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Q62205 (SCN9A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium channel protein type 9 subunit alpha
Alternative name(s):
Peripheral sodium channel 1
Short name=PN1
Sodium channel protein type IX subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.7
Gene names
Name:Scn9a
Synonyms:Kiaa4197
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1984 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in pain mechanisms, especially in the development of inflammatory pain. Ref.5

Subunit structure

Interacts with NEDD4 and NEDD4L. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4. Ref.4

Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. [View classification]

Contains 1 IQ domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19841984Sodium channel protein type 9 subunit alpha
PRO_0000048503

Regions

Transmembrane122 – 14524Helical; Name=S1 of repeat I; Potential
Transmembrane154 – 17320Helical; Name=S2 of repeat I; Potential
Transmembrane187 – 20519Helical; Name=S3 of repeat I; Potential
Transmembrane212 – 23120Helical; Voltage-sensor; Name=S4 of repeat I; Potential
Transmembrane248 – 27124Helical; Name=S5 of repeat I; Potential
Transmembrane379 – 40426Helical; Name=S6 of repeat I; Potential
Transmembrane738 – 76225Helical; Name=S1 of repeat II; Potential
Transmembrane774 – 79724Helical; Name=S2 of repeat II; Potential
Transmembrane806 – 82520Helical; Name=S3 of repeat II; Potential
Transmembrane832 – 85120Helical; Voltage-sensor; Name=S4 of repeat II; Potential
Transmembrane868 – 88821Helical; Name=S5 of repeat II; Potential
Transmembrane942 – 96726Helical; Name=S6 of repeat II; Potential
Transmembrane1186 – 120924Helical; Name=S1 of repeat III; Potential
Transmembrane1223 – 124826Helical; Name=S2 of repeat III; Potential
Transmembrane1255 – 127622Helical; Name=S3 of repeat III; Potential
Transmembrane1281 – 130222Helical; Voltage-sensor; Name=S4 of repeat III; Potential
Transmembrane1322 – 134928Helical; Name=S5 of repeat III; Potential
Transmembrane1429 – 145527Helical; Name=S6 of repeat III; Potential
Transmembrane1509 – 153224Helical; Name=S1 of repeat IV; Potential
Transmembrane1544 – 156724Helical; Name=S2 of repeat IV; Potential
Transmembrane1574 – 159724Helical; Name=S3 of repeat IV; Potential
Transmembrane1608 – 162922Helical; Voltage-sensor; Name=S4 of repeat IV; Potential
Transmembrane1645 – 166723Helical; Name=S5 of repeat IV; Potential
Transmembrane1734 – 175825Helical; Name=S6 of repeat IV; Potential
Repeat121 – 405285I
Repeat737 – 968232II
Repeat1185 – 1456272III
Repeat1508 – 1759252IV
Domain1887 – 191630IQ
Coiled coil402 – 44948 Potential
Coiled coil684 – 70825 Potential

Amino acid modifications

Modified residue14881Phosphoserine; by PKC By similarity
Glycosylation8671N-linked (GlcNAc...) Potential
Glycosylation9741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q62205 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 51A8DBA38EC7EF38

FASTA1,984225,813
        10         20         30         40         50         60 
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS SDLEAGKQLP 

        70         80         90        100        110        120 
FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 

       130        140        150        160        170        180 
KILVHSLFSM LIMCTILTNC IFMTMSNPPD WTKNVEYTFT GIYTFESLIK ILARGFCVGE 

       190        200        210        220        230        240 
FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 

       250        260        270        280        290        300 
SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 

       310        320        330        340        350        360 
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA FLALFRLMTQ 

       370        380        390        400        410        420 
DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE 

       430        440        450        460        470        480 
LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL GRSRIMGLSE SSSETSRLSS KSAKERRNRR 

       490        500        510        520        530        540 
KKKKQKLSSG EEKGDDEKLS KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG 

       550        560        570        580        590        600 
SLFSARRSSR TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 

       610        620        630        640        650        660 
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID KATSDDSGTT 

       670        680        690        700        710        720 
NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHTF 

       730        740        750        760        770        780 
LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL 

