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Protein

Transcription termination factor 1

Gene

Ttf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA replication inhibitor, DNA-binding
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

ReactomeiR-MMU-5683826. Surfactant metabolism.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73863. RNA Polymerase I Transcription Termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 1
Short name:
TTF-1
Alternative name(s):
RNA polymerase I termination factor
Transcription termination factor I
Short name:
TTF-I
Short name:
mTFF-I
Gene namesi
Name:Ttf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:105044. Ttf1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504731 – 859Transcription termination factor 1Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei451PhosphoserineBy similarity1
Modified residuei457PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Cross-linki673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei845PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ62187.
MaxQBiQ62187.
PaxDbiQ62187.
PeptideAtlasiQ62187.
PRIDEiQ62187.

PTM databases

iPTMnetiQ62187.
PhosphoSitePlusiQ62187.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026803.
CleanExiMM_TTF1.
GenevisibleiQ62187. MM.

Interactioni

Subunit structurei

Oligomer. The oligomeric structure enables to interact simultaneously with two separatee DNA fragments (PubMed:9092622). Interacts with BAZ2A/TIP5 (PubMed:15292447). Interacts with CAVIN1 (PubMed:9582279, PubMed:27528195).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BAZ2AQ9UIF93EBI-11705418,EBI-934890From Homo sapiens.

Protein-protein interaction databases

BioGridi204361. 2 interactors.
IntActiQ62187. 1 interactor.
STRINGi10090.ENSMUSP00000097809.

Structurei

3D structure databases

ProteinModelPortaliQ62187.
SMRiQ62187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini585 – 634Myb-like 1Add BLAST50
Domaini634 – 718Myb-like 2Add BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 210N-terminal region (NRD)Add BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi359 – 368Poly-Lys10

Domaini

The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0051. Eukaryota.
COG5147. LUCA.
GeneTreeiENSGT00530000063659.
HOGENOMiHOG000231811.
HOVERGENiHBG084694.
InParanoidiQ62187.
KOiK15225.
OMAiTLESEWP.
OrthoDBiEOG091G0QEE.
PhylomeDBiQ62187.
TreeFamiTF333537.

Family and domain databases

CDDicd00167. SANT. 1 hit.
InterProiView protein in InterPro
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
SMARTiView protein in SMART
SM00717. SANT. 2 hits.
PROSITEiView protein in PROSITE
PS50090. MYB_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGTSKFKT HTETLYKKKK WSSVSEKRPQ KCPSQCLESK QPQVSVLGKR
60 70 80 90 100
RRASQTPAQE TLESEWPQKA KRKKRRREPQ TPAQETLESE WPQKAKKKKR
110 120 130 140 150
RGEPQTPTQE SLESEQPPVS LLGKRRRESQ TPAQENSESE QPRKAKRRRK
160 170 180 190 200
KRKGSQQPTS SLLKTPETFL KAKKTTSAHK KKKNSVLEVD METGIILVDK
210 220 230 240 250
ENMENLLETS RKDVDIVYVD MSKGQRSAKV RETGELPAAK PQEHGCRELL
260 270 280 290 300
GDVRSRKKQK HLQKVAPWDV VQGSQPESIS LPPSEPLSSE DLEGKSTEAA
310 320 330 340 350
VFCKKKSKKN VFRSQELEPI PDSLDDSETI SERLDSTHHG GAVGAGEECE
360 370 380 390 400
STKESHSIKK KSKKKKHKSV ALATSSDSAS VTDSKAKNAL VDSSEGSGAV
410 420 430 440 450
REEDVDHRPA EAEAQACSTE KHREAMQRLE PTHEEESNSE SASNSAARHI
460 470 480 490 500
SEDRRESDDS DVDLGSAVRQ LREFIPDIQE RAATTIRRMY RDDLGRFKEF
510 520 530 540 550
KAQGVAIRFG KFSAKENKQI EKNVQDFLSL TGIESADKLL YTDRYPEEKT
560 570 580 590 600
LITNLKRKHA FRLHIGKGIA RPWKLVYYRA KKIFDVNNYK GRYNEEDTKK
610 620 630 640 650
LKAYHSLHGN DWKKIGAMVA RSSLSVALKF SQIGGTRNQG AWSKAETQRL
660 670 680 690 700
IKAVEDVILK KMSPQELREL DSKLQEDPEG RLSIVREKLY KGISWVEVEA
710 720 730 740 750
RVETRNWMQC KSKWTEILTK RMTHGGFVYR GVNALQAKIT LIERLYELNV
760 770 780 790 800
NDANEIDWED LASAIGDVPP PFVQAKFYKL KAACVPFWQK KTFPEIIDYL
810 820 830 840 850
YKNSLPLLKE KLDKKMKKKD GQIQTPAAPK QDFLFKDIFH CDDDSDEGSP

EEPSASDVQ
Length:859
Mass (Da):97,723
Last modified:October 3, 2006 - v2
Checksum:iD47950ECB3A08DCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72 – 96Missing in CAA58808 (PubMed:7720715).CuratedAdd BLAST25
Sequence conflicti305 – 307KKS → RSL in CAA58808 (PubMed:7720715).Curated3
Sequence conflicti348Missing in CAA58808 (PubMed:7720715).Curated1
Sequence conflicti496R → L AA sequence (PubMed:7720715).Curated1
Sequence conflicti762A → C in CAA58808 (PubMed:7720715).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83974 mRNA. Translation: CAA58808.1.
AF237703 mRNA. Translation: AAF43448.1.
BC059011 mRNA. Translation: AAH59011.1.
CCDSiCCDS38089.1.
PIRiS54776.
RefSeqiNP_033468.2. NM_009442.2.
XP_006497915.1. XM_006497852.1.
UniGeneiMm.252195.

Genome annotation databases

EnsembliENSMUST00000100237; ENSMUSP00000097809; ENSMUSG00000026803.
GeneIDi22130.
KEGGimmu:22130.
UCSCiuc008izk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTTF1_MOUSE
AccessioniPrimary (citable) accession number: Q62187
Secondary accession number(s): Q9JKK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 22, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot