UniProtKB - Q62205 (SCN9A_MOUSE)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Sodium channel protein type 9 subunit alpha
Gene
Scn9a
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (PubMed:15123669). It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:15314237).By similarity2 Publications
GO - Molecular functioni
- sodium ion binding Source: Ensembl
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: UniProtKB
GO - Biological processi
- behavioral response to pain Source: MGI
- inflammatory response Source: MGI
- membrane depolarization during action potential Source: GO_Central
- neuronal action potential Source: GO_Central
- post-embryonic development Source: MGI
- regulation of ion transmembrane transport Source: UniProtKB-KW
- response to toxic substance Source: MGI
- sensory perception of pain Source: UniProtKB
- sodium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-5576892. Phase 0 - rapid depolarisation. |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel protein type 9 subunit alphaBy similarityAlternative name(s): Peripheral sodium channel 1 Short name: PN1By similarity Sodium channel protein type IX subunit alpha Voltage-gated sodium channel subunit alpha Nav1.7 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107636. Scn9a. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 126 | CytoplasmicCuratedAdd BLAST | 126 | |
Transmembranei | 127 – 145 | Helical; Name=S1 of repeat IBy similarityAdd BLAST | 19 | |
Topological domaini | 146 – 152 | ExtracellularCurated | 7 | |
Transmembranei | 153 – 173 | Helical; Name=S2 of repeat IBy similarityAdd BLAST | 21 | |
Topological domaini | 174 – 187 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 188 – 205 | Helical; Name=S3 of repeat IBy similarityAdd BLAST | 18 | |
Topological domaini | 206 – 211 | ExtracellularCurated | 6 | |
Transmembranei | 212 – 228 | Helical; Name=S4 of repeat IBy similarityAdd BLAST | 17 | |
Topological domaini | 229 – 247 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 248 – 267 | Helical; Name=S5 of repeat IBy similarityAdd BLAST | 20 | |
Topological domaini | 268 – 346 | ExtracellularCuratedAdd BLAST | 79 | |
Intramembranei | 347 – 371 | Pore-formingBy similarityAdd BLAST | 25 | |
Topological domaini | 372 – 378 | ExtracellularCurated | 7 | |
Transmembranei | 379 – 399 | Helical; Name=S6 of repeat IBy similarityAdd BLAST | 21 | |
Topological domaini | 400 – 743 | CytoplasmicCuratedAdd BLAST | 344 | |
Transmembranei | 744 – 762 | Helical; Name=S1 of repeat IIBy similarityAdd BLAST | 19 | |
Topological domaini | 763 – 773 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 774 – 793 | Helical; Name=S2 of repeat IIBy similarityAdd BLAST | 20 | |
Topological domaini | 794 – 807 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 808 – 827 | Helical; Name=S3 of repeat IIBy similarityAdd BLAST | 20 | |
Topological domaini | 828 – 829 | ExtracellularCurated | 2 | |
Transmembranei | 830 – 847 | Helical; Name=S4 of repeat IIBy similarityAdd BLAST | 18 | |
Topological domaini | 848 – 863 | CytoplasmicCuratedAdd BLAST | 16 | |
Transmembranei | 864 – 882 | Helical; Name=S5 of repeat IIBy similarityAdd BLAST | 19 | |
Topological domaini | 883 – 911 | ExtracellularCuratedAdd BLAST | 29 | |
Intramembranei | 912 – 932 | Pore-formingBy similarityAdd BLAST | 21 | |
Topological domaini | 933 – 945 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 946 – 966 | Helical; Name=S6 of repeat IIBy similarityAdd BLAST | 21 | |
Topological domaini | 967 – 1191 | CytoplasmicCuratedAdd BLAST | 225 | |
Transmembranei | 1192 – 1209 | Helical; Name=S1 of repeat IIIBy similarityAdd BLAST | 18 | |
Topological domaini | 1210 – 1222 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 1223 – 1241 | Helical; Name=S2 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1242 – 1255 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 1256 – 1274 | Helical; Name=S3 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1275 – 1282 | ExtracellularCurated | 8 | |
Transmembranei | 1283 – 1301 | Helical; Name=S4 of repeat IIIBy similarityAdd BLAST | 19 | |
Topological domaini | 1302 – 1318 | CytoplasmicCuratedAdd BLAST | 17 | |
Transmembranei | 1319 – 1338 | Helical; Name=S5 of repeat IIIBy similarityAdd BLAST | 20 | |
