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Protein

CD180 antigen

Gene

Cd180

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.1 Publication

GO - Molecular functioni

GO - Biological processi

  • B cell proliferation involved in immune response Source: MGI
  • cellular response to lipopolysaccharide Source: MGI
  • inflammatory response Source: GO_Central
  • innate immune response Source: UniProtKB-KW
  • positive regulation of lipopolysaccharide-mediated signaling pathway Source: MGI
  • toll-like receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
CD180 antigen
Alternative name(s):
Lymphocyte antigen 78
Short name:
Ly-78
Radioprotective 105 kDa protein
CD_antigen: CD180
Gene namesi
Name:Cd180
Synonyms:Ly78, Rp105
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1194924. Cd180.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 626ExtracellularAdd BLAST606
Transmembranei627 – 650HelicalSequence analysisAdd BLAST24
Topological domaini651 – 661CytoplasmicAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003474221 – 661CD180 antigenAdd BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)1 Publication1
Glycosylationi53N-linked (GlcNAc...)1 Publication1
Glycosylationi70N-linked (GlcNAc...)1 Publication1
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)1 Publication1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)1 Publication1
Glycosylationi402N-linked (GlcNAc...)1 Publication1
Glycosylationi451N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62192.
PaxDbiQ62192.
PRIDEiQ62192.

PTM databases

iPTMnetiQ62192.
PhosphoSitePlusiQ62192.

Expressioni

Tissue specificityi

B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.

Gene expression databases

BgeeiENSMUSG00000021624.
CleanExiMM_CD180.
ExpressionAtlasiQ62192. baseline and differential.
GenevisibleiQ62192. MM.

Interactioni

Subunit structurei

M-shaped tetramer of two CD180-LY86 heterodimers.1 Publication

Protein-protein interaction databases

DIPiDIP-30961N.
IntActiQ62192. 1 interactor.
STRINGi10090.ENSMUSP00000022124.

Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Turni33 – 35Combined sources3
Beta strandi36 – 38Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi66 – 68Combined sources3
Beta strandi80 – 83Combined sources4
Turni94 – 99Combined sources6
Beta strandi105 – 107Combined sources3
Beta strandi114 – 116Combined sources3
Turni118 – 121Combined sources4
Beta strandi129 – 131Combined sources3
Helixi140 – 142Combined sources3
Beta strandi153 – 155Combined sources3
Beta strandi177 – 179Combined sources3
Helixi190 – 194Combined sources5
Turni195 – 198Combined sources4
Beta strandi201 – 205Combined sources5
Turni216 – 221Combined sources6
Beta strandi223 – 228Combined sources6
Helixi235 – 241Combined sources7
Turni242 – 244Combined sources3
Beta strandi246 – 251Combined sources6
Helixi265 – 273Combined sources9
Beta strandi274 – 280Combined sources7
Turni291 – 296Combined sources6
Beta strandi301 – 304Combined sources4
Beta strandi325 – 327Combined sources3
Helixi336 – 339Combined sources4
Helixi341 – 343Combined sources3
Beta strandi348 – 351Combined sources4
Turni365 – 368Combined sources4
Beta strandi374 – 376Combined sources3
Beta strandi384 – 388Combined sources5
Turni389 – 394Combined sources6
Beta strandi400 – 402Combined sources3
Beta strandi409 – 411Combined sources3
Turni413 – 418Combined sources6
Beta strandi423 – 426Combined sources4
Turni440 – 443Combined sources4
Beta strandi449 – 451Combined sources3
Turni462 – 467Combined sources6
Beta strandi473 – 475Combined sources3
Helixi482 – 484Combined sources3
Helixi491 – 494Combined sources4
Beta strandi500 – 502Combined sources3
Turni513 – 518Combined sources6
Beta strandi524 – 526Combined sources3
Helixi534 – 540Combined sources7
Beta strandi547 – 549Combined sources3
Helixi560 – 562Combined sources3
Helixi563 – 567Combined sources5
Beta strandi569 – 573Combined sources5
Helixi583 – 585Combined sources3
Helixi586 – 594Combined sources9
Helixi596 – 598Combined sources3
Helixi602 – 604Combined sources3
Beta strandi606 – 610Combined sources5
Helixi611 – 613Combined sources3
Helixi618 – 620Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T6QX-ray1.90A/B21-626[»]
ProteinModelPortaliQ62192.
SMRiQ62192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 53LRRNTAdd BLAST21
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati201 – 221LRR 7Add BLAST21
Repeati275 – 296LRR 8Add BLAST22
Repeati299 – 321LRR 9Add BLAST23
Repeati322 – 343LRR 10Add BLAST22
Repeati346 – 366LRR 11Add BLAST21
Repeati371 – 391LRR 12Add BLAST21
Repeati397 – 418LRR 13Add BLAST22
Repeati421 – 442LRR 14Add BLAST22
Repeati446 – 466LRR 15Add BLAST21
Repeati470 – 493LRR 16Add BLAST24
Repeati497 – 518LRR 17Add BLAST22
Repeati521 – 544LRR 18Add BLAST24
Repeati546 – 566LRR 19Add BLAST21
Domaini577 – 627LRRCTAdd BLAST51

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000146395.
HOVERGENiHBG050848.
InParanoidiQ62192.
KOiK06555.
OMAiTEAFKEC.
OrthoDBiEOG091G01RC.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDISCFFL VALFLASCRA TTSSDQKCIE KEVNKTYNCE NLGLNEIPGT
60 70 80 90 100
LPNSTECLEF SFNVLPTIQN TTFSRLINLT FLDLTRCQIY WIHEDTFQSQ
110 120 130 140 150
HRLDTLVLTA NPLIFMAETA LSGPKALKHL FFIQTGISSI DFIPLHNQKT
160 170 180 190 200
LESLYLGSNH ISSIKLPKGF PTEKLKVLDF QNNAIHYLSK EDMSSLQQAT
210 220 230 240 250
NLSLNLNGND IAGIELGAFD SAVFQSLNFG GTQNLLVIFK GLKNSTIQSL
260 270 280 290 300
WLGTFEDMDD EDISPAVFEG LCEMSVESIN LQKHYFFNIS SNTFHCFSGL
310 320 330 340 350
QELDLTATHL SELPSGLVGL STLKKLVLSA NKFENLCQIS ASNFPSLTHL
360 370 380 390 400
SIKGNTKRLE LGTGCLENLE NLRELDLSHD DIETSDCCNL QLRNLSHLQS
410 420 430 440 450
LNLSYNEPLS LKTEAFKECP QLELLDLAFT RLKVKDAQSP FQNLHLLKVL
460 470 480 490 500
NLSHSLLDIS SEQLFDGLPA LQHLNLQGNH FPKGNIQKTN SLQTLGRLEI
510 520 530 540 550
LVLSFCDLSS IDQHAFTSLK MMNHVDLSHN RLTSSSIEAL SHLKGIYLNL
560 570 580 590 600
ASNRISIILP SLLPILSQQR TINLRQNPLD CTCSNIYFLE WYKENMQKLE
610 620 630 640 650
DTEDTLCENP PLLRGVRLSD VTLSCSMAAV GIFFLIVFLL VFAILLIFAV
660
KYFLRWKYQH I
Length:661
Mass (Da):74,302
Last modified:July 27, 2011 - v2
Checksum:i12F91AAB4224602E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22T → D AA sequence (PubMed:7897216).Curated1
Sequence conflicti24S → N AA sequence (PubMed:7897216).Curated1
Sequence conflicti28C → L AA sequence (PubMed:7897216).Curated1
Sequence conflicti216L → P in BAA07043 (PubMed:7897216).Curated1
Sequence conflicti554R → H in BAA07043 (PubMed:7897216).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37797 mRNA. Translation: BAA07043.1.
AK089255 mRNA. Translation: BAC40816.1.
CCDSiCCDS26741.1.
PIRiI56258.
RefSeqiNP_032559.2. NM_008533.2.
UniGeneiMm.373974.

Genome annotation databases

EnsembliENSMUST00000022124; ENSMUSP00000022124; ENSMUSG00000021624.
GeneIDi17079.
KEGGimmu:17079.
UCSCiuc007rry.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37797 mRNA. Translation: BAA07043.1.
AK089255 mRNA. Translation: BAC40816.1.
CCDSiCCDS26741.1.
PIRiI56258.
RefSeqiNP_032559.2. NM_008533.2.
UniGeneiMm.373974.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T6QX-ray1.90A/B21-626[»]
ProteinModelPortaliQ62192.
SMRiQ62192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-30961N.
IntActiQ62192. 1 interactor.
STRINGi10090.ENSMUSP00000022124.

PTM databases

iPTMnetiQ62192.
PhosphoSitePlusiQ62192.

Proteomic databases

MaxQBiQ62192.
PaxDbiQ62192.
PRIDEiQ62192.

Protocols and materials databases

DNASUi17079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022124; ENSMUSP00000022124; ENSMUSG00000021624.
GeneIDi17079.
KEGGimmu:17079.
UCSCiuc007rry.1. mouse.

Organism-specific databases

CTDi4064.
MGIiMGI:1194924. Cd180.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000146395.
HOVERGENiHBG050848.
InParanoidiQ62192.
KOiK06555.
OMAiTEAFKEC.
OrthoDBiEOG091G01RC.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiR-MMU-166016. Toll Like Receptor 4 (TLR4) Cascade.

Miscellaneous databases

PROiQ62192.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021624.
CleanExiMM_CD180.
ExpressionAtlasiQ62192. baseline and differential.
GenevisibleiQ62192. MM.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCD180_MOUSE
AccessioniPrimary (citable) accession number: Q62192
Secondary accession number(s): Q8C251
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.