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Protein

Dihydropyrimidinase-related protein 3

Gene

Dpysl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-399956. CRMPs in Sema3A signaling.

Protein family/group databases

MEROPSiM38.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 3
Short name:
DRP-3
Alternative name(s):
Unc-33-like phosphoprotein 1
Short name:
ULIP-1
Gene namesi
Name:Dpysl3
Synonyms:Drp3, Ulip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1349762. Dpysl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Dihydropyrimidinase-related protein 3PRO_0000165918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei431 – 4311PhosphotyrosineCombined sources
Modified residuei499 – 4991PhosphotyrosineCombined sources
Modified residuei509 – 5091PhosphothreonineCombined sources
Modified residuei514 – 5141Phosphothreonine; by GSK3Combined sources
Modified residuei518 – 5181Phosphoserine; by GSK3Combined sources
Modified residuei522 – 5221Phosphoserine; by DYRK2Combined sources
Modified residuei536 – 5361PhosphoserineCombined sources
Modified residuei539 – 5391PhosphoserineCombined sources
Modified residuei541 – 5411PhosphoserineCombined sources
Modified residuei543 – 5431PhosphothreonineCombined sources

Post-translational modificationi

Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62188.
PaxDbiQ62188.
PeptideAtlasiQ62188.
PRIDEiQ62188.

2D gel databases

REPRODUCTION-2DPAGEIPI00122349.
Q62188.

PTM databases

iPTMnetiQ62188.
PhosphoSiteiQ62188.
SwissPalmiQ62188.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024501.
CleanExiMM_DPYSL3.
ExpressionAtlasiQ62188. baseline and differential.
GenevisibleiQ62188. MM.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity).By similarity

GO - Molecular functioni

  • filamin binding Source: MGI
  • phosphoprotein binding Source: BHF-UCL
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204437. 2 interactions.
IntActiQ62188. 2 interactions.
MINTiMINT-4093552.
STRINGi10090.ENSMUSP00000025379.

Structurei

3D structure databases

ProteinModelPortaliQ62188.
SMRiQ62188. Positions 12-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ62188.
PhylomeDBiQ62188.
TreeFamiTF314706.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62188-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI
60 70 80 90 100
VPGGVKTIEA NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPESSLTEAY EKWREWADGK SCCDYALHVD ITHWNDSVKQ
160 170 180 190 200
EVQSLSKEKG VNSFMVYMAY KDLYQVSNTE LYEIFTCLGE LGAIAQVHAE
210 220 230 240 250
NGDIIAQEQA RMLEMGITGP EGHVLSRPEE LEAEAVFRAI TVASQTNCPL
260 270 280 290 300
YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA
360 370 380 390 400
IPEGTNGVEE RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDSDLV IWDPDALKIV SAKNHQSVAE YNIFEGMELR GAPLVVICQG
460 470 480 490 500
KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK RIKARRKMAD LHAVPRGMYD
510 520 530 540 550
GPVFDLTTTP KGGTPAGSTR GSPTRPNPPV RNLHQSGFSL SGTQVDEGVR
560 570
SASKRIVAPP GGRSNITSLS
Length:570
Mass (Da):61,936
Last modified:November 1, 1996 - v1
Checksum:i14C339BF90015D96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87817 mRNA. Translation: CAA61082.1.
BC023003 mRNA. Translation: AAH23003.1.
CCDSiCCDS37801.1.
PIRiS55525.
RefSeqiNP_033494.1. NM_009468.5.
UniGeneiMm.428551.
Mm.8180.

Genome annotation databases

EnsembliENSMUST00000025379; ENSMUSP00000025379; ENSMUSG00000024501.
GeneIDi22240.
KEGGimmu:22240.
UCSCiuc008euh.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87817 mRNA. Translation: CAA61082.1.
BC023003 mRNA. Translation: AAH23003.1.
CCDSiCCDS37801.1.
PIRiS55525.
RefSeqiNP_033494.1. NM_009468.5.
UniGeneiMm.428551.
Mm.8180.

3D structure databases

ProteinModelPortaliQ62188.
SMRiQ62188. Positions 12-497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204437. 2 interactions.
IntActiQ62188. 2 interactions.
MINTiMINT-4093552.
STRINGi10090.ENSMUSP00000025379.

Protein family/group databases

MEROPSiM38.976.

PTM databases

iPTMnetiQ62188.
PhosphoSiteiQ62188.
SwissPalmiQ62188.

2D gel databases

REPRODUCTION-2DPAGEIPI00122349.
Q62188.

Proteomic databases

MaxQBiQ62188.
PaxDbiQ62188.
PeptideAtlasiQ62188.
PRIDEiQ62188.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025379; ENSMUSP00000025379; ENSMUSG00000024501.
GeneIDi22240.
KEGGimmu:22240.
UCSCiuc008euh.3. mouse.

Organism-specific databases

CTDi1809.
MGIiMGI:1349762. Dpysl3.

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ62188.
PhylomeDBiQ62188.
TreeFamiTF314706.

Enzyme and pathway databases

ReactomeiR-MMU-399956. CRMPs in Sema3A signaling.

Miscellaneous databases

ChiTaRSiDpysl3. mouse.
PROiQ62188.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024501.
CleanExiMM_DPYSL3.
ExpressionAtlasiQ62188. baseline and differential.
GenevisibleiQ62188. MM.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL3_MOUSE
AccessioniPrimary (citable) accession number: Q62188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.