       790        800        810        820        830        840 
VFTGIFAAEM VLKLIAMDPY EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR 

       850        860        870        880        890        900 
VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE 

       910        920        930        940        950        960 
NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV MVIGNLVVLN 

       970        980        990       1000       1010       1020 
LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY VKQTLREFIL KSFSKKPKGS 

      1030       1040       1050       1060       1070       1080 
KDTKRTADPN NKRENYISNR TLAEISKDHN FLKEKDKISG FSSSLDKSFM DENDYQSFIH 

      1090       1100       1110       1120       1130       1140 
NPSLTVTVPI APGESDLENM NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE 

      1150       1160       1170       1180       1190       1200 
AEPINADEPE ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 

      1210       1220       1230       1240       1250       1260 
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT YFTNAWCWLD 

      1270       1280       1290       1300       1310       1320 
FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS RFEGMRVVVN ALIGAIPSIM 

      1330       1340       1350       1360       1370       1380 
NVLLVCLIFW LIFSIMGVNL FAGKFYECVN TTDGSRFSVS QVANRSECFA LMNVSGNVRW 

      1390       1400       1410       1420       1430       1440 
KNLKVNFDNV GLGYLSLLQV ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII 

      1450       1460       1470       1480       1490       1500 
FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 

      1510       1520       1530       1540       1550       1560 
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV VFIILFTGEC 

      1570       1580       1590       1600       1610       1620 
VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY FVSPTLFRVI RLARIGRILR 

      1630       1640       1650       1660       1670       1680 
LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKKE AGINDMFNFE 

      1690       1700       1710       1720       1730       1740 
TFGNSMICLF QITTSAGWDG LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS 

      1750       1760       1770       1780       1790       1800 
YIIISFLVVV NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 

      1810       1820       1830       1840       1850       1860 
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE SGEMDSLRSQ 

      1870       1880       1890       1900       1910       1920 
MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR YRLRQNVKNI SSIYIKDGDR 

      1930       1940       1950       1960       1970       1980 
DDDLPNKEDI VFDNVNENSS PEKTDATAST ISPPSYDSVT KPDQEKYETD KTEKEDKEKD 


ESRK 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Mouse sodium channel 25 in m13mp19."
Jover E., Shah V.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1675-1983.
Tissue: Brain.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1740-1983.
Tissue: Fetal brain.
[4]"Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2."
Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S.
J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NEDD4 AND NEDD4L, UBIQUITINATION.
[5]"Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain."
Nassar M.A., Stirling L.C., Forlani G., Baker M.D., Matthews E.A., Dickenson A.H., Wood J.N.
Proc. Natl. Acad. Sci. U.S.A. 101:12706-12711(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN INFLAMMATORY PAIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL928623, AL928726 Genomic DNA. Translation: CAM19365.1.
AL928726, AL928623 Genomic DNA. Translation: CAM23210.1.
L42338 mRNA. Translation: AAA67106.1.
AK220540 mRNA. Translation: BAD90315.1.
RefSeqXP_006499095.1. XM_006499032.1.
UniGeneMm.440889.

3D structure databases

ProteinModelPortalQ62205.
SMRQ62205. Positions 116-413, 753-967, 1186-1463, 1506-1914.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62205.

Proteomic databases

PaxDbQ62205.
PRIDEQ62205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316.
ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316.
GeneID20274.
UCSCuc008jxe.2. mouse.

Organism-specific databases

MGIMGI:107636. Scn9a.
RougeSearch...

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00560000076721.
HOGENOMHOG000231755.
HOVERGENHBG053100.
InParanoidQ62205.
OMALMNVSQN.
OrthoDBEOG7DJSK9.
PhylomeDBQ62205.
TreeFamTF323985.

Gene expression databases

BgeeQ62205.
CleanExMM_SCN9A.
GenevestigatorQ62205.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSPR00170. NACHANNEL.
SMARTSM00015. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ62205.
SOURCESearch...

Entry information

Entry nameSCN9A_MOUSE
AccessionPrimary (citable) accession number: Q62205
Secondary accession number(s): A2ASI7, Q5DTI0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot