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Protein

Semaphorin-3C

Gene

Sema3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.3 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: MGI

GO - Biological processi

  • axon guidance Source: UniProtKB
  • blood vessel remodeling Source: MGI
  • cardiac right ventricle morphogenesis Source: BHF-UCL
  • dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  • heart development Source: MGI
  • limb bud formation Source: BHF-UCL
  • negative chemotaxis Source: GO_Central
  • negative regulation of axon extension involved in axon guidance Source: GO_Central
  • neural crest cell migration Source: MGI
  • neural tube development Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • positive regulation of cell migration Source: GO_Central
  • post-embryonic development Source: MGI
  • pulmonary myocardium development Source: BHF-UCL
  • semaphorin-plexin signaling pathway Source: GO_Central
  • somitogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:Sema3c
Synonyms:Semae, SemE
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107557. Sema3c.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Perinatal lethality. Mice display severe defects in cardiovascular development, including aortic arch malformations and septation defects in the cardiac outflow tract.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003231221 – 751Semaphorin-3CAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi101 ↔ 112By similarity
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi130 ↔ 139By similarity
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 378By similarity
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi290 ↔ 338By similarity
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi514 ↔ 532By similarity
Glycosylationi585N-linked (GlcNAc...)Sequence analysis1
Glycosylationi586N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62181.
PaxDbiQ62181.
PeptideAtlasiQ62181.
PRIDEiQ62181.

PTM databases

iPTMnetiQ62181.
PhosphoSitePlusiQ62181.

Expressioni

Developmental stagei

Expressed from day 10 in the embryo. Maximum expression between days 10-12 with moderate levels from day 13 until birth.

Gene expression databases

BgeeiENSMUSG00000028780.
ExpressionAtlasiQ62181. baseline and differential.
GenevisibleiQ62181. MM.

Interactioni

Subunit structurei

Interacts with PLXND1.1 Publication

GO - Molecular functioni

  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568.

Structurei

3D structure databases

ProteinModelPortaliQ62181.
SMRiQ62181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 511SemaPROSITE-ProRule annotationAdd BLAST484
Domaini571 – 655Ig-like C2-typeAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi714 – 717Poly-Gln4
Compositional biasi724 – 745Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ62181.
KOiK06840.
OMAiAEIVQYG.
OrthoDBiEOG091G01W0.
TreeFamiTF352628.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRAICVLV GVFICSICVR GSSQPQARVY LTFDELRETK TSEYFSLSHQ
60 70 80 90 100
QLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEPLSVF WPASTIKVEE
110 120 130 140 150
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED
160 170 180 190 200
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR
210 220 230 240 250
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKERLTD
260 270 280 290 300
NNRSTKQIHS MIARICPNDT GGQRSLVNKW TTFLKARLVC SVTDEDGPET
310 320 330 340 350
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN
360 370 380 390 400
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KDFPDDVVTF
410 420 430 440 450
IRNHPLMYNS IYPIHRRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG
460 470 480 490 500
TDRGTVQKVV VLPTNSSASG ELILEELEVF KNHVPITTMK ISSKKQQLYV
510 520 530 540 550
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS
560 570 580 590 600
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVRNNSTFL ECAPKSPQAS
610 620 630 640 650
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQDSDQGL YHCIATENSF
660 670 680 690 700
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA GSVRALPFHP KDILGAFSHS
710 720 730 740 750
EMQLINQYCK DTRQQQQLGE EPQKMRGDYG KLKALINSRK SRNRRNQLPE

S
Length:751
Mass (Da):85,289
Last modified:July 27, 2011 - v2
Checksum:i32537E9D664123EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206 – 208NAV → MQL in CAA59986 (PubMed:7748561).Curated3
Sequence conflicti412Y → S in CAA59986 (PubMed:7748561).Curated1
Sequence conflicti490K → E in CAA59986 (PubMed:7748561).Curated1
Sequence conflicti615V → G in CAA59986 (PubMed:7748561).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA. Translation: CAA59986.1.
CH466586 Genomic DNA. Translation: EDL03234.1.
BC066852 mRNA. Translation: AAH66852.1.
CCDSiCCDS19099.1.
PIRiI48748.
RefSeqiNP_038685.3. NM_013657.5.
UniGeneiMm.5071.

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780.
GeneIDi20348.
KEGGimmu:20348.
UCSCiuc008wnl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA. Translation: CAA59986.1.
CH466586 Genomic DNA. Translation: EDL03234.1.
BC066852 mRNA. Translation: AAH66852.1.
CCDSiCCDS19099.1.
PIRiI48748.
RefSeqiNP_038685.3. NM_013657.5.
UniGeneiMm.5071.

3D structure databases

ProteinModelPortaliQ62181.
SMRiQ62181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568.

PTM databases

iPTMnetiQ62181.
PhosphoSitePlusiQ62181.

Proteomic databases

MaxQBiQ62181.
PaxDbiQ62181.
PeptideAtlasiQ62181.
PRIDEiQ62181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780.
GeneIDi20348.
KEGGimmu:20348.
UCSCiuc008wnl.1. mouse.

Organism-specific databases

CTDi10512.
MGIiMGI:107557. Sema3c.

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ62181.
KOiK06840.
OMAiAEIVQYG.
OrthoDBiEOG091G01W0.
TreeFamiTF352628.

Miscellaneous databases

PROiQ62181.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028780.
ExpressionAtlasiQ62181. baseline and differential.
GenevisibleiQ62181. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3C_MOUSE
AccessioniPrimary (citable) accession number: Q62181
Secondary accession number(s): Q6NXW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.