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Q62168

- K1H2_MOUSE

UniProt

Q62168 - K1H2_MOUSE

Protein

Keratin, type I cuticular Ha2

Gene

Krt32

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei304 – 3041Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha2
    Alternative name(s):
    Hair keratin, type I Ha2
    Keratin-32
    Short name:
    K32
    Gene namesi
    Name:Krt32
    Synonyms:Hka2, Krt1-2, Krtha2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1309995. Krt32.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Keratin, type I cuticular Ha2PRO_0000063687Add
    BLAST

    Proteomic databases

    PaxDbiQ62168.
    PRIDEiQ62168.

    PTM databases

    PhosphoSiteiQ62168.

    Expressioni

    Tissue specificityi

    Cuticle of the hair shaft.

    Gene expression databases

    BgeeiQ62168.
    CleanExiMM_KRT32.
    GenevestigatoriQ62168.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000103042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62168.
    SMRiQ62168. Positions 58-90, 105-203, 273-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5555HeadAdd
    BLAST
    Regioni56 – 362307RodAdd
    BLAST
    Regioni56 – 9035Coil 1AAdd
    BLAST
    Regioni91 – 10111Linker 1Add
    BLAST
    Regioni102 – 202101Coil 1BAdd
    BLAST
    Regioni203 – 21816Linker 12Add
    BLAST
    Regioni219 – 362144Coil 2Add
    BLAST
    Regioni363 – 40745TailAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG149251.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ148N4.
    KOiK07604.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSVCMPTTY RPASCLSKTY LSSSCQPSNR RPTGCISSSM GTYGLFCEGA    50
    FNGNEKETMQ VLNDRLANYL EKVRQLEKEN AELEGKIQDV YQGQVLTMCP 100
    DYQSYFQTIE ELQQKVLCTK AENARMIVHI DNAKLAADDF RTKYETELAL 150
    RQLVEADTNG LRRILDELTL NKADLEAQVE SLKEELLCLK RNHEEEVGVL 200
    RQQLGDRLNI EVDAAPPVDL TRMLEEMRCQ YETMVETNHR DVEEWFNMQM 250
    EELNKQVATS SEQLQSYQSD IIDLRRTVNT LEIELQAQHS LRDSLENTLG 300
    ETEGRFTSQL SQMQCMITNV ESQLSDIRCD LERQNQEYKV LLDVKARLEC 350
    EIDTYRGLLE SEDSKLPCNP CSTPSCQPCA PSPGVSRTVC VPHTVCVPCS 400
    PCLQTRY 407
    Length:407
    Mass (Da):46,422
    Last modified:July 27, 2011 - v2
    Checksum:i32D4D9FC1F1D642B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271M → V in CAA53304. (PubMed:7514534)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75649 mRNA. Translation: CAA53304.1.
    CH466662 Genomic DNA. Translation: EDL02584.1.
    BC117553 mRNA. Translation: AAI17554.1.
    BC118064 mRNA. Translation: AAI18065.1.
    PIRiI48739.
    RefSeqiNP_001152846.2. NM_001159374.2.
    UniGeneiMm.4161.

    Genome annotation databases

    GeneIDi16670.
    KEGGimmu:16670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75649 mRNA. Translation: CAA53304.1 .
    CH466662 Genomic DNA. Translation: EDL02584.1 .
    BC117553 mRNA. Translation: AAI17554.1 .
    BC118064 mRNA. Translation: AAI18065.1 .
    PIRi I48739.
    RefSeqi NP_001152846.2. NM_001159374.2.
    UniGenei Mm.4161.

    3D structure databases

    ProteinModelPortali Q62168.
    SMRi Q62168. Positions 58-90, 105-203, 273-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000103042.

    PTM databases

    PhosphoSitei Q62168.

    Proteomic databases

    PaxDbi Q62168.
    PRIDEi Q62168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16670.
    KEGGi mmu:16670.

    Organism-specific databases

    CTDi 3882.
    MGIi MGI:1309995. Krt32.

    Phylogenomic databases

    eggNOGi NOG149251.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q148N4.
    KOi K07604.

    Miscellaneous databases

    NextBioi 290395.
    PROi Q62168.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62168.
    CleanExi MM_KRT32.
    Genevestigatori Q62168.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and expression of murine type I hair keratins mHa2 and mHa3."
      Winter H., Siry P., Tobiasch E., Schweizer J.
      Exp. Cell Res. 212:190-200(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NMRI.
      Tissue: Hair.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiK1H2_MOUSE
    AccessioniPrimary (citable) accession number: Q62168
    Secondary accession number(s): Q148N4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3