Topological domaini | 1339 – 1390 | ExtracellularCuratedAdd BLAST | 52 | |
Intramembranei | 1391 – 1412 | Pore-formingBy similarityAdd BLAST | 22 | |
Topological domaini | 1413 – 1429 | ExtracellularCuratedAdd BLAST | 17 | |
Transmembranei | 1430 – 1451 | Helical; Name=S6 of repeat IIIBy similarityAdd BLAST | 22 | |
Topological domaini | 1452 – 1514 | CytoplasmicCuratedAdd BLAST | 63 | |
Transmembranei | 1515 – 1532 | Helical; Name=S1 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1533 – 1543 | ExtracellularCuratedAdd BLAST | 11 | |
Transmembranei | 1544 – 1562 | Helical; Name=S2 of repeat IVBy similarityAdd BLAST | 19 | |
Topological domaini | 1563 – 1574 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 1575 – 1592 | Helical; Name=S3 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1593 – 1605 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 1606 – 1622 | Helical; Name=S4 of repeat IVBy similarityAdd BLAST | 17 | |
Topological domaini | 1623 – 1641 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 1642 – 1659 | Helical; Name=S5 of repeat IVBy similarityAdd BLAST | 18 | |
Topological domaini | 1660 – 1681 | ExtracellularCuratedAdd BLAST | 22 | |
Intramembranei | 1682 – 1704 | Pore-formingBy similarityAdd BLAST | 23 | |
Topological domaini | 1705 – 1734 | ExtracellularCuratedAdd BLAST | 30 | |
Transmembranei | 1735 – 1757 | Helical; Name=S6 of repeat IVBy similarityAdd BLAST | 23 | |
Topological domaini | 1758 – 1984 | CytoplasmicCuratedAdd BLAST | 227 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048503 | 1 – 1984 | Sodium channel protein type 9 subunit alphaAdd BLAST | 1984 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 275 ↔ 324 | By similarity | ||
Disulfide bondi | 894 | Interchain; with SCN2B or SCN4BBy similarity | ||
Disulfide bondi | 894 | Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)By similarity | ||
Disulfide bondi | 934 ↔ 943 | By similarity | ||
Modified residuei | 1488 | Phosphoserine; by PKCBy similarity | 1 |
Post-translational modificationi
Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.1 Publication
Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.By similarity
Keywords - PTMi
Disulfide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q62205. |
PaxDbi | Q62205. |
PRIDEi | Q62205. |
PTM databases
iPTMneti | Q62205. |
PhosphoSitePlusi | Q62205. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000075316. |
CleanExi | MM_SCN9A. |
ExpressionAtlasi | Q62205. baseline and differential. |
Genevisiblei | Q62205. MM. |
Interactioni
Subunit structurei
The sodium channel complex consists of a large, channel-forming alpha subunit and 2-3 smaller, ancillary beta subunits (By similarity). Interacts with NEDD4 and NEDD4L. Interacts with the conotoxin GVIIJ (By similarity).By similarity1 Publication
Protein-protein interaction databases
BioGridi | 203104. 2 interactors. |
STRINGi | 10090.ENSMUSP00000097641. |
Chemistry databases
BindingDBi | Q62205. |
Structurei
3D structure databases
ProteinModelPortali | Q62205. |
SMRi | Q62205. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 112 – 410 | ICuratedAdd BLAST | 299 | |
Repeati | 725 – 988 | IICuratedAdd BLAST | 264 | |
Repeati | 1178 – 1486 | IIICuratedAdd BLAST | 309 | |
Repeati | 1495 – 1793 | IVCuratedAdd BLAST | 299 | |
Domaini | 1887 – 1916 | IQAdd BLAST | 30 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 402 – 449 | Sequence analysisAdd BLAST | 48 | |
Coiled coili | 684 – 708 | Sequence analysisAdd BLAST | 25 |
Domaini
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated
Sequence similaritiesi
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. [View classification]Curated
Keywords - Domaini
Coiled coil, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2301. Eukaryota. ENOG410XNP6. LUCA. |
GeneTreei | ENSGT00830000128242. |
HOGENOMi | HOG000231755. |
HOVERGENi | HBG053100. |
InParanoidi | Q62205. |
KOi | K04841. |
OMAi | RQKCPPW. |
OrthoDBi | EOG091G00FK. |
PhylomeDBi | Q62205. |
TreeFami | TF323985. |
Family and domain databases
Gene3Di | 1.20.120.350. 4 hits. |
InterProi | View protein in InterPro IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. IPR024583. Na_trans_cytopl. IPR028803. SCN9A. IPR027359. Volt_channel_dom_sf. |
PANTHERi | PTHR10037:SF221. PTHR10037:SF221. 1 hit. |
Pfami | View protein in Pfam PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. PF11933. Na_trans_cytopl. 1 hit. |
PRINTSi | PR00170. NACHANNEL. |
SMARTi | View protein in SMART SM00015. IQ. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q62205-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS
60 70 80 90 100
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF
110 120 130 140 150
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD
160 170 180 190 200
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
210 220 230 240 250
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
260 270 280 290 300
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK
310 320 330 340 350
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA
360 370 380 390 400
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV
410 420 430 440 450
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL
460 470 480 490 500
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS
510 520 530 540 550
KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR
560 570 580 590 600
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN
610 620 630 640 650
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID
660 670 680 690 700
KATSDDSGTT NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE
710 720 730 740 750
ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT
760 770 780 790 800
ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL VFTGIFAAEM VLKLIAMDPY
810 820 830 840 850
EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT
860 870 880 890 900
LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE
910 920 930 940 950
NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV
960 970 980 990 1000
MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY
1010 1020 1030 1040 1050
VKQTLREFIL KSFSKKPKGS KDTKRTADPN NKRENYISNR TLAEISKDHN
1060 1070 1080 1090 1100
FLKEKDKISG FSSSLDKSFM DENDYQSFIH NPSLTVTVPI APGESDLENM
1110 1120 1130 1140 1150
NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE AEPINADEPE
1160 1170 1180 1190 1200
ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI
1210 1220 1230 1240 1250
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT
1260 1270 1280 1290 1300
YFTNAWCWLD FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS
1310 1320 1330 1340 1350
RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYECVN
1360 1370 1380 1390 1400
TTDGSRFSVS QVANRSECFA LMNVSGNVRW KNLKVNFDNV GLGYLSLLQV
1410 1420 1430 1440 1450
ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII FGSFFTLNLF
1460 1470 1480 1490 1500
IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN
1510 1520 1530 1540 1550
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV
1560 1570 1580 1590 1600
VFIILFTGEC VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY
1610 1620 1630 1640 1650
FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
1660 1670 1680 1690 1700
LVMFIYAIFG MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG
1710 1720 1730 1740 1750
LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV
1760 1770 1780 1790 1800
NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL
1810 1820 1830 1840 1850
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE
1860 1870 1880 1890 1900
SGEMDSLRSQ MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR
1910 1920 1930 1940 1950
YRLRQNVKNI SSIYIKDGDR DDDLPNKEDI VFDNVNENSS PEKTDATAST
1960 1970 1980
ISPPSYDSVT KPDQEKYETD KTEKEDKEKD ESRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928623, AL928726 Genomic DNA. Translation: CAM19365.1. AL928726, AL928623 Genomic DNA. Translation: CAM23210.1. L42338 mRNA. Translation: AAA67106.1. AK220540 mRNA. Translation: BAD90315.1. |
CCDSi | CCDS71063.1. |
RefSeqi | NP_001277603.1. NM_001290674.1. |
UniGenei | Mm.440889. |
Genome annotation databases
Ensembli | ENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316. ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316. |
GeneIDi | 20274. |
KEGGi | mmu:20274. |
UCSCi | uc008jxe.4. mouse. |
Similar proteinsi
Entry informationi
Entry namei | SCN9A_MOUSE | |
Accessioni | Q62205Primary (citable) accession number: Q62205 Secondary accession number(s): A2ASI7, Q5DTI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | January 9, 2007 | |
Last modified: | February 28, 2018 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |