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Protein

Rho-related GTP-binding protein RhoC

Gene

Rhoc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi117 – 120GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-416572 Sema4D induced cell migration and growth-cone collapse
R-MMU-5625740 RHO GTPases activate PKNs
R-MMU-5625900 RHO GTPases activate CIT
R-MMU-5627117 RHO GTPases Activate ROCKs
R-MMU-5663220 RHO GTPases Activate Formins

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Alternative name(s):
Silica-induced gene 61 protein
Short name:
SIG-61
Gene namesi
Name:Rhoc
Synonyms:Arhc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106028 Rhoc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420241 – 190Rho-related GTP-binding protein RhoCAdd BLAST190
PropeptideiPRO_0000042025191 – 193Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190Cysteine methyl esterBy similarity1
Lipidationi190S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ62159
MaxQBiQ62159
PaxDbiQ62159
PeptideAtlasiQ62159
PRIDEiQ62159
TopDownProteomicsiQ62159

PTM databases

iPTMnetiQ62159
PhosphoSitePlusiQ62159
SwissPalmiQ62159

Expressioni

Inductioni

Up-regulated in silica-treated macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000002233
CleanExiMM_RHOC
ExpressionAtlasiQ62159 baseline and differential
GenevisibleiQ62159 MM

Interactioni

Subunit structurei

Interacts with RTKN (PubMed:8662891). Interacts with AKAP13. Interacts with DIAPH1 (By similarity). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2. Interacts with ARHGDIA. Interacts with RIPOR1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi198197, 2 interactors
IntActiQ62159, 3 interactors
MINTiQ62159
STRINGi10090.ENSMUSP00000002303

Structurei

3D structure databases

ProteinModelPortaliQ62159
SMRiQ62159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ62159
KOiK07857
OMAiWISEVVH
OrthoDBiEOG091G0QVS
PhylomeDBiQ62159
TreeFamiTF300837

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR
160 170 180 190
ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL
Length:193
Mass (Da):22,006
Last modified:April 13, 2004 - v2
Checksum:iA193DA581560F131
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → Q in CAA56682 (PubMed:7868905).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80638 mRNA Translation: CAA56682.1
AK011599 mRNA Translation: BAB27724.1
AK152802 mRNA Translation: BAE31507.1
AK160650 mRNA Translation: BAE35941.1
BC004627 mRNA Translation: AAH04627.1
CCDSiCCDS17704.1
RefSeqiNP_001278788.1, NM_001291859.1
NP_031510.2, NM_007484.2
UniGeneiMm.262

Genome annotation databases

EnsembliENSMUST00000002303; ENSMUSP00000002303; ENSMUSG00000002233
ENSMUST00000106787; ENSMUSP00000102399; ENSMUSG00000002233
ENSMUST00000196817; ENSMUSP00000142697; ENSMUSG00000002233
GeneIDi11853
KEGGimmu:11853
UCSCiuc008qul.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRHOC_MOUSE
AccessioniPrimary (citable) accession number: Q62159
Secondary accession number(s): Q3TUN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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