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Q62168 (K1H2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha2
Alternative name(s):
Hair keratin, type I Ha2
Keratin-32
Short name=K32
Gene names
Name:Krt32
Synonyms:Hka2, Krt1-2, Krtha2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Cuticle of the hair shaft.

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Keratin, type I cuticular Ha2
PRO_0000063687

Regions

Region1 – 5555Head
Region56 – 362307Rod
Region56 – 9035Coil 1A
Region91 – 10111Linker 1
Region102 – 202101Coil 1B
Region203 – 21816Linker 12
Region219 – 362144Coil 2
Region363 – 40745Tail

Sites

Site3041Stutter

Experimental info

Sequence conflict2271M → V in CAA53304. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q62168 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 32D4D9FC1F1D642B

FASTA40746,422
        10         20         30         40         50         60 
MPSVCMPTTY RPASCLSKTY LSSSCQPSNR RPTGCISSSM GTYGLFCEGA FNGNEKETMQ 

        70         80         90        100        110        120 
VLNDRLANYL EKVRQLEKEN AELEGKIQDV YQGQVLTMCP DYQSYFQTIE ELQQKVLCTK 

       130        140        150        160        170        180 
AENARMIVHI DNAKLAADDF RTKYETELAL RQLVEADTNG LRRILDELTL NKADLEAQVE 

       190        200        210        220        230        240 
SLKEELLCLK RNHEEEVGVL RQQLGDRLNI EVDAAPPVDL TRMLEEMRCQ YETMVETNHR 

       250        260        270        280        290        300 
DVEEWFNMQM EELNKQVATS SEQLQSYQSD IIDLRRTVNT LEIELQAQHS LRDSLENTLG 

       310        320        330        340        350        360 
ETEGRFTSQL SQMQCMITNV ESQLSDIRCD LERQNQEYKV LLDVKARLEC EIDTYRGLLE 

       370        380        390        400 
SEDSKLPCNP CSTPSCQPCA PSPGVSRTVC VPHTVCVPCS PCLQTRY 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and expression of murine type I hair keratins mHa2 and mHa3."
Winter H., Siry P., Tobiasch E., Schweizer J.
Exp. Cell Res. 212:190-200(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NMRI.
Tissue: Hair.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75649 mRNA. Translation: CAA53304.1.
CH466662 Genomic DNA. Translation: EDL02584.1.
BC117553 mRNA. Translation: AAI17554.1.
BC118064 mRNA. Translation: AAI18065.1.
PIRI48739.
RefSeqNP_001152846.2. NM_001159374.2.
UniGeneMm.4161.

3D structure databases

ProteinModelPortalQ62168.
SMRQ62168. Positions 58-90, 105-203, 273-360.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000103042.

PTM databases

PhosphoSiteQ62168.

Proteomic databases

PaxDbQ62168.
PRIDEQ62168.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16670.
KEGGmmu:16670.

Organism-specific databases

CTD3882.
MGIMGI:1309995. Krt32.

Phylogenomic databases

eggNOGNOG149251.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ148N4.
KOK07604.

Gene expression databases

BgeeQ62168.
CleanExMM_KRT32.
GenevestigatorQ62168.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290395.
PROQ62168.
SOURCESearch...

Entry information

Entry nameK1H2_MOUSE
AccessionPrimary (citable) accession number: Q62168
Secondary accession number(s): Q148N4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot