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Protein

U1 small nuclear ribonucleoprotein A

Gene

Snrpa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U1 small nuclear ribonucleoprotein A
Short name:
U1 snRNP A
Short name:
U1-A
Short name:
U1A
Gene namesi
Name:Snrpa
Synonyms:Rnu1a-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1855690. Snrpa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287U1 small nuclear ribonucleoprotein APRO_0000081888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ62189.
MaxQBiQ62189.
PaxDbiQ62189.
PeptideAtlasiQ62189.
PRIDEiQ62189.
TopDownProteomicsiQ62189.

PTM databases

iPTMnetiQ62189.
PhosphoSiteiQ62189.

Expressioni

Gene expression databases

BgeeiQ62189.
CleanExiMM_SNRPA.
ExpressionAtlasiQ62189. baseline and differential.
GenevisibleiQ62189. MM.

Interactioni

Subunit structurei

U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SFPQ; component of a snRNP-free complex with SFPQ (By similarity).By similarity

Protein-protein interaction databases

BioGridi207327. 1 interaction.
IntActiQ62189. 1 interaction.
MINTiMINT-1867254.
STRINGi10090.ENSMUSP00000079228.

Structurei

3D structure databases

ProteinModelPortaliQ62189.
SMRiQ62189. Positions 9-123, 200-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini213 – 28775RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi145 – 21167Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM U1 A/B'' family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4206. Eukaryota.
ENOG410XPZI. LUCA.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000217519.
HOVERGENiHBG000895.
InParanoidiQ62189.
KOiK11091.
OMAiVQPVPGM.
OrthoDBiEOG77DJ77.
PhylomeDBiQ62189.
TreeFamiTF313834.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. RRM_U1_A/B''.
[Graphical view]
PANTHERiPTHR10501. PTHR10501. 1 hit.
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIATMPVP ETRANHTIYI NNLNEKIKKD ELKKSLYAIF SQFGQILDIL
60 70 80 90 100
VSRIMKMRGQ AFVIFKEVTS ATNALRSMQG FPFYDKPMRI QYAKTDSDII
110 120 130 140 150
AKMKGTYVER DRKREKRKPK SQETPAAKKA VQGGAAAPVV GAVQPVPGMP
160 170 180 190 200
PMPQAPRIMH HMPGQPPYMP PPGMIPPPGL APGQIPPGAM PPQQLMPGQM
210 220 230 240 250
PPAQPLSENP PNHILFLTNL PEETNELMLS MLFNQFPGFK EVRLVPGRHD
260 270 280
IAFVEFDNEV QAGAARDALQ GFKITQNNAM KISFAKK
Length:287
Mass (Da):31,835
Last modified:January 23, 2007 - v3
Checksum:iEEAFEC9A793759FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15447 mRNA. Translation: AAC37611.1.
BC003229 mRNA. Translation: AAH03229.1.
BC094006 mRNA. Translation: AAH94006.1.
BC096648 mRNA. Translation: AAH96648.1.
CCDSiCCDS21014.1.
PIRiS42113. S42114.
RefSeqiNP_001040102.1. NM_001046637.1.
NP_001272754.1. NM_001285825.1.
NP_056597.3. NM_015782.3.
UniGeneiMm.386890.

Genome annotation databases

EnsembliENSMUST00000080356; ENSMUSP00000079228; ENSMUSG00000061479.
ENSMUST00000122202; ENSMUSP00000113678; ENSMUSG00000061479.
ENSMUST00000163311; ENSMUSP00000131897; ENSMUSG00000061479.
GeneIDi53607.
KEGGimmu:53607.
UCSCiuc009fvg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15447 mRNA. Translation: AAC37611.1.
BC003229 mRNA. Translation: AAH03229.1.
BC094006 mRNA. Translation: AAH94006.1.
BC096648 mRNA. Translation: AAH96648.1.
CCDSiCCDS21014.1.
PIRiS42113. S42114.
RefSeqiNP_001040102.1. NM_001046637.1.
NP_001272754.1. NM_001285825.1.
NP_056597.3. NM_015782.3.
UniGeneiMm.386890.

3D structure databases

ProteinModelPortaliQ62189.
SMRiQ62189. Positions 9-123, 200-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207327. 1 interaction.
IntActiQ62189. 1 interaction.
MINTiMINT-1867254.
STRINGi10090.ENSMUSP00000079228.

PTM databases

iPTMnetiQ62189.
PhosphoSiteiQ62189.

Proteomic databases

EPDiQ62189.
MaxQBiQ62189.
PaxDbiQ62189.
PeptideAtlasiQ62189.
PRIDEiQ62189.
TopDownProteomicsiQ62189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080356; ENSMUSP00000079228; ENSMUSG00000061479.
ENSMUST00000122202; ENSMUSP00000113678; ENSMUSG00000061479.
ENSMUST00000163311; ENSMUSP00000131897; ENSMUSG00000061479.
GeneIDi53607.
KEGGimmu:53607.
UCSCiuc009fvg.1. mouse.

Organism-specific databases

CTDi6626.
MGIiMGI:1855690. Snrpa.

Phylogenomic databases

eggNOGiKOG4206. Eukaryota.
ENOG410XPZI. LUCA.
GeneTreeiENSGT00390000007046.
HOGENOMiHOG000217519.
HOVERGENiHBG000895.
InParanoidiQ62189.
KOiK11091.
OMAiVQPVPGM.
OrthoDBiEOG77DJ77.
PhylomeDBiQ62189.
TreeFamiTF313834.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ62189.
SOURCEiSearch...

Gene expression databases

BgeeiQ62189.
CleanExiMM_SNRPA.
ExpressionAtlasiQ62189. baseline and differential.
GenevisibleiQ62189. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR024888. RRM_U1_A/B''.
[Graphical view]
PANTHERiPTHR10501. PTHR10501. 1 hit.
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence analysis of the A protein of the U1 small nuclear ribonucleoprotein particle: the murine protein contains a 5' amino-terminal tag."
    Bennett M.M., Baron M.A., Craft J.
    Nucleic Acids Res. 21:4404-4404(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSNRPA_MOUSE
AccessioniPrimary (citable) accession number: Q62189
Secondary accession number(s): Q52LA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.