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Protein

Keratin, type I cuticular Ha2

Gene

Krt32

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei304 – 3041Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha2
Alternative name(s):
Hair keratin, type I Ha2
Keratin-32
Short name:
K32
Gene namesi
Name:Krt32
Synonyms:Hka2, Krt1-2, Krtha2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1309995. Krt32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Keratin, type I cuticular Ha2PRO_0000063687Add
BLAST

Proteomic databases

PaxDbiQ62168.
PRIDEiQ62168.

PTM databases

PhosphoSiteiQ62168.

Expressioni

Tissue specificityi

Cuticle of the hair shaft.

Gene expression databases

BgeeiQ62168.
CleanExiMM_KRT32.
ExpressionAtlasiQ62168. baseline and differential.
GenevisibleiQ62168. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103042.

Structurei

3D structure databases

ProteinModelPortaliQ62168.
SMRiQ62168. Positions 105-203, 273-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5555HeadAdd
BLAST
Regioni56 – 362307RodAdd
BLAST
Regioni56 – 9035Coil 1AAdd
BLAST
Regioni91 – 10111Linker 1Add
BLAST
Regioni102 – 202101Coil 1BAdd
BLAST
Regioni203 – 21816Linker 12Add
BLAST
Regioni219 – 362144Coil 2Add
BLAST
Regioni363 – 40745TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149251.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ62168.
KOiK07604.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62168-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVCMPTTY RPASCLSKTY LSSSCQPSNR RPTGCISSSM GTYGLFCEGA
60 70 80 90 100
FNGNEKETMQ VLNDRLANYL EKVRQLEKEN AELEGKIQDV YQGQVLTMCP
110 120 130 140 150
DYQSYFQTIE ELQQKVLCTK AENARMIVHI DNAKLAADDF RTKYETELAL
160 170 180 190 200
RQLVEADTNG LRRILDELTL NKADLEAQVE SLKEELLCLK RNHEEEVGVL
210 220 230 240 250
RQQLGDRLNI EVDAAPPVDL TRMLEEMRCQ YETMVETNHR DVEEWFNMQM
260 270 280 290 300
EELNKQVATS SEQLQSYQSD IIDLRRTVNT LEIELQAQHS LRDSLENTLG
310 320 330 340 350
ETEGRFTSQL SQMQCMITNV ESQLSDIRCD LERQNQEYKV LLDVKARLEC
360 370 380 390 400
EIDTYRGLLE SEDSKLPCNP CSTPSCQPCA PSPGVSRTVC VPHTVCVPCS

PCLQTRY
Length:407
Mass (Da):46,422
Last modified:July 27, 2011 - v2
Checksum:i32D4D9FC1F1D642B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271M → V in CAA53304 (PubMed:7514534).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75649 mRNA. Translation: CAA53304.1.
CH466662 Genomic DNA. Translation: EDL02584.1.
BC117553 mRNA. Translation: AAI17554.1.
BC118064 mRNA. Translation: AAI18065.1.
PIRiI48739.
RefSeqiNP_001152846.2. NM_001159374.2.
UniGeneiMm.4161.

Genome annotation databases

GeneIDi16670.
KEGGimmu:16670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75649 mRNA. Translation: CAA53304.1.
CH466662 Genomic DNA. Translation: EDL02584.1.
BC117553 mRNA. Translation: AAI17554.1.
BC118064 mRNA. Translation: AAI18065.1.
PIRiI48739.
RefSeqiNP_001152846.2. NM_001159374.2.
UniGeneiMm.4161.

3D structure databases

ProteinModelPortaliQ62168.
SMRiQ62168. Positions 105-203, 273-360.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103042.

PTM databases

PhosphoSiteiQ62168.

Proteomic databases

PaxDbiQ62168.
PRIDEiQ62168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16670.
KEGGimmu:16670.

Organism-specific databases

CTDi3882.
MGIiMGI:1309995. Krt32.

Phylogenomic databases

eggNOGiNOG149251.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ62168.
KOiK07604.

Miscellaneous databases

NextBioi290395.
PROiQ62168.
SOURCEiSearch...

Gene expression databases

BgeeiQ62168.
CleanExiMM_KRT32.
ExpressionAtlasiQ62168. baseline and differential.
GenevisibleiQ62168. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression of murine type I hair keratins mHa2 and mHa3."
    Winter H., Siry P., Tobiasch E., Schweizer J.
    Exp. Cell Res. 212:190-200(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NMRI.
    Tissue: Hair.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiK1H2_MOUSE
AccessioniPrimary (citable) accession number: Q62168
Secondary accession number(s): Q148N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.