYIKDGDR 

      1930       1940       1950       1960       1970       1980 
DDDLPNKEDI VFDNVNENSS PEKTDATAST ISPPSYDSVT KPDQEKYETD KTEKEDKEKD 


ESRK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Mouse sodium channel 25 in m13mp19." Jover E., Shah V. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1675-1983. Tissue: Brain.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1740-1983. Tissue: Fetal brain.
[4]	"Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2." Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S. J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NEDD4 AND NEDD4L, UBIQUITINATION.
[5]	"Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain." Nassar M.A., Stirling L.C., Forlani G., Baker M.D., Matthews E.A., Dickenson A.H., Wood J.N. Proc. Natl. Acad. Sci. U.S.A. 101:12706-12711(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN INFLAMMATORY PAIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL928623, AL928726 Genomic DNA. Translation: CAM19365.1. AL928726, AL928623 Genomic DNA. Translation: CAM23210.1. L42338 mRNA. Translation: AAA67106.1. AK220540 mRNA. Translation: BAD90315.1.
RefSeq	XP_006499095.1. XM_006499032.1.
UniGene	Mm.440889.
3D structure databases
ProteinModelPortal	Q62205.
SMR	Q62205. Positions 116-413, 753-967, 1186-1463, 1506-1914.
ModBase	Search...
MobiDB	Search...
PTM databases
PhosphoSite	Q62205.
Proteomic databases
PaxDb	Q62205.
PRIDE	Q62205.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316. ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316.
GeneID	20274.
UCSC	uc008jxe.2. mouse.
Organism-specific databases
MGI	MGI:107636. Scn9a.
Rouge	Search...
Phylogenomic databases
eggNOG	COG1226.
GeneTree	ENSGT00560000076721.
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
InParanoid	Q62205.
OMA	LMNVSQN.
OrthoDB	EOG7DJSK9.
PhylomeDB	Q62205.
TreeFam	TF323985.
Gene expression databases
Bgee	Q62205.
CleanEx	MM_SCN9A.
Genevestigator	Q62205.
Family and domain databases
Gene3D	1.20.120.350. 4 hits.
InterPro	IPR027359. Channel_four-helix_dom. IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. IPR028803. SCN9A. [Graphical view]
PANTHER	PTHR10037:SF28. PTHR10037:SF28. 1 hit.
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL.
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
PRO	Q62205.
SOURCE	Search...

Entry information

Entry name

SCN9A_MOUSE

Accession

Primary (citable) accession number: Q62205
Secondary accession number(s): A2ASI7, Q5DTI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	January 9, 2007
Last modified:	April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents