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Protein

Rho GDP-dissociation inhibitor 3

Gene

Arhgdig

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

GO - Molecular functioni

  • GDP-dissociation inhibitor activity Source: MGI
  • GTPase activator activity Source: UniProtKB-KW
  • GTPase regulator activity Source: MGI
  • Rho GDP-dissociation inhibitor activity Source: InterPro

GO - Biological processi

  • regulation of protein localization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 3
Short name:
Rho GDI 3
Alternative name(s):
Rho-GDI gamma
Rho-GDI2
Gene namesi
Name:Arhgdig
Synonyms:Gdi5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:108430. Arhgdig.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190191 – 225Rho GDP-dissociation inhibitor 3Add BLAST225

Proteomic databases

PaxDbiQ62160.
PRIDEiQ62160.

PTM databases

iPTMnetiQ62160.
PhosphoSitePlusiQ62160.

Expressioni

Tissue specificityi

Detected only in brain, lung, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000073433.
CleanExiMM_ARHGDIG.
ExpressionAtlasiQ62160. baseline and differential.
GenevisibleiQ62160. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025019.

Structurei

3D structure databases

ProteinModelPortaliQ62160.
SMRiQ62160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ62160.
KOiK12462.
OMAiMLGLDAC.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ62160.
TreeFamiTF105387.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLDACELG EQLLELLRLA LCARVLLADK DGESTPSDEV LDEIVPEYQA
60 70 80 90 100
PGKKSMLAIW QLDPGDVSLV KYKQALLGPL PPIMDPSLPN VQVTRLTLLT
110 120 130 140 150
EQAPGPIIMD LTGDLDALKN QVFVLKEGIE YKVKITFKVN KEIVSGLKCL
160 170 180 190 200
HHTYRRGLRV DKAIFMVGSY GPRAQEYEFV TSVEEAPRGA LARGLYVVRS
210 220
LFTDDDRLNH LSWEWHLHVC QDWKD
Length:225
Mass (Da):25,296
Last modified:November 1, 1997 - v1
Checksum:iBBCA9B71AC9AAED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42463 mRNA. Translation: AAC37704.1.
U73198 mRNA. Translation: AAB18196.1.
BC002032 mRNA. Translation: AAH02032.1.
CCDSiCCDS28548.1.
RefSeqiNP_032139.1. NM_008113.3.
UniGeneiMm.1383.

Genome annotation databases

EnsembliENSMUST00000025019; ENSMUSP00000025019; ENSMUSG00000073433.
ENSMUST00000176961; ENSMUSP00000135717; ENSMUSG00000073433.
GeneIDi14570.
KEGGimmu:14570.
UCSCiuc008bdp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42463 mRNA. Translation: AAC37704.1.
U73198 mRNA. Translation: AAB18196.1.
BC002032 mRNA. Translation: AAH02032.1.
CCDSiCCDS28548.1.
RefSeqiNP_032139.1. NM_008113.3.
UniGeneiMm.1383.

3D structure databases

ProteinModelPortaliQ62160.
SMRiQ62160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025019.

PTM databases

iPTMnetiQ62160.
PhosphoSitePlusiQ62160.

Proteomic databases

PaxDbiQ62160.
PRIDEiQ62160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025019; ENSMUSP00000025019; ENSMUSG00000073433.
ENSMUST00000176961; ENSMUSP00000135717; ENSMUSG00000073433.
GeneIDi14570.
KEGGimmu:14570.
UCSCiuc008bdp.1. mouse.

Organism-specific databases

CTDi398.
MGIiMGI:108430. Arhgdig.

Phylogenomic databases

eggNOGiKOG3205. Eukaryota.
ENOG4111K44. LUCA.
GeneTreeiENSGT00390000006233.
HOGENOMiHOG000175765.
HOVERGENiHBG000206.
InParanoidiQ62160.
KOiK12462.
OMAiMLGLDAC.
OrthoDBiEOG091G0MBU.
PhylomeDBiQ62160.
TreeFamiTF105387.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ62160.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073433.
CleanExiMM_ARHGDIG.
ExpressionAtlasiQ62160. baseline and differential.
GenevisibleiQ62160. MM.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGDIR3_MOUSE
AccessioniPrimary (citable) accession number: Q62160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.