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Q62205

- SCN9A_MOUSE

UniProt

Q62205 - SCN9A_MOUSE

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Protein
Sodium channel protein type 9 subunit alpha
Gene
Scn9a, Kiaa4197
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in pain mechanisms, especially in the development of inflammatory pain.1 Publication

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RefGenome

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. inflammatory response Source: MGI
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: RefGenome
  5. post-embryonic development Source: MGI
  6. response to toxic substance Source: MGI
  7. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 9 subunit alpha
Alternative name(s):
Peripheral sodium channel 1
Short name:
PN1
Sodium channel protein type IX subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.7
Gene namesi
Name:Scn9a
Synonyms:Kiaa4197
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107636. Scn9a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei122 – 14524Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei154 – 17320Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei187 – 20519Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei212 – 23120Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei248 – 27124Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei379 – 40426Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei738 – 76225Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei774 – 79724Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei806 – 82520Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei832 – 85120Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei868 – 88821Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei942 – 96726Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei1186 – 120924Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1223 – 124826Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1255 – 127622Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1281 – 130222Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1322 – 134928Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1429 – 145527Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1509 – 153224Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1544 – 156724Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1574 – 159724Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1608 – 162922Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1645 – 166723Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1734 – 175825Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19841984Sodium channel protein type 9 subunit alpha
PRO_0000048503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi867 – 8671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi974 – 9741N-linked (GlcNAc...) Reviewed prediction
Modified residuei1488 – 14881Phosphoserine; by PKC By similarity

Post-translational modificationi

Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.1 Publication
Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62205.
PRIDEiQ62205.

PTM databases

PhosphoSiteiQ62205.

Expressioni

Gene expression databases

BgeeiQ62205.
CleanExiMM_SCN9A.
GenevestigatoriQ62205.

Interactioni

Subunit structurei

Interacts with NEDD4 and NEDD4L.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ62205.
SMRiQ62205. Positions 128-267, 753-967, 1186-1456, 1506-1914.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati121 – 405285I
Add
BLAST
Repeati737 – 968232II
Add
BLAST
Repeati1185 – 1456272III
Add
BLAST
Repeati1508 – 1759252IV
Add
BLAST
Domaini1887 – 191630IQ
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili402 – 44948 Reviewed prediction
Add
BLAST
Coiled coili684 – 70825 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00560000076721.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ62205.
OMAiLMNVSQN.
OrthoDBiEOG7DJSK9.
PhylomeDBiQ62205.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62205-1 [UniParc]FASTAAdd to Basket

« Hide

MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 300
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA 350
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV 400
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL 450
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS 500
KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR 550
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID 650
KATSDDSGTT NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE 700
ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT 750
ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL VFTGIFAAEM VLKLIAMDPY 800
EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT 850
LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE 900
NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV 950
MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY 1000
VKQTLREFIL KSFSKKPKGS KDTKRTADPN NKRENYISNR TLAEISKDHN 1050
FLKEKDKISG FSSSLDKSFM DENDYQSFIH NPSLTVTVPI APGESDLENM 1100
NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE AEPINADEPE 1150
ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 1200
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT 1250
YFTNAWCWLD FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS 1300
RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYECVN 1350
TTDGSRFSVS QVANRSECFA LMNVSGNVRW KNLKVNFDNV GLGYLSLLQV 1400
ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII FGSFFTLNLF 1450
IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 1500
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV 1550
VFIILFTGEC VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY 1600
FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF 1650
LVMFIYAIFG MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG 1700
LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV 1750
NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 1800
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE 1850
SGEMDSLRSQ MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR 1900
YRLRQNVKNI SSIYIKDGDR DDDLPNKEDI VFDNVNENSS PEKTDATAST 1950
ISPPSYDSVT KPDQEKYETD KTEKEDKEKD ESRK 1984
Length:1,984
Mass (Da):225,813
Last modified:January 9, 2007 - v2
Checksum:i51A8DBA38EC7EF38
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623, AL928726 Genomic DNA. Translation: CAM19365.1.
AL928726, AL928623 Genomic DNA. Translation: CAM23210.1.
L42338 mRNA. Translation: AAA67106.1.
AK220540 mRNA. Translation: BAD90315.1.
CCDSiCCDS71063.1.
RefSeqiNP_001277603.1. NM_001290674.1.
UniGeneiMm.440889.

Genome annotation databases

EnsembliENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316.
ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316.
GeneIDi20274.
UCSCiuc008jxe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 , AL928726 Genomic DNA. Translation: CAM19365.1 .
AL928726 , AL928623 Genomic DNA. Translation: CAM23210.1 .
L42338 mRNA. Translation: AAA67106.1 .
AK220540 mRNA. Translation: BAD90315.1 .
CCDSi CCDS71063.1.
RefSeqi NP_001277603.1. NM_001290674.1.
UniGenei Mm.440889.

3D structure databases

ProteinModelPortali Q62205.
SMRi Q62205. Positions 128-267, 753-967, 1186-1456, 1506-1914.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62205.

Proteomic databases

PaxDbi Q62205.
PRIDEi Q62205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100064 ; ENSMUSP00000097642 ; ENSMUSG00000075316 .
ENSMUST00000164384 ; ENSMUSP00000126528 ; ENSMUSG00000075316 .
GeneIDi 20274.
UCSCi uc008jxe.2. mouse.

Organism-specific databases

MGIi MGI:107636. Scn9a.
Rougei Search...

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00560000076721.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q62205.
OMAi LMNVSQN.
OrthoDBi EOG7DJSK9.
PhylomeDBi Q62205.
TreeFami TF323985.

Miscellaneous databases

PROi Q62205.
SOURCEi Search...

Gene expression databases

Bgeei Q62205.
CleanExi MM_SCN9A.
Genevestigatori Q62205.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view ]
PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Mouse sodium channel 25 in m13mp19."
    Jover E., Shah V.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1675-1983.
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1740-1983.
    Tissue: Fetal brain.
  4. "Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2."
    Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S.
    J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEDD4 AND NEDD4L, UBIQUITINATION.
  5. "Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain."
    Nassar M.A., Stirling L.C., Forlani G., Baker M.D., Matthews E.A., Dickenson A.H., Wood J.N.
    Proc. Natl. Acad. Sci. U.S.A. 101:12706-12711(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN INFLAMMATORY PAIN.

Entry informationi

Entry nameiSCN9A_MOUSE
AccessioniPrimary (citable) accession number: Q62205
Secondary accession number(s): A2ASI7, Q5DTI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi