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Protein

Translocon-associated protein subunit delta

Gene

Ssr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit delta
Short name:
TRAP-delta
Alternative name(s):
Signal sequence receptor subunit delta
Short name:
SSR-delta
Gene namesi
Name:Ssr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1099464. Ssr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 143120LumenalSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 1728CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 172149Translocon-associated protein subunit deltaPRO_0000033293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 56By similarity
Cross-linki72 – 72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ62186.
MaxQBiQ62186.
PaxDbiQ62186.
PRIDEiQ62186.

PTM databases

iPTMnetiQ62186.
PhosphoSiteiQ62186.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002014.
CleanExiMM_SSR4.
ExpressionAtlasiQ62186. baseline and differential.
GenevisibleiQ62186. MM.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.By similarity

Protein-protein interaction databases

BioGridi203511. 3 interactions.
IntActiQ62186. 1 interaction.
MINTiMINT-4997295.
STRINGi10090.ENSMUSP00000131386.

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-delta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOVERGENiHBG002293.
InParanoidiQ62186.
KOiK04571.
TreeFamiTF313158.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMASFGAL ALLLLSGLSC CSEACLEPQI TPSYYTTSDA VISTETVFIV
60 70 80 90 100
EISLTCKNRV QNMALYADVS GKQFPVTRGQ DVGRYQVSWS LEHKSAHAGT
110 120 130 140 150
YEVRFFDEES YSLLRKAQRN NEDVSIIPPL FTVSVDHRGT WNGPWVSTEV
160 170
LAAVIGIVIY YLAFSAKSHI QA
Length:172
Mass (Da):18,937
Last modified:November 1, 1996 - v1
Checksum:iAA8A9B9147046649
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90582 mRNA. Translation: CAA62210.1.
AF133093 Genomic DNA. No translation available.
CCDSiCCDS30213.1.
PIRiS59864.
RefSeqiNP_033305.1. NM_009279.3.
UniGeneiMm.831.

Genome annotation databases

EnsembliENSMUST00000002090; ENSMUSP00000002090; ENSMUSG00000002014.
GeneIDi20832.
KEGGimmu:20832.
UCSCiuc009tmr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90582 mRNA. Translation: CAA62210.1.
AF133093 Genomic DNA. No translation available.
CCDSiCCDS30213.1.
PIRiS59864.
RefSeqiNP_033305.1. NM_009279.3.
UniGeneiMm.831.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203511. 3 interactions.
IntActiQ62186. 1 interaction.
MINTiMINT-4997295.
STRINGi10090.ENSMUSP00000131386.

PTM databases

iPTMnetiQ62186.
PhosphoSiteiQ62186.

Proteomic databases

EPDiQ62186.
MaxQBiQ62186.
PaxDbiQ62186.
PRIDEiQ62186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002090; ENSMUSP00000002090; ENSMUSG00000002014.
GeneIDi20832.
KEGGimmu:20832.
UCSCiuc009tmr.2. mouse.

Organism-specific databases

CTDi6748.
MGIiMGI:1099464. Ssr4.

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOVERGENiHBG002293.
InParanoidiQ62186.
KOiK04571.
TreeFamiTF313158.

Miscellaneous databases

ChiTaRSiSsr4. mouse.
PROiQ62186.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002014.
CleanExiMM_SSR4.
ExpressionAtlasiQ62186. baseline and differential.
GenevisibleiQ62186. MM.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRD_MOUSE
AccessioniPrimary (citable) accession number: Q62186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.