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Q62205

- SCN9A_MOUSE

UniProt

Q62205 - SCN9A_MOUSE

Protein

Sodium channel protein type 9 subunit alpha

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a role in pain mechanisms, especially in the development of inflammatory pain.1 Publication

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. behavioral response to pain Source: MGI
    2. inflammatory response Source: MGI
    3. membrane depolarization during action potential Source: RefGenome
    4. neuronal action potential Source: RefGenome
    5. post-embryonic development Source: MGI
    6. response to toxic substance Source: MGI
    7. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 9 subunit alpha
    Alternative name(s):
    Peripheral sodium channel 1
    Short name:
    PN1
    Sodium channel protein type IX subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.7
    Gene namesi
    Name:Scn9a
    Synonyms:Kiaa4197
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107636. Scn9a.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: RefGenome
    2. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19841984Sodium channel protein type 9 subunit alphaPRO_0000048503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi867 – 8671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi974 – 9741N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1488 – 14881Phosphoserine; by PKCBy similarity

    Post-translational modificationi

    Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.1 Publication
    Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ62205.
    PRIDEiQ62205.

    PTM databases

    PhosphoSiteiQ62205.

    Expressioni

    Gene expression databases

    BgeeiQ62205.
    CleanExiMM_SCN9A.
    GenevestigatoriQ62205.

    Interactioni

    Subunit structurei

    Interacts with NEDD4 and NEDD4L.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ62205.
    SMRiQ62205. Positions 128-267, 753-967, 1186-1456, 1506-1914.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei122 – 14524Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei154 – 17320Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei187 – 20519Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei212 – 23120Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei248 – 27124Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei379 – 40426Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei738 – 76225Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei774 – 79724Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei806 – 82520Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei832 – 85120Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei868 – 88821Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei942 – 96726Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1186 – 120924Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1223 – 124826Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1255 – 127622Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1281 – 130222Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1322 – 134928Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1429 – 145527Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1509 – 153224Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1544 – 156724Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1574 – 159724Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1608 – 162922Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1645 – 166723Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1734 – 175825Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati121 – 405285IAdd
    BLAST
    Repeati737 – 968232IIAdd
    BLAST
    Repeati1185 – 1456272IIIAdd
    BLAST
    Repeati1508 – 1759252IVAdd
    BLAST
    Domaini1887 – 191630IQAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili402 – 44948Sequence AnalysisAdd
    BLAST
    Coiled coili684 – 70825Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IQ domain.Curated

    Keywords - Domaini

    Coiled coil, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00560000076721.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    InParanoidiQ62205.
    OMAiLMNVSQN.
    OrthoDBiEOG7DJSK9.
    PhylomeDBiQ62205.
    TreeFamiTF323985.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view]
    PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
    SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
    NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
    WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
    LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
    LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 300
    RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA 350
    FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV 400
    VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL 450
    GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS 500
    KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR 550
    TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600
    ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID 650
    KATSDDSGTT NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE 700
    ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT 750
    ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL VFTGIFAAEM VLKLIAMDPY 800
    EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT 850
    LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE 900
    NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV 950
    MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY 1000
    VKQTLREFIL KSFSKKPKGS KDTKRTADPN NKRENYISNR TLAEISKDHN 1050
    FLKEKDKISG FSSSLDKSFM DENDYQSFIH NPSLTVTVPI APGESDLENM 1100
    NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE AEPINADEPE 1150
    ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 1200
    LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT 1250
    YFTNAWCWLD FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS 1300
    RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYECVN 1350
    TTDGSRFSVS QVANRSECFA LMNVSGNVRW KNLKVNFDNV GLGYLSLLQV 1400
    ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII FGSFFTLNLF 1450
    IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 1500
    KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV 1550
    VFIILFTGEC VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY 1600
    FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF 1650
    LVMFIYAIFG MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG 1700
    LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV 1750
    NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 1800
    SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE 1850
    SGEMDSLRSQ MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR 1900
    YRLRQNVKNI SSIYIKDGDR DDDLPNKEDI VFDNVNENSS PEKTDATAST 1950
    ISPPSYDSVT KPDQEKYETD KTEKEDKEKD ESRK 1984
    Length:1,984
    Mass (Da):225,813
    Last modified:January 9, 2007 - v2
    Checksum:i51A8DBA38EC7EF38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623, AL928726 Genomic DNA. Translation: CAM19365.1.
    AL928726, AL928623 Genomic DNA. Translation: CAM23210.1.
    L42338 mRNA. Translation: AAA67106.1.
    AK220540 mRNA. Translation: BAD90315.1.
    CCDSiCCDS71063.1.
    RefSeqiNP_001277603.1. NM_001290674.1.
    UniGeneiMm.440889.

    Genome annotation databases

    EnsembliENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316.
    ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316.
    GeneIDi20274.
    UCSCiuc008jxe.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623 , AL928726 Genomic DNA. Translation: CAM19365.1 .
    AL928726 , AL928623 Genomic DNA. Translation: CAM23210.1 .
    L42338 mRNA. Translation: AAA67106.1 .
    AK220540 mRNA. Translation: BAD90315.1 .
    CCDSi CCDS71063.1.
    RefSeqi NP_001277603.1. NM_001290674.1.
    UniGenei Mm.440889.

    3D structure databases

    ProteinModelPortali Q62205.
    SMRi Q62205. Positions 128-267, 753-967, 1186-1456, 1506-1914.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62205.

    Proteomic databases

    PaxDbi Q62205.
    PRIDEi Q62205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100064 ; ENSMUSP00000097642 ; ENSMUSG00000075316 .
    ENSMUST00000164384 ; ENSMUSP00000126528 ; ENSMUSG00000075316 .
    GeneIDi 20274.
    UCSCi uc008jxe.2. mouse.

    Organism-specific databases

    MGIi MGI:107636. Scn9a.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00560000076721.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    InParanoidi Q62205.
    OMAi LMNVSQN.
    OrthoDBi EOG7DJSK9.
    PhylomeDBi Q62205.
    TreeFami TF323985.

    Miscellaneous databases

    PROi Q62205.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62205.
    CleanExi MM_SCN9A.
    Genevestigatori Q62205.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view ]
    PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Mouse sodium channel 25 in m13mp19."
      Jover E., Shah V.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1675-1983.
      Tissue: Brain.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1740-1983.
      Tissue: Fetal brain.
    4. "Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2."
      Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S.
      J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NEDD4 AND NEDD4L, UBIQUITINATION.
    5. "Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain."
      Nassar M.A., Stirling L.C., Forlani G., Baker M.D., Matthews E.A., Dickenson A.H., Wood J.N.
      Proc. Natl. Acad. Sci. U.S.A. 101:12706-12711(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMATORY PAIN.

    Entry informationi

    Entry nameiSCN9A_MOUSE
    AccessioniPrimary (citable) accession number: Q62205
    Secondary accession number(s): A2ASI7, Q5DTI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3