Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semaphorin-3C

Gene

Sema3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.3 Publications

GO - Molecular functioni

  • semaphorin receptor binding Source: MGI

GO - Biological processi

  • axon guidance Source: UniProtKB
  • blood vessel remodeling Source: MGI
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  • heart development Source: MGI
  • limb bud formation Source: BHF-UCL
  • neural crest cell migration Source: MGI
  • neural tube development Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • post-embryonic development Source: MGI
  • pulmonary myocardium development Source: BHF-UCL
  • somitogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:Sema3c
Synonyms:Semae, SemE
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107557. Sema3c.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Perinatal lethality. Mice display severe defects in cardiovascular development, including aortic arch malformations and septation defects in the cardiac outflow tract.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 751731Semaphorin-3CPRO_0000032312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 112By similarity
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi130 ↔ 139By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi266 ↔ 378By similarity
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi290 ↔ 338By similarity
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi514 ↔ 532By similarity
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62181.
PaxDbiQ62181.
PRIDEiQ62181.

PTM databases

PhosphoSiteiQ62181.

Expressioni

Developmental stagei

Expressed from day 10 in the embryo. Maximum expression between days 10-12 with moderate levels from day 13 until birth.

Gene expression databases

BgeeiQ62181.
ExpressionAtlasiQ62181. baseline and differential.
GenevisibleiQ62181. MM.

Interactioni

Subunit structurei

Interacts with PLXND1.1 Publication

GO - Molecular functioni

  • semaphorin receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568.

Structurei

3D structure databases

ProteinModelPortaliQ62181.
SMRiQ62181. Positions 28-657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 511484SemaPROSITE-ProRule annotationAdd
BLAST
Domaini571 – 65585Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi714 – 7174Poly-Gln
Compositional biasi724 – 74522Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ62181.
KOiK06840.
OMAiAEIVQYG.
OrthoDBiEOG7034G7.
TreeFamiTF352628.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRAICVLV GVFICSICVR GSSQPQARVY LTFDELRETK TSEYFSLSHQ
60 70 80 90 100
QLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEPLSVF WPASTIKVEE
110 120 130 140 150
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED
160 170 180 190 200
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR
210 220 230 240 250
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKERLTD
260 270 280 290 300
NNRSTKQIHS MIARICPNDT GGQRSLVNKW TTFLKARLVC SVTDEDGPET
310 320 330 340 350
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN
360 370 380 390 400
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KDFPDDVVTF
410 420 430 440 450
IRNHPLMYNS IYPIHRRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG
460 470 480 490 500
TDRGTVQKVV VLPTNSSASG ELILEELEVF KNHVPITTMK ISSKKQQLYV
510 520 530 540 550
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS
560 570 580 590 600
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVRNNSTFL ECAPKSPQAS
610 620 630 640 650
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQDSDQGL YHCIATENSF
660 670 680 690 700
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA GSVRALPFHP KDILGAFSHS
710 720 730 740 750
EMQLINQYCK DTRQQQQLGE EPQKMRGDYG KLKALINSRK SRNRRNQLPE

S
Length:751
Mass (Da):85,289
Last modified:July 27, 2011 - v2
Checksum:i32537E9D664123EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2083NAV → MQL in CAA59986 (PubMed:7748561).Curated
Sequence conflicti412 – 4121Y → S in CAA59986 (PubMed:7748561).Curated
Sequence conflicti490 – 4901K → E in CAA59986 (PubMed:7748561).Curated
Sequence conflicti615 – 6151V → G in CAA59986 (PubMed:7748561).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA. Translation: CAA59986.1.
CH466586 Genomic DNA. Translation: EDL03234.1.
BC066852 mRNA. Translation: AAH66852.1.
CCDSiCCDS19099.1.
PIRiI48748.
RefSeqiNP_038685.3. NM_013657.5.
UniGeneiMm.5071.

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780.
GeneIDi20348.
KEGGimmu:20348.
UCSCiuc008wnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA. Translation: CAA59986.1.
CH466586 Genomic DNA. Translation: EDL03234.1.
BC066852 mRNA. Translation: AAH66852.1.
CCDSiCCDS19099.1.
PIRiI48748.
RefSeqiNP_038685.3. NM_013657.5.
UniGeneiMm.5071.

3D structure databases

ProteinModelPortaliQ62181.
SMRiQ62181. Positions 28-657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568.

PTM databases

PhosphoSiteiQ62181.

Proteomic databases

MaxQBiQ62181.
PaxDbiQ62181.
PRIDEiQ62181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780.
GeneIDi20348.
KEGGimmu:20348.
UCSCiuc008wnl.1. mouse.

Organism-specific databases

CTDi10512.
MGIiMGI:107557. Sema3c.

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ62181.
KOiK06840.
OMAiAEIVQYG.
OrthoDBiEOG7034G7.
TreeFamiTF352628.

Miscellaneous databases

NextBioi298195.
PROiQ62181.
SOURCEiSearch...

Gene expression databases

BgeeiQ62181.
ExpressionAtlasiQ62181. baseline and differential.
GenevisibleiQ62181. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension."
    Pueschel A.W., Adams R.H., Betz H.
    Neuron 14:941-948(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Embryo.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1.
    Tissue: Neural stem cell.
  4. "Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption."
    Feiner L., Webber A.L., Brown C.B., Lu M.M., Jia L., Feinstein P., Mombaerts P., Epstein J.A., Raper J.A.
    Development 128:3061-3070(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  5. "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development."
    Gitler A.D., Lu M.M., Epstein J.A.
    Dev. Cell 7:107-116(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PLXND1.
  6. "Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidance."
    Gonthier B., Nasarre C., Roth L., Perraut M., Thomasset N., Roussel G., Aunis D., Bagnard D.
    Cereb. Cortex 17:1712-1721(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSEM3C_MOUSE
AccessioniPrimary (citable) accession number: Q62181
Secondary accession number(s): Q6NXW